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hepatic steatosis

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https://www.readbyqxmd.com/read/29050301/mir-377-promotes-white-adipose-tissue-inflammation-and-decreases-insulin-sensitivity-in-obesity-via-suppression-of-sirtuin-1-sirt1
#1
Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
Obesity is associated with a wide range of metabolic disorders including inflammation and insulin-resistance. Sirtuin-1 (SIRT1) is an important regulator of metabolic homeostasis and stress response pathways in white adipose tissue. However, involvement of microRNAs (miRNAs) in regulating SIRT1 during obesity-induced inflammation and insulin-resistance remains unclear. Here, we found that miR-377 was upregulated in adipose tissue and showed a negative correlation with SIRT1 in chronic high fat diet (HFD)-fed mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050073/-clinicopathologic-features-of-three-cases-of-erythropoietic-protoporphyria-with-liver-involvement
#2
J Shi, X Q Li, Z H Lu
Objective: To investigate the clinicopathologic features of the erythropoietic protoporphyria (EPP) with liver involvement. Methods: The clinical findings and hepatic biopsy of 3 cases of EPP diagnosed between July, 2011 to August, 2014 with liver involvement were reviewed, with relevant literature review. Results: All patients presented with persistent and refractory abdominal pain, with obvious jaundice and deranged liver function. Imaging showed homogeneous hepatomegaly in all patients. Histologically, the hepatocytes were edematous, and contained numerous cytoplasmic globular brown pigments and bile pigments, which were also found in Kupffer cells, in the bile canaliculi and in some of dilated sinusoid...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29049355/aberrant-hepatic-lipid-storage-and-metabolism-in-canine-portosystemic-shunts
#3
Lindsay Van den Bossche, Vivien A C Schoonenberg, Iwan A Burgener, Louis C Penning, Ingrid M Schrall, Hedwig S Kruitwagen, Monique E van Wolferen, Guy C M Grinwis, Anne Kummeling, Jan Rothuizen, Jeroen F van Velzen, Nikolas Stathonikos, Martijn R Molenaar, Bernd J Helms, Jos F H M Brouwers, Bart Spee, Frank G van Steenbeek
Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was to gain detailed insight into the pathogenesis of steatosis in this large animal model. Hepatic lipid accumulation, gene-expression analysis and HPLC-MS of neutral lipids and phospholipids in extrahepatic (EHPSS) and intrahepatic portosystemic shunts (IHPSS) was compared to healthy control dogs...
2017: PloS One
https://www.readbyqxmd.com/read/29048675/naringenin-inhibits-alcoholic-injury-by-improving-lipid-metabolism-and-reducing-apoptosis-in-zebrafish-larvae
#4
Haiyan Lin, Zhenting Zhou, Weichao Zhong, Peng Huang, Ning Ma, Yuqing Zhang, Chuying Zhou, Yuling Lai, Shaohui Huang, Haiyan An, Xuegang Sun, Lei Gao, Zhiping Lv
Alcoholic liver disease (ALD) includes a spectrum of hepatic abnormalities that range from isolated alcoholic steatosis to steatohepatitis and cirrhosis. Naringenin, a predominant flavanone in grapefruit, increases resistance to oxidative stress and inflammation and protects against multiple organ injury in various animal models. However, the specific mechanisms responsible for protection against alcoholic injury are poorly understood. In the present study, we aimed to investigate the effect of naringenin on alcoholic events and the molecular regulatory mechanisms of naringenin in the liver and whole body of zebrafish larvae following exposure to 350 mmol/l ethanol for 32 h...
