Manuel Quintana-Diaz, Pasquale Anania, Raúl Juárez-Vela, Emmanuel Echaniz-Serrano, Clara Isabel Tejada-Garrido, Pilar Sanchez-Conde, Kapil Nanwani-Nanwani, Ainhoa Serrano-Lázaro, Pilar Marcos-Neira, María Gero-Escapa, Jorge García-Criado, Daniel Agustín Godoy
INTRODUCTION: Coagulopathy associated with isolated traumatic brain injury (C-iTBI) is a frequent complication associated with poor outcomes, primarily due to its role in the development or progression of haemorrhagic brain lesions. The independent risk factors for its onset are age, severity of traumatic brain injury (TBI), volume of fluids administered during resuscitation, and pre-injury use of antithrombotic drugs. Although the pathophysiology of C-iTBI has not been fully elucidated, two distinct stages have been identified: an initial hypocoagulable phase that begins within the first 24 h, dominated by platelet dysfunction and hyperfibrinolysis, followed by a hypercoagulable state that generally starts 72 h after the trauma...
2023: Frontiers in Public Health