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https://www.readbyqxmd.com/read/29707879/recent-advances-in-polyanhydride-based-biomaterials
#1
REVIEW
Arijit Basu, Abraham J Domb
This review focusses on recent developments of polyanhydrides, a class of degradable synthetic biopolymers. Polyanhydrides have been used as carriers for controlled delivery of drugs. A polyanhydride copolymer of carboxyphenoxy propane and sebacic acid has been used in Gliadel brain tumor implants for the controlled delivery of carmustine or bis-chloroethylnitrosourea. They are easy and inexpensive to synthesize (especially scale up). However, polyanhydrides possess a short shelf-life. Hydrolytic cleavage and anhydride interchanges lower their molecular weights during storage...
April 30, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29706869/fibronectin-promotes-the-malignancy-of-glioma-stem-like-cells-via-modulation-of-cell-adhesion-differentiation-proliferation-and-chemoresistance
#2
Qi Yu, Yixue Xue, Jing Liu, Zhuo Xi, Zhen Li, Yunhui Liu
Glioma stem-like cells (GSCs) are regarded as the sources of oncogenesis, recurrence, invasion and chemoresistance in malignant gliomas. Growing evidence suggests that the microenvironment surrounding GSCs interacts with tumor cells to influence biological behavior; however, the functional mechanisms involved are still unclear. In the present study, we investigated the modulation of GSCs triggered by fibronectin (FN), a main component of the extracellular matrix (ECM), in terms of cell adhesion, differentiation, proliferation and chemoresistance...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29676445/systematic-patient-involvement-for-homebased-outpatient-administration-of-complex-chemotherapy-in-acute-leukemia-and-lymphoma
#3
Katrine S Fridthjof, Peter Kampmann, Anne Dünweber, Jette S Gørløv, Connie Nexø, Lone S Friis, Kristina H Nørskov, Pernille C Welinder, Claus Moser, Lars Kjeldsen, Tom Møller
Based on experience with comprehensive patient involvement, we present data from implementation of portable, programmable infusion pumps (PPP) for home-based chemotherapy administration in patients with acute leukaemia and in lymphoma patients receiving (carmustine, etoposide, cytarabine, melphalan) BEAM regimen. Data from 84 patients, receiving 177 cycles of PPP administered chemotherapy, showed convincing safety with minor equipment errors encountered and with high patient satisfaction. In-hospital days could be reduced with 52% out of a total of 1197 treatment days...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29658349/biodegradable-hybrid-structured-nanofibrous-membrane-supported-chemoprotective-gene-therapy-enhances-chemotherapy-tolerance-and-efficacy-in-malignant-glioma-rats
#4
Shih-Jung Liu, Tao-Chieh Yang, Shun-Tai Yang, Ying-Chun Chen, Yuan-Yun Tseng
Chemotherapy is ineffective for treating malignant glioma (MG) because of the low therapeutic levels of pharmaceuticals in tumour tissues and the well-known tumour resistance. The resistance to alkylators is modulated by the DNA repair protein O6 -alkylguanine-DNA alkyltransferase (AGT). O6 -benzylguanine (O6 -BG) can irreversibly inactivate AGT by competing with O6 -methylguanine and has been confirmed to increase the therapeutic activity of alkylators. We developed hybrid-structured poly[(d,l)-lactide-co-glycolide] nanofibrous membranes (HSNMs) that enable the sequential and sustained release of O6 -BG and two alkylators (carmustine and temozolomide [TMZ])...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29570984/effects-of-the-green-tea-polyphenol-epigallocatechin-3-gallate-on-glioma-a-critical-evaluation-of-the-literature
#5
Chung T Le, William P J Leenders, Remco J Molenaar, Cornelis J F van Noorden
The review discusses the effects of Epigallocatechin-3-gallate Gallate (EGCG) on glioma as a basis for future research on clinical application of EGCG. Epidemiological studies on the effects of green tea or EGCG on the risk of glioma is inconclusive due to the limited number of studies, the inclusion of all tea types in these studies, and the focus on caffeine rather than EGCG. In vivo experiments using EGCG monotherapy are inconclusive. Nevertheless, EGCG induces cell death, prevents cellular proliferation, and limits invasion in multiple glioma cell lines...
