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job exposure matrices

Melissa C Friesen, Bryan A Bassig, Roel Vermeulen, Xiao-Ou Shu, Mark P Purdue, Patricia A Stewart, Yong-Bing Xiang, Wong-Ho Chow, Bu-Tian Ji, Gong Yang, Martha S Linet, Wei Hu, Yu-Tang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan
Objectives: To provide insight into the contributions of exposure measurements to job exposure matrices (JEMs), we examined the robustness of an association between occupational benzene exposure and non-Hodgkin lymphoma (NHL) to varying exposure assessment methods. Methods: NHL risk was examined in a prospective population-based cohort of 73087 women in Shanghai. A mixed-effects model that combined a benzene JEM with >60000 short-term, area benzene inspection measurements was used to derive two sets of measurement-based benzene estimates: 'job/industry-specific' estimates (our presumed best approach) were derived from the model's fixed effects (year, JEM intensity rating) and random effects (occupation, industry); 'calibrated JEM' estimates were derived using only the fixed effects...
January 1, 2017: Annals of Work Exposures and Health
Tom Koeman, Pauline Slottje, Leo J Schouten, Susan Peters, Anke Huss, Jan H Veldink, Hans Kromhout, Piet A van den Brandt, Roel Vermeulen
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69 years at enrolment in 1986 were followed up for 17.3 years on ALS mortality. Information on occupational history and potential confounders were collected at baseline through a self-administered questionnaire and entered for a random subcohort (2092 men and 2074 women) and ALS deaths (76 men and 60 women)...
March 29, 2017: Occupational and Environmental Medicine
Arnaud Florentin, Denis Zmirou-Navier, Christophe Paris
OBJECTIVES: To detect new hazards ("signals"), occupational health monitoring systems mostly rest on the description of exposures in the jobs held and on reports by medical doctors; these are subject to declarative bias. Our study aims to assess whether job-exposure matrices (JEMs) could be useful tools for signal detection by improving exposure reporting. METHODS: Using the French national occupational disease surveillance and prevention network (RNV3P) data from 2001 to 2011, we explored the associations between disease and exposure prevalence for 3 well-known pathology/exposure couples and for one debatable couple...
March 16, 2017: International Archives of Occupational and Environmental Health
Madar Talibov, Raili Salmelin, Susanna Lehtinen-Jacks, Anssi Auvinen
BACKGROUND: Job-exposure matrices (JEM) are used for exposure assessment in occupational studies, but they can involve errors. We assessed agreement between the Nordic Occupational Cancer Studies JEM (NOCCA-JEM) and aggregate and individual dose estimates for cosmic radiation exposure among Finnish airline personnel. METHODS: Cumulative cosmic radiation exposure for 5,022 airline crew members was compared between a JEM and aggregate and individual dose estimates...
March 6, 2017: American Journal of Industrial Medicine
Steven Sadhra, Om P Kurmi, Sandeep S Sadhra, Kin Bong Hubert Lam, Jon G Ayres
BACKGROUND: The association between occupational exposure and COPD reported previously has mostly been derived from studies relying on self-reported exposure to vapors, gases, dust, or fumes (VGDF), which could be subjective and prone to biases. The aim of this study was to assess the strength of association between exposure and COPD from studies that derived exposure by job exposure matrices (JEMs). METHODS: A systematic search of JEM-based occupational COPD studies published between 1980 and 2015 was conducted in PubMed and EMBASE, followed by meta-analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
Trang VoPham, Kimberly A Bertrand, Jaime E Hart, Francine Laden, Maria M Brooks, Jian-Min Yuan, Evelyn O Talbott, Darren Ruddell, Chung-Chou H Chang, Joel L Weissfeld
PURPOSE: To review the epidemiologic literature examining pesticide exposure and liver cancer incidence. METHODS: A search of the MEDLINE and Embase databases was conducted in October 2015. Eligibility criteria included examining hepatocellular carcinoma (HCC) or primary liver cancer, pesticides as an exposure of interest, and individual-level incidence. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
March 2017: Cancer Causes & Control: CCC
Pascal Petit, Anne Maître, Renaud Persoons, Dominique J Bicout
BACKGROUND: The health risk assessment associated with polycyclic aromatic hydrocarbon (PAH) mixtures faces three main issues: the lack of knowledge regarding occupational exposure mixtures, the accurate chemical characterization and the estimation of cancer risks. OBJECTIVES: To describe industries in which PAH exposures are encountered and construct working context-exposure function matrices, to enable the estimation of both the PAH expected exposure level and chemical characteristic profile of workers based on their occupational sector and activity...