September 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29046730/aliskiren-effect-on-non-alcoholic-steatohepatitis-in-metabolic-syndrome
#5
F N Ramalho, S C Sanches, M C Foss, M J Augusto, D M Silva, A M Oliveira, L N Ramalho
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of aliskiren, a direct renin inhibitor, on metabolic syndrome-related NASH. METHODS: C57BL/6 male mice (n = 45) were divided into three groups: controls; animals inoculated with streptozotocin (STZ) (40 mg/kg/day) for 5 days and fed with high fat diet (HFD) for 8 weeks; and animals inoculated with STZ for 5 days, fed with HFD for 8 weeks and treated with aliskiren (100 mg/kg/day) for the final 2 weeks...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29046367/pkc%C3%AE-silencing-alleviates-saturated-fatty-acid-induced-er-stress%C3%A2-by-enhancing-serca-activity
#6
Shujie Lai, Yan Li, Yi Kuang, Hongli Cui, Yang Yang, Wenjing Sun, Kaijun Liu, Dongfeng Chen, Qixian Yan, Liangzhi Wen
Aim : Protein Kinase C δ (PKCδ) plays an important role in non-alcoholic fatty liver disease (NAFLD), however the mechanism remains unknown. This study explored the role of PKCδ in NAFLD development and investigated the relationships between PKCδ, calcium homeostasis and endoplasmic reticulum stress (ERS). Methods : Hepatic steatosis cell model was induced by palmitic acid (PA) in L02 cells. Lipid accretion was evaluated using Oil Red O staining and a triglyceride detection kit. PKCδ was down-regulated by siRNA...
October 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29042644/hiv-1-viral-protein-r-vpr-induces-fatty-liver-in-mice-via-lxr%C3%AE-and-ppar%C3%AE-dysregulation-implications-for-hiv-specific-pathogenesis-of-nafld
#7
Neeti Agarwal, Dinakar Iyer, Chiara Gabbi, Pradip Saha, Sanjeet G Patel, Qianxing Mo, Benny Chang, Biman Goswami, Ulrich Schubert, Jeffrey B Kopp, Dorothy E Lewis, Ashok Balasubramanyam
HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and adipose tissues, and WT mice infused with synthetic Vpr. Vpr-Tg mice developed increased liver triglyceride content and elevated ALT, bilirubin and alkaline phosphatase due to three hepatic defects: 1.6-fold accelerated de novo lipogenesis (DNL), 45% slower fatty acid ß-oxidation, and 40% decreased VLDL-triglyceride export. Accelerated hepatic DNL was due to coactivation by Vpr of liver X receptor-α (LXRα) with increased expression of its lipogenic targets Srebp1c, Chrebp, Lpk, Dgat, Fasn and Scd1, and intranuclear SREBP1c and ChREBP...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042402/ginsenoside-rg3-ameliorated-hfd-induced-hepatic-steatosis-through-downregulation-of-stat5-ppar%C3%AE
#8
Jin-Bong Lee, Sung-Jin Yoon, Sang-Hyun Lee, Moo-Seung Lee, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Inpyo Choi, Ik-Soo Kim, Su Wol Chung, Hee Gu Lee, Jeong-Ki Min, Young-Jun Park
Healthy expansion of adipose tissue maintains metabolic homeostasis by storing excess chemical energy in increased fat mass. The STAT5-PPAR gamma pathway reportedly regulates adipocyte differentiation, lipid metabolism and adipogenesis. Ginsenoside Rg3 is one of the diverse groups of steroidal saponins, the major active components of ginseng, which have demonstrated pharmacological properties. In this study, we evaluated the therapeutic effects of ginsenoside Rg3 under pathological conditions in vitro and in vivo We examined the effects of ginsenoside Rg3 on glucose level, insulin sensitivity and lipogenesis in high-fat diet-fed C57BL/6 mice...