April 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29552779/factors-affecting-the-survival-of-patients-with-glioblastoma-multiforme
#6
Vesna Nikolov, Miodrag Stojanovic, Aleksandar Kostic, Misa Radisavljevic, Natasa Simonovic, Boban Jelenkovic, Luka Berilazic
PURPOSE: Glioblastoma multiforme (GBM) is the most aggressive malignant tumor in the brain and no therapy can achieve full recovery/cure. The aim of this study was to identify which factors could improve the survival of operated patients, and to determine which kind of therapy was most successful. METHODS: The study was conducted at the Clinic for Neurosurgery in Nis, Clinical Centre Nis and the Oncology Institute, Clinical Center Nis. A cohort of patients who underwent surgery between January 2013 and December 2015 was studied and continuous monitoring of survival lasted until June 2017...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29507697/differential-scanning-calorimetry-of-plasma-in-glioblastoma-toward-a-new-prognostic-monitoring-tool
#7
Philipp O Tsvetkov, Emeline Tabouret, Andrei Y Roman, Sylvie Romain, Céline Bequet, Olga Ishimbaeva, Stéphane Honoré, Dominique Figarella-Branger, Olivier Chinot, François Devred
Glioblastoma is the most frequent and aggressive primary brain tumor in adults. Recently, a growing number of studies have shown that denaturation profile of plasma samples obtained by differential scanning calorimetry (DSC) can represent a signature of a disease. In this study, we analyzed for the first time the DSC denaturation profiles of the plasma from patients with recurrent glioblastoma (n=17). Comparison to the one of healthy individuals (n=10) and to already described profiles in others cancer showed clear differences suggesting that this DSC profile may constitute a signature of glioblastoma...
February 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29502594/interim-pet-response-adapted-strategy-in-untreated-advanced-stage-hodgkin-lymphoma-results-of-goelams-lh-2007-phase-2-multicentric-trial
#8
Sylvain Carras, Benjamin Dubois, Delphine Senecal, Jean-Philippe Jais, Michel Peoc'h, Philippe Quittet, Charles Foussard, Krimo Bouabdallah, Thomas Gastinne, Eric Jourdan, Laurence Sanhes, Marjan Ertault, Thierry Lamy, Lysiane Molina
BACKGROUND: Patients with advanced stage Hodgkin lymphoma still present unsatisfactory outcomes. PATIENTS AND METHODS: The Groupe d'étude des Leucémies Aigues et des Maladies du Sang (GOELAMS) group conducted a prospective multicentric trial (NCT00920153) for advanced stage Hodgkin lymphoma to evaluate a positron emission tomography (PET)-adapted strategy. Patients received an intensive regimen (VABEM [vindesine, doxorubicin, carmustine, etoposide, and methylprednisolone]) in front-line and interim 18F FDG-PET evaluation after 2 courses (PET-2)...
March 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29500148/thiotepa-etoposide-cyclophosphamide-cytarabine-and-melphalan-tecam-conditioning-regimen-for-autologous-stem-cell-transplantation-in-lymphoma
#9
Sigal Grisariu, Michael Y Shapira, Reuven Or, Batia Avni
BACKGROUND: High-dose chemotherapy and autologous stem cell transplantation (ASCT) is the current standard of care for relapsed non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Conditioning regimens with high-dose carmustine have been associated with idiopathic pneumonitis syndrome. We, therefore, created a modified alternative TECAM conditioning regimen, consisting of etoposide, thiotepa, cytarabine, cyclophosphamide, and melphalan. PATIENTS AND METHODS: We retrospectively analyzed our cohort of 212 NHL and HL patients, who had undergone ASCT with the TECAM conditioning regimen from 2000 to 2013...
