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https://www.readbyqxmd.com/read/29161717/subconjunctival-prgf-fibrin-membrane-as-an-adjuvant-to-nonpenetrating-deep-sclerectomy-a-2-year-pilot-study
#1
Iñaki Rodríguez-Agirretxe, Vanesa Freire, Francisco Muruzabal, Gorka Orive, Eduardo Anitua, Elio Díez-Feijóo, Arantxa Acera
PURPOSE: To evaluate the potential role of the autologous PRGF (plasma rich in growth factors) fibrin membrane in tissue regeneration after glaucoma filtering surgery. MATERIALS AND METHODS: Ten patients with medically uncontrolled primary open-angle glaucoma underwent nonpenetrating deep sclerectomy and were treated with PRGF fibrin membrane as adjuvant. Intraocular pressure reduction was the primary outcome. This variable was measured preoperatively and also at each follow-up visit...
November 22, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29161694/immunohistochemical-localization-of-darpp-32-in-the-brain-of-two-lungfishes-further-assessment-of-its-relationship-with-the-dopaminergic-system
#2
Jesús M López, Ruth Morona, Agustín González
The distribution of DARPP-32 (a phosphoprotein related to the dopamine D1 receptor) has been widely used as a means to clarify the brain regions with dopaminoceptive cells, primarily in representative species of tetrapods. The relationship between dopaminergic and dopaminoceptive elements is frequently analyzed using the catecholamine marker tyrosine hydroxylase (TH). In the present study, by means of combined immunohistochemistry, we have analyzed these relationships in lungfishes, the only group of sarcopterygian fishes represented by 6 extant species that are the phylogenetically closest living relatives of tetrapods...
November 22, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/29161596/an-in-toto-approach-to-dissecting-cellular-interactions-in-complex-tissues
#3
Pavak Kirit Shah, Anthony Santella, Adrian Jacobo, Kimberly Siletti, A J Hudspeth, Zhirong Bao
Single-cell measurements have broadened our understanding of heterogeneity in biology, yet have been limited to mostly observational studies of normal or globally perturbed systems. Typically, perturbations are utilized in an open-ended approach wherein an endpoint is assayed during or after the biological event of interest. Here we describe ShootingStar, a platform for perturbation analysis in vivo, which combines live imaging, real-time image analysis, and automated optical perturbations. ShootingStar builds a quantitative record of the state of the sample being analyzed, which is used to automate the identification of target cells for perturbation, as well as to validate the impacts of the perturbation...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161349/relation-of-retinal-and-serum-lutein-and-zeaxanthin-to-white-matter-integrity-in-older-adults-a-diffusion-tensor-imaging-study
#4
Catherine M Mewborn, Douglas P Terry, Lisa M Renzi-Hammond, Billy R Hammond, L Stephen Miller
Objective: Lutein (L) and zeaxanthin (Z) are phytonutrients that accumulate in human brain tissue and positively impact cognition. Given their antioxidant and anti-inflammatory properties and their role in stabilizing cell membranes, L&Z may relate to measures of white matter integrity (WMI). Method: The current study tested the relation of retinal (macular pigment optical density/MPOD) and blood serum concentrations of L&Z to WMI in community-dwelling older adults (n = 54) using diffusion tensor imaging (DTI)...
November 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29161320/in-vivo-effects-of-intraocular-and-intracranial-pressures-on-the-lamina-cribrosa-microstructure
#5
Bo Wang, Huong Tran, Matthew A Smith, Tigran Kostanyan, Samantha E Schmitt, Richard A Bilonick, Ning-Jiun Jan, Larry Kagemann, Elizabeth C Tyler-Kabara, Hiroshi Ishikawa, Joel S Schuman, Ian A Sigal, Gadi Wollstein
There is increasing clinical evidence that the eye is not only affected by intraocular pressure (IOP), but also by intracranial pressure (ICP). Both pressures meet at the optic nerve head of the eye, specifically the lamina cribrosa (LC). The LC is a collagenous meshwork through which all retinal ganglion cell axons pass on their way to the brain. Distortion of the LC causes a biological cascade leading to neuropathy and impaired vision in situations such as glaucoma and idiopathic intracranial hypertension...