December 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29039050/the-protective-effect-of-fish-oil-lipid-emulsions-on-intestinal-failure-associated-liver-disease-in-a-rat-model-of-short-bowel-syndrome
#9
Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri
PURPOSE: Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis. METHODS: Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group)...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29038049/inhibition-of-egfr-attenuates-fibrosis-and-stellate-cell-activation-in-diet-induced-model-of-nonalcoholic-fatty-liver-disease
#10
Dandan Liang, Hongjin Chen, Leping Zhao, Wenxin Zhang, Jie Hu, Zhiguo Liu, Peng Zhong, Wei Wang, Jingying Wang, Guang Liang
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD begins with steatosis and advances to nonalcoholic steatohepatitis (NASH) and cirrhosis. The molecular mechanisms involved in NAFLD progression are not understood. Based on recent studies showing dysregulation of epidermal growth factor receptor (EGFR) in animal models of liver injury, we sought to determine if inhibition of EGFR mitigates liver fibrosis and HSC activation in NAFLD. We utilized the high fat diet (HFD)-induced murine model of liver injury to study the role of EGFR in NAFLD...
October 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29037475/chronic-arsenicosis-and-cadmium-exposure-in-wild-snowshoe-hares-lepus-americanus-breeding-near-yellowknife-northwest-territories-canada-part-1-evaluation-of-oxidative-stress-antioxidant-activities-and-hepatic-damage
#11
S Amuno, A Jamwal, B Grahn, S Niyogi
Previous gold mining activities and arsenopyrite ore roasting activities at the Giant mine site (1948 to 2004) resulted in the release of high amounts of arsenic and trace metals into the terrestrial and aquatic ecosystems of Yellowknife, Northwest Territories, Canada. While elevated levels of arsenic has been consistently reported in surface soils and vegetation near the vicinity of the Giant mine area and in surrounding locations, systematic studies evaluating the overall health status of terrestrial small mammals endemic to the area are lacking...
October 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29035368/activation-of-intestinal-hypoxia-inducible-factor-2%C3%AE-during-obesity-contributes-to-hepatic-steatosis
#12
Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang, Frank J Gonzalez
Nonalcoholic fatty liver disease is becoming the most common chronic liver disease in Western countries, and limited therapeutic options are available. Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis. Human-intestine biopsies from individuals with or without obesity revealed that intestinal HIF-2α signaling was positively correlated with body-mass index and hepatic toxicity. The causality of this correlation was verified in mice with an intestine-specific disruption of Hif2a, in which high-fat-diet-induced hepatic steatosis and obesity were substantially lower as compared to control mice...
October 9, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29035092/vitamin-d-supplementation-and-non-alcoholic-fatty-liver-disease-a-critical-and-systematic-review-of-clinical-trials
#13
Nasrin Sharifi, Reza Amani
Previous observational studies have found a relationship between vitamin D deficiency and non-alcoholic fatty liver disease (NAFLD). However, this type of study could not show the causal relationship between these two conditions. Therefore, we systematically and critically reviewed the available clinical trials to elucidate such relationship. We searched databases such as Medline, Scopus and Cochrane to identify the clinical trials that assessed the effects of vitamin D supplementation in adults with NAFLD...
October 16, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29034440/risperidone-induced-metabolic-dysfunction-is-attenuated-by-curcuma-longa-extract-administration-in-mice
#14
Florent Auger, Françoise Martin, Olivier Pétrault, Jennifer Samaillie, Thierry Hennebelle, Mohamed-Sami Trabelsi, François Bailleul, Bart Staels, Régis Bordet, Patrick Duriez
Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia, hyperglycemia, low HDL-cholesterol and high blood pressure). Curcumin is a major component of traditional turmeric (Curcuma longa) which has been reported to improve lipid and glucose metabolism and to decrease weight in obese mice...
