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anemia in the elderly

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https://www.readbyqxmd.com/read/28072603/dyserythropoiesis-of-myelodysplastic-syndromes
#1
Carine Lefèvre, Sabrina Bondu, Salomé Le Goff, Olivier Kosmider, Michaela Fontenay
PURPOSE OF REVIEW: Myelodysplastic syndromes (MDS) are heterogeneous diseases of the hematopoietic stem cell in the elderly. Anemia is the main symptom that mostly correlates with dysplastic erythropoiesis in the bone marrow. We will review the recent advances in understanding the diverse mechanisms of dyserythropoiesis. RECENT FINDINGS: Dyserythropoiesis defined as 10% dysplastic erythroid cells in the bone marrow is found in more than 80% of early MDS. Immature erythroblasts accumulate at the expense of mature erythroblasts due to differentiation arrest and apoptosis...
January 7, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28059982/morbidity-of-adult-spinal-deformity-surgery-in-elderly-has-declined-over-time
#2
Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Brian Neuman, Rafael de la Garza-Ramos, Emily Miller, Amit Jain, Daniel Sciubba, Shearwood McClelland, Louis Day, Subbu Ramachadran, Shaleen Vira, Bassel Diebo, Evan Isaacs, Olivia Bono, Shay Bess, Michael Gerling, Virginie Lafage
STUDY DESIGN: A retrospective review of a prospectively collected database, the Nationwide Inpatient Sample (NIS), years 2003 to 2012. OBJECTIVES: The aim of this study was to examine trends in the management of scoliosis in elderly (age >75 yrs) patients from 2003 to 2012. SUMMARY OF BACKGROUND DATA: Scoliosis incidence rises with increasing age, and age has been shown to be an independent risk factor for surgical complications in scoliosis surgery...
January 4, 2017: Spine
https://www.readbyqxmd.com/read/28045555/clinicopathologic-characteristics-of-elderly-with-gastric-cancer-and-the-risk-factors-of-postoperative-complications
#3
Yong Li, Bibo Tan, Liqiao Fan, Qun Zhao, Ming Tan, Dong Wang, Nan Jia, Qingwei Liu
PURPOSE: In China, gastric cancer (GC), which is one of the most common malignant tumors, has an increasing incidence in elderly population due to aging process. Since a considerable number of elderly patients with GC accepting surgical treatments developed postoperative complications, it is necessary to evaluate risk factors for postoperative complications. MATERIALS AND METHODS: In the present study, the clinicopathologic characteristics of 3,024 elderly patients (aged ≥65 years) with GC, who underwent surgery between 1996 and 2006, were examined and contributing factors for postoperative complications were analyzed...
January 3, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28005996/correction-factors-associated-with-anemia-in-the-institutionalized-elderly
#4
Emanuelle Cruz da Silva, Anna Karla Carneiro Roriz, Michaela Eickemberg, Adriana Lima Mello, Elvira Barbosa Quadros Côrtes, Caroline Alves Feitosa, Jairza Maria Barreto Medeiros, Lílian Barbosa Ramos
[This corrects the article DOI: 10.1371/journal.pone.0162240.].
2016: PloS One
https://www.readbyqxmd.com/read/27999879/-perioperative-patient-management-in-orthogeriatrics
#5
P Moldzio, J Peters
The management of major orthopedic surgery in the elderly prototypically reflects the perioperative risks of geriatric, often very frail patients reflecting an aging population. To improve outcome, the risks of anesthesia and surgery as well as of patient comorbidities must be thoroughly assessed and balanced using a multidisciplinary approach. Particular risks include cardiopulmonary morbidity, anemia, risk of hemorrhage and the management by anticoagulation, cerebral impairments as well as frailty and limited physiological reserves in general...
December 20, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27916048/-the-impact-of-red-blood-cell-distribution-width-on-outcome-of-elective-percutaneous-coronary-intervention-in-non-anemia-patients
#6
X M Liu, J Z Dong, X H Liu, J P Kang, T Y Luo, Y Guan, T Y Dai, Y Zhang, R Bai, X Du, C S Ma
Objective: Previous studies have revealed that the red blood cell distribution width (RDW) was associated with long-term prognosis in patients undergoing percutaneous coronary intervention (PCI). However, they did not exclude patients with anemia. This study, thus, investigated the association between RDW and prognosis in non-anemia patients. Methods: A total of 2 732 patients underwent elective PCI from July 2009 to September 2011 were enrolled in the study. These patients were divided into two groups based on their baseline median RDW levels: low RDW group (RDW<12...
