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hepatic steatosis

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https://www.readbyqxmd.com/read/29452209/prolactin-improves-hepatic-steatosis-via-cd36-pathway
#1
Pengzi Zhang, Zhijuan Ge, Hongdong Wang, Wenhuan Feng, Xitai Sun, Xuehui Chu, Can Jiang, Yan Wang, Dalong Zhu, Yan Bi
BACKGROUND & AIMS: Prolactin (PRL) is a multifunctional polypeptide with effects on metabolism; however, little is known about its effect on hepatic steatosis and lipid metabolism. METHODS: The serum PRL levels of 456 non-alcoholic fatty liver disease (NAFLD) patients and 403 non-NAFLD controls diagnosed by ultrasound, and 85 subjects with liver histology obtained during metabolic surgery (44 female and 30 male NAFLD patients and 11 age-matched non-NAFLD female subjects) were evaluated...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29452206/snx10-mediates-alcohol-induced-liver-injury-and-steatosis-via-regulating-chaperone-mediated-autophagy-activation
#2
Yan You, Wan-Zhen Li, Sulin Zhang, Bin Hu, Yue-Xuan Li, Hai-Dong Li, Huan-Huan Tang, Qian-Wen Li, Yun-Yun Guan, Li-Xin Liu, Wei-Lian Bao, Xiaoyan Shen
BACKGROUND & AIMS: Alcoholic liver disease is a major cause of morbidity and mortality worldwide. However, the cellular defense mechanisms underlying ALD are not well understood. Recent studies highlight the involvement of chaperone-mediated autophagy (CMA) in regulating hepatic lipid metabolism. Sorting nexin (SNX) 10 has a regulatory function in endo-lysosomal trafficking and stabilization. Here we investigated the roles of SNX10 in CMA activation and the pathogenesis of alcohol-induced liver injury and steatosis...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29452135/evidence-based-exercise-recommendations-to-reduce-hepatic-fat-content-in-youth-a-systematic-review-and-meta-analysis
#3
REVIEW
María Medrano, Cristina Cadenas-Sanchez, Celia Álvarez-Bueno, Iván Cavero-Redondo, Jonatan R Ruiz, Francisco B Ortega, Idoia Labayen
The main purposes of this study were to elucidate the effects of supervised-exercise training (ET) interventions on hepatic fat content and on non-alcoholic fatty liver disease (NAFLD) prevalence in children and adolescents and to provide information about the optimal ET prescription (type, intensity, volume, and frequency) needed to reduce hepatic fat content in youths. Supervised-ET interventions performed in children and adolescents (6-19 years) that provided results of exercise effects on hepatic fat content or NAFLD prevalence were included...
February 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29450729/physical-activity-and-mediterranean-diet-based-on-olive-tree-phenolic-compounds-from-two-different-geographical-areas-have-protective-effects-on-early-osteoarthritis-muscle-atrophy-and-hepatic-steatosis
#4
Marta Anna Szychlinska, Paola Castrogiovanni, Francesca Maria Trovato, Houda Nsir, Mokhtar Zarrouk, Debora Lo Furno, Michelino Di Rosa, Rosa Imbesi, Giuseppe Musumeci
PURPOSE: Osteoarthitis (OA) leads to progressive loss of articular cartilage, pain and joint disability. An acute injury constitutes an important risk factor for early OA, determining an inflammatory process responsible of cartilage degeneration and muscle atrophy, due to the joint pain and immobility. The study aims to assess the effects of conjugation of physical activity and diet enriched by olive tree compounds [extra virgin olive oil (EVOO) and olive leaf extract (OLE)], on the musculoskeletal system in OA rat model...
February 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29450137/liver-and-metformin-lessons-of-a-fructose-diet-in-mice
#5
Iara Karise, Fernanda Ornellas, Sandra Barbosa-da-Silva, Cristiane Matsuura, Mariano Del Sol, Marcia Barbosa Aguila, Carlos A Mandarim-de-Lacerda
Studies show that the continuous consumption of fructose can lead to nonalcoholic fatty liver disease (NAFLD) and steatohepatitis. We aimed to investigate the role of Metformin in an animal model of liver injury caused by fructose intake, focusing on the molecular markers of lipogenesis, beta-oxidation, and antioxidant defenses. Male three months old C57BL/6 mice were divided into control group (C) and fructose group (F, 47% fructose), maintained for ten weeks. After, the groups received Metformin or vehicle for a further eight weeks: control (C), control + Metformin (CM), fructose (F), and fructose + Metformin (FM)...
