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https://www.readbyqxmd.com/read/29344385/improving-attendance-to-genetic-counselling-services-for-gynaecological-oncology-patients
#1
Hanoon P Pokharel, Neville F Hacker, Lesley Andrews
Background: Gynaecological cancers may be the sentinel malignancy in women who carry a mutation in BRCA1 or 2, a mis-match repair gene causing Lynch Syndrome or other genes. Despite published guidelines for referral to a genetics service, a substantial number of women do not attend for the recommended genetic assessment. The study aims to determine the outcomes of systematic follow-up of patients diagnosed with ovarian or endometrial cancer from Gynaecologic-oncology multidisciplinary meetings who were deemed appropriate for genetics assessment...
2018: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29333623/evaluation-of-universal-immunohistochemical-screening-of-sebaceous-neoplasms-in-a-service-setting
#2
K Schon, E Rytina, J Drummond, J Simmonds, S Abbs, R Sandford, M Tischkowitz
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies. AIM: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting...
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29329881/defining-and-mitigating-the-challenges-of-an-older-and-obese-population-in-minimally-invasive-gynecologic-cancer-surgery
#3
Andrea R Hagemann, Carolyn K McCourt, Swarup S Varaday, Kathleen N Moore
The incidence of endometrial cancer (EC) is steadily increasing due in large part to an aging world population and rise in rates of obesity. Patients with obesity and advancing age can be seen as vulnerable populations, as they are both often subject to physician bias regarding surgical choices and assumptions regarding long-term outcomes. As we operate on an older and/or obese patient population, it is increasingly important that we adopt peri-operative management strategies and surgical techniques to best serve this complex patient population...
January 9, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29324539/trial-of-optimal-personalised-care-after-treatment-gynaecological-cancer-topcat-g-a-randomized-feasibility-trial
#4
Val Morrison, Llinos H Spencer, Nikki Totton, Kirstie Pye, Seow Tien Yeo, Caryl Butterworth, Liz Hall, Rhiannon Whitaker, Rhiannon Tudor Edwards, Laura J Timmis, Zoe Hoare, Richard D Neal, Clare Wilkinson, Simon Leeson
OBJECTIVE: This study aimed to evaluate the feasibility of completing a parallel-group randomized controlled trial to compare usual follow-up care for women who have completed treatment of gynecological cancer against a nurse-led telephone intervention, known as Optimal Personalised Care After Treatment-Gynaecological. METHODS: The unblinded trial aimed to recruit patients who had completed treatment of cervical, endometrial, epithelial ovarian, or vulval cancer within the previous 3 months at 3 North Wales hospitals...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29312627/a-proteomic-approach-for-the-identification-of-biomarkers-in-endometrial-cancer-uterine-aspirate
#5
Blendi Ura, Lorenzo Monasta, Giorgio Arrigoni, Cinzia Franchin, Oriano Radillo, Isabel Peterlunger, Giuseppe Ricci, Federica Scrimin
Endometrial cancer arises from the endometrium. It has a slow progression and a reported survival rate of 75%. The identification of soluble biomarkers in the uterine aspirate may be very useful for its early diagnosis. Uterine aspirates from 10 patients with endometrial cancer and 6 non-endometrial cancer controls were analyzed by two-dimensional gel electrophoresis coupled with mass spectrometry and western blotting for data verification. A total of 25 proteins with fold change in %V ≥2 or ≤0.5 in intensity were observed to change significantly (P<0...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290489/the-utility-of-sentinel-lymph-node-mapping-in-the-management-of-endometrial-atypical-hyperplasia
#6
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Marie Plante
OBJECTIVES: To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of "AH-only" versus "AH - cannot rule out carcinoma" and to study the value of SLN mapping. METHODS: We reviewed all patients with a preoperative diagnosis of atypical hyperplasia, who underwent primary surgery with SLN mapping followed by pelvic lymphadenectomy. Sensitivity and negative predictive value (NPV) of SLN and rates of endometrial cancer were calculated...
December 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29289418/long-term-adverse-genitourinary-outcomes-among-endometrial-cancer-survivors-in-a-large-population-based-cohort-study
#7
Sean Soisson, Patricia A Ganz, David Gaffney, Kerry Rowe, John Snyder, Yuan Wan, Vikrant Deshmukh, Mike Newman, Alison Fraser, Ken Smith, Kimberly Herget, Heidi A Hanson, Yelena P Wu, Joseph Stanford, Theresa L Werner, Veronica Wendy Setiawan, Mia Hashibe
OBJECTIVE: With the increasing incidence of endometrial cancer, the high survival rate, and the large number of endometrial cancer survivors, investigations of long-term genitourinary outcomes are important for the management of these outcomes among endometrial cancer survivors. METHODS: Cohorts of 2648 endometrial cancer survivors diagnosed in the state of Utah between 1997 and 2012 and 10,503 general population women were identified. All ICD-9 diagnosis codes were collected from the state's two largest healthcare systems and statewide databases...
