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https://www.readbyqxmd.com/read/28427116/current-trends-in-the-management-of-gastroesophageal-reflux-disease
#1
REVIEW
Dalbir S Sandhu, Ronnie Fass
Gastroesophageal reflux disease (GERD) defined as heartburn and/or regurgitation is one of the most common gastrointestinal disorder managed by gastroenterologists and primary care physicians. There is an increase in GERD prevalence since 1995 particularly in North America and East Asia. Over the past three decades proton pump inhibitors (PPIs) had become the mainstay medical therapy for management of GERD. However, over the last decade there is an increasing awareness amongst physicians and patient population regarding the side effects of otherwise considered safe PPIs...
April 24, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28425145/prevalence-of-gastroesophageal-reflux-in-cats-during-anesthesia-and-effect-of-omeprazole-on-gastric-ph
#2
R S Garcia, P C Belafsky, A Della Maggiore, J M Osborn, B H Pypendop, T Pierce, V J Walker, A Fulton, S L Marks
BACKGROUND: Gastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation. OBJECTIVE: To determine whether pre-anesthetic orally administered omeprazole increases gastric and esophageal pH and increases serum gastrin concentrations in anesthetized cats, and to determine the prevalence of GER using combined multichannel impedance and pH monitoring. ANIMALS: Twenty-seven healthy cats undergoing elective dental procedures...
April 19, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28421172/aspiration-risk-and-respiratory-complications-in-patients-with-esophageal-atresia
#3
REVIEW
Thomas Kovesi
Chronic, long-term respiratory morbidity (CRM) is common in patients with a history of repaired congenital esophageal atresia, typically associated with tracheoesophageal fistula (EA/TEF). EA/TEF patients are at high risk of having aspiration, and retrospective studies have associated CRM with both recurrent aspiration and atopy. However, studies evaluating the association between CRM in this population and either aspiration or atopy have reported conflicting results. Furthermore, CRM in this population may be due to other related conditions as well, such as tracheomalacia and/or recurrent infections...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28405322/specific-dyspeptic-symptoms-are-associated-with-poor-response-to-therapy-in-patients-with-gastroesophageal-reflux-disease
#4
A D'Alessandro, F P Zito, M Pesce, P Andreozzi, E Efficie, M Cargiolli, F Maione, G D De Palma, R Cuomo, G Sarnelli
INTRODUCTION: In patients with gastroesophageal reflux disease (GORD), co-existence of functional dyspepsia (FD) is known to be associated with poor response to proton pump inhibitors (PPIs), but the contribution of specific dyspepsia symptoms has not yet been systematically investigated. OBJECTIVE: We aimed to characterize the impact of dyspepsia symptoms on response to PPIs in patients with GORD. METHODS: The enrolled subjects were consecutive patients with a diagnosis of GORD...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28403034/national-study-of-off-label-proton-pump-inhibitor-use-among-new-zealand-infants-in-the-first-year-of-life-2005-2012
#5
Mei-Ling Blank, Lianne Parkin
OBJECTIVE: Off-label prescribing of proton pump inhibitors (PPIs) to infants to treat symptoms attributed to gastroesophageal reflux disease (GERD) is widely reported, despite evidence that PPIs are no more effective than placebo in relieving those symptoms. To initiate discussion about appropriate prescribing of these drugs for infants, we describe the characteristics of PPI use among infants in New Zealand. METHODS: In this population-based study we used routinely collected dispensing data to identify all children born between 2005 and 2012 who were dispensed a government-subsidized PPI (omeprazole, lansoprazole, pantoprazole) before their first birthday...
April 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28385468/approach-attitudes-and-knowledge-of-general-practitioners-in-relation-to-helicobacter-pylori-is-inadequate-there-is-much-room-for-improvement
#6
A D Cano-Contreras, O Rascón, M Amieva-Balmori, S Ríos-Gálvez, Y J Maza, A Meixueiro-Daza, F Roesch-Dietlen, J M Remes-Troche
BACKGROUND: Helicobacter pylori (Hp) infection is one of the most common infections in humans. Due to its worldwide prevalence, a series of guidelines and recommendations has been developed for the appropriate screening, diagnosis, and management of patients with Hp infection. AIM: To evaluate the approach, attitudes, and knowledge of a group of Mexican general practitioners in relation to Hp. MATERIALS AND METHODS: A cross-sectional study was conducted that evaluated the knowledge of Hp diagnosis and treatment through the application of a questionnaire...