April 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29488744/magnetic-oleosome-as-a-functional-lipophilic-drug-carrier-for-cancer-therapy
#10
Hyeon-Yeol Cho, Taek Lee, Jinho Yoon, Zhenlin Han, Hudifah Rabie, Ki-Bum Lee, Wei Wen Su, Jeong-Woo Choi
In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by a phospholipid monolayer with embedded oleosin fusion proteins. The oleosin was genetically fused to a nanobody of a green fluorescent protein (GFP). A recombinant protein consisting of immunoglobulin-binding protein LG fused to GFP was used to couple the oleosome to an antibody for targeted delivery to breast cancer cells...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29476996/advantages-and-disadvantages-of-combined-chemotherapy-with-carmustine-wafer-and-bevacizumab-in-patients-with-newly-diagnosed-glioblastoma-a-single-institutional-experience
#11
Yukinori Akiyama, Yuusuke Kimura, Rei Enatsu, Takeshi Mikami, Masahiko Wanibuchi, Nobuhiro Mikuni
OBJECTIVE: To retrospectively determine the safety and efficacy of combined chemotherapy with carmustine (BCNU) wafer, bevacizumab, and temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma (GBM). METHODS: A total of 54 consecutive newly diagnosed GBMs were resected at our institution between 2010 and 2016. Twenty-nine patients underwent BCNU wafer implantation into the resection cavity followed by standard radiochemotherapy with temozolomide (TMZ, Stupp regimen) plus additional bevacizumab treatment between 2013 and 2016...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29476361/combining-clinical-and-molecular-data-to-predict-the-benefits-of-carmustine-wafers-in-newly-diagnosed-high-grade-gliomas
#12
REVIEW
Tamara Ius, Daniela Cesselli, Miriam Isola, Giovanni Toniato, Giada Pauletto, Giovanni Sciacca, Sara Fabbro, Enrico Pegolo, Simona Rizzato, Antonio Paolo Beltrami, Carla di Loreto, Miran Skrap
PURPOSE OF REVIEW: The purpose of this study was to retrospectively evaluate the use of carmustine wafers (CWs) in the management of high-grade gliomas (HGGs). The data from our monoinstitutional series was compared with studies reported in the literature. Special emphasis was placed on the evaluation of side effects and the analysis of extent of resection and molecular profile as risk factors. RECENT FINDINGS: The implantation of CWs into the resection cavity during HGG treatment to deliver localized chemotherapy, followed by the Stupp protocol, remains debated in a clinical setting, largely due to the lack of appropriate phase III studies...
February 23, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29476021/updated-results-of-rituximab-pre-and-post-beam-with-or-without-90-yttrium-ibritumomab-tiuxetan-during-autologous-transplant-for-diffuse-large-b-cell-lymphoma
#13
Jad Chahoud, Dawen Sui, William D Erwin, Alison M Gulbis, Martin Korbling, Mingzhi Zhang, Sairah Ahmed, Gheath Alatrash, Paolo Anderlini, Stefan O Ciurea, Betul Oran, Luis E Fayad, Roland L Bassett, Elias J Jabbour, L Jeffrey Medeiros, Homer A Macapinlac, Ken H Young, Issa F Khouri
Purpose: We evaluated the effect on long-term survival of adding rituximab (R) to BEAM (carmustine, etoposide, cytarabine, and melphalan) conditioning with or without yttrium-90 ibritumomab tiuxetan (90 YIT) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) undergoing autologous stem cell transplant (ASCT). Experimental design: Patients were enrolled on three consecutive phase II clinical trials. Patients received two doses of rituximab (375 and 1,000 mg/m2 ) during mobilization of stem cells, followed by 1,000 mg/m2 on days +1 and +8 after ASCT with R-BEAM or 90 YIT-R-BEAM (90 YIT dose of 0...
February 23, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29473209/bendamustine-based-conditioning-prior-to-autologous-stem-cell-transplantation-asct-results-of-a-french-multicenter-study-of-474-patients-from-lymphoma-study-association-lysa-centers
#14
Sylvain P Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie-Virginie Larcher, Momar Diouf, Luc-Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne-Claire Gac, Emilie Reboursière, Jean-Pierre Vilque, Mohamed-Amine Bekadja, Rene-Olivier Casasnovas, Remy Gressin, Stéphanie Guidez, Diane Coso, Charles Herbaux, Ibrahim Yakoub-Agha, Krimo Bouabdallah, Eric Durot, Gandhi Damaj
Carmustine shortage has led to an increase use of alternative conditioning regimens prior to autologous stem cell transplantation for the treatment of lymphoma, including Bendamustine-based (BeEAM). The aim of this study was to evaluate the safety of the BeEAM regimen in a large cohort of patients. A total of 474 patients with a median age of 56 years were analyzed. The majority of patients had diffuse large B-cell lymphoma (43.5%). Bendamustine was administered at a median dose of 197 mg/m2 /day (50-250) on days-7 and -6...
February 23, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29468458/axon-initial-segment-structural-plasticity-is-involved-in-seizure-susceptibility-in-a-rat-model-of-cortical-dysplasia
#15
Zong-Wei Yue, Ye-Lan Wang, Bo Xiao, Li Feng
Cortical dysplasia is the most common etiology of intractable epilepsy. Both excitability changes in cortical neurons and neural network reconstitution play a role in cortical dysplasia epileptogenesis. Recent research shows that the axon initial segment, a subcompartment of the neuron important to the shaping of action potentials, adjusts its position in response to changes in input, which contributes to neuronal excitability and local circuit balance. It is unknown whether axon initial segment plasticity occurs in neurons involved in seizure susceptibility in cortical dysplasia...