December 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29288294/haplotype-analysis-suggest-that-the-mlh1-c-2059c%C3%A2-%C3%A2-t-mutation-is-a-swedish-founder-mutation
#8
Jenny von Salomé, Tao Liu, Markku Keihäs, Moni Morak, Elke Holinski-Feder, Ian R Berry, Jukka S Moilanen, Stéphanie Baert-Desurmont, Annika Lindblom, Kristina Lagerstedt-Robinson
Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of developing colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by defects in DNA mismatch-repair genes MLH1, MSH2, MSH6 or PMS2, with the vast majority detected in MLH1 and MSH2. Recurrent LS-associated variants observed in apparently unrelated individuals, have either arisen de novo in different families due to mutation hotspots, or are inherited from a founder (a common ancestor) that lived several generations back...
December 29, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29286137/microrna-124a-inhibits-cell-proliferation-and-migration-in-liver-cancer-by-regulating-interleukin-11
#9
Liedao Yu, Shuo Wang, Xiangjin Lin, Yang Lu, Pengcheng Gu
Liver cancer is the sixth most common malignant tumour and ranks in the top three cancers with regard to mortality due to metastasis and postsurgical recurrence. It is significant to understand the mechanisms underlying liver cancer for diagnosis and treatment. Cumulative evidence suggests that the abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the development and metastasis of cancer. miR‑124a acts as a tumour suppressor in osteosarcoma, endometrial carcinoma, prostate cancer, and glioblastoma...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29285365/dedifferentiated-endometrial-carcinoma-a-report-of-three-cases-and-review-of-the-literature
#10
Ryo Yokomizo, Kyosuke Yamada, Yasushi Iida, Takako Kiyokawa, Kazu Ueda, Motoaki Saito, Nozomu Yanaihara, Mayo Nakamura, Aikou Okamoto
Dedifferentiated endometrial carcinoma, which is defined microscopically as the co-existence of undifferentiated carcinoma and grade 1 or 2 endometrioid adenocarcinoma, is an aggressive type of cancer regardless of the percentage of undifferentiated components. It is reported that undifferentiated carcinoma comprises 9% of endometrial carcinoma. The percentage of dedifferentiated endometrial carcinoma has been hypothesized to be 40% of undifferentiated carcinoma. A precise pathological diagnosis is essential for defining the appropriate therapeutic approach and prognosis...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29284899/myometrium-invasion-tumour-size-and-lymphovascular-invasion-as-a-prognostic-factor-in-dissemination-of-pelvic-lymphatics-at-endometrial-carcinoma
#11
Nenad Lucic, Dragica Draganovic, Sanja Sibincic, Vesna Ecim-Zlojutro, Snjezana Milicevic
Objective: The aim of this work is to show the importance of the depth of myometrium invasion, tumour size and lymphovascular invasion as prognostic factors in dissemination of lymphatic nodes at endometrial carcinoma (CE). Materials and methods: In the period from 2010 to 2015 at the University Clinic for Gynecology and Obstetrics in Banja Luka, 221 endometrial cancer surgeries were done (laparatomy 184-83%, laparascopy 37-16,74%). Patients who had uterus bleeding in peri/postmenopause or those whose endometrium thickness was bigger than 5 mm which was established by ultrasound, or those who had in their cavum uteri pathological (PH) diagnosis, underwent fractional curettage (FC) or hysteroscopy in order to obtain pathohistological endometrium diagnosis...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29259453/polycystic-ovary-syndrome-early-diagnosis-and-intervention-are-necessary-for-fertility-preservation-in-young-women-with-endometrial-cancer-under-35%C3%A2-years-of-age
#12
Yoshinori Okamura, Fumitaka Saito, Kiyomi Takaishi, Takeshi Motohara, Ritsuo Honda, Takashi Ohba, Hidetaka Katabuchi
Aim: Polycystic ovary syndrome (PCOS) is a significant risk factor for premenopausal endometrial cancer (EC) and/or atypical endometrial hyperplasia (AEH). The aim was to elucidate the clinical background and detailed menstrual history of EC and/or AEH in young women with PCOS. Methods: From January 2001 to December 2013, women under 35 years of age who had been diagnosed with EC and/or AEH and who had been treated at Kumamoto University Hospital, Japan, were recruited...
January 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29250506/development-of-second-primary-cancer-in-korean-breast-cancer-survivors
#13
Hong Kyu Jung, Suyeon Park, Nam Won Kim, Jong Eun Lee, Zisun Kim, Sun Wook Han, Sung Mo Hur, Sung Young Kim, Cheol Wan Lim, Min Hyuk Lee, Jihyoun Lee
Purpose: Breast cancer survivors have slightly increased the risk of second primary cancers. Breast, colon, uterine, and ovarian cancers are common secondary cancers in breast cancer survivors. In this study, we assessed the development of second primary cancers of breast cancer survivors in Korea. Methods: Medical records of patients with breast cancer in 3 tertiary medical institutions were reviewed retrospectively. We evaluated secondary malignancy diagnosed at least 2 months after the breast cancer diagnosis...