December 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27913464/new-challenges-in-evaluating-anemia-in-older-persons-in-the-era-of-molecular-testing
#7
David P Steensma
Anemia is common in older persons, and often remains unexplained despite a thorough clinical history, physical examination, and focused laboratory testing, including marrow aspiration, biopsy, and karyotyping. The advent of molecular genetic testing panels in hematology clinical practice has complicated the evaluation of older patients with unexplained anemia. While the presence of a somatic mutation provides evidence of clonal hematopoiesis and may support a diagnosis of a hematologic neoplasm such as one of the myelodysplastic syndromes (MDS), with rare exceptions, individual mutations are not strongly associated with one specific diagnosis, nor are they by themselves diagnostic of neoplasia...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27912734/prevalence-and-predictive-importance-of-anemia-in-swedish-nursing-home-residents-a-longitudinal-study
#8
Björn Westerlind, Carl Johan Östgren, Sigvard Mölstad, Patrik Midlöv
BACKGROUND: Anemia is common in elderly people and especially in nursing home residents. Few studies have been performed on the consequences of anemia in a nursing home population. This study explored the prevalence of anemia in nursing homes in Sweden, including risk factors and mortality associated with anemia or hemoglobin (Hb) decline. METHODS: Three hundred ninety patients from 12 nursing homes were included during 2008-2011. Information about medication, blood samples, questionnaire responses and information about physical and social activities was recorded...
December 2, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27901246/chemotherapy-for-advanced-non-small-cell-lung-cancer-in-the-elderly-population
#9
Fábio Nasser Santos, Tiago Biachi de Castria, Marcelo Rocha Souza Cruz, Rachel Riera
BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these patients are controversial, and the role of single-agent or combination therapy is unclear. In this setting, a critical systematic review of RCTs in this group of patients is warranted. OBJECTIVES: To assess the effectiveness and safety of different cytotoxic chemotherapy regimens for previously untreated elderly patients with advanced (stage IIIB and IV) NSCLC...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27889956/red-blood-cell-function-and-dysfunction-redox-regulation-nitric-oxide-metabolism-anemia
#10
Viktoria Kuhn, Lukas Diederich, T C Stevenson Keller, Christian M Kramer, Wiebke Lückstädt, Christina Panknin, Tatsiana Suvorava, Brant E Isakson, Malte Kelm, Miriam M Cortese-Krott
SIGNIFICANCE: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events, stroke, hypertension, arrhythmias, and inflammation, particularly in elderly patients. The underlying mechanisms of these complications are largely unidentified. Recent Advances: Previously, red blood cells (RBCs) were considered exclusively as transporters of oxygen and nutrients to the tissues. More recent experimental evidence indicates that RBCs are important interorgan communication systems with additional functions, including participation in control of systemic nitric oxide metabolism, redox regulation, blood rheology, and viscosity...
January 18, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27872759/impact-of-moderate-intensity-aerobic-exercise-on-chemotherapy-induced-anemia-in-elderly-women-with-breast-cancer-a-randomized-controlled-clinical-trial
#11
Heba M Mohamady, Hany F Elsisi, Yasser M Aneis
Exercises are often recommended for patients suffering from anemia to improve physical conditioning and hematologic parameters. Hence, the present study aimed to investigate the impact of moderate intensity aerobic exercise on chemotherapy-induced anemia. Thirty elderly women with breast cancer underwent chemotherapy and were randomly assigned into two equal groups; Group A received aerobic exercise for 25-40 min at 50-70% of the maximum heart rate, 3 times/week for 12 weeks in addition to usual daily living activities, medication and nutritional support...
January 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27846276/the-prevalence-of-anemia-and-moderate-severe-anemia-in-the-us-population-nhanes-2003-2012
#12
Chi Huu Hong Le
Since anemia is associated with poor health outcomes, the prevalence of anemia is a significant public health indicator. Even though anemia is primarily caused by iron deficiency, low oxygen-carrying capacity may result from other conditions such as chronic diseases, which remain a relevant health concern in the United States. However, studies examining current rates of anemia in the total US population and in more specific subgroups are limited. Data from five National Health and Nutrition Examination Surveys (NHANES) from 2003 to 2012 were analyzed to assess two outcomes: anemia and moderate-severe anemia, which were based upon serum hemoglobin levels (Hb) as per World Health Organization (WHO) definitions...
2016: PloS One
https://www.readbyqxmd.com/read/27844360/-anemia-in-the-elderly-three-steps-towards-diagnosis
#13
REVIEW
Joachim Zeeh
No abstract text is available yet for this article.
