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https://www.readbyqxmd.com/read/27895986/combined-frequency-domain-photoacoustic-and-ultrasound-imaging-for-intravascular-applications
#1
Robin F Castelino, Michael Hynes, Chelsea E Munding, Sergey Telenkov, F Stuart Foster
Intravascular photoacoustic (IVPA) imaging has the potential to characterize lipid-rich structures based on the optical absorption contrast of tissues. In this study, we explore frequency domain photoacoustics (FDPA) for intravascular applications. The system employed an intensity-modulated continuous wave (CW) laser diode, delivering 1W over an intensity modulated chirp frequency of 4-12MHz. We demonstrated the feasibility of this approach on an agar vessel phantom with graphite and lipid targets, imaged using a planar acoustic transducer co-aligned with an optical fibre, allowing for the co-registration of IVUS and FDPA images...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27895243/contrast-less-stent-placement-for-vertebral-artery-origin-stenosis
#2
Shinzo Ota, Yoshinobu Sekihara, Takahiro Himeno, Yasue Tanaka, Tatsuya Ohtonari
We performed stent placement under intravascular ultrasound (IVUS), without the use of contrast medium, in a male patient in his 70s who had vertebral artery origin stenosis and decreased renal function. Satisfactory dilatation was achieved without complications, and the patient remained asymptomatic at 2 years of follow-up. We now report the details of this procedure. Stent placement under IVUS guidance may be useful in patients in whom contrast medium is contraindicated.
November 28, 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/27893376/a-modulated-excitation-imaging-system-for-intravascular-ultrasound
#3
Weibao Qiu, Xingying Wang, Yan Chen, Qiang Fu, Min Su, Lining Zhang, Jingjing Xia, Jiyan Dai, Yaonan Zhang, Hairong Zheng
Advances in methodologies and tools often lead to new insights into cardiovascular diseases. Intravascular ultrasound (IVUS) is a well-established diagnostic method that provides high-resolution images of the vessel wall and atherosclerotic plaques. High-frequency (>50 MHz) ultrasound enables the spatial resolution of IVUS to approach that of optical imaging methods. However, the penetration depth decreases when using higher imaging frequencies due to the greater acoustic attenuation. An imaging method that improves the penetration depth of high-resolution IVUS would therefore be of major clinical importance...
November 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27893049/a-novel-approach-to-assess-the-in-situ-versus-ex-vivo-mechanical-behaviors-of-the-coronary-artery
#4
Ruoya Wang, Julia Raykin, Luke P Brewster, Rudolph L Gleason
Ex vivo mechanical testing has provided tremendous insight toward prediction of the in vivo mechanical behavior and local mechanical environment of the arterial wall; however, the role of perivascular support on the local mechanical behavior of arteries is not well understood. Here, we present a novel approach for quantifying the impact of the perivascular support on arterial mechanics using intravascular ultrasound (IVUS) on cadaveric porcine hearts. We performed pressure-diameter tests (n = 5) on the left anterior descending coronary arteries (LADCAs) in situ while embedded in their native perivascular environment using IVUS imaging and after removal of the perivascular support of the artery...
January 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27876264/intravascular-ultrasound-and-near-infrared-spectroscopic-characterization-of-thin-cap-fibroatheroma
#5
Shinji Inaba, Gary S Mintz, Allen P Burke, Gregg W Stone, Renu Virmani, Mitsuaki Matsumura, Rupa Parvataneni, Rishi Puri, Stephen J Nicholls, Akiko Maehara
Thin-cap fibroatheromas (TCFAs) are considered precursors for plaque rupture and subsequent acute coronary events. We investigated intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) characteristics of lesions that were histopathologic TCFAs. IVUS, NIRS, and histopathology were performed in 271 atherosclerotic lesions from 107 fresh coronary arteries from 54 patients at necropsy. The plaque burden and remodeling index calculated by IVUS and maximum lipid core burden index within any 4-mm segment (maxLCBI4mm) calculated by NIRS were compared among each plaque type based on histopathologic classifications but focusing on TCFA...
