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accelerated corneal

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https://www.readbyqxmd.com/read/29331377/%C3%AE-cellulin-promotes-the-proliferation-of-corneal-epithelial-stem-cells-through-the-phosphorylation-of-erk1-2
#1
Won-Yong Jeong, Hye-Young Yoo, Chan-Wha Kim
The proliferation of corneal epithelial stem cells (CESCs) is a very important process in the recovery of corneal wounds. Recent studies have shown that β-cellulin (BC) is effective in the repair of other tissues. However, its mechanism of action in corneal wound healing is not yet clear. The purpose of this study was to investigate how BC accelerates wound healing of the cornea. Here, we confirmed that the proliferation of CESCs was induced at a specific concentration (0.2, 2 and 20 ng/mL) by treatment with BC...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29300266/visibility-and-depth-of-the-stromal-demarcation-line-after-corneal-collagen-cross-linking-using-anterior-segment-optical-coherence-tomography-comparison-between-isoosmolar-and-hypoosmolar-riboflavin
#2
Louis Lhuillier, Cedric Ghetemme, Mathilde Boiché, Rekia Yahia, Naila Houmad, Mohamed Zaidi, Christophe Goetz, Jean Marc Perone
PURPOSE: To evaluate and compare visibility and depth of the stromal demarcation line (DL) created after corneal collagen cross-linking (CXL) using anterior segment optical coherence tomography (AS-OCT) between 2 groups: CXL with isoosmolar and hypoosmolar riboflavin. METHODS: In this retrospective study performed at Metz-Thionville Regional Hospital, consecutive patients with progressive keratoconus underwent CXL using an accelerated protocol (10 min, 9 mW/cm ultraviolet-A)...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29300262/accelerated-corneal-cross-linking-with-photoactivated-chromophore-for-moderate-therapy-resistant-infectious-keratitis
#3
Boris Knyazer, Yonit Krakauer, Yael Baumfeld, Tova Lifshitz, Sabine Kling, Farhad Hafezi
PURPOSE: To evaluate the effect of accelerated corneal cross-linking with photoactivated chromophore (PACK-CXL) as additional treatment for therapy-resistant infectious keratitis. METHODS: In this interventional cohort study, 20 patients (11 men and 9 women), aged 65.5 (interquartile range = 21.5-78.5) years, who were hospitalized for moderate-sized therapy-resistant bacterial corneal ulcers (11/20 microbiologically confirmed) were treated with hypoosmolar 0.1% riboflavin solution and Ultraviolet A (UVA) irradiation for 3 minutes at 30 mW/cm (5...
January 3, 2018: Cornea
https://www.readbyqxmd.com/read/29284455/visual-rehabilitation-in-moderate-keratoconus-combined-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-and-high-fluence-accelerated-corneal-collagen-cross-linking-after-intracorneal-ring-segment-implantation
#4
Hun Lee, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: To investigate the effects of combined corneal wavefront-guided transepithelial photorefractive keratectomy (tPRK) and accelerated corneal collagen cross-linking (CXL) after intracorneal ring segment (ICRS) implantation in patients with moderate keratoconus. METHODS: Medical records of 23 eyes of 23 patients undergoing combined tPRK and CXL after ICRS implantation were retrospectively analyzed. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE), corneal indices based on Scheimpflug tomography, higher-order aberrations (HOAs), and corneal biomechanical properties were evaluated before and after ICRS implantation, and at 1, 3, and 6 months after combined tPRK and CXL...