April 15, 2017: Science of the Total Environment
Matthieu Carton, Christine Barul, Gwenn Menvielle, Diane Cyr, Marie Sanchez, Corinne Pilorget, Brigitte Trétarre, Isabelle Stücker, Danièle Luce
OBJECTIVE: Our objective was to investigate the association between head and neck cancer and occupational exposure to chlorinated, oxygenated and petroleum solvents in women. METHODS: Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE), a French population-based case-control study, included 296 squamous cell carcinomas of the head and neck (HNSCC) in women and 775 female controls. Lifelong occupational history was collected. Job-exposure matrices allowed to assess exposure to 5 chlorinated solvents (carbon tetrachloride; chloroform; methylene chloride; perchloroethylene; trichloroethylene), 5 petroleum solvents (benzene; special petroleum product; gasoline; white spirits and other light aromatic mixtures; diesel, fuels and kerosene) and 5 oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran)...
January 9, 2017: BMJ Open
Tine Gjedde Sommer, Susanne Wulff Svendsen, Poul Frost
OBJECTIVE: The aim of this study was to examine if combined pain (pain in the upper and lower body), high occupational mechanical exposures, and job strain predict sickness absence and permanent work disability, particularly if co-occurring. METHODS: This longitudinal study was based on the musculoskeletal research database at the Danish Ramazzini Centre. We linked baseline information from 2001-2004 on musculoskeletal pain, job titles, and covariates with register information on sickness absence and permanent work disability...
June 1, 2016: Scandinavian Journal of Work, Environment & Health
C Quinot, O Dumas, P K Henneberger, R Varraso, A S Wiley, F E Speizer, M Goldberg, J P Zock, C A Camargo, N Le Moual
OBJECTIVES: Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM. METHODS: Disinfectant use was assessed by an occupational questionnaire in 9073 US female registered nurses without asthma, aged 49-68 years, drawn from the Nurses' Health Study II...
February 2017: Occupational and Environmental Medicine
Kayo Togawa, Charlotte Le Cornet, Maria Feychting, Tore Tynes, Eero Pukkala, Johnni Hansen, Ann Olsson, Susanne Oksbjerg Dalton, Karl-Christian Nordby, Sanni Uuksulainen, Pernilla Wiebert, Torill Woldbæk, Niels E Skakkebæk, Béatrice Fervers, Joachim Schüz
BACKGROUND: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT) in offspring. We examined parental occupational exposures to heavy metals and welding fumes in relation to TGCT in offspring in a registry-based case-control study (NORD-TEST Study). METHODS: We identified TGCT cases diagnosed at ages 14-49 years in Finland (1988-2012), Norway (1978-2010), and Sweden (1979-2011) through nationwide cancer registries...
October 2016: Cancer Epidemiology, Biomarkers & Prevention
Camille Carles, Ghislaine Bouvier, Pierre Lebailly, Isabelle Baldi
The health effects of pesticides have been extensively studied in epidemiology, mainly in agricultural populations. However, pesticide exposure assessment remains a key methodological issue for epidemiological studies. Besides self-reported information, expert assessment or metrology, job-exposure matrices still appear to be an interesting tool. We reviewed all existing matrices assessing occupational exposure to pesticides in epidemiological studies and described the exposure parameters they included. We identified two types of matrices, (i) generic ones that are generally used in case-control studies and document broad categories of pesticides in a large range of jobs, and (ii) specific matrices, developed for use in agricultural cohorts, that generally provide exposure metrics at the active ingredient level...
May 18, 2016: Journal of Exposure Science & Environmental Epidemiology
Sheikh M Alif, Shyamali C Dharmage, Gayan Bowatte, Amalia Karahalios, Geza Benke, Martine Dennekamp, Amar J Mehta, David Miedinger, Nino Künzli, Nicole Probst-Hensch, Melanie C Matheson
INTRODUCTION: Due to contradictory literature we have performed a systematic review and meta-analyse of population-based studies that have used Job Exposure Matrices to assess occupational exposure and risk of Chronic Obstructive Pulmonary Disease (COPD). AREAS COVERED: Two researchers independently searched databases for published articles using predefined inclusion criteria. Study quality was assessed, and results pooled for COPD and chronic bronchitis for exposure to biological dust, mineral dust, and gases/fumes using a fixed and random effect model...