November 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27835718/low-hemoglobin-levels-and-risk-of-developing-depression-in-the-elderly-results-from-the-prospective-pro-v-a-study
#14
Caterina Trevisan, Nicola Veronese, Francesco Bolzetta, Marina De Rui, Christoph U Correll, Sabina Zambon, Estella Musacchio, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Marco Solmi, Enzo Manzato, Giuseppe Sergi
OBJECTIVE: Low hemoglobin negatively affects health in the elderly, but research about the association with risk for depression is limited. We investigated the association between baseline hemoglobin concentrations and incident depression in a cohort of nondepressed elderly individuals. METHODS: As part of the Northern Italian Progetto Veneto Anziani (PRO.V.A.) study, randomly drawn, community-dwelling subjects aged ≥ 65 years underwent prospective clinical and laboratory assessments between October 1995 and December 2002...
December 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27830968/patterns-of-use-and-survival-outcomes-of-positron-emission-tomography-for-initial-staging-in-elderly-follicular-lymphoma-patients
#15
Ashish Rai, Loretta J Nastoupil, Jessica N Williams, Joseph Lipscomb, Kevin C Ward, David H Howard, Daniel Lee, Christopher R Flowers
The role of positron emission tomography (PET) in the initial assessment of follicular lymphoma (FL) has been a topic of debate. We examined the patterns of utilization of PET staging in FL and assessed the association of PET with survival. Using the SEER-Medicare database, we identified 5712 patients diagnosed with first primary FL between 2000 and 2009. Older age, African-American race, poor performance status, B-symptoms and history of anemia were negatively associated with PET staging. Receipt of PET staging was positively associated with treatment at institutions affiliated with research networks and with residence in areas with higher concentrations of nuclear medicine specialists...
November 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27826252/unexplained-anemia-in-the-elderly-potential-role-of-arterial-stiffness
#16
David Montero, Candela Diaz-Cañestro, Andreas Flammer, Carsten Lundby
No abstract text is available yet for this article.
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27825182/practical-aspects-of-monitoring-of-antiplatelet-therapy
#17
Ljubica Jovanovic, Nebojsa Antonijevic, Tina Novakovic, Nebojsa Savic, Branka Terzic, Ivana Zivkovic, Nebojsa Radovanovic, Milika Asanin
Despite the application of new antiplatelet drugs (prasugrel and ticagrelor), dual antiplatelet therapy with clopidogrel and aspirin remains the standard for patients with acute coronary syndrome undergoing percutaneous coronary intervention, especially in countries of low socioeconomic status. Regardless of the proven benefits, numerous studies have shown that certain groups of patients who receive standard doses of clopidogrel and aspirin do not respond adequately, and many of them also exhibit adverse cardiovascular events...
November 8, 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27822071/biosimilar-epoetin-for-the-management-of-chemotherapy-induced-anemia-in-elderly-patients
#18
Jean-Emmanuel Kurtz, Pierre Soubeyran, Mauricette Michallet, Elisabeth Luporsi, Hélène Albrand
INTRODUCTION: Chemotherapy-induced anemia (CIA) is a frequent complication among cancer patients, with elderly patients more likely to suffer severe effects. Biosimilar erythropoiesis-stimulating agents lower costs of supportive cancer treatment, and thus are particularly relevant in the elderly cancer population, which is growing rapidly worldwide. The goal of this subanalysis was to compare the tolerability and effectiveness of an epoetin biosimilar for treating CIA in patients <70 years old vs patients ≥70 years old...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27818982/total-hip-arthroplasty-complications-in-patients-with-or-without-controlled-diabetes-mellitus-during-hospitalization
#19
Fernanda Rezende Campos Falcão, Bruno Anderson Gomes Dias, Liz Araujo Wolfovitch, David Sadigursky
INTRODUCTION: Total hip arthroplasty (THA) is a procedure that aims to restore the function of the hip joint. Diabetes mellitus (DM) is one of the most prevalent comorbidities among patients undergoing THA. DM involves various immunological and metabolic aspects, which lead to limitations and surgical complications. OBJECTIVE: To evaluate the association between THA complications and controlled DM during hospitalization period. METHODS: Cross-sectional research through the analysis of retrospective records of a private hospital in Salvador, Bahia...
September 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27812118/identification-of-hemoglobin-levels-based-on-anthropometric-indices-in-elderly-koreans
#20
Bum Ju Lee, Jong Yeol Kim
OBJECTIVES: Anemia is independently and strongly associated with an increased risk of mortality in older people and is also strongly associated with obesity. The objectives of the present study were to examine the associations