April 3, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28343226/the-effect-of-ineffective-esophageal-motility-on-gastroesophageal-reflux-disease
#7
Shingo Kasamatsu, Tomoaki Matsumura, Yuki Ohta, Shinsaku Hamanaka, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Tatsuro Katsuno, Mai Fujie, Atsuko Kikuchi, Makoto Arai
BACKGROUND/AIMS: Ineffective esophageal motility (IEM) is the most common gastrointestinal motility disorder. Studies have reported that IEM is related to gastroesophageal reflux disease (GERD). However, the relationship between IEM and GERD remains uncertain. This study aims to clarify this relationship retrospectively. METHODS: We analyzed 195 subjects who underwent high-resolution manometry between January 2011 and September 2016. Of these subjects, 72 had normal esophageal motility (NEM) and 26 had IEM...
March 25, 2017: Digestion
https://www.readbyqxmd.com/read/28328160/co-morbidities-in-severe-asthma-clinical-impact-and-management
#8
REVIEW
Celeste Porsbjerg, Andrew Menzies-Gow
Patients with severe asthma represent a minority of the total asthma population, but carry a majority of the morbidity and healthcare costs. Achieving better asthma control in this group of patients is therefore of key importance. Systematic assessment of patients with possible severe asthma to identify treatment barriers and triggers of asthma symptoms, including co-morbidities, improves asthma control and reduces healthcare costs and is recommended by international guidelines on management of severe asthma...
March 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28317233/pirfenidone-and-nintedanib-for-pulmonary-fibrosis-in-clinical-practice-tolerability-and-adverse-drug-reactions
#9
Jonathan A Galli, Aloknath Pandya, Michelle Vega-Olivo, Chandra Dass, Huaqing Zhao, Gerard J Criner
BACKGROUND AND OBJECTIVE: The real-world tolerability of pirfenidone and nintedanib in non-clinical trial patients is unknown. Many patients with pulmonary fibrosis have significant medical co-morbidities or baseline characteristics that exclude them from clinical trial participation. METHODS: We conducted a retrospective chart review study on subjects prescribed nintedanib or pirfenidone for pulmonary fibrosis treatment (any aetiology) from September 2014 to February 2016...
March 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28302442/symptoms-endoscopic-findings-and-reflux-monitoring-results-in-candidates-for-bariatric-surgery
#10
Benjamin Heimgartner, Marcus Herzig, Yves Borbély, Dino Kröll, Philipp Nett, Radu Tutuian
BACKGROUND: Gastroesophageal reflux disease (GERD) is common in patients with obesity. Diagnosing GERD is important as bariatric operations have different influence on GERD. We assessed reflux symptoms and objective findings prior to surgery. METHODS: Work-up included esophageal symptoms quantification by VAS-scores, esophagogastroduodenoscopy (EGD) and 24-h impedance-pH (imp-pH) monitoring off PPI therapy. Imp-pH was classified as abnormal if either %time pH<4 was abnormal, total number of reflux episodes was elevated or symptom index (SI) was positive...
February 3, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28278241/the-prevalence-of-diagnosed-chronic-conditions-and-multimorbidity-in-australia-a-method-for-estimating-population-prevalence-from-general-practice-patient-encounter-data
#11
Christopher Harrison, Joan Henderson, Graeme Miller, Helena Britt
OBJECTIVES: To estimate the prevalence of common chronic conditions and multimorbidity among patients at GP encounters and among people in the Australian population. To assess the extent to which use of each individual patient's GP attendance over the previous year, instead of the average for their age-sex group, affects the precision of national population prevalence estimates of diagnosed chronic conditions. DESIGN, SETTING AND PARTICIPANTS: A sub-study (between November 2012 and March 2016) of the Bettering the Evaluation and Care of Health program, a continuous national study of GP activity...