August 2016: Expert Review of Respiratory Medicine
Adrienne C Eastlake, Catherine Beaucham, Kenneth F Martinez, Matthew M Dahm, Christopher Sparks, Laura L Hodson, Charles L Geraci
Engineered nanomaterial emission and exposure characterization studies have been completed at more than 60 different facilities by the National Institute for Occupational Safety and Health (NIOSH). These experiences have provided NIOSH the opportunity to refine an earlier published technique, the Nanoparticle Emission Assessment Technique (NEAT 1.0), into a more comprehensive technique for assessing worker and workplace exposures to engineered nanomaterials. This change is reflected in the new name Nanomaterial Exposure Assessment Technique (NEAT 2...
September 2016: Journal of Occupational and Environmental Hygiene
Hanhua Liu, Richard Wakeford, Anthony Riddell, Jacqueline O'Hagan, David MacGregor, Raymond Agius, Christine Wilson, Mark Peace, Frank de Vocht
Any potential health effects of radiation emitted from radionuclides deposited in the bodies of workers exposed to radioactive materials can be directly investigated through epidemiological studies. However, estimates of radionuclide exposure and consequent tissue-specific doses, particularly for early workers for whom monitoring was relatively crude but exposures tended to be highest, can be uncertain, limiting the accuracy of risk estimates. We review the use of job-exposure matrices (JEMs) in peer-reviewed epidemiological and exposure assessment studies of nuclear industry workers exposed to radioactive materials as a method for addressing gaps in exposure data, and discuss methodology and comparability between studies...
March 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Sander Greenland, Heidi J Fischer, Leeka Kheifets
Job exposure matrices (JEMs) are used to measure exposures based on information about particular jobs and tasks. JEMs are especially useful when individual exposure data cannot be obtained. Nonetheless, there may be other workplace exposures associated with the study disease that are not measured in available JEMs. When these exposures are also associated with the exposures measured in the JEM, biases due to uncontrolled confounding will be introduced. Furthermore, individual exposures differ from JEM measurements due to differences in job conditions and worker practices...
January 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
Andreas Lundin, Alma Sörberg Wallin, Daniel Falkstedt, Peter Allebeck, Tomas Hemmingsson
OBJECTIVE: To investigate the association between intelligence and disability pension due to mental, musculoskeletal, cardiovascular, and substance-use disorders among men and women, and to assess the role of childhood social factors and adulthood work characteristics. METHODS: Two random samples of men and women born 1948 and 1953 (n = 10 563 and 9 434), and tested for general intelligence at age 13, were followed in registers for disability pension until 2009...
2015: PloS One
Madar Talibov, Monica Guxens, Eero Pukkala, Anke Huss, Hans Kromhout, Pauline Slottje, Jan Ivar Martinsen, Kristina Kjaerheim, Pär Sparén, Elisabete Weiderpass, Laufey Tryggvadottir, Sanni Uuksulainen, Roel Vermeulen
OBJECTIVE: We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA). METHODS: We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices...
August 2015: Cancer Causes & Control: CCC
Heidi J Fischer, Ximena P Vergara, Michael Yost, Michael Silva, David A Lombardi, Leeka Kheifets
Job exposure matrices (JEMs) are tools used to classify exposures for job titles based on general job tasks in the absence of individual level data. However, exposure uncertainty due to variations in worker practices, job conditions, and the quality of data has never been quantified systematically in a JEM. We describe a methodology for creating a JEM which defines occupational exposures on a continuous scale and utilizes elicitation methods to quantify exposure uncertainty by assigning exposures probability distributions with parameters determined through expert involvement...
January 2017: Journal of Exposure Science & Environmental Epidemiology
Tom Koeman, Leo J Schouten, Piet A van den Brandt, Pauline Slottje, Anke Huss, Susan Peters, Hans Kromhout, Roel Vermeulen
BACKGROUND: Occupational exposures may be associated with non-vascular dementia. METHODS: We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available...
June 2015: American Journal of Industrial Medicine
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