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https://www.readbyqxmd.com/read/28220312/preventing-hiv-and-hepatitis-infections-among-people-who-inject-drugs-leveraging-an-indiana-outbreak-response-to-break-the-impasse
#1
EDITORIAL
Jeffrey S Crowley, Gregorio A Millett
Providing clean needles through syringe services programs (SSPs) prevents the spread of disease among people who inject drugs (PWID). The recent HIV outbreak in Scott County, Indiana was a wakeup call with particular significance because modeling suggests that Scott County is but one of many counties in the United States highly vulnerable to an HIV outbreak among PWID. It is a painful recognition that some policy makers ignored the evidence in support of SSPs when it was primarily blacks in inner cities that were affected, yet swung into action in the wake of Scott County where 99% of the cases were white...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28212540/expression-of-met-in-circulating-tumor-cells-correlates-with-expression-in-tumor-tissue-from-advanced-stage-lung-cancer-patients
#2
Marius Ilie, Edith Szafer-Glusman, Véronique Hofman, Elodie Long-Mira, Rebecca Suttmann, Walter Darbonne, Catherine Butori, Salomé Lalvée, Julien Fayada, Eric Selva, Wei Yu, Charles-Hugo Marquette, David S Shames, Elizabeth Punnoose, Paul Hofman
Given the difficulty in obtaining adequate tissue in NSCLC, we investigated the utility of circulating tumor cells (CTCs) for MET status assessment in NSCLC patients. We used two platforms for CTC capture, and assessed MET expression in CTCs and matched-bronchial biopsies in patients with advanced-stage III/IV lung adenocarcinoma. Baseline peripheral blood was collected from 256 advanced-stage III/IV NSCLC patients from Genentech clinical trials, and from 106 patients with advanced-stage III/IV lung adenocarcinoma treated at the Department of Pneumology, Pasteur Hospital, Nice...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211552/incidence-of-postpartum-depression-and-couple-relationship-quality
#3
Aleksandra Małus, Justyna Szyluk, Beata Galińska-Skok, Beata Konarzewska
OBJECTIVES: The childbirth constitutes a significant event in a woman's life and in the marital/ couple dyad. The changes which follow childbirth require re-organization of previous coping styles and development of new methods of adaptation, which proves difficult. The current study evaluated to what extent the development of postpartum depression symptoms in new mothers was associated with their level of satisfaction in marital relationship. METHODS: The study included 100 women in their first month after delivery...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28209746/a-phase-ii-randomized-trial-go27827-of-first-line-folfox-plus-bevacizumab-with-or-without-the-met-inhibitor-onartuzumab-in-patients-with-metastatic-colorectal-cancer
#4
Johanna C Bendell, Howard Hochster, Lowell L Hart, Irfan Firdaus, Joseph R Mace, Joshua J McFarlane, Mark Kozloff, Daniel Catenacci, Jessie J Hsu, Stephen P Hack, David S Shames, See-Chun Phan, Hartmut Koeppen, Allen L Cohn
BACKGROUND: Dysregulated hepatocyte growth factor/mesenchymal-epithelial transition (MET) signaling is associated with poor prognosis and resistance to vascular endothelial growth factor inhibition in metastatic colorectal cancer (mCRC). We report outcomes from a double-blind, multicenter phase II trial of the MET inhibitor onartuzumab in combination with mFOLFOX-6 and bevacizumab for mCRC (GO27827; NCT01418222). MATERIALS AND METHODS: Patients were randomized 1:1 to receive onartuzumab (10 mg/kg intravenously [IV]) or placebo plus mFOLFOX-6 and bevacizumab (5 mg/kg IV)...
February 16, 2017: Oncologist
https://www.readbyqxmd.com/read/28199913/new-dsm-5-ptsd-guilt-and-shame-symptoms-among-italian-earthquake-survivors-impact-on-maladaptive-behaviors
#5
Claudia Carmassi, Carlo Antonio Bertelloni, Camilla Gesi, Ciro Conversano, Paolo Stratta, Gabriele Massimetti, Alessandro Rossi, Liliana Dell'Osso
Important changes were introduced concerning posttraumatic-stress disorder (PTSD) by the DSM-5 recognizing the role of negative emotions such as guilt and shame, but little evidence is yet available on their prevalence in population assessed by means of DSM-5 criteria. In this study we explored the rates of guilt and shame DSM-5 PTSD diagnostic symptoms among Italian survivors to a massive earthquake and their possible correlation with PTSD and maladaptive behaviors. 869 residents of the town of L'Aquila exposed to the earthquake of April 6th, 2009 were investigated by the Trauma and Loss Spectrum-Self Report (TALS-SR) with particular attention to guilt and shame feelings...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28195741/behavior-of-ppi-g2-dendrimer-in-a-microemulsion
#6
Shifra Rokach, Maria Francesca Ottaviani, Alexander I Shames, Abraham Aserin, Nissim Garti
Dendrimer nanostructures are of eminent interest in biomedical applications because of their uniform and well-defined molecular size and shape, and their ability to cross cell membranes and reduce the risk of premature clearance from the human body. Dendrimers perform as gene and drug carriers and have also shown significant therapeutic properties for treating cancer and neurodegenerative diseases. A complex drug delivery system, based on a dendrimer solubilized in the aqueous core of a water-in-oil (W/O) microemulsion (ME) along with the drug may combine the advantages of both dendrimers and MEs to provide better control of drug release...
