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Nutrition genetic engineering

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https://www.readbyqxmd.com/read/28500672/telomere-length-and-fetal-programming-a-review-of-recent-scientific-advances
#1
Valerie E Whiteman, Anjali Goswami, Hamisu M Salihu
We sought to synthesize a comprehensive literature review comprising recent research linking fetal programming to fetal telomere length. We also explored the potential effects fetal telomere length shortening has on fetal phenotypes. Utilizing the PubMed database as our primary search engine, we retrieved and reviewed 165 articles of published research. The inclusion criteria limited the articles to those that appeared within the last ten years, were pertinent to humans, and without restriction to language of publication...
May 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28429079/the-r2r3-myb-tt2b-and-the-bhlh-tt8-genes-are-the-major-regulators-of-proanthocyanidin-biosynthesis-in-the-leaves-of-lotus-species
#2
Francisco José Escaray, Valentina Passeri, Ana Perea-García, Cristian Javier Antonelli, Francesco Damiani, Oscar Adolfo Ruiz, Francesco Paolocci
By exploiting interspecific hybrids and their progeny, we identified key regulatory and transporter genes intimately related to proanthocyanidin biosynthesis in leaves of Lotus spp. Proanthocyanidins (PAs), known as condensed tannins, are polymeric flavonoids enriching forage legumes of key nutritional value to prevent bloating in ruminant animals. Unfortunately, major forage legumes such as alfalfa and clovers lack PAs in edible tissues. Therefore, engineering the PA trait in herbage of forage legumes is paramount to improve both ecological and economical sustainability of cattle production system...
April 20, 2017: Planta
https://www.readbyqxmd.com/read/28369505/predator-preference-for-bt-fed-spodoptera-frugiperda-lepidoptera-noctuidae-prey-implications-for-insect-resistance-management-in-bt-maize-seed-blends
#3
Z Svobodová, E C Burkness, O Skoková Habuštová, W D Hutchison
Understanding indirect, trophic-level effects of genetically engineered plants, expressing insecticidal proteins derived from the bacterium, Bacillus thuringiensis (Bt), is essential to the ecological risk assessment process. In this study, we examine potential indirect, trophic-level effects of Bt-sensitive prey using the predator, Harmonia axyridis (Pallas), feeding upon Spodoptera frugiperda (J.E. Smith) larvae, which had delayed development (lower body mass) following ingestion of Cry1Ab maize leaves. We found no adverse effects on development and survival when H...
March 28, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28364624/biocontrol-of-the-internalization-of-salmonella-enterica-and-enterohaemorrhagic-escherichia-coli-in-mung-bean-sprouts-with-an-endophytic-bacillus-subtilis
#4
Zhenyu Shen, Azlin Mustapha, Mengshi Lin, Guolu Zheng
Internalization of Salmonella enterica and enterohaemorrhagic Escherichia coli (EHEC) in seed sprouts poses a health risk to consumers, and the conventional sanitization methods are not always effective to reduce this risk. This study initiated a biocontrol approach to limit the internalization using endophytic Bacillus subtilis strains, which were isolated from the inner tissue of mung bean seeds or lettuce stems. By using the deferred agar method, 12 strains of B. subtilis out of 94 putative Bacillus isolates displayed inhibitory activity against at least one of the pathogenic indicators, S...
March 24, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28294619/concurrent-overexpression-of-arabidopsis-thaliana-cystathionine-%C3%AE-synthase-and-silencing-of-endogenous-methionine-%C3%AE-lyase-enhance-tuber-methionine-content-in-solanum-tuberosum
#5
Pavan Kumar, Georg Jander
Potatoes (Solanum tuberosum) are deficient in methionine, an essential amino acid in human and animal diets. Higher methionine levels increase the nutritional quality and promote the typically pleasant aroma associated with baked and fried potatoes. Several attempts have been made to elevate tuber methionine levels by genetic engineering of methionine biosynthesis and catabolism. Overexpressing Arabidopsis thaliana cystathionine γ-synthase (AtCGS) in S. tuberosum up-regulates a rate-limiting step of methionine biosynthesis and increases tuber methionine levels...
March 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28288329/gm-biofortified-crops-potential-effects-on-targeting-the-micronutrient-intake-gap-in-human-populations
#6
REVIEW
Hans De Steur, Saurabh Mehta, Xavier Gellynck, Julia L Finkelstein
Genetic engineering has been successfully applied to increase micronutrient content in staple crops. Nutrition evidence is key to ensure scale-up and successful implementation. Unlike conventional plant breeding efforts, research on the efficacy or effectiveness of GM biofortified crops on nutritional status in human populations is lacking. This review reports on the potential role of GM biofortified crops in closing the micronutrient gap - increasing the dietary intake of micronutrients in human populations...
