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https://www.readbyqxmd.com/read/29455359/eosinophilic-esophagitis-an-important-comorbid-condition-of-asthma
#1
REVIEW
Sandy R Durrani, Vincent A Mukkada, Theresa W Guilbert
Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically...
February 18, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29453868/coexistent-solid-malignancies-in-pemphigus-a-population-based-study
#2
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. Design, Setting, and Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#3
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447372/small-fiber-polyneuropathy-is-prevalent-in-patients-experiencing-complex-chronic-pelvic-pain
#4
Annie Chen, Elise De, Charles Argoff
Objective: To demonstrate the prevalence of small fiber polyneuropathy (SFPN) in patients with refractory chronic pelvic pain (CPP). Design: Retrospective study of prospective database. Subjects: Participants were complex CPP patients recruited from subspecity referral clinics defined as those who were refractory to initial treatment and/or exhibited comorbid pain syndromes at initial presentation. Methods: Comprehensive treatment history for CPP was obtained, and participants referred as above; 3-mm punch biopsies were obtained of the lower extremity and sent to diagnostic reference labs to evaluate for SFPN...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29444329/gastroesophageal-reflux-symptoms-are-not-sufficient-to-guide-esophageal-function-testing-in-lung-transplant-candidates
#5
S Posner, J Zheng, R K Wood, R A Shimpi, M G Hartwig, S-C Chow, D A Leiman
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testing as part of the wait-listing process but guidelines for testing in this population are lacking. The aim of this study is to describe whether symptoms of gastroesophageal reflux correlate with abnormal results on pH-metry and high-resolution manometry and can be used to identify those who require testing...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444254/high-resolution-esophageal-manometry-in-a-mexican-population-diagnostic-outcome
#6
G Vazquez-Elizondo, L E Hernández-González, S R Achem
High-resolution esophageal manometry (HREM) has become the method of choice for evaluation of esophageal motility disorders. There is a paucity of data with this technique from Hispanic countries. This study aims to characterize the diagnostic outcome of HREM in a large cohort of consecutive patients in Mexico.This study was conducted in Monterrey, Mexico from March 1, 2013 to March 31, 2015. Our diverse study population included patients from a major academic institution and the community. HREM was done applying the Chicago Classification 3...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444224/a-systematic-review-with-meta-analysis-of-the-prevalence-of-gastroesophageal-reflux-in-congenital-diaphragmatic-hernia-pediatric-survivors
#7
J V Arcos-Machancoses, C Ruiz Hernández, J Martin de Carpi, S Pinillos Pisón
Congenital diaphragmatic hernia survivors are a well-known group at risk for developing gastroesophageal reflux disease that may be particularly long-term severe. The aim of this study is to provide a systematic review of the prevalence of gastroesophageal reflux in infant and children survivors treated for congenital diaphragmatic hernia.Electronic and manual searches were performed with keywords related to congenital diaphragmatic hernia, gastroesophageal reflux disease, and epidemiology terms. Summary estimates of the prevalence were calculated...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444213/systematic-review-methodological-flaws-in-racial-ethnic-reporting-for-gastroesophageal-reflux-disease
#8
M R Craven, L Kia, L C O'Dwyer, E Stern, T H Taft, L Keefer
Health care disparities affecting the care of multiple disease groups are of growing concern internationally. Research guidelines, governmental institutions, and scientific journals have attempted to minimize disparities through policies regarding the collection and reporting of racial/ethnic data. One area where shortcomings remain is in gastroesophageal reflux disease (GERD). This systematic review, which adheres to the PRISMA statement, focuses on characterizing existing methodological weaknesses in research focusing on studies regarding the assessment, prevalence, treatment, and outcomes of GERD patients...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29436213/gastric-reflux-comparison-between-the-gastroenterologist-and-the-otorhinolaryngologist%C3%A2-s-approach-pragmatic-conclusive-remarks
#9
G Ciprandi, M Gelardi