December 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29279651/mesopic-quality-of-vision-after-accelerated-18-mw-cm2-corneal-cross-linking-mid-term-results
#5
Hassan Hashemi, Mohammad Miraftab, Soheila Asgari
PURPOSE: The purpose of the study was to determine 2-year changes in mesopic higher-order aberrations (HOAs) and contrast sensitivity (CS) after accelerated corneal cross-linking (CXL) in keratoconus patients. MATERIALS AND METHODS: In this before-after interventional case series, patients with progressive keratoconus were subjected to accelerated CXL (18 mW/cm2, 5 min). Patients were examined with the OPD-Scan III and CVS-1000 grating charts under mesopic conditions at baseline and at 12 and 24 months after CXL...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29259913/trans-epithelial-accelerated-corneal-cross-linking-for-keratoconus-in-children
#6
Andrew Olivo-Payne, Juan Carlos Serna-Ojeda, Erick Hernandez-Bogantes, Alexandra Abdala-Figuerola, Lucero Pedro-Aguilar, Alejandro Lichtinger, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernandez
The aim of the study is to evaluate the safety and efficacy of trans-epithelial accelerated corneal cross-linking (TE-ACXL) in children with progressive keratoconus. Retrospective, case-series of 23 eyes of 14 children who underwent TE-ACXL. Evaluations were performed at baseline and 1, 3, 6, 12 and 18mo postoperatively. Mean follow-up time of 23.82±3.15mo and mean age was 13.7±1.4y (range 11 to 16y). Mean preoperative uncorrected distance visual acuity changed from 0.92±0.45 logMAR (20/160) to 0.71±0.40 logMAR (20/100) (P=0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29251403/rebamipide-suppresses-tnf-%C3%AE-production-and-macrophage-infiltration-in-the-conjunctiva
#7
Kazuki Tajima, Takaaki Hattori, Hiroki Takahashi, Haruki Katahira, Akitomo Narimatsu, Shigeto Kumakura, Hiroshi Goto
PURPOSE: To evaluate the anti-inflammatory effect of rebamipide during corneal epithelial wound healing using a mouse wound repair model. METHODS: A 2-mm circular disc of the central cornea was demarcated in the right eye of C57BL/6 mice and the epithelium removed. Rebamipide 2% eyedrop was instilled onto the wounded eye 5 times a day (n = 26). Phosphate-buffered saline (PBS) was used in the control group (n = 26). Corneal and conjunctival IL-1β and TNF-α levels were measured at 6 h and 24 h postinjury by ELISA...
December 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29242757/differential-gene-transcription-of-extracellular-matrix-components-in-response-to-in-vivo-corneal-crosslinking-cxl-in-rabbit-corneas
#8
Sabine Kling, Arthur Hammer, Emilio A Torres Netto, Farhad Hafezi
Purpose: We studied changes in gene transcription after corneal crosslinking (CXL) in the rabbit cornea in vivo and identified potential molecular signaling pathways. Methods: A total of 15 corneas of eight male New-Zealand-White rabbits were de-epithelialized and equally divided into five groups. Group 1 served as an untreated control. Groups 2 to 5 were soaked with 0.1% riboflavin for 20 minutes, which in Groups 3 to 5 was followed by UV-A irradiation at a fluence of 5...
December 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29233738/prevalence-of-transforming-growth-factor-%C3%AE-induced-gene-corneal-dystrophies-in-chinese-refractive-surgery-candidates
#9
Yanzheng Song, Mingshen Sun, Ningli Wang, Xingtao Zhou, Jing Zhao, Qinmei Wang, Shihao Chen, Yingping Deng, Lemei Qiu, Yueguo Chen, Anthony J Aldave, Fengju Zhang
PURPOSE: To determine the prevalence of the transforming growth factor (TGF) β-induced gene corneal dystrophies in refractive surgery candidates in China. SETTING: Five hospitals in China. DESIGN: Prospective case series. METHOD: Refractive surgical candidates from 5 preselected eye hospitals/centers in China were recruited after providing informed consent. All patients had slitlamp biomicroscopy and collection of a buccal swab as a source of DNA for screening of the TGF β-induced gene for the 5 most common mutations associated with Reis-Bückler corneal dystrophy, Thiel-Behnke corneal dystrophy, granular corneal dystrophy type 1, granular corneal dystrophy type 2, and lattice corneal dystrophy type 1...