April 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29468445/tumor-microenvironment-after-biodegradable-bcnu-wafer-implantation-special-consideration-of-immune-system
#16
Ichiyo Shibahara, Mitsuto Hanihara, Takashi Watanabe, Mitsuru Dan, Sumito Sato, Hiroki Kuroda, Akinori Inamura, Madoka Inukai, Atsuko Hara, Yoshie Yasui, Toshihiro Kumabe
Biomaterials to treat cancers hold therapeutic potential; however, their translation to bedside treatment requires further study. The carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea; BCNU) wafer, a biodegradable polymer, currently is the only drug that is able to be placed at the surgical site to treat malignant tumors. However, how this wafer affects the surrounding tumor microenvironment is not well understood to date. We retrospectively reviewed all patients with glioblastoma treated with and without BCNU wafers who underwent repeat resection at tumor recurrence...
April 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29455370/incomplete-copolymer-degradation-of-in-situ-chemotherapy
#17
Pierre Bourdillon, Tanguy Boissenot, Lauriane Goldwirt, Julien Nicolas, Caroline Apra, Alexandre Carpentier
In situ carmustine wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) are commonly used for the treatment of recurrent glioblastoma to overcome the brain-blood barrier. In theory, this chemotherapy diffuses into the adjacent parenchyma and the excipient degrades in maximum 8 weeks but no clinical data confirms this evolution, because patients are rarely operated again. A 75-year-old patient was operated twice for recurrent glioblastoma, and a carmustine wafer was implanted during the second surgery...
February 17, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29381124/the-computational-study-of-the-%C3%AE-fe-2-o-3-nanoparticle-as-carmustine-drug-delivery-system-dft-approach
#18
Rabeeh Khorram, Heidar Raissi, Ali Morsali, Mahnaz Shahabi
In the present study, it is attempted to scrutinize the properties of the maghemite nanoparticle as a Carmustine drug delivery system by means of the density functional theory calculations regarding their geometries, adsorption energies, vibrational frequencies, and topological features of the electron density. Based on the density functional theory results, it is found that the interaction between Carmustine drug molecule and maghemite nanoparticle is weak; so that, the adsorption of the Carmustine drug is typically physisorption...
February 2, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29330390/freezing-the-graft-is-not-necessary-for-autotransplants-for-plasma-cell-myeloma-and-lymphomas
#19
Amado Kardduss-Urueta, Robert Peter Gale, César H Gutierrez-Aguirre, Miguel Angel Herrera-Rojas, Iván Murrieta-Álvarez, Rosendo Perez-Fontalvo, Guillermo J Ruiz-Delgado, Giovanni Ruiz-Rojas, Gregorio Jaimovich, Leonardo Feldman, Nancy Labastida-Mercado, Alicia Endara, Martín Castro, Samantha Galindo-Becerra, María Angélica Cardona-Molina, David Gomez-Almaguer, Guillermo J Ruiz-Argüelles
We studied rates of granulocyte and platelets recovery in 359 consecutive subjects receiving blood cell infusions in the context of autotransplants for plasma cell myeloma (N = 216) and lymphomas (N = 143). Blood cells were mobilised with filgrastim given for 4-5 days and collected after a median of 2 (range, 1-2) apheresis. Apheresis products were stored at 4° C for a median of 3 days (range, 2-6 days). Most subjects received carmustine, etoposide, cytarabine and melphalan (BEAM), cyclophosphamide, carmustine and etoposide (CBV) or high-dose melphalan...
April 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29322918/a-linear-programming-computational-framework-integrates-phosphor-proteomics-and-prior-knowledge-to-predict-drug-efficacy
#20
Zhiwei Ji, Bing Wang, Ke Yan, Ligang Dong, Guanmin Meng, Lei Shi
BACKGROUND: In recent years, the integration of 'omics' technologies, high performance computation, and mathematical modeling of biological processes marks that the systems biology has started to fundamentally impact the way of approaching drug discovery. The LINCS public data warehouse provides detailed information about cell responses with various genetic and environmental stressors. It can be greatly helpful in developing new drugs and therapeutics, as well as improving the situations of lacking effective drugs, drug resistance and relapse in cancer therapies, etc...
December 21, 2017: BMC Systems Biology
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