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Hypoxia muscle atrophy

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https://www.readbyqxmd.com/read/29069356/glucocorticoid-receptor-signaling-impairs-protein-turnover-regulation-in-hypoxia-induced-muscle-atrophy-in-male-mice
#1
Chiel C de Theije, Annemie M W J Schols, Wouter H Lamers, Judith J M Ceelen, Rick H van Gorp, J J Rob Hermans, S Elonore Köhler, Ramon C J Langen
Hypoxemia may contribute to muscle wasting in conditions such as Chronic Obstructive Pulmonary Disease. Muscle wasting develops when muscle proteolysis exceeds protein synthesis. Hypoxia induces skeletal muscle atrophy in mice, which can in part be attributed to reduced food intake. We hypothesized that hypoxia elevates circulating corticosterone concentrations by reduced food intake and enhances GR signaling in muscle, which causes elevated protein degradation signaling and dysregulates protein synthesis signaling during hypoxia-induced muscle atrophy...
October 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/29065889/injury-induced-expression-of-caveolar-proteins-in-human-kidney-tubules-role-of-megakaryoblastic-leukemia-1
#2
Krzysztof M Krawczyk, Jennifer Hansson, Helén Nilsson, Katarzyna K Krawczyk, Karl Swärd, Martin E Johansson
BACKGROUND: Caveolae are membrane invaginations measuring 50-100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles in human kidneys. Induction of caveolin-1/CAV1 in diseased tubules has been described previously, but the responsible mechanism remains to be defined. METHODS: Healthy and atrophying human kidneys were stained for caveolar proteins, (caveolin 1-3 and cavin 1-4) and examined by electron microscopy...
October 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28862673/igf-1-attenuates-hypoxia-induced-atrophy-but-inhibits-myoglobin-expression-in-c2c12-skeletal-muscle-myotubes
#3
Eva L Peters, Sandra M van der Linde, Ilse S P Vogel, Mohammad Haroon, Carla Offringa, Gerard M J de Wit, Pieter Koolwijk, Willem J van der Laarse, Richard T Jaspers
Chronic hypoxia is associated with muscle wasting and decreased oxidative capacity. By contrast, training under hypoxia may enhance hypertrophy and increase oxidative capacity as well as oxygen transport to the mitochondria, by increasing myoglobin (Mb) expression. The latter may be a feasible strategy to prevent atrophy under hypoxia and enhance an eventual hypertrophic response to anabolic stimulation. Mb expression may be further enhanced by lipid supplementation. We investigated individual and combined effects of hypoxia, insulin-like growth factor (IGF)-1 and lipids, in mouse skeletal muscle C2C12 myotubes...
September 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28819164/hypoxia-triggers-ifn-i-production-in-muscle-implications-in-dermatomyositis
#4
Noemí De Luna, Xavier Suárez-Calvet, Cinta Lleixà, Jordi Diaz-Manera, Montse Olivé, Isabel Illa, Eduard Gallardo
Dermatomyositis is an inflammatory myopathy characterized by symmetrical proximal muscle weakness and skin changes. Muscle biopsy hallmarks include perifascicular atrophy, loss of intramuscular capillaries, perivascular and perimysial inflammation and the overexpression of IFN-inducible genes. Among them, the retinoic-acid inducible gene 1 (RIG-I) is specifically overexpressed in perifascicular areas of dermatomyositis muscle. The aim of this work was to study if RIG-I expression may be modulated by hypoxia using an in vitro approach...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706950/effects-of-cobalt-chloride-a-hypoxia-mimetic-agent-on-autophagy-and-atrophy-in-skeletal-c2c12-myotubes
#5
Rui Chen, Ting Jiang, Yanling She, Jiehua Xu, Cheng Li, Shanyao Zhou, Huijuan Shen, Huacai Shi, Shuang Liu
BACKGROUND: Hypoxia-induced autophagy and muscle wasting occur in several environmental and pathological conditions. However, the molecular mechanisms underlying the effects of the hypoxia-mimetic agent CoCl2 on autophagy and muscle atrophy are still unclear. METHODS: C2C12 myotubes were exposed to increasing concentrations of CoCl2 for 24 hours. Quantitative RT-PCR, Western blotting, and transmission electron microscopy were performed to confirm autophagy occurs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28382782/fatty-acid-binding-protein-4-regulates-fatty-infiltration-after-rotator-cuff-tear-by-hypoxia-inducible-factor-1-in-mice
#6
Yong-Soo Lee, Ja-Yeon Kim, Kyung-Soo Oh, Seok Won Chung
BACKGROUND: Fatty infiltration in skeletal muscle is directly linked to loss of muscle strength and is associated with various adverse physical outcomes such as muscle atrophy, inflammation, insulin resistance, mobility impairments, and even mortality in the elderly. Aging, mechanical unloading, muscle injury, and hormonal imbalance are main causes of muscle fat accumulation, and the fat cells are derived from muscle stem cells via adipogenic differentiation. However, the pathogenesis and molecular mechanisms of fatty infiltration in muscles are still not fully defined...