December 9, 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29223236/mechanical-outcome-of-accelerated-corneal-crosslinking-evaluated-by%C3%A2-brillouin%C3%A2-microscopy
#10
Joshua N Webb, Johnny P Su, Giuliano Scarcelli
PURPOSE: To quantify corneal mechanical changes induced by corneal crosslinking (CXL) procedures of different ultraviolet-A (UVA) intensity and exposure time using Brillouin microscopy. SETTINGS: University of Maryland, College Park, Maryland, USA. DESIGN: Experimental study. METHODS: Porcine cornea samples were debrided of epithelia and soaked with riboflavin 0.1% solution. Samples were exposed to a standard 5.4 J/cm2 of UVA radiation with varying intensity and exposure time as follows: 3 mW/cm2 for 30...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29219951/comparative-study-of-long-term-outcomes-of-accelerated-and-conventional-collagen-crosslinking-for-progressive-keratoconus
#11
J J Males, D Viswanathan
PurposeTo compare the long-term outcomes of accelerated corneal collagen crosslinking (CXL) to conventional CXL for progressive keratoconus.Patients and methodsComparative clinical study of consecutive progressive keratoconic eyes that underwent either accelerated CXL (9 mW/cm2 ultraviolet A (UVA) light irradiance for 10 min) or conventional CXL (3 mW/cm2 UVA light irradiance for 30 min). Eyes with minimum 12 months' follow-up were included. Post-procedure changes in keratometry readings (Flat meridian: K1; steep meridian: K2), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and manifest refraction spherical equivalent (MRSE) were analysed...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29215396/outcomes-of-corneal-cross-linking-correlate-with-cone-specific-lysyl-oxidase-expression-in-patients-with-keratoconus
#12
Rohit Shetty, Nimisha Rajiv Kumar, Natasha Pahuja, Rashmi Deshmukh, KrishnaPoojita Vunnava, Valsala Gopalakrishnan Abilash, Abhijit Sinha Roy, Arkasubhra Ghosh
PURPOSE: To evaluate the correlation of visual and keratometry outcomes after corneal cross-linking (CXL) in patients with keratoconus with cone epithelium-specific gene expression levels. METHODS: Corneal epithelium was obtained from 35 eyes that underwent accelerated CXL (KXLII, 9 mW/cm for 10 min). Using corneal topography, epithelium over the cone and periphery was obtained separately from each subject. The ratio of gene expression for lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), bone morphogenic protein 7, tissue inhibitor of metalloproteinase 1, collagen, type I, alpha 1, and collagen, type IV, alpha 1 (COL IVA1) from the cone and peripheral cornea was correlated with the outcome of cross-linking surgery...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29201459/algorithm-for-correcting-the-keratometric-error-in-the-estimation-of-the-corneal-power-in-keratoconus-eyes-after-accelerated-corneal-collagen-crosslinking
#13
David P Piñero, Vicente J Camps, Esteban Caravaca-Arens, Dolores de Fez, Francisco J Blanes-Mompó
Purpose: To analyze the errors associated to corneal power calculation using the keratometric approach in keratoconus eyes after accelerated corneal collagen crosslinking (CXL) surgery and to obtain a model for the estimation of an adjusted corneal refractive index (nkadj ) minimizing such errors. Methods: Potential differences (ΔPc) among keratometric (Pk ) and Gaussian corneal power (PcGauss) were simulated. Three algorithms based on the use of nkadj for the estimation of an adjusted keratometric corneal power (Pkadj ) were developed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29198823/microrna-184-induces-a-commitment-switch-to-epidermal-differentiation
#14
Sara Nagosa, Friederike Leesch, Daria Putin, Swarnabh Bhattacharya, Anna Altshuler, Laura Serror, Aya Amitai-Lange, Waseem Nasser, Edith Aberdam, Matthieu Rouleau, Sudhir G Tattikota, Matthew N Poy, Daniel Aberdam, Ruby Shalom-Feuerstein
miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related function in vivo remained unclear. Here, we report that the miR-184 knockout mouse model displayed increased p63 expression in line with epidermal hyperplasia, while forced expression of miR-184 by stem/progenitor cells enhanced the Notch pathway and induced epidermal hypoplasia...
November 23, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29183298/differences-in-corneal-clinical-findings-after-standard-and-accelerated-cross-linking-in-patients-with-progressive-keratoconus
#15
Karsten U Kortuem, Efstathios Vounotrypidis, Alexandros Athanasiou, Michael Müller, Alexander Babenko, Christoph Kern, Siegfried Priglinger, Wolfgang J Mayer
BACKGROUND: The purpose of this study was to identify differences in clinical corneal findings after standard and accelerated epithelial off cross-linking (CXL) during a long-term follow-up. METHODS: Two hundred forty-one patients (184 male) were included in this monocentric, retrospective, non-randomized and unmasked study. One hundred forty-eight eyes were treated with the accelerated protocol and 138 with the standard protocol with epithelial off CXL, if diagnosed with keratoconus and a progression in Kmax of more than one dioptre during the preceding 6 months, plus a minimal pachymetry measurement of 400 μm in keratometry (Pentacam, Oculus GmbH, Wetzlar, Germany)...