Gastroesophageal reflux (GER) is a normal physiological process that usually happens after eating in healthy infants, children, young people and adults. In contrast, gastroesophageal reflux disease (GERD) occurs when the effect of GER leads to symptoms severe enough to merit medical treatment. In clinical practice, it is difficult to differentiate between GER and GERD, and health professionals and families use the terms interchangeably alike. There is no simple, reliable and accurate diagnostic test to confirm whether the condition is GER or GERD, and this in turn affects research and clinical decisions (1-6)...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#10
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29428028/chronic-obstructive-pulmonary-disease-exacerbations-are-influenced-by-gastroesophageal-reflux-disease
#11
Amilcar M Bigatao, Fernando A M Herbella, Leonardo M Del Grande, Oliver A Nascimento, Jose R Jardim, Marco G Patti
Gastroesophageal reflux disease (GERD) is associated with different pulmonary diseases, including chronic obstructive pulmonary disease (COPD). Whether GERD is contributory to COPD severity remains unclear. This study aims to evaluate the contribution of GERD to the clinical manifestation of COPD based on ventilatory parameters and yearly clinical exacerbations. We studied 48 patients (56% females, age 66 years) with COPD. All patients underwent high-resolution manometry and esophageal pH monitoring. The patients were separated into two groups according to the presence of GERD...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29421814/herbal-preparation-stw%C3%A2-5-for-functional-gastrointestinal-disorders-clinical-experience-in-everyday-practice
#12
Tatiana L Lapina, Alexander S Trukhmanov
BACKGROUND: The most common functional gastrointestinal disorders (FGID) are functional dyspepsia (FD) and irritable bowel syndrome (IBS), with a prevalence in the general population of 15-20% (FD) and 10% (IBS), respectively. The complexity of pathophysiologic mechanisms and limitations in therapeutic options make the management of FD and IBS patients a challenge in routine clinical practice. SUMMARY: Syndromes classified as FGID frequently overlap, and coexist with gastroesophageal reflux disease (GERD)...
February 8, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29416581/prevalence-of-gastroesophageal-reflux-disease-in-saudi-arabia
#13
Obaidallah Buraykan Alsuwat, Abdulrahman Ahmad Alzahrani, Mohammed Abdullah Alzhrani, Ali Mesfer Alkhathami, Mohammad Eid Mahmoud Mahfouz
Background: Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal tract disease. The incidence is higher in Asian and Arab countries. In Saudi Arabia, there are few studies that have assessed the prevalence of GERD among some cities' communities. Hence, this study aims to study the prevalence of GERD among the general population of Saudi Arabia. Methods: A cross-sectional study was designed to determine the prevalence of GERD among the community of Saudi Arabia...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29404836/characterization-of-the-nasopharyngeal-and-middle-ear-microbiota-in-gastroesophageal-reflux-prone-versus-gastroesophageal-reflux-non-prone-children
#14
Stefan A Boers, Marjolein de Zeeuw, Ruud Jansen, Marc P van der Schroeff, Annemarie M C van Rossum, John P Hays, Suzanne J C Verhaegh
Otitis media (OM) is one of the most common pediatric infections worldwide, but the complex microbiology associated with OM is poorly understood. Previous studies have shown an association between OM and gastroesophageal reflux (GER) in children. Therefore, in order to bridge the gap in our current understanding of the interaction between GER and OM, we investigated the nasopharyngeal and middle ear microbiota of children suffering from GER-associated OM and OM only, using culture-independent 16S rRNA gene sequencing...
February 5, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29372475/acid-secretion-and-its-relationship-to-esophageal-reflux-symptom-in-patients-with-subtotal-gastrectomy
#15
Hyun Jin Oh, Myung-Gyu Choi, Jae Myung Park, Kyo Young Song, Han Mo Yoo
BACKGROUND: Esophageal reflux symptom has been reported as common in patients with subtotal gastrectomy. Management of postoperative esophageal reflux symptom is not satisfactory. The aim of this study is to investigate prevalence of esophageal reflux symptom after subtotal gastrectomy and assess factors affecting esophageal reflux symptom in subtotal gastrectomy patients. METHODS: We prospectively enrolled 100 consecutive patients with subtotal gastrectomy who were regularly followed up by endoscopic examination...