February 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28183475/obamacare-change-the-name-but-avoid-the-shame
#7
EDITORIAL
Spencer B King
No abstract text is available yet for this article.
February 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28182491/thwarted-belongingness-perceived-burdensomeness-and-depression-among-asian-americans-a-longitudinal-study-of-interpersonal-shame-as-a-mediator-and-perfectionistic-family-discrepancy-as-a-moderator
#8
Stephanie G Carrera, Meifen Wei
This short-term longitudinal study applied Joiner's (2005) Interpersonal-Psychological Theory of Suicide to Asian Americans' experiences with depression. Interpersonal shame (i.e., the experience of inadequacy arising from interpersonal concerns) was hypothesized to mediate the effects of (a) thwarted belongingness and (b) perceived burdensomeness on future depression. Furthermore, the positive associations between (a) thwarted belongingness and (b) perceived burdensomeness on future depression were hypothesized to vary depending on students' experiences with perfectionistic family discrepancy (PFD; their perceived gap between their actual performance and what their parents expect of them)...
February 9, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28182490/factor-structure-factorial-invariance-and-validity-of-the-multidimensional-shame-related-response-inventory-21-msri-21
#9
Antonio F Garcia, Melina Acosta, Saifa Pirani, Daniel Edwards, Augustine Osman
We describe 2 studies designed to evaluate scores on the Multidimensional Shame-related Response Inventory-21 (MSRI-21), a recently developed instrument that measures affective and behavioral responses to shame. The inventory assesses shame-related responses in 3 categories: negative self-evaluation, fear of social consequences, and maladaptive behavior tendency. For Study 1, (N = 743) undergraduates completed the MSRI-21. Confirmatory factor analysis supported the validity of the MSRI-21 3-factor structure...
February 9, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28179417/green-shoots-of-recovery-a-realist-evaluation-of-a-team-to-support-change-in-general-practice
#10
Maggie Bartlett, Ruth Basten, Robert K McKinley
OBJECTIVE: A multidisciplinary support team for general practice was established in April 2014 by a local National Health Service (NHS) England management team. This work evaluates the team's effectiveness in supporting and promoting change in its first 2 years, using realist methodology. SETTING: Primary care in one area of England. PARTICIPANTS: Semistructured interviews were conducted with staff from 14 practices, 3 key senior NHS England personnel and 5 members of the support team...
February 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28176309/achievement-emotions-and-academic-performance-longitudinal-models-of-reciprocal-effects
#11
Reinhard Pekrun, Stephanie Lichtenfeld, Herbert W Marsh, Kou Murayama, Thomas Goetz
A reciprocal effects model linking emotion and achievement over time is proposed. The model was tested using five annual waves of the Project for the Analysis of Learning and Achievement in Mathematics (PALMA) longitudinal study, which investigated adolescents' development in mathematics (Grades 5-9; N = 3,425 German students; mean starting age = 11.7 years; representative sample). Structural equation modeling showed that positive emotions (enjoyment, pride) positively predicted subsequent achievement (math end-of-the-year grades and test scores), and that achievement positively predicted these emotions, controlling for students' gender, intelligence, and family socioeconomic status...
February 8, 2017: Child Development
https://www.readbyqxmd.com/read/28164420/an-exploration-of-caregiver-choice-through-the-lens-of-sartrean-existentialism
#12
Kristin L Corey, Mary K McCurry
There are innumerable social and ethical factors which affect one's decision to become an informal caregiver for someone with chronic illness. The existential philosophy of Jean-Paul Sartre provides unique insight into human motivation and choice. The purpose of this paper was to examine the social and ethical influences on the individual's decision to become a caregiver through the lens of Sartrean existentialism and discuss how this unique philosophy can advance nursing knowledge. The factors affecting one's choice to become a caregiver were considered using the Sartrean existential concepts of The Other, human freedom, choice, bad faith, shame and authenticity...
February 6, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/28160114/an-investigation-of-the-association-between-shame-and-problem-gambling-the-mediating-role-of-maladaptive-coping-motives
#13
Hera E Schlagintweit, Kara Thompson, Abby L Goldstein, Sherry H Stewart
Despite often being considered equivalent affective states, shame and guilt have differential associations with problem gambling with only shame showing a strong positive association with problem gambling. However, little is known about the mechanisms underlying the shame-problem gambling association. Further, shame and guilt are associated with distinct coping strategies, with shame motivating maladaptive coping (e.g., avoidance, escape) and guilt motivating adaptive coping (e.g., taking corrective action)...