2017: PloS One
https://www.readbyqxmd.com/read/29161306/comparison-of-methods-for-determining-the-effectiveness-of-antibacterial-functionalized-textiles
#6
Hajo Haase, Lisa Jordan, Laura Keitel, Claudia Keil, Boris Mahltig
Antimicrobial functionalization of textiles is important for various applications, such as protection of textile materials from decomposition, generation of more effective wound dressings, and the prevention of infections or malodors resulting from bacterial growth. In order to test the efficacy of new products, their antibacterial activity needs to be evaluated. At present, several different procedures are being used for this purpose, hindering comparisons among different studies. The present paper compares five of these assays using a sample panel of different textiles functionalized with copper (Cu) and silver (Ag) as antibacterial agents, and discusses the suitability of these methods for different analytical requirements...
2017: PloS One
https://www.readbyqxmd.com/read/29161237/bilateral-visual-field-defects-in-a-patient-treated-with-the-mek-and-braf-inhibitors-trametinib-and-dabrafenib-for-melanoma-of-unknown-origin
#7
Jakob Siedlecki, Marc Mackert, Armin Wolf, Carola Berking, Siegfried G Priglinger, Kirsten Eibl-Lindner
INTRODUCTION: Although the introduction of BRAF and MEK inhibitors has greatly enhanced treatment possibilities in advanced BRAFV600-mutated melanoma, class-related toxicities are rather frequent and often involve the eye. Ophthalmologic side effects most commonly include central/diffuse serous retinopathy and retinal vein occlusion. Affection of the optic nerve head however has not been described clinically. CASE REPORT: A 29-year-old man presented in our eye clinic with bilateral blurred vision...
April 17, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29161162/patient-perceived-and-laboratory-measured-halos-associated-with-diffractive-bifocal-and-trifocal-intraocular-lenses
#8
Francisco Alba-Bueno, Nuria Garzón, Fidel Vega, Francisco Poyales, María S Millán
PURPOSE: To examine and assess the halos generated in distance vision by multifocal intraocular lenses (IOLs) using both in vitro objective and in vivo subjective methods. SETTING: The objective method was carried out in the optics laboratory of the Applied Optics and Image Processing Group (Universitat Politècnica de Catalunya -Barcelona). The psychophysical and subjective methods were carried out in the Instituto de Oftalmología Avanzada Madrid Innova Ocular...
November 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29161049/on-the-empirical-analysis-of-optical-kerr-effect-spectra-a-case-for-constraint
#9
John S Bender, John T Fourkas, Benoit Coasne
Ultrafast optical Kerr effect (OKE) spectroscopy is a widely used method for studying the depolarized, Raman-active intermolecular dynamics of liquids. Through appropriate manipulation of OKE data, it is possible to determine the reduced spectral density (RSD), which is the Bose-Einstein-corrected, low-frequency Raman spectrum with the contribution of diffusive reorientation removed. OKE RSDs for van der Waals liquids can often be fit well to an empirical function that is the sum of a Bucaro-Litovitz function and an antisymmetrized Gaussian (AG)...