December 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29241920/learning-curve-in-concurrent-application-of-laparoscopic-and-robotic-assisted-hysterectomy-with-lymphadenectomy-in-endometrial%C3%A2-cancer
#14
Pao-Ling Torng, Song-Po Pan, Jing-Shiang Hwang, Ho-Jun Shih, Chi-Ling Chen
OBJECTIVE: To evaluate the concurrent interaction of laparoscopic and robotic-assisted surgery in the initial learning period of endometrial cancer staging. MATERIALS AND METHODS: A retrospective cohort study was performed for the first 44 consecutive patients with endometrial cancer underwent laparoscopic (LSS) or robotic-assisted staging surgery (RSS) from February 2012 to October 2015 by a single surgeon in a tertiary care referral hospital. Demographics, diagnosis, perioperative variables, and complications were recorded...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29238349/the-roles-of-glycodelin-in-cancer-development-and-progression
#15
REVIEW
Juan Cui, Yanguo Liu, Xiuwen Wang
Glycodelin is a kind of glycoprotein expressed in secretory endometrium, pregnancy deciduas, and amniotic fluid originally, which is vital for the maintenance of normal human reproductive activities. Recent researches have reported that glycodelin is specifically expressed in various malignancies, including female-specific cancers such as endometrial cancer, ovarian cancer and breast cancer, and non-gender specific cancers including lung cancer, and colon cancer, and glycodelin expression correlates with the diagnosis and prognosis of cancer patients...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29234950/the-evolution-of-endometrial-carcinoma-classification-through-application-of-immunohistochemistry-and-molecular-diagnostics-past-present-and-future
#16
REVIEW
Emily A Goebel, August Vidal, Xavier Matias-Guiu, C Blake Gilks
Uterine cancer was first subclassified based on anatomic site, separating those tumours arising from the endometrium from cervical cancers. There was then further subclassification of endometrial cancers based on cell type, and this correlated with the Type I and Type II categories identified through the epidemiological studies of Bokhman, with endometrioid carcinoma corresponding (approximately) to Type I and serous carcinoma to Type II. These histotypes are not clearly separable in practice, however, with considerable interobserver variability in histotype diagnosis, especially for high-grade tumours...
December 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29234720/radiation-induced-circumscribed-superficial-morphea-after-brachytherapy-for-endometrial-adenocarcinoma
#17
Apoorva Trivedi, Corey M DeWitt, Laura McGevna
Radiation-induced morphea (RIM) is a rare and underrecognized complication of radiation therapy that most commonly occurs in women after treatment for breast cancer. Although not fully understood, RIM is hypothesized to arise from an increase in cytokines that stimulate collagen production and extracellular matrix formation. Most documented cases of RIM occur 1 year after radiation therapy and are localized to areas that were treated for breast cancer. We report on a case of a female patient with stage IB endometrial adenocarcinoma who was treated with 24 Gray of adjuvant brachytherapy...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29223698/risk-factors-for-unsuccessful-office-based-endometrial-biopsy-a-comparative-study-of-office-based-endometrial-biopsy-pipelle-and-diagnostic-dilation-and-curettage-d-c
#18
Bingying Xie, Cuifeng Qian, Bingyi Yang, Chengcheng Ning, Xiaoying Yao, Yan Du, Yue Shi, Xuezhen Luo, Xiaojun Chen
STUDY OBJECTIVE: To determine the risk factors for Pipelle diagnostic failure, which might help health care providers to choose the appropriate protocol for endometrial evaluation individually. DESIGN: A single-center prospective study (Canadian Task Force II) SETTING: The Obstetrics and Gynecology Hospital of Fudan University PATIENTS: 466 patients with an indication for endometrial biopsy INTERVENTIONS: All patients received Pipelle and then diagnostic dilation and curettage (D&C)...
December 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#19
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29209483/guiding-histological-assessment-of-uterine-lesions-using-3d-in-vitro-ultrasonography-and-stereotaxis
#20
Lieselore Vandermeulen, Ann Cornelis, Christina Kjaergaard Rasmussen, Dirk Timmerman, Thierry Van den Bosch
Objective: To compare ultrasonographic features of uterine lesions with the findings at macroscopy and microscopy. Methods: Case series of ten consecutive women undergoing a hysterectomy for uterine pathology. A preoperative transvaginal ultrasound examination was performed. After hysterectomy, the uterus was re-evaluated by 3D in vitro ultrasonography and in vitro gel instillation sonography (iGIS). The lesion of interest was pinpointed by inserting an intramuscular injection needle using a free-hand 2D-ultrasound guided technique to focus the macroscopic and the microscopic examination by the pathologist...
June 2017: Facts, Views & Vision in ObGyn
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