2017: PloS One
https://www.readbyqxmd.com/read/28262205/characterization-of-mast-cell-activation-syndrome
#12
Lawrence B Afrin, Sally Self, Jeremiah Menk, John Lazarchick
BACKGROUND: Mast cell activation syndrome (MCAS), a recently recognized nonneoplastic mast cell disease driving chronic multisystem inflammation and allergy, appears prevalent and thus important. We report the first systematic characterization of a large MCAS population. METHOD: Demographics, comorbidities, symptoms, family histories, physical examination and laboratory findings were reviewed in 298 retrospective and 115 prospective patients with MCAS. Blood samples from prospective subjects were examined by flow cytometry for clonal mast cell disease and tested for cytokines potentially driving the monocytosis frequent in MCAS...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28258457/from-heartburn-to-barrett-s-esophagus-and-beyond
#13
Francisco Schlottmann, Marco G Patti, Nicholas J Shaheen
BACKGROUND: Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the USA, and its prevalence is increasing worldwide. About 10-15% of patients with GERD will develop Barrett's esophagus (BE). AIMS: The aims of this study were to review the available evidence of the pathophysiology of BE and the role of anti-reflux surgery in the treatment of this disease. RESULTS: The transformation of the squamous epithelium into columnar epithelium with goblet cells is due to the chronic injury produced by repeated reflux episodes...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28258448/surgical-treatment-of-gastroesophageal-reflux-disease
#14
Francisco Schlottmann, Fernando A Herbella, Marco E Allaix, Fabrizio Rebecchi, Marco G Patti
BACKGROUND: Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the USA, and its prevalence is increasing worldwide. Lifestyle modifications and proton pump inhibitors (PPI) therapy are effective in the majority of patients and remain the mainstay of treatment of GERD. However, some patients will need surgical intervention because they have partial control of symptoms, do not want to be on long-term medical treatment, or suffer complications related to PPI therapy...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28256048/multiple-functional-gastrointestinal-disorders-linked-to-gastroesophageal-reflux-and-somatization-a-population-based-study
#15
R S Choung, G Richard Locke, C D Schleck, A R Zinsmeister, N J Talley
BACKGROUND: It is unknown why functional gastrointestinal disorders (FGIDs) overlap and limited information exists on risk factors for those with overlap. Our aim was to estimate the prevalence of combinations of FGIDs including reflux (FGIDs-gastroesophageal reflux [GER]), and evaluate potential risk factors for people with multiple disorders in a representative US community. METHODS: A population-based study was conducted by mailing a valid GI symptom questionnaire to an age- and gender-stratified random sample of residents of Olmsted County, MN...
March 3, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28247277/diagnosis-and-treatment-of-eosinophilic-esophagitis-in-clinical-practice
#16
REVIEW
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Takao Yaoita, Shoichi Nishise, Yoshiyuki Ueno
Eosinophilic esophagitis (EoE) is a chronic and abnormal Th2 type immunological response characterized by intense eosinophilic inflammation localized within the esophagus. This leads to esophageal dysfunction and remodeling accompanied by subepithelial fibrosis. Recently, EoE has been recognized as one of the major causes of dysphagia or food impaction in adults. The prevalence of EoE has been increasing over the past several decades, particularly in Western countries. EoE should be differentiated from secondary esophageal eosinophilia (EE) in gastroesophageal reflux disease (GERD) and eosinophilic gastroenteritis, involving the entire gastrointestinal tract...
April 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28239077/a-review-of-diagnosis-of-gerd
#17
REVIEW
In Du Jeong
The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the accumulation in our understanding on the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to the GERD have changed dramatically over the past decade. However, The GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extraesophageal manifestations...
February 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28215067/epidemiology-and-natural-history-of-gastro-esophageal-reflux-disease
#18
Edoardo Savarino, Elisa Marabotto, Giorgia Bodini, Gaia Pellegatta, Claudia Coppo, Elisa Giambruno, Matteo Brunacci, Patrizia Zentilin, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is highly prevalent in Western countries, particularly when considering its most classic symptom, that is heartburn. This symptom is very frequent in the community and ranges from 10% to more than 30%, according to the various population-based studies. This disease is much more represented in Europe and US than in Asiatic countries. It has been shown that GERD prevalence increases in parallel with the remarkable growth of obesity, as this condition is able to favor all the pathogenetic mechanisms leading to it...
February 17, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28210089/prevalence-of-gastroesophageal-reflux-disease-in-a-country-with-a-high-occurrence-of-helicobacter-pylori
#19
Serhat Bor, Gul Kitapcioglu, Elmas Kasap
AIM: To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS: Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. "Frequent symptoms" were defined heartburn and/or regurgitation occurring at least weekly. RESULTS: The prevalence of GERD was 22...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28209602/a-novel-murine-model-of-esophageal-non-erosive-reflux-disease-nerd-from-inflammation-to-impairment-in-mucosal-integrity
#20
Renan O Silva, Francisco Fábio B Oliveira, Rudy D Bingana, Mailton O Arruda, Philip Woodland, Chung Lee, Miguel A Nobre E Souza, Pedro Marcos G Soares, Armenio A Santos, Daniel Sifrim, Marcellus H L P Souza
Non-erosive reflux disease (NERD) is a highly prevalent phenotype of the gastroesophageal reflux disease (GERD). In this study, we developed a novel murine model of NERD in mice with microscopic inflammation and impairment in the epithelial esophageal barrier. Female Swiss mice were subjected to the following surgical procedure: the transitional region between the forestomach and the glandular portion of the stomach was ligated, and a nontoxic ring was placed around the duodenum near the pylorus. The control group underwent sham surgery...
February 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
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