October 31, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27876181/analysis-of-suboptimal-stent-deployment-using-intravascular-ultrasound-and-coronary-pressure-pullback-measurement
#6
Nobuhiro Tanaka, Nico H J Pijls, Jun Yamashita, Yo Kimura, Masashi Ogawa, Naotaka Murata, Kunihiro Sakoda, Kou Hoshino, Youhei Hokama, Akira Yamashina
BACKGROUND: There are some cases in whom a sufficient improvement in fractional flow reserve (FFR) could not be achieved even if anatomical results indicated satisfactory stent deployment. We investigated the relation of abnormal findings between intravascular ultrasound (IVUS) and coronary pressure pullback measurement (CP-PB). METHODS: IVUS and CP-PB were investigated after stent deployment in 60 vessels in 53 patients. CP-PB criterion for adequate stent deployment was defined as a ratio of coronary pressure at the stent distal edge to the proximal edge (Psd/Psp) that is greater than 0...
November 18, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27876049/geographical-predisposition-influences-on-the-distribution-and-tissue-characterisation-of-eccentric-coronary-plaques-in-non-branching-coronary-arteries-cross-sectional-study-of-coronary-plaques-analysed-by-intravascular-ultrasound
#7
Hidenori Komiyama, Hitoshi Takano, Shunichi Nakamura, Masamichi Takano, Noritake Hata, Miyauchi Yasushi, Yoshihiko Seino, Kyoichi Mizuno, Wataru Shimizu
BACKGROUND: We investigated the influence of geographical predisposition on the spatial distribution and composition of coronary plaques. METHODS: Thirty coronary arteries were evaluated. A total of 1441 cross-sections were collected from intravascular ultrasound (IVUS) and radio-frequency signal-based virtual histology (VH-IVUS) imaging. To exclude complex geographical effects of side branches and to localise the plaque distribution, we analysed only eccentric plaques in non-branching regions...
November 22, 2016: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27869217/magnesium-alloy-covered-stent-for-treatment-of-a-lateral-aneurysm-model-in-rabbit-common-carotid-artery-an-in-vivo-study
#8
Wu Wang, Yong-Li Wang, Mo Chen, Liang Chen, Jian Zhang, Yong-Dong Li, Ming-Hua Li, Guang-Yin Yuan
Magnesium alloy covered stents have rarely been used in the common carotid artery (CCA). We evaluated the long-term efficacy of magnesium alloy covered stents in a lateral aneurysm model in rabbit CCA. Magnesium alloy covered stents (group A, n = 7) or Willis covered stents (group B, n = 5) were inserted in 12 New Zealand White rabbits and they were followed up for 12 months. The long-term feasibility for aneurysm occlusion was studied through angiograms; the changes in vessel area and lumen area were assessed with IVUS...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867141/sex-differences-in-plaque-characteristics-by-intravascular-imaging-in-patients-with-coronary-artery-disease
#9
Monique E Ten Haaf, Melissa Rijndertse, Jin M Cheng, Sanneke P de Boer, Hector M Garcia Garcia, Robert-Jan M van Geuns, Evelyn Regar, Mattie J Lenzen, Yolande Appelman, Eric Boersma
AIMS: We aimed to study sex differences in coronary plaque burden and plaque composition in patients with coronary artery disease (CAD). METHODS AND RESULTS: Virtual histology intravascular ultrasound (VH-IVUS) and near-infrared spectroscopy (NIRS) imaging of a non-culprit coronary artery was performed in 178 (23.5%) women and 581 men who underwent invasive management of stable angina pectoris (SAP) or acute coronary syndrome (ACS). Women were older and had a worse cardiovascular risk profile than men, but less extended angiographic coronary disease...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27866137/clinical-and-multimodality-imaging-results-at-6-months-of-a-bioresorbable-sirolimus-eluting-scaffold-for-patients-with-single-de-novo-coronary-artery-lesions-the-neovas-first-in-man-trial
#10
Yao-Jun Zhang, Xiao-Zeng Wang, Guosheng Fu, Quan-Min Jing, Geng Wang, Chong-Ying Jin, Li-Hua Xie, Jin-Zan Cai, Bo Xu, Ya-Ling Han
AIMS: The study sought to investigate clinical and multimodality imaging assessment of a bioresorbable sirolimus-eluting scaffold (NeoVas, Lepu Medical, Beijing, China) for patients with single de novo coronary artery lesions. METHODS AND RESULTS: The NeoVas first-in-man study was a prospective, open-label study which enrolled 31 patients with single de novo lesions treated with a bioresorbable sirolimus-eluting scaffold. The primary endpoint was target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction and clinically indicated target lesion revascularisation (TLR)...