April 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28275380/genetic-transformation-and-genomic-resources-for-next-generation-precise-genome-engineering-in-vegetable-crops
#7
REVIEW
Teodoro Cardi, Nunzio D'Agostino, Pasquale Tripodi
In the frame of modern agriculture facing the predicted increase of population and general environmental changes, the securement of high quality food remains a major challenge to deal with. Vegetable crops include a large number of species, characterized by multiple geographical origins, large genetic variability and diverse reproductive features. Due to their nutritional value, they have an important place in human diet. In recent years, many crop genomes have been sequenced permitting the identification of genes and superior alleles associated with desirable traits...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28265278/seed-specific-overexpression-of-the-pyruvate-transporter-bass2-increases-oil-content-in-arabidopsis-seeds
#8
Eun-Jung Lee, Minwoo Oh, Jae-Ung Hwang, Yonghua Li-Beisson, Ikuo Nishida, Youngsook Lee
Seed oil is important not only for human and animal nutrition, but also for various industrial applications. Numerous genetic engineering strategies have been attempted to increase the oil content per seed, but few of these strategies have involved manipulating the transporters. Pyruvate is a major source of carbon for de novo fatty acid biosynthesis in plastids, and the embryo's demand for pyruvate is reported to increase during active oil accumulation. In this study, we tested our hypothesis that oil biosynthesis could be boosted by increasing pyruvate flux into plastids...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28253441/availability-production-and-consumption-of-crops-biofortified-by-plant-breeding-current-evidence-and-future-potential
#9
Amy Saltzman, Ekin Birol, Adewale Oparinde, Meike S Andersson, Dorene Asare-Marfo, Michael T Diressie, Carolina Gonzalez, Keith Lividini, Mourad Moursi, Manfred Zeller
Biofortification is the process of increasing the density of vitamins and minerals in a crop through plant breeding-using either conventional methods or genetic engineering-or through agronomic practices. Over the past 15 years, conventional breeding efforts have resulted in the development of varieties of several staple food crops with significant levels of the three micronutrients most limiting in diets: zinc, iron, and vitamin A. More than 15 million people in developing countries now grow and consume biofortified crops...
February 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28223994/enhanced-grain-iron-levels-in-rice-expressing-an-iron-regulated-metal-transporter-nicotianamine-synthase-and-ferritin-gene-cassette
#10
Kulaporn Boonyaves, Ting-Ying Wu, Wilhelm Gruissem, Navreet K Bhullar
Micronutrient malnutrition is widespread, especially in poor populations across the globe, and iron deficiency anemia is one of the most prevalent forms of micronutrient deficiencies. Iron deficiency anemia has severe consequences for human health, working ability, and quality of life. Several interventions including iron supplementation and food fortification have been attempted and met with varied degrees of success. Rice, which is a staple food for over half of the world's population, is an important target crop for iron biofortification...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28174082/%C3%AE-propeller-phytases-diversity-catalytic-attributes-current-developments-and-potential-biotechnological-applications
#11
REVIEW
Vinod Kumar, Ajar Nath Yadav, Priyanka Verma, Punesh Sangwan, Abhishake Saxena, Krishan Kumar, Bijender Singh
Phytases are phosphatases which stepwise remove phosphates from phytic acid or its salts. β-Propeller phytase (BPPhy) belongs to a special class of microbial phytases that is regarded as most diverse, isolated and characterized from different microbes, mainly from Bacillus spp. BPPhy class is unique for its Ca(2+)-dependent catalytic activity, strict substrate specificity, active at neutral to alkaline pH and high thermostability. Numerous sequence and structure based studies have revealed unique attributes and catalytic properties of this class, as compared to other classes of phytases...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28146083/the-use-of-gene-modification-and-advanced-molecular-structure-analyses-towards-improving-alfalfa-forage
#12
REVIEW
Yaogeng Lei, Abdelali Hannoufa, Peiqiang Yu
Alfalfa is one of the most important legume forage crops in the world. In spite of its agronomic and nutritive advantages, alfalfa has some limitations in the usage of pasture forage and hay supplement. High rapid degradation of protein in alfalfa poses a risk of rumen bloat to ruminants which could cause huge economic losses for farmers. Coupled with the relatively high lignin content, which impedes the degradation of carbohydrate in rumen, alfalfa has unbalanced and asynchronous degradation ratio of nitrogen to carbohydrate (N/CHO) in rumen...
January 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28095718/key-players-associated-with-tuberization-in-potato-potential-candidates-for-genetic-engineering
#13
Som Dutt, Anshul Sharma Manjul, Pinky Raigond, Brajesh Singh, Sundaresha Siddappa, Vinay Bhardwaj, Prashant G Kawar, Virupakshagouda U Patil, Hemant Balasaheb Kardile
Tuberization in potato (Solanum tuberosum L.) is a complex biological phenomenon which is affected by several environmental cues, genetic factors and plant nutrition. Understanding the regulation of tuber induction is essential to devise strategies to improve tuber yield and quality. It is well established that short-day photoperiods promote tuberization, whereas long days and high-temperatures inhibit or delay tuberization. Worldwide research on this complex biological process has yielded information on the important bio-molecules (proteins, RNAs, plant growth regulators) associated with the tuberization process in potato...