October 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28294416/hypoxia-impairs-muscle-function-and-reduces-myotube-size-in-tissue-engineered-skeletal-muscle
#7
Neil R W Martin, Kathyrn Aguilar-Agon, George P Robinson, Darren J Player, Mark C Turner, Stephen D Myers, Mark P Lewis
Contemporary tissue engineered skeletal muscle models display a high degree of physiological accuracy compared with native tissue, and therefore may be excellent platforms to understand how various pathologies affect skeletal muscle. Chronic obstructive pulmonary disease (COPD) is a lung disease which causes tissue hypoxia and is characterized by muscle fiber atrophy and impaired muscle function. In the present study we exposed engineered skeletal muscle to varying levels of oxygen (O2 ; 21-1%) for 24 h in order to see if a COPD like muscle phenotype could be recreated in vitro, and if so, at what degree of hypoxia this occurred...
September 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28108482/inhibition-of-prolyl-4-hydroxylase-decreases-muscle-fibrosis-following-chronic-rotator-cuff-tear
#8
J P Gumucio, M D Flood, A Bedi, H F Kramer, A J Russell, C L Mendias
OBJECTIVES: Rotator cuff tears are among the most frequent upper extremity injuries. Current treatment strategies do not address the poor quality of the muscle and tendon following chronic rotator cuff tears. Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that activates many genes that are important in skeletal muscle regeneration. HIF-1α is inhibited under normal physiological conditions by the HIF prolyl 4-hydroxylases (PHDs). In this study, we used a pharmacological PHD inhibitor, GSK1120360A, to enhance the activity of HIF-1α following the repair of a chronic cuff tear, and measured muscle fibre contractility, fibrosis, gene expression, and enthesis mechanics...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/27932681/acute-intermittent-hypoxia-in-rats-activates-muscle-proteolytic-pathways-through-a-glucocorticoid-dependent-mechanism
#9
Franciele Przygodda, Leandro Henrique Manfredi, Juliano Machado, Dawit A P Gonçalves, Neusa Maria Zanon, Leni G H Bonagamba, Benedito H Machado, Isis do Carmo Kettelhut, Luiz C C Navegantes
Although it is well known that chronic hypoxia induces muscle wasting, the effects of intermit-tent hypoxia on skeletal muscle protein metabolism remains unclear. We hypothesized that acute intermittent hypoxia (AIH), a challenge that activates the hypothalamic-pituitary-adrenal axis, would alter muscle protein homeostasis through a glucocorticoid-dependent mechanism. Three-week-old rats were submitted to adrenalectomy (ADX) and exposed to 8 h of AIH (6% O2 for 40s at 9 min intervals). Animals were sacrificed and the soleus and extensor digitorum longus (EDL) muscles were harvested and incubated in vitro for measurements of protein turn-over...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27800505/fifteen-days-of-3-200-m-simulated-hypoxia-marginally-regulates-markers-for-protein-synthesis-and-degradation-in-human-skeletal-muscle
#10
Gommaar D'Hulst, Alessandra Ferri, Damien Naslain, Luc Bertrand, Sandrine Horman, Marc Francaux, David J Bishop, Louise Deldicque
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal muscle and whether these regulations were related to the regulation of the hypoxia-inducible factor (HIF) pathway. Eight young male subjects lived in a normobaric hypoxic hotel (FiO2 14.1%, 3,200 m) for 15 days in well-controlled conditions for nutrition and physical activity...