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27862314/impact-of-diabetes-mellitus-on-intravascular-ultrasound-guided-provisional-stenting-in-coronary-bifurcation-lesions-j-reverse-sub-study
#11
Masahiro Yamawaki, Daisuke Terashita, Hachidai Takahashi, Toshiro Shinke, Kenichi Fujii, Yoshihisa Shimada, Yoshihiro Takeda, Shinichiro Yamada, Yoshihisa Kinoshita, Yoshinobu Murasato
OBJECTIVE: To investigate the impact of diabetes mellitus (DM) on provisional coronary bifurcation stenting under the complete guidance of intravascular-ultrasound (IVUS). BACKGROUND: The efficacy of such intervention has not yet been fully elucidated in the DM patients. METHODS: A total of 100 DM and 139 non-DM patients in a prospective multi-center registry of IVUS-guided bifurcation stenting were compared in angiographic results at 9 months...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27846344/effect-of-evolocumab-on-progression-of-coronary-disease-in-statin-treated-patients-the-glagov-randomized-clinical-trial
#12
Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Robert Scott, Imre Ungi, Jakub Podolec, Antonius Oude Ophuis, Jan H Cornel, Marilyn Borgman, Danielle M Brennan, Steven E Nissen
Importance: Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in statin-treated patients; however, the effects of these drugs on coronary atherosclerosis have not been evaluated. Objective: To determine the effects of PCSK9 inhibition with evolocumab on progression of coronary atherosclerosis in statin-treated patients...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27844239/quantification-of-the-focal-progression-of-coronary-atherosclerosis-through-automated-co-registration-of-virtual-histology-intravascular-ultrasound-imaging-data
#13
Lucas H Timmins, David S Molony, Parham Eshtehardi, Emad Rasoul-Arzrumly, Adrian Lam, Olivia Y Hung, Michael C McDaniel, John N Oshinski, Don P Giddens, Habib Samady
The goal of this study was to evaluate the accuracy of a novel algorithm that circumferentially co-registers serial virtual histology-intravascular ultrasound (VH-IVUS) data for the focal assessment of coronary atherosclerosis progression. Thirty-three patients with an abnormal non-invasive cardiac stress test or stable angina underwent baseline and follow-up (6 or 12 months) invasive evaluation that included acquisition of VH-IVUS image data. Baseline and follow-up image pairs (n = 4194) were automatically co-registered in the circumferential direction via a multi-variate cross-correlation algorithm...
November 14, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27836501/evaluation-of-a-framework-for-the-co-registration-of-intravascular-ultrasound-and-optical-coherence-tomography-coronary-artery-pullbacks
#14
David S Molony, Lucas H Timmins, Emad Rasoul-Arzrumly, Habib Samady, Don P Giddens
A growing number of studies have used a combination of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for the assessment of atherosclerotic plaques. Given their respective strengths these imaging modalities highly complement each other. Correlations of hemodynamics and coronary artery disease (CAD) have been extensively investigated with both modalities separately, though not concurrently due to challenges in image registration. Manual co-registration of these modalities is a time expensive task subject to human error, and the development of an automatic method has not been previously addressed...
October 28, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27822889/intravascular-ultrasound-guided-drug-eluting-stent-implantation
#15
REVIEW
Tadayuki Kadohira, Yoshio Kobayashi
Intravascular ultrasound (IVUS) is a reliable imaging tool to guide percutaneous coronary intervention. There has been increasing evidence supporting the clinical utility of IVUS-guided drug-eluting stent (DES) implantation, including randomized trials, observational studies, and meta-analyses of both. IVUS provides cross-sectional views of the coronary artery wall, and allows us to assess stenosis severity, identify plaque morphology, optimize stent implantation, and understand mechanism of stent failure. IVUS guidance can increase DES efficacy and decrease clinical events...