January 18, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#14
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stephen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea-Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum K Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, on June 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealed the basic aspects of alcohol metabolism that may be responsible for the development of liver disease as well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28076487/technological-information-regarding-prebiotics-and-probiotics-nutrition-versus-the-patent-registers-what-is-new
#15
José Maciel Caldas Dos Reis, Maurício Fortuna Pinheiro, André Takashi Oti, Denilson José Silva Feitosa-Junior, Mauro de Souza Pantoja, Rui Sérgio Monteiro Barros
Introduction: Food is a key factor both in prevention and in promoting human health. Among the functional food are highlighted probiotics and prebiotics. Patent databases are the main source of technological information about innovation worldwide, providing extensive library for research sector. Objective: Perform mapping in the main patent databases about pre and probiotics, seeking relevant information regarding the use of biotechnology, nanotechnology and genetic engineering in the production of these foods...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28032195/versatility-of-hydrocarbon-production-in-cyanobacteria
#16
REVIEW
Min Xie, Weihua Wang, Weiwen Zhang, Lei Chen, Xuefeng Lu
Cyanobacteria are photosynthetic microorganisms using solar energy, H2O, and CO2 as the primary inputs. Compared to plants and eukaryotic microalgae, cyanobacteria are easier to be genetically engineered and possess higher growth rate. Extensive genomic information and well-established genetic platform make cyanobacteria good candidates to build efficient biosynthetic pathways for biofuels and chemicals by genetic engineering. Hydrocarbons are a family of compounds consisting entirely of hydrogen and carbon...
February 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27989563/preclinical-evidence-for-the-addiction-potential-of-highly-palatable-foods-current-developments-related-to-maternal-influence
#17
David A Wiss, Kristen Criscitelli, Mark Gold, Nicole Avena
It is well established that obesity has reached pandemic proportions. Over the last four decades the prevalence of obesity and morbid obesity have risen substantially in both men and women worldwide. Although there are many causative factors leading to excessive weight gain including genetics and sedentary lifestyle, the transformation of the food environment has undoubtedly contributed to the dangerously high rates of obesity. The current food landscape is inundated with food engineered to contain artificially high levels of sugar and fat...
December 15, 2016: Appetite
https://www.readbyqxmd.com/read/27920297/role-of-ribonucleotide-reductase-in-bacillus-subtilis-stress-associated-mutagenesis
#18
Karla Viridiana Castro-Cerritos, Ronald E Yasbin, Eduardo A Robleto, Mario Pedraza-Reyes
The Gram-positive microorganism Bacillus subtilis relies on a single class Ib ribonucleotide reductase (RNR) to generate 2'-deoxyribonucleotides (dNDPs) for DNA replication and repair. In this work, we investigated the influence of RNR levels on B. subtilis stationary-phase-associated mutagenesis (SPM). Since RNR is essential in this bacterium, we engineered a conditional mutant of strain B. subtilis YB955 (hisC952 metB5 leu427) in which expression of the nrdEF operon was modulated by isopropyl-β-d-thiogalactopyranoside (IPTG)...
February 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/27801985/global-regulatory-framework-for-production-and-marketing-of-crops-biofortified-with-vitamins-and-minerals
#19
Luis A Mejia, Omar Dary, Hala Boukerdenna
Biofortification of crops is being introduced in several countries as a strategy to reduce micronutrient deficiencies. Biofortified products, with increased contents of micronutrients, are currently produced by conventional plant breeding, genetic modification, or nutrient-enhanced fertilization. Corn, rice, wheat, beans, pearl millet, sweet potato, and cassava have been biofortified with increased contents of provitamin A carotenoids, iron, or zinc. However, regulatory considerations are rare or nonexistent...
February 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27770864/enzymes-from-rare-actinobacterial-strains
#20
J Suriya, S Bharathiraja, P Manivasagan, S-K Kim
Actinobacteria constitute rich sources of novel biocatalysts and novel natural products for medical and industrial utilization. Although actinobacteria are potential source of economically important enzymes, the isolation and culturing are somewhat tough because of its extreme habitats. But now-a-days, the rate of discovery of novel compounds producing actinomycetes from soil, freshwater, and marine ecosystem has increased much through the developed culturing and genetic engineering techniques. Actinobacteria are well-known source of their bioactive compounds and they are the promising source of broad range of industrially important enzymes...
2016: Advances in Food and Nutrition Research
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