2016: Hypoxia
https://www.readbyqxmd.com/read/27776552/scleroderma-and-dentistry-two-case-reports
#11
Shantanu Dixit, Chaithra Kalkur, Atul P Sattur, Michael M Bornstein, Fred Melton
BACKGROUND: Scleroderma is a chronic connective tissue disorder with unknown etiology. It is characterized by excessive deposition of extracellular matrix in the connective tissues causing vascular disturbances which can result in tissue hypoxia. These changes are manifested as atrophy of the skin and/or mucosa, subcutaneous tissue, muscles, and internal organs. Such changes can be classified into two types, namely, morphea (localized) and diffuse (systemic). Morphea can manifest itself as hemifacial atrophy (Parry-Romberg syndrome) although this remains debatable...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27742801/human-skeletal-muscle-wasting-in-hypoxia-a-matter-of-hypoxic-dose
#12
Gommaar D'Hulst, Louise Deldicque
Skeletal muscle wasting has been shown to be a mechanism by which humans are able to adapt to extreme altitude. Nonetheless, the literature is conflicting regarding the altitude or time point at which this phenomenon starts to occur. Using the metric recently suggested by Garvivan-Lewis et al. (8), we propose an hypoxic dose of 5000 km·h as the cut-off point above which hypoxia-induced muscle atrophy starts to develop. As such, we suggest that both elevation and hours of altitude exposure should be incorporated in future studies unraveling hypoxic regulation of muscle mass...
October 14, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27592228/enhanced-in-vivo-survival-of-schwann-cells-by-a-synthetic-oxygen-carrier-promotes-sciatic-nerve-regeneration-and-functional-recovery
#13
Teng Ma, Lei Zhu, Yafeng Yang, Xin Quan, Liangliang Huang, Zhongyang Liu, Zhen Sun, Shu Zhu, Jinghui Huang, Zhuojing Luo
Local hypoxia in the early stages of peripheral nerve injury is a challenge for axonal regeneration. To address this issue, perfluorotributylamine (PFTBA)-based oxygen carrying fibrin hydrogel was prepared and injected into Schwann cell (SC)-seeded collagen-chitosan conduits to increase oxygen supply to SCs within the conduits. The conduit containing PFTBA-SC gel was then applied to bridge a 15-mm sciatic nerve defect in rats. It was observed that most of the GFP-labeled SCs initially seeded in the PFTBA hydrogel remained alive for approximately 28 days after their in vivo implantation...
September 4, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27121733/differential-roles-of-hypoxia-and-innate-immunity-in-juvenile-and-adult-dermatomyositis
#14
Corinna Preuße, Yves Allenbach, Olaf Hoffmann, Hans-Hilmar Goebel, Debora Pehl, Josefine Radke, Alexandra Doeser, Udo Schneider, Rieke H E Alten, Tilmann Kallinich, Olivier Benveniste, Arpad von Moers, Benedikt Schoser, Ulrike Schara, Werner Stenzel
Dermatomyositis (DM) can occur in both adults and juveniles with considerable clinical differences. The links between immune-mediated mechanisms and vasculopathy with respect to development of perifascicular pathology are incompletely understood. We investigated skeletal muscle from newly diagnosed, treatment-naïve juvenile (jDM) and adult dermatomyositis (aDM) patients focusing on hypoxia-related pathomechanisms, vessel pathology, and immune mechanisms especially in the perifascicular region. Therefore, we assessed the skeletal muscle biopsies from 21 aDM, and 15 jDM patients by immunohistochemistry and electron microscopy...
April 27, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/26836890/contribution-of-the-mitochondria-to-locomotor-muscle-dysfunction-in-patients-with-copd
#15
REVIEW
Tanja Taivassalo, Sabah N A Hussain
COPD is a significant public health challenge, notably set to become the third leading cause of death and fifth leading cause of chronic disability worldwide by the next decade. Skeletal muscle impairment is now recognized as a disabling, extrapulmonary consequence of COPD that is associated with reduced quality of life and premature mortality. Because COPD typically manifests in older individuals, these clinical features may overlie normal age-associated declines in muscle function and performance. Although physical inactivity, oxidative stress, inflammation, hypoxia, malnutrition, and medications all likely contribute to this comorbidity, a better understanding of the underlying mechanism is needed to develop effective therapies...
