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endometrial cancer diagnosis

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https://www.readbyqxmd.com/read/27914067/5q-syndrome-like-features-as-the-first-manifestation-of-myelodysplastic-syndrome-in-a-patient-with-an-unbalanced-whole-arm-translocation-der-5-19-p10-q10
#1
Hiroshi Ureshino, Haruna Kizuka, Kana Kusaba, Haruhiko Sano, Atsujiro Nishioka, Takero Shindo, Yasushi Kubota, Toshihiko Ando, Kensuke Kojima, Shinya Kimura
Derivative (5;19)(p10;q10) [der(5;19)(p10;q10)] is a rare chromosomal abnormality in myelodysplastic syndrome (MDS), and is genetically similar to deletion 5q [del(5q)]. However, MDS with der(5;19)(p10;q10) and 5q- syndrome are generally characterized as distinct subtypes. Here, we report a case of a patient with 5q- syndrome-like features as the first manifestation of MDS with der(5; 19)(p10;q10). A 59-year-old woman was admitted to our hospital for anemia without leukopenia and thrombocytopenia. She had received chemotherapy comprising carboplatin and docetaxel for endometrial cancer eight years before...
December 2, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27903147/weight-loss-randomized-intervention-trials-in-female-cancer-survivors
#2
Rowan T Chlebowski, Marina M Reeves
Purpose Observational study evidence has associated overweight/obesity with decreased survival in women with breast cancer and with several other cancers. Although full-scale, definitive weight loss adjuvant intervention trials with cancer end points remain to be conducted, a number of randomized controlled trials have evaluated weight loss interventions in survivors of cancer in women. Findings from these trials in breast, endometrial, and ovarian cancer are reviewed. Methods A systematic review of randomized controlled clinical trials evaluating weight loss interventions was updated (for studies published 2013 to 2016), and clinical trials registers were searched for ongoing trials...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27899185/genetic-predisposition-in-gynecologic-cancers
#3
REVIEW
Molly S Daniels, Karen H Lu
This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27891577/statin-use-and-risk-of-endometrial-cancer-a-nationwide-registry-based-case-control-study
#4
Cecilie Dyg Sperling, Freija Verdoodt, Søren Friis, Christian Dehlendorff, Susanne K Kjaer
INTRODUCTION: Laboratory and epidemiological evidence have suggested that statin use may protect against the development of certain cancers, including endometrial cancer. In a nationwide registry-based case-control study, we examined the association between statin use and risk of endometrial cancer. MATERIAL AND METHODS: Cases were female residents of Denmark with a primary diagnosis of endometrial cancer during 2000-2009. For each case, we selected 15 female population controls matched on date of birth (± 1 month) using risk-set sampling...
November 27, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27869363/is-the-memorial-sloan-kettering-cancer-centre-mskcc-sarcoma-nomogram-useful-in-an-asian-population
#5
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Cindy Xindi Lim, Soo Khee Chee, Richard Hong Hui Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: A nomogram for prediction of 12-year sarcoma-specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven. MATERIALS AND METHODS: Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore...
November 21, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27865222/endometrial-tuberculosis-simulating-an-ovarian-cancer-a-case-report
#6
Silvia Eleonora Di Giovanni, Teresa Margarida Cunha, Ana Luisa Duarte, Ines Alves
Female genital tuberculosis remains a major health problem in developing countries and is an important cause of infertility. As symptoms, laboratory data and physical findings are non-specific, its diagnosis can be difficult. We describe a case of a 39-year-old woman suffering from peri-umbilical pain and increased abdominal size for one year, anorexia, asthenia, weight loss, occasionally dysuria and dyspareunia, and four months amenorrhea. Laboratory data revealed cancer antigen 125 (CA-125) level of 132.3 U/mL, erythrocyte sedimentation rate of 42 mm/h, and gamma-globulins of 2...
June 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27863382/an-early-screening-biomarker-of-endometrial-carcinoma-ngal-is-associated-with-epithelio-mesenchymal-transition
#7
Ting Li, Li Yu, Jia Wen, Qinping Liao, Zhaohui Liu
neutrophilgelatinase-associated lipocalin is currently one of the most interesting and enigmatic proteins involved in the development of malignancies. In this study, we found that the expression of neutrophilgelatinase-associated lipocalin was up-regulated in endometrial cancer tissues and cell lines, significantly increased in early-grade ones, suggesting it may serve as a biomarker for early-stage screening for endometrial carcinoma. Moreover, neutrophilgelatinase-associated lipocalin was up-regulated in Ishikawa cells under going epithelio-mesenchymal transition induced by epidermal growth factor (5 ng/ml)...
