Pooja Yedehalli Thimmappa, Aswathy S Nair, Sian D'silva, Anjana Aravind, Sandeep Mallya, Sreelakshmi Pathappillil Soman, Kanive Parashiva Guruprasad, Shamee Shastry, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad, Manjunath B Joshi
Neutrophils play a vital role in the innate immunity by perform effector functions through phagocytosis, degranulation, and forming extracellular traps. However, over-functioning of neutrophils has been associated with sterile inflammation such as Type 2 Diabetes, atherosclerosis, cancer and autoimmune disorders. Neutrophils exhibiting phenotypical and functional heterogeneity in both homeostatic and pathological conditions suggests distinct signaling pathways are activated in disease-specific stimuli and alter neutrophil functions...
April 3, 2024: International Immunopharmacology