November 28, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29171504/intraoperative-optical-coherence-tomography-to-evaluate-the-effect-of-the-eyelid-speculum-on-corneal-pachymetry-during-accelerated-corneal-cross-linking-9%C3%A2-mw-cm-2
#16
R Ghaffari, M Mortazavi, P Anvari, A Salamat Rad, F Alipour, F Hafezi, S Asgari, H Hashemi
PurposeTo investigate intraoperative anterior segment optical coherence tomography (AS-OCT) to compare pachymetry changes between two methods (group 1: speculum-on, group 2: speculum-off during riboflavin instillation stage) during corneal cross-linking /CXL) (9 mW/cm(2) for 10 min) in keratoconic patients.MethodsIn this interventional case series, 11 eyes (11 patients) in group 1 and 14 eyes (14 patients) in group 2 were enrolled. Pachymetry measurements by spectral domain OCT was performed at baseline, after epithelial removal, after 30 min of imbibition with riboflavin, and after UV irradiation...
November 24, 2017: Eye
https://www.readbyqxmd.com/read/29167270/ubia-prenyltransferase-domain-containing-protein-1-modulates-hmg-coa-reductase-degradation-to-coordinate-synthesis-of-sterol-and-nonsterol-isoprenoids
#17
Marc M Schumacher, Dong-Jae Jun, Brittany M Johnson, Russell A DeBose-Boyd
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2. We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)-localized HMG CoA reductase. UBIAD1 binding inhibits sterol-accelerated, ER-associated degradation (ERAD) of reductase, one of several mechanisms for feedback control of this rate-limiting enzyme in the branched pathway that produces cholesterol and nonsterol isoprenoids such as GGpp. Accumulation of GGpp in ER membranes triggers release of UBIAD1 from reductase, permitting its maximal ERAD and ER-to-Golgi transport of UBIAD1...
November 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29155856/treatment-with-solubilized-silk-derived-protein-sdp-enhances-rabbit-corneal-epithelial-wound-healing
#18
Waleed Abdel-Naby, Brigette Cole, Aihong Liu, Jingbo Liu, Pengxia Wan, Ryan Schreiner, David W Infanger, Nicholas B Paulson, Brian D Lawrence, Mark I Rosenblatt
There is a significant clinical need to improve current therapeutic approaches to treat ocular surface injuries and disease, which affect hundreds of millions of people annually worldwide. The work presented here demonstrates that the presence of Silk-Derived Protein (SDP) on the healing rabbit corneal surface, administered in an eye drop formulation, corresponds with an enhanced epithelial wound healing profile. Rabbit corneas were denuded of their epithelial surface, and then treated for 72-hours with either PBS or PBS containing 5 or 20 mg/mL SDP in solution four times per day...
2017: PloS One
https://www.readbyqxmd.com/read/29123375/sequential-keraring-implantation-and-corneal-cross-linking-for-the-treatment-of-keratoconus-in-children-with-vernal-keratoconjunctivitis
#19
Mortada A Abozaid
Purpose: The purpose of this study was to assess the safety and efficacy of femtosecond laser-assisted Keraring implantation followed by transepithelial accelerated corneal collagen cross-linking (CXL) for the treatment of keratoconus in children with vernal keratoconjunctivitis (VKC). Study design: This is a prospective interventional non-comparative case series. Patients and methods: Eighteen eyes of 11 children with keratoconus and VKC were included in this study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29122823/comparative-evaluation-of-progression-rate-in-keratoconus-before-and-after-collagen-crosslinking
#20
Yu Meng Wang, Tommy Cy Chan, Marco C Y Yu, Vishal Jhanji
PURPOSE: To compare the rate of disease progression in keratoconus before and after corneal collagen crosslinking (CXL). METHODS: 145 eyes were followed without CXL (no-CXL group) for a median duration of 31 months whereas 45 eyes were followed up for 41 months before (pre-CXL) and after (post-CXL) accelerated, epithelium-off crosslinking. Progression was defined based on significant slope found in linear mixed effect models against time. Swept-source optical coherence tomography was used for measurement of anterior steep keratometry, anterior flat keratometry (Ant Kf), anterior average keratometry (Ant Avg K); posterior steep keratometry, posteriorflat keratometry (Post Kf), posterior average keratometry (Post Avg K) and corneal thickness...
November 9, 2017: British Journal of Ophthalmology
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