June 2017: Biochimie open
https://www.readbyqxmd.com/read/29448843/cenicriviroc-for-the-treatment-of-non-alcoholic-steatohepatitis-and-liver-fibrosis
#6
Frank Tacke
Nonalcoholic fatty liver disease (NAFLD) has an increasing prevalence worldwide. At present, no specific pharmacotherapy is approved for NAFLD. Simple steatosis and nonalcoholic steatohepatitis (NASH) can progress to liver fibrosis that is associated with mortality in NAFLD. The recruitment of inflammatory monocytes and macrophages via chemokine receptor CCR2 as well as of lymphocytes and hepatic stellate cells via CCR5 promote the progression of NASH to fibrosis. Areas covered: I summarize preclinical and clinical data on the efficacy and safety of the dual CCR2/CCR5 inhibitor cenicriviroc (CVC, also TBR-652 or TAK-652) for the treatment of NASH and fibrosis...
February 16, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29438564/erratum-for-%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-ameliorates-nicotine-plus-high-fat-diet-induced-hepatic-steatosis-in-male-mice-by-inhibiting-oxidative-stress-and-stimulating-ampk-signaling
#7
https://www.readbyqxmd.com/read/29437549/hepatic-and-renal-histology-and-mercury-concentrations-of-north-west-and-north-east-greenland-narwhals-monodon-monoceros
#8
Christian Sonne, Pall S Leifsson, Jens Søndergaard, Rune Dietz
Narwhals (Monodon monoceros) are at the top of the Arctic food web and therefore might biomagnify high total mercury (Hg) concentrations in organs and tissues. The aim of this study was to determine histopathology and Hg concentrations in liver and kidneys from 15 North East Greenland narwhals (3 subadult females, 8 adult females, 3 subadult males, and 1 adult male) and compare data with previous observations of 12 North West Greenland specimens (1 subadult female, 4 adult females, 1 subadult male, and 6 adult males)...
February 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29435319/serum-magnesium-concentration-is-independently-associated-with-non-alcoholic-fatty-liver-and-non-alcoholic-steatohepatitis
#9
Ahad Eshraghian, Saman Nikeghbalian, Bita Geramizadeh, Seyed Ali Malek-Hosseini
Background: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) has not been well recognized yet. Objective: This study aimed to investigate the association between serum magnesium concentration and NAFLD. Methods: Study participants were healthy individuals who had undergone liver biopsies between January 2012 and August 2015 as a routine pre-transplant check-up before living donor liver transplantation. Liver biopsy specimens were evaluated by an expert pathologist regarding presence of hepatic steatosis and steatohepatitis...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29434074/validation-of-simple-indexes-for-nonalcoholic-fatty-liver-disease-in-western-china-a-retrospective-cross-sectional-study
#10
Jinzhou Zhu, Mingqing He, Yong Zhang, Tingxin Li, Yuping Liu, Zhiye Xu, Weichang Chen
Various noninvasive algorithms have been developed for predicting the presence of nonalcoholic fatty liver disease (NAFLD). The evaluation of the indexes' diagnostic performance has been reported in Europe and Asia over the past decade; however, external validation of them in China is rare. This study was aimed to evaluate various indexes for NAFLD in western China. It was a retrospective cross-sectional study, using data from a large-scale health check-up project at Sichuan provincial hospital. Receiver operating characteristic (ROC) curves of eight indexes, including the fatty liver index (FLI), the hepatic steatosis index, lipid accumulation product and etc...
February 9, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29431616/role-of-the-pregnane-x-receptor-in-binge-ethanol-induced-steatosis-and-hepatotoxicity
#11
Sora Choi, Afua A Gyamfi, Prince Neequaye, Samuel Addo, Frank J Gonzalez, Maxwell A Gyamfi
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that defends against toxic agents. We have shown that PXR promotes chronic ethanol (EtOH)-induced steatosis. Therefore, we examined the role of PXR in binge EtOH-induced hepatotoxicity. Male wild type (WT) and Pxr-null mice were orally administered three binge doses of EtOH (4.5 g/kg, every 12 hours) and euthanized four hours after the final dose. Pxr-null mice displayed higher basal mRNA levels of hepatic lipogenic transcription factor sterol regulatory element binding protein 1c (Srebp-1c) and its target stearoyl-CoA desaturase 1 (Scd1) and the lipid peroxide detoxifying aldo-keto reductase 1b7 (Akr1b7) and higher protein levels of EtOH-metabolizing alcohol dehydrogenase 1 (ADH1)...