November 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29161035/synthesis-of-photoswitchable-%C3%AE-9-tetrahydrocannabinol-derivatives-enables-optical-control-of-cannabinoid-receptor-1-signaling
#10
Matthias Westphal, Michael Andreas Schafroth, Roman Sarott, Michael Imhof, Christian Bold, Philipp Leippe, Amey Dhopeshwarkar, Jessica Grandner, Vsevolod Katritch, Ken Mackie, Dirk Trauner, Erick M Carreira, James Allen Frank
The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nerv-ous system. It has rich pharmacology and largely accounts for the recreational use of cannabis. We describe efficient asymmetric syntheses of four photoswitchable Δ(9)-tetrahydrocannabinol derivatives (azo-THCs) from a central building block 3-Br-THC. Using electrophysiology and a FRET-based cAMP assay, two compounds are identified as potent CB1 agonists that change their effect upon illumination...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29161019/local-enhancement-of-lipid-membrane-permeability-induced-by-irradiated-gold-nanoparticles
#11
Andrea Torchi, Federica Simonelli, Riccardo Ferrando, Giulia Rossi
Photothermal therapies are based on the optical excitation of plasmonic nanoparticles in the biological environment. The effects of the irradiation on the biological medium depend critically on the heat transfer process at the nanoparticle interface, on the temperature reached by the tissues as well as on the spatial extent of temperature gradients. Unfortunately, both the temperature and its biological effects are difficult to be probed experimentally at the molecular scale. Here, we approach this problem using non-equilibrium molecular dynamics simulations...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29161014/toward-an-axial-nanoscale-ruler-for-fluorescence-microscopy
#12
Sabrina Simoncelli, Maria Makarova, William Wardley, Dylan M Owen
In the discussion of resolution in optical microscopy, axial precision has often come second to its lateral counterpart. However, biological systems make no special arrangements for our preferred direction of imaging. The ability to measure axial distances, that is, the heights of fluorophores relative to a plane of reference, is thus of paramount importance and has been the subject of several recent advances. A novel method is to modify the fluorescence emission based on the height of the individual fluorophore, such that its z-position is encoded somehow in the detected signal...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29160942/bioinspired-mesoporous-chiral-nematic-graphitic-carbon-nitride-for-ultrahigh-photocatalytic-activity-with-polarized-light-modulations
#13
Wensheng Lin, Wei Hong, Lu Sun, Di Yu, Dingshan Yu, Xudong Chen
Endowing materials with chirality and exploring the responses of the material under circularly polarized light (CPL) can gain further insight into the physical and chemical properties of the semiconductors, thus expand the optoelectronic applications. Herein we report a bioinspired mesoporous chiral nematic graphitic carbon nitride (g-C3N4) for efficient hydrogen evolutions with polarized light modulations based on chiral nematic cellulose nanocrystal films through silica templating. The mesoporous nematic chiral g-C3N4 exhibits an ultrahigh hydrogen evolution rate of 219...
November 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29160862/time-resolved-photoluminescence-microscopy-for-the-analysis-of-semiconductor-based-paint-layers
#14
Daniela Comelli, Alessia Artesani, Austin Nevin, Sara Mosca, Victor Gonzalez, Myriam Eveno, Gianluca Valentini
In conservation, science semiconductors occur as the constituent matter of the so-called semiconductor pigments, produced following the Industrial Revolution and extensively used by modern painters. With recent research highlighting the occurrence of various degradation phenomena in semiconductor paints, it is clear that their detection by conventional optical fluorescence imaging and microscopy is limited by the complexity of historical painting materials. Here, we illustrate and prove the capabilities of time-resolved photoluminescence (TRPL) microscopy, equipped with both spectral and lifetime sensitivity at timescales ranging from nanoseconds to hundreds of microseconds, for the analysis of cross-sections of paint layers made of luminescent semiconductor pigments...
November 21, 2017: Materials
https://www.readbyqxmd.com/read/29160860/self-assembled-inas-nanowires-as-optical-reflectors
#15
Francesco Floris, Lucia Fornasari, Andrea Marini, Vittorio Bellani, Francesco Banfi, Stefano Roddaro, Daniele Ercolani, Mirko Rocci, Fabio Beltram, Marco Cecchini, Lucia Sorba, Francesco Rossella
Subwavelength nanostructured surfaces are realized with self-assembled vertically-aligned InAs nanowires, and their functionalities as optical reflectors are investigated. In our system, polarization-resolved specular reflectance displays strong modulations as a function of incident photon energy and angle. An effective-medium model allows one to rationalize the experimental findings in the long wavelength regime, whereas numerical simulations fully reproduce the experimental outcomes in the entire frequency range...