November 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27861200/imaging-of-hereditary-tumors-of-the-female-genital-system
#8
Sarah M Rothan, Christine O Menias, Yehia M ElGuindy, Corey T Jensen, Akram Shaaban, Priya Bhosale, Michelle V Lee, Venkata S Katabathina, Khaled M Elsayes
Cancers of the female genital system, particularly endometrial and ovarian cancers, can be associated with hereditary cancer syndromes such as hereditary breast and ovarian cancer and Lynch syndrome. Cancers that are found in the setting of a hereditary cancer syndrome are often unique in presentation, clinical features, and pathologic profiles when compared with sporadic tumors. This article reviews the hereditary cancer syndromes associated with gynecological malignancies, as well as the imaging findings and staging system of endometrial and ovarian cancers...
November 17, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27847479/understanding-molecular-landscape-of-endometrial-cancer-through-next-generation-sequencing-what-we-have-learned-so-far
#9
Siti-Syazani Suhaimi, Nurul-Syakima Ab Mutalib, Rahman Jamal
Endometrial cancer (EC) is among the most common gynecological cancers affecting women worldwide. Despite the early detection and rather high overall survival rate, around 20% of the cases recur with poor prognosis. The Next Generation Sequencing (NGS) technology, also known as massively parallel sequencing, symbolizes a high-throughput, fast, sensitive and accurate way to study the molecular landscape of a cancer and this has indeed revolutionized endometrial cancer research. Understanding the potential, advantages, and limitations of NGS will be crucial for the healthcare providers and scientists in providing the genome-driven care in this era of precision medicine and pharmacogenomics...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27834005/figo-stage-iiic-endometrial-cancer-identification-among-patients-with-complex-atypical-hyperplasia-grade-1-and-2-endometrioid-endometrial-cancer-laparoscopic-indocyanine-green-sentinel-lymph-node-mapping-versus-frozen-section-of-the-uterus-why-get-around-the
#10
Andrea Papadia, Maria Luisa Gasparri, Franziska Siegenthaler, Sara Imboden, Stefan Mohr, Michael D Mueller
PURPOSE: To compare two surgical strategies used to identify lymph node metastases in patients with preoperative diagnosis of complex atypical hyperplasia (CAH), grade 1 and 2 endometrial cancer (EC). METHODS: Data on patients with preoperative diagnosis of CAH, grade 1 and 2 EC undergoing laparoscopic indocyanine green (ICG) sentinel lymph node (SLN) mapping followed by frozen section of the uterus were collected. When risk factors were identified at frozen section, patients were subjected to a systematic lymphadenectomy...
November 11, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27831653/a-study-of-ccnd1-with-epithelial-ovarian-cancer-cell-proliferation-and-apoptosis
#11
J Dai, R-J Wei, R Li, J-B Feng, Y-L Yu, P-S Liu
OBJECTIVE: Ovarian cancer is a gynecological malignancy with high mortality rates all over the world. Markers for diagnosis, prognosis and therapy are urgently required to improve the mortality rates. As a key proto-oncogene, CCND1 is known to be amplified in many different carcinomas, including breast cancer, esophageal cancer, bladder cancer, endometrial cancer and ovarian cancer, etc. CCND1 plays an important role in cancer development and progression. However, its function and mechanism have not been completely elucidated in ovarian cancer...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27829198/role-of-diffusion-weighted-mri-in-the-differential-diagnosis-of-endometrial-cancer-polyp-hyperplasia-and-physiological-thickening
#12
Baris Bakir, Sükrü Sanli, Vuslat Lale Bakir, Selcuk Ayas, Sevda Ozel Yildiz, Ahmet Cem Iyibozkurt, Merve Gülbiz Kartal, Ekrem Yavuz
Our purpose was to evaluate the role of diffusion-weighted imaging (DWI) in the diagnosis of various common pathologies of the uterine cavity, by comparing them with contrast-enhanced MRI findings. One hundred sixty-four patients with lesions in endometrial cavity were included in the study. The patients were grouped in four (one malignant and three benign groups). We have observed that the differences of the apparent diffusion coefficient, b1000q, and Cq values between various common benign and malignant lesions were statistically significant (P<...