February 5, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29428719/combination-effects-of-alogliptin-and-pioglitazone-on-steatosis-and-hepatic-fibrosis-formation-in-a-mouse-model-of-non-alcoholic-steatohepatitis
#12
Yuichiro Amano, Shuntarou Tsuchiya, Mayumi Imai, Kimio Tohyama, Jun Matsukawa, Osamu Isono, Hironobu Yasuno, Kazuaki Enya, Emiko Koumura, Hiroshi Nagabukuro
This study aimed to evaluate the effects of combination therapy with a dipeptidyl peptidase-4 inhibitor, alogliptin, and a peroxisome proliferator-activated receptor-γ agonist, pioglitazone, in a preclinical model of nonalcoholic steatohepatitis using low-density lipoprotein receptor-knockout mice fed a modified choline-deficient l-amino acid-defined diet. Monotherapy with either alogliptin (10-200 mg/kg) or pioglitazone (6-20 mg/kg) significantly decreased hepatic triglyceride content and fibrosis. The concomitant treatment of alogliptin (30 mg/kg), pioglitazone (20 mg/kg) also decreased hepatic triglyceride and hepatic collagen-I mRNA at greater extent compared to monotherapy...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29428667/silybum-marianum-oil-attenuates-hepatic-steatosis-and-oxidative-stress-in-high-fat-diet-fed-mice
#13
Shu Yun Zhu, Ning Jiang, Jing Yang, Jie Tu, Yue Zhou, Xiang Xiao, Ying Dong
In the present study, the effects of Silybum marianum oil (SMO) on hepatic steatosis and oxidative stress were investigated during the development of nonalcoholic fatty liver disease (NAFLD) in high fat diet (HFD)-fed mice. The results showed that body weight, fat mass, and serum biochemical parameters such as triglyceride, free fatty acid, glucose and insulin were reduced by SMO treatment. Meanwhile, SMO decreased the histological injury of liver and the levels of hepatic triglyceride, cholesterol and free fatty acid in HFD-fed mice...
February 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29426937/ultraconserved-element-uc-372-drives-hepatic-lipid-accumulation-by-suppressing-mir-195-mir4668-maturation
#14
Jun Guo, Weiwei Fang, Libo Sun, Yonggang Lu, Lin Dou, Xiuqing Huang, Weiqing Tang, Liqing Yu, Jian Li
Ultraconserved (uc) RNAs, a class of long non-coding RNAs (lncRNAs), are conserved across humans, mice, and rats, but the physiological significance and pathological role of ucRNAs is largely unknown. Here we show that uc.372 is upregulated in the livers of db/db mice, HFD-fed mice, and NAFLD patients. Gain-of-function and loss-of-function studies indicate that uc.372 drives hepatic lipid accumulation in mice by promoting lipogenesis. We further demonstrate that uc.372 binds to pri-miR-195/pri-miR-4668 and suppresses maturation of miR-195/miR-4668 to regulate expression of genes related to lipid synthesis and uptake, including ACC, FAS, SCD1, and CD36...
February 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29424449/viral-eradication-reduces-both-liver-stiffness-and-steatosis-in-patients-with-chronic-hepatitis-c-virus-infection-who-received-direct-acting-anti-viral-therapy
#15
T Tada, T Kumada, H Toyoda, Y Sone, K Takeshima, S Ogawa, T Goto, A Wakahata, M Nakashima, M Nakamuta, J Tanaka
BACKGROUND: Whether direct-acting anti-viral therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (HCV) infection is unclear. AIMS: To evaluate changes in liver stiffness and steatosis in patients with HCV who received direct-acting anti-viral therapy and achieved sustained virological response (SVR). METHODS: A total of 198 patients infected with HCV genotype 1 or 2 who achieved SVR after direct-acting anti-viral therapy were analysed...