November 21, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29160823/in-doped-zno-hexagonal-stepped-nanorods-and-nanodisks-as-potential-scaffold-for-highly-sensitive-phenyl-hydrazine-chemical-sensors
#16
Ahmad Umar, Sang Hoon Kim, Rajesh Kumar, Mohammad S Al-Assiri, A E Al-Salami, Ahmed A Ibrahim, Sotirios Baskoutas
Herein, we report the growth of In-doped ZnO (IZO) nanomaterials, i.e., stepped hexagonal nanorods and nanodisks by the thermal evaporation process using metallic zinc and indium powders in the presence of oxygen. The as-grown IZO nanomaterials were investigated by several techniques in order to examine their morphological, structural, compositional and optical properties. The detailed investigations confirmed that the grown nanomaterials, i.e., nanorods and nanodisks possess well-crystallinity with wurtzite hexagonal phase and grown in high density...
November 21, 2017: Materials
https://www.readbyqxmd.com/read/29160803/solution-growth-of-two-dimensional-bi%C3%A2-se%C3%A2-nanosheets-for-two-color-all-optical-switching
#17
Xinghua Wu, Chao Tan, Qingkai Wang, Yanyan Guo, Dianyuan Wang, Yongqian Wang, Dawei Meng
Two-dimensional Bi₂Se₃ nanosheets with hexagonal shape are synthesized by a solution synthetic route. The Bi₂Se₃ nanosheets are 120 nm in edge width and 7 nm in thickness. The size of the Bi₂Se₃ nanosheets can be controlled by choosing different kinds of reducing agents including hydroxylamine and ethylenediamine. Subsequently, we demonstrate a configuration of two-color all-optical switching based on plasma channels effect using the as-synthesized Bi₂Se₃ nanosheets as an optical media. The signal light can be modulated as two states including dot and ring shape by changing the intensity of control light...
November 21, 2017: Materials
https://www.readbyqxmd.com/read/29160787/functional-and-anatomical-significance-of-the-ectopic-inner-foveal-layers-in-eyes-with-idiopathic-epiretinal-membranes-surgical-results-at-12-months
#18
Andrea Govetto, Gianni Virgili, Francisco J Rodriguez, Marta S Figueroa, David Sarraf, Jean Pierre Hubschman
PURPOSE: To describe the functional and anatomical outcomes of pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel in eyes with and without ectopic inner foveal layers (EIFLs). METHODS: In this retrospective multicenter study, patients diagnosed with idiopathic epiretinal membranes who underwent pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel were enrolled, with a minimum follow-up of 12 months. Preoperative and postoperative spectral domain optical coherence tomography scans were qualitatively and quantitatively evaluated...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160785/scleral-pits-in-choroideremia-implications-for-retinal-gene-therapy
#19
Abdullah A Al-Qahtani, Shakoor Ba-Ali, Talal Alabduljalil, Aaron S Coyner, Rachel C Patel, Richard G Weleber, Aniz Girach, Søren K Christensen, Michael Larsen, Mark E Pennesi, Paul Yang
PURPOSE: We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). METHODS: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160781/choroidal-thickness-changes-in-acute-zonal-occult-outer-retinopathy
#20
Hiroki Maehara, Tetsuju Sekiryu, Yukinori Sugano, Ichiro Maruko
PURPOSE: To investigate the longitudinal morphologic choroidal changes in eyes with acute zonal occult outer retinopathy. METHODS: In this retrospective observational case series, we studied 10 patients (11 eyes) with unilateral acute zonal occult outer retinopathy at the first visit who were followed more than 12 months by enhanced depth optical coherence tomography. The retinal and choroidal thicknesses (CTs) were measured at six sites in the macula. RESULTS: The integrity of the ellipsoid zone was lost 1,500 μm and 3,000 μm nasally in all 11 eyes at the first visit...
November 16, 2017: Retina
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