October 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29033906/long-non-coding-rnas-in-hepatitis-c-virus-infected-cells
#15
REVIEW
Marina Barriocanal, Puri Fortes
Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29031724/elevated-hepatic-dpp4-activity-promotes-insulin-resistance-and-non-alcoholic-fatty-liver-disease
#16
Christian Baumeier, Luisa Schlüter, Sophie Saussenthaler, Thomas Laeger, Maria Rödiger, Stella Amelie Alaze, Louise Fritsche, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche, Robert Wolfgang Schwenk, Annette Schürmann
OBJECTIVE: Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this is causative for the development of NAFLD is not yet clarified. Here we investigate the effect of hepatic DPP4 overexpression on the development of liver steatosis in a mouse model of diet-induced obesity. METHODS: Plasma DPP4 activity of subjects with or without NAFLD was analyzed. Wild-type (WT) and liver-specific Dpp4 transgenic mice (Dpp4-Liv-Tg) were fed a high-fat diet and characterized for body weight, body composition, hepatic fat content and insulin sensitivity...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031242/dietary-creatine-supplementation-lowers-hepatic-triacylglycerol-by-increasing-lipoprotein-secretion-in-rats-fed-high-fat-diet
#17
Robin P da Silva, Kelly-Ann Leonard, René L Jacobs
Recent studies have shown that dietary creatine supplementation can prevent lipid accumulation in the liver. Creatine is a small molecule that plays a large role in energy metabolism, but since the enzyme creatine kinase is not present in the liver, the classical role in energy metabolism does not hold in this tissue. Fat accumulation in the liver can lead to the development of nonalcoholic fatty liver disease (NAFLD), a progressive disease that is prevalent in humans. We have previously reported that creatine can directly influence lipid metabolism in cell culture to promote lipid secretion and oxidation...
September 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29028128/diagnostic-accuracy-of-magnetic-resonance-imaging-hepatic-proton-density-fat-fraction-in-pediatric-nonalcoholic-fatty-liver-disease
#18
Michael S Middleton, Mark L Van Natta, Elhamy R Heba, Adina Alazraki, Andrew T Trout, Prakash Masand, Elizabeth M Brunt, David E Kleiner, Edward Doo, James Tonascia, Joel E Lavine, Wei Shen, Gavin Hamilton, Jeffrey B Schwimmer, Claude B Sirlin
We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment in the Cysteamine Bitartrate Delayed-Release for the Treatment of Nonalcoholic Fatty Liver Disease in Children (CyNCh) trial, using centrally-scored histology as reference. Participants had multi-echo 1.5T or 3T MRI on scanners from three manufacturers. Of 169 enrolled children, 110 (65%) and 83 (49%) had MRI and liver biopsy at baseline and at end-of-treatment (EOT; 52-weeks), respectively...
October 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29026311/artesunate-prevents-rats-from-the-clozapine-induced-hepatic-steatosis-and-elevation-in-plasma-triglycerides
#19
Yanmei Li, Ruibing Su, Shuqin Xu, Qingjun Huang, Haiyun Xu
Clozapine is an atypical antipsychotic with therapeutic efficacy in treatment-resistant schizophrenia patients and low incidence of extrapyramidal side effects. However, the use of clozapine has been limited by its adverse effects on metabolism. Artesunate is a semisynthetic derivative of artemisinin and was shown to decrease the plasma cholesterol and triglyceride in rabbits and rats in recent studies. The aim of this study was to examine possible effects of artesunate on the clozapine-induced metabolic alterations in rats given saline, clozapine, artesunate, or clozapine plus artesunate for 6 weeks...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29025734/dietary-copper-fructose-interactions-alter-gut-microbial-activity-in-male-rats
#20
Ming Song, Xiaohong Li, Xiang Zhang, Hongxue Shi, Miriam B Vos, Xiaoli Wei, Yuhua Wang, Hong Gao, Eric C Rouchka, Xinmin Yin, Zhanxiang Zhou, Russell A Prough, Matthew C Cave, Craig J McClain
Dietary copper-fructose interactions contribute to the development of nonalcoholic fatty liver disease (NAFLD). Gut microbiota play critical roles in the pathogenesis of NAFLD. The aim of this study was to determine the effect of different dietary doses of copper and their interactions with high fructose on gut microbiome. Male weanling Sprague-Dawley rats were fed diets with adequate copper (6 ppm, CuA), marginal copper (1.5 ppm, CuM) (low-copper) or supplemented copper (20 ppm, CuS) (high-copper) for 4 weeks...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
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