February 3, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28159124/knowledge-experience-and-utilisation-of-sexual-and-reproductive-health-services-amongst-nepalese-youth-living-in-the-kathmandu-valley
#14
Laxmi Tamang, Camille Raynes-Greenow, Kevin McGeechan, Kirsten I Black
OBJECTIVE: Youth have the right to utilise sexual and reproductive health (SRH) services and information to protect themselves from negative SRH outcomes. This study aimed to assess knowledge, experience and use of SRH services amongst youth living in urban areas of the Kathmandu Valley. METHODS: We conducted a two stage cluster sampling cross-sectional household survey of young men and women aged 15-24 living in the Kathmandu Valley using a structured questionnaire...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28141707/bullying-and-adhd-which-came-first-and-does-it-matter
#15
Robert Keder, Robert Sege, Peter C Raffalli, Marilyn Augustyn
Aiden, a 13-year-old boy in the sixth grade who is relatively new to your practice, is seen for follow-up after his routine physical last month when you noted concerns for possible attention-deficit hyperactivity disorder (ADHD) and gave the family Vanderbilt Scales to complete. Aiden has a family history of ADHD, specific learning disabilities, and mood disorder.His mother reports that she is concerned about how Aiden is doing at school; his teachers are complaining that he is not doing his work, and she is worried that he may be kept back in school...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28140776/mapping-the-social-determinants-of-substance-use-for-pregnant-involved-young-aboriginal-women
#16
Sana Z Shahram, Joan L Bottorff, Nelly D Oelke, Donna L M Kurtz, Victoria Thomas, Patricia M Spittal, And For The Cedar Project Partnership
There is a dearth of knowledge about the social determinants of substance use among young pregnant-involved Indigenous women in Canada from their perspectives. As part of life history interviews, 17 young pregnant-involved Indigenous women with experiences with substances completed a participant-generated mapping activity CIRCLES (Charting Intersectional Relationships in the Context of Life Experiences with Substances). As women created their maps, they discussed how different social determinants impacted their experiences with pregnancy and substance use...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28134980/initial-treatment-seeking-from-professional-health-care-providers-for-eating-disorders-a-review-and-synthesis-of-potential-barriers-to-and-facilitators-of-first-contact
#17
REVIEW
Pamela Regan, Fary M Cachelin, Alyssa M Minnick
The objective of this study is to provide a comprehensive review of empirical research exploring barriers to and facilitators of initial treatment seeking ("first contact") from professional health care providers by adults and young adults with eating disorders (EDs). A search of databases PsycINFO and MEDLINE using the terms "treatment" and "eating disorder*" yielded 9,468 peer-reviewed articles published from January 1945 to June 2016. Screening identified 31 articles meeting the following criteria: (1) participants were 16 or older and presented with a self-reported or clinically diagnosed ED; (2) studies focused on (a) initial treatment seeking (b) for an ED (c) from professional health care providers; (3) articles were empirical, and (4) peer reviewed...
January 30, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28127728/arteriovenous-access-does-not-perform-as-well-for-plasmapheresis
#18
Mathew Wooster, Rachel Wilson, Murray Shames, Neil Moudgill
PURPOSE: Access surgeons are occasionally asked to create arteriovenous access for non-dialysis functions. Subjectively noting overall poor results, we seek to present our experience with arteriovenous access creation for apheresis. METHODS: Billing records were reviewed using Current Procedural Terminology (CPT) and International Classification of Diseases (ICD-9) codes to identify patients undergoing arteriovenous access creation for diseases other than renal failure from January 2007 to August 2014...
January 25, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28125173/binge-eating-disorder-and-comorbid-conditions-differential-diagnosis-and-implications-for-treatment
#19
Leslie Citrome
Many patients with symptoms of binge-eating disorder (BED) are not diagnosed. Perhaps the biggest obstacles are the failure of physicians to recognize BED as a distinct disorder and the lack of awareness among patients that binge-eating is a well-studied abnormal behavior that is amenable to treatment. In addition, patients may avoid seeking treatment because they feel a general sense of shame over their eating habits and do not want to bring up these symptoms during visits with their physicians. In general, negative attitudes and biases regarding overweight and obesity are common...
2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28124451/befree-a-new-psychological-program-for-binge-eating-that-integrates-psychoeducation-mindfulness-and-compassion
#20
José Pinto-Gouveia, Sérgio A Carvalho, Lara Palmeira, Paula Castilho, Cristiana Duarte, Cláudia Ferreira, Joana Duarte, Marina Cunha, Marcela Matos, Joana Costa
: Binge eating disorder (BED) is associated with several psychological and medical problems, such as obesity. Approximately 30% of individuals seeking weight loss treatments present binge eating symptomatology. Moreover, current treatments for BED lack efficacy at follow-up assessments. Developing mindfulness and self-compassion seem to be beneficial in treating BED, although there is still room for improvement, which may include integrating these different but complimentary approaches...
January 25, 2017: Clinical Psychology & Psychotherapy
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