October 20, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27829038/long-term-secondary-care-costs-of-endometrial-cancer-a-prospective-cohort-study-nested-within-the-united-kingdom-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#13
Mark Pennington, Aleksandra Gentry-Maharaj, Chloe Karpinskyj, Alec Miners, Julie Taylor, Ranjit Manchanda, Rema Iyer, Michelle Griffin, Andy Ryan, Ian Jacobs, Usha Menon, Rosa Legood
BACKGROUND: There is limited evidence on the costs of Endometrial Cancer (EC) by stage of disease. We estimated the long-term secondary care costs of EC according to stage at diagnosis in an English population-based cohort. METHODS: Women participating in UKCTOCS and diagnosed with EC following enrolment (2001-2005) and prior to 31st Dec 2009 were identified to have EC through multiple sources. Survival was calculated through data linkage to death registry. Costs estimates were derived from hospital records accessed from Hospital Episode Statistics (HES) with additional patient level covariates derived from case notes and patient questionnaires...
2016: PloS One
https://www.readbyqxmd.com/read/27822422/association-of-insulin-resistance-with-breast-ovarian-endometrial-and-cervical-cancers-in-non-diabetic-women
#14
Wanwan Sun, Jieli Lu, Shengli Wu, Yufang Bi, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Tao Yang, Li Yan, Qin Wan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao, Qing Su, Zhen Ye, Youmin Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Tiange Wang, Jichao Sun, Min Xu, Yu Xu, Yuhong Chen, Meng Dai, Jie Zhang, Di Zhang, Shenghan Lai, Donghui Li, Guang Ning, Weiqing Wang
Hyperinsulinemia and insulin resistance were reported to play a crucial role in diabetes-cancer relationship. This study aimed to explore the associations between insulin resistance and several female cancers in a non-diabetic population. This cross-sectional study was conducted in 121,230 middle-aged and elderly non-diabetic women. Cancer diagnosis was self-reported and further validated by medical records. Insulin resistance was defined as homeostasis model assessment of insulin resistance (HOMA-IR) ≥ 2...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27822395/generational-expression-of-muir-torre-syndrome-in-a-canadian-family
#15
Kaitlin Alexandra Vanderbeck, R Gary Sibbald, Nirosha Murugan
Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Recently she presented with two nodular lesions. Histologic examination confirmed these lesions to be sebaceous neoplasms. The patient has a history of endometrial and colorectal adenocarcinoma as well as several nonspecific sebaceous lesions throughout her life...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#16
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27818130/structured-imaging-technique-in-the-gynecologic-office-for-the-diagnosis-of-abnormal-uterine-bleeding
#17
REVIEW
Margit Dueholm, Ina Marie D Hjorth
: The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27817223/discovery-of-biomarkers-for-endometrial-cancer-current-status-and-prospects
#18
Tea Lanišnik Rižner
Endometrial cancer is the most frequent gynecological malignancy in the developed world. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid noninvasive diagnostic methods available. Biomarkers for endometrial cancer would be invaluable for screening of high-risk women, detection of primary and recurrent disease, and preoperative stratification of patients as high-risk and low-risk categories, enabling personalized therapeutic approaches. Areas covered: This report reviews publications of blood biomarkers evaluated in patients with endometrial cancer and/or control patients, over the last five years...
December 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27817040/female-infertility-infertility-associated-diagnoses-and-comorbidities-a-review
#19
REVIEW
Brent Hanson, Erica Johnstone, Jessie Dorais, Bob Silver, C Matthew Peterson, James Hotaling
PURPOSE: The purpose of the study is to evaluate existing literature for possible associations between female infertility, infertility-associated diagnoses, and the following areas of disease: psychiatric disorders, breast cancer, ovarian cancer, endometrial cancer, cardiovascular disease, and metabolic dysfunction. METHODS: The design of the study is a literature review. The patients were women included in 26 selected studies due to a diagnosis of infertility or a reproductive disorder associated with infertility...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27816832/the-nature-of-early-stage-endometrial-cancer-recurrence-a-national-cohort-study
#20
Mette Moustgaard Jeppesen, Pernille Tine Jensen, Dorte Gilså Hansen, Maria Iachina, Ole Mogensen
BACKGROUND AND AIMS: The aim of the study was to present a comprehensive analysis of disease recurrence in a large Danish cohort of women with early-stage endometrial cancer treated according to national guidelines. METHODS: All women diagnosed with stage I or II endometrial cancer in 2005-2009 were included in a population-based historical cohort derived from the Danish Gynaecological Cancer Database. Disease recurrence up to 3 years after the primary diagnosis was identified using national registers and hospital charts...
November 3, 2016: European Journal of Cancer
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