May 2016: Chest
https://www.readbyqxmd.com/read/26681636/redox-remodeling-is-pivotal-in-murine-diaphragm-muscle-adaptation-to-chronic-sustained-hypoxia
#16
Philip Lewis, David Sheehan, Renata Soares, Ana Varela Coelho, Ken D O'Halloran
Mechanisms underpinning chronic sustained hypoxia (CH)-induced structural and functional adaptations in respiratory muscles are unclear despite the clinical relevance to respiratory diseases. The objectives of the present study were to thoroughly assess the putative role of CH-induced redox remodeling in murine diaphragm muscle over time and the subsequent effects on metabolic enzyme activities, catabolic signaling and catabolic processes, and diaphragm muscle contractile function. C57Bl6/J mice were exposed to normoxia or normobaric CH (fraction of inspired oxygen = 0...
July 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/26509589/at1-receptor-antagonism-before-ischemia-prevents-the-transition-of-acute-kidney-injury-to-chronic-kidney-disease
#17
Roxana Rodríguez-Romo, Kenia Benítez, Jonatan Barrera-Chimal, Rosalba Pérez-Villalva, Arturo Gómez, Diana Aguilar-León, Jesús F Rangel-Santiago, Sara Huerta, Gerardo Gamba, Norma Uribe, Norma A Bobadilla
Despite clinical recovery of patients from an episode of acute kidney injury (AKI), progression to chronic kidney disease (CKD) is possible on long-term follow-up. However, mechanisms of this are poorly understood. Here, we determine whether activation of angiotensin-II type 1 receptors during AKI triggers maladaptive mechanisms that lead to CKD. Nine months after AKI, male Wistar rats develop CKD characterized by renal dysfunction, proteinuria, renal hypertrophy, glomerulosclerosis, tubular atrophy, and tubulointerstitial fibrosis...
February 2016: Kidney International
https://www.readbyqxmd.com/read/26506088/vascular-defects-and-spinal-cord-hypoxia-in-spinal-muscular-atrophy
#18
Eilidh Somers, Robert D Lees, Katie Hoban, James N Sleigh, Haiyan Zhou, Francesco Muntoni, Kevin Talbot, Thomas H Gillingwater, Simon H Parson
OBJECTIVE: Spinal muscular atrophy (SMA) is a major inherited cause of infant death worldwide. It results from mutations in a single, ubiquitously expressed gene (SMN1), with loss of lower motor neurons being the primary pathological signature. Systemic defects have also been reported in SMA patients and animal models. We investigated whether defects associated with the vasculature contribute to motor neuron pathology in SMA. METHODS: Development and integrity of the capillary bed was examined in skeletal muscle and spinal cord of SMA mice, and muscle biopsies from SMA patients and controls, using quantitative morphometric approaches on immunohistochemically labeled tissue...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26315408/mitochondrial-aldehyde-dehydrogenase-2-regulates-revascularization-in-chronic-ischemia-potential-impact-on-the-development-of-coronary-collateral-circulation
#19
COMPARATIVE STUDY
Xiangwei Liu, Xiaolei Sun, Hua Liao, Zhen Dong, Jingjing Zhao, Hong Zhu, Peng Wang, Li Shen, Lei Xu, Xin Ma, Cheng Shen, Fan Fan, Cong Wang, Kai Hu, Yunzeng Zou, Junbo Ge, Jun Ren, Aijun Sun
OBJECTIVE: Revascularization is an essential process to compensate for cardiac underperfusion and, therefore, preserves cardiac function in the face of chronic ischemic injury. Recent evidence suggested a vital role of aldehyde dehydrogenase 2 (ALDH2) in cardiac protection after ischemia. This study was designed to determine whether ALDH2 regulates chronic ischemia-induced angiogenesis and to explore the underlying mechanism involved. Moreover, the clinical impact of the ALDH2 mutant allele on the development of coronary collateral circulation (CCC) was evaluated...
October 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/26298291/hif-1-driven-skeletal-muscle-adaptations-to-chronic-hypoxia-molecular-insights-into-muscle-physiology
#20
REVIEW
F B Favier, F A Britto, D G Freyssenet, X A Bigard, H Benoit
Skeletal muscle is a metabolically active tissue and the major body protein reservoir. Drop in ambient oxygen pressure likely results in a decrease in muscle cells oxygenation, reactive oxygen species (ROS) overproduction and stabilization of the oxygen-sensitive hypoxia-inducible factor (HIF)-1α. However, skeletal muscle seems to be quite resistant to hypoxia compared to other organs, probably because it is accustomed to hypoxic episodes during physical exercise. Few studies have observed HIF-1α accumulation in skeletal muscle during ambient hypoxia probably because of its transient stabilization...
December 2015: Cellular and Molecular Life Sciences: CMLS
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