November 7, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27814787/relation-between-renal-function-and-coronary-plaque-morphology-from-the-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-virtual-histology-intravascular-ultrasound-substudy
#16
Chee Yang Chin, Gary S Mintz, Shigeo Saito, Bernhard Witzenbichler, D Christopher Metzger, Michael J Rinaldi, Ernest L Mazzaferri, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Claire Litherland, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
We sought to examine the relation between various degrees of renal function and coronary plaque morphology by grayscale and virtual histology intravascular ultrasound (IVUS). ADAPT-DES was a prospective, multicenter registry of 8,582 consecutive patients treated using coronary drug-eluting stents with a prespecified grayscale and virtual histology-IVUS substudy. A lesion-level analysis of study participants was performed by comparing IVUS parameters of culprit and nonculprit lesions across tertiles of estimated creatinine clearance (CrCl)...
October 7, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27814429/effects-of-residual-stress-axial-stretch-and-circumferential-shrinkage-on-coronary-plaque-stress-and-strain-calculations-a-modeling-study-using-ivus-based-near-idealized-geometries
#17
Liang Wang, Jian Zhu, Habib Samady, David Monoly, Jie Zheng, Xiaoya Guo, Akiko Maehara, Chun Yang, Genshan Ma, Gary S Mintz, Dalin Tang
Accurate stress and strain calculations are important for plaque progression and vulnerability assessment. Models based on in vivo data often need to form geometries with zero-stress/strain conditions. The goal of this paper is to use IVUS-based near-idealized geometries and introduce a three-step model construction process to include residual stress, axial shrinkage, and circumferential shrinkage and investigate their impacts on stress and strain calculations. In Vivo intravascular ultrasound (IVUS) data of human coronary were acquired for model construction...
January 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27806900/optical-coherence-tomography-compared-with-intravascular-ultrasound-and-with-angiography-to-guide-coronary-stent-implantation-ilumien-iii-optimize-pci-a-randomised-controlled-trial
#18
Ziad A Ali, Akiko Maehara, Philippe Généreux, Richard A Shlofmitz, Franco Fabbiocchi, Tamim M Nazif, Giulio Guagliumi, Perwaiz M Meraj, Fernando Alfonso, Habib Samady, Takashi Akasaka, Eric B Carlson, Massoud A Leesar, Mitsuaki Matsumura, Melek Ozgu Ozan, Gary S Mintz, Ori Ben-Yehuda, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) is most commonly guided by angiography alone. Intravascular ultrasound (IVUS) guidance has been shown to reduce major adverse cardiovascular events (MACE) after PCI, principally by resulting in a larger postprocedure lumen than with angiographic guidance. Optical coherence tomography (OCT) provides higher resolution imaging than does IVUS, although findings from some studies suggest that it might lead to smaller luminal diameters after stent implantation...
November 26, 2016: Lancet
https://www.readbyqxmd.com/read/27806099/plaque-vulnerability-as-assessed-by-radiofrequency-intravascular-ultrasound-in-patients-with-valvular-calcification
#19
Nagendra Boopathy Senguttuvan, Sharath Kumar, Wang-Soo Lee, Sundeep Mishra, Jun Hwan Cho, Jee Eun Kwon, Seong Hyeop Hyeon, Yun Sang Jeong, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim, Sang-Wook Kim
BACKGROUND: Cardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability. METHODS: Transthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS)...
2016: PloS One
https://www.readbyqxmd.com/read/27802928/incidence-and-impact-on-midterm-outcome-of-intimal-versus-subintimal-tracking-with-both-antegrade-and-retrograde-approach-in-patients-with-successful-recanalization-of-chronic-total-occlusions-j-proctor2-study
#20
Katsuyuki Hasegawa, Etsuo Tsuchikane, Atsunori Okamura, Tsutomu Fujita, Masahisa Yamane, Yuji Oikawa, Yoriyasu Suzuki, Yasumi Igarashi, Eisho Kyo, Toshiya Muramatsu
AIMS: To assess the incidence and impact on the midterm outcomes of intimal versus subintimal tracking with both antegrade and retrograde approaches in patients undergoing successful percutaneous coronary intervention for chronic total occlusion (CTO). METHODS AND RESULTS: In 2012, a total of 1573 CTO cases from 30 hospitals were enrolled in the Japanese CTO registry. Successful guidewire crossing was performed in 1411 cases (89.7%). Among them, the guidewire penetration position was clearly identified using intravascular ultrasound (IVUS) imaging in 352 cases, and clinical follow-up at 12 months was performed in 323 cases...
November 2, 2016: EuroIntervention
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