February 9, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29422939/associations-between-fatty-acid-oxidation-hepatic-mitochondrial-function-and-plasma-acylcarnitine-levels-in-mice
#16
Bodil Bjørndal, Eva Katrine Alterås, Carine Lindquist, Asbjørn Svardal, Jon Skorve, Rolf K Berge
Background: The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit mitochondrial β-oxidation, and can be used as chemically induced hepatic steatosis-model in rodents, while 3-thia fatty acid tetradecylthioacetic acid (TTA) stimulates fatty acid oxidation through activation of peroxisome proliferator activated receptor alpha (PPARα). We wished to determine how these two compounds affected in vivo respiration and mitochondrial efficiency, with an additional goal to elucidate whether mitochondrial function is reflected in plasma acylcarnitine levels...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29421579/polyphenol-enriched-extract-of-rosa-rugosa-thunb-regulates-lipid-metabolism-in-diabetic-rats-by-activation-of-ampk-pathway
#17
Liu Liu, Mireguli Yasen, Dan Tang, Jianping Ye, Haji Akber Aisa, Xuelei Xin
This study was designed to investigate the mechanism of polyphenol-enriched extract of Rosa rugosa Thunb (RPE) in the control of dyslipidemia in diabetic rats. RPE was tested at three dosages (37.5 mg/kg, 75 mg/kg and 150 mg/kg) in the rat dyslipidemia model established with high fat diet feeding in combination with STZ injection (30 mg/kg). The RPE effect was evaluated after 4 weeks of treatment. In the RPE-treated rats, hepatic total cholesterol (TC) and triglyceride (TG) were significantly reduced, lipoprotein lipase (LPL) and liver lipase (HL) were significantly increased...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29421523/maraviroc-improves-hepatic-triglyceride-content-but-not-inflammation-in-a-murine-nonalcoholic-fatty-liver-disease-model-induced-by-a-chronic-exposure-to-high-fat-diet
#18
Laura Pérez-Martínez, Laura Ochoa-Callejero, Susana Rubio-Mediavilla, Judit Narro, Iván Bernardo, José-Antonio Oteo, José-Ramón Blanco
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the general population. Its severity ranges from simple steatosis to cirrhosis. C-C chemokine ligand type 5 or RANTES plays an important role in the progression of hepatic inflammation and fibrosis. Our objective was to examine the preventive and therapeutic effects of maraviroc (MVC), a C-C chemokine receptor 5 antagonist, on liver pathology in an NAFLD mouse model. A total of 60 male C57BL/6 mice were randomly assigned to 1 of 4 groups: (1) high-fat diet (HFD) group or control group, (2) preventive group (HFD group plus MVC in drinking water since the beginning of the study), (3) early-therapeutic group (HFD group plus MVC in drinking starting at week 24 of the study), and (4) late-therapeutic group (HFD group plus MVC in drinking water starting at week 36 of the study)...
January 31, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29420235/loss-of-mitochondrial-protease-clpp-protects-mice-from-diet-induced-obesity-and-insulin-resistance
#19
Shylesh Bhaskaran, Gavin Pharaoh, Rojina Ranjit, Ashley Murphy, Satoshi Matsuzaki, Binoj C Nair, Brittany Forbes, Suzana Gispert, Georg Auburger, Kenneth M Humphries, Michael Kinter, Timothy M Griffin, Sathyaseelan S Deepa
Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPRmt), a retrograde signaling response that helps to maintain mitochondrial protein homeostasis. Mitochondrial dysfunction is associated with the development of metabolic disorders, and to understand the effect of a defective UPRmt on metabolism, ClpP knockout (ClpP-/-) mice were analyzed. ClpP-/- mice fed ad libitum have reduced adiposity and paradoxically improved insulin sensitivity...
February 2, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29419350/swim-exercise-training-ameliorates-hepatocyte-ultrastructural-alterations-in-rats-fed-on-a-high-fat-and-sugar-diet
#20
Mohammed A Dallak, Ismaeel Bin-Jaliah, Alia Albawardi, Mohamed A Haidara, Hussein F Sakr, Refaat A Eid, W N Hassan, Bahjat Al-Ani
Excessive consumption of carbohydrate and fat increases the risk of liver disease. We hypothesized that swim exercise can protect hepatocytes from ultra-structural damage induced by high cholesterol and fructose diets (HCFD). Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. Swim exercise trained rats started the treatment from the 11th week until the sacrifice day, end of week 15. Blood samples were assayed for biomarkers of liver injury and adiponectin...
February 8, 2018: Ultrastructural Pathology
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