January 25, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29333824/eosinophilic-esophagitis-and-esophageal-atresia-coincidence-or-causality
#16
Karen V Stave Salgado, Ana M Rocca
Eosinophilic esophagitis is an immune-mediated chronic disease of the esophagus characterized by symptoms related to esophageal dysfunction and tissue eosinophilia. In the endoscopy, the esophageal mucosa may appear normal or show exudates, rings, edema, furrows, and strictures. Its management is based on elimination diet, topical corticosteroids and/or esophageal dilation. Atresia is the most common congenital alteration of the esophagus; it requires surgical repair and poses potential complications, such as gastroesophageal reflux, strictures, and esophageal dysmotility...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29327262/risk-of-neoplastic-progression-among-patients-with-an-irregular-z-line-on-long-term-follow-up
#17
David Itskoviz, Zohar Levi, Doron Boltin, Alex Vilkin, Yifat Snir, Rachel Gingold-Belfer, Yaron Niv, Iris Dotan, Ram Dickman
BACKGROUND: Barrett's esophagus (BE) is a known complication of gastroesophageal reflux disease. In a previous study, we described a high prevalence of intestinal metaplasia (IM) in patients with an irregular Z line. However, the clinical importance of this finding is unclear. GOALS: To evaluate the long-term development of BE and relevant complications in patients diagnosed with an irregular Z line, with or without IM, on routine esophago-gastro-duodenoscopy (EGD)...
January 11, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29325919/patients-with-cerebral-stroke-have-an-increased-risk-of-gastroesophageal-reflux-disease-a-population-based-cohort-study
#18
Chen-Shu Chang, Hsuan-Ju Chen, Chun-Hui Liao
BACKGROUND: Medical complications following stroke often result in significant morbidity. This study was designed to investigate the prevalence and risk of gastroesophageal reflux disease (GERD) between patients with stroke and those without stroke in Taiwan. METHODS AND RESULTS: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. The study included 18,412 patients newly diagnosed as having stroke during 2000-2006 and 18,412 patients without stroke frequency-matched by sex, age, and index year...
January 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29320988/prevalence-and-key-radiographic-spinal-malalignment-parameters-that-influence-the-risk-for-gastroesophageal-reflux-disease-in-patients-treated-surgically-for-adult-spinal-deformity
#19
Tetsuro Ohba, Shigeto Ebata, Kensuke Koyama, Hirotaka Haro
BACKGROUND: Gastroesophageal reflux disease (GERD) is a factor that has a significant negative impact on the quality of life (QoL). Vertebral fractures and/or spinal malalignment may influence the frequency of GERD. However, the epidemiology and pathology of GERD in patients with adult spinal deformity (ASD) are still largely unknown. To establish the optimal surgical strategy for GERD in patients treated surgically for ASD, we sought to clarify the GERD prevalence, determine radiographically which spinal malalignment parameters influence GERD risk, and evaluate GERD improvement postoperatively...
January 10, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29279574/sports-drink-consumption-and-dental-erosion-among-amateur-runners
#20
Leonardo S Antunes, Lais Veiga, Victor S Nery, Caio C Nery, Lívia A Antunes
This cross-sectional study assessed the prevalence and potential risk factors for dental erosion in amateur athletes at running events. After a sample calculation, 108 runners from the state of Rio de Janeiro, Brazil, were selected and examined for dental wear by a single trained and calibrated evaluator (kappa = 1.00). To identify risk factors, the runners were interviewed by using a standardized, semi-structured questionnaire. The average (SD) age of the runners was 34.2 (11.45), and the prevalence of dental erosion was 19...
2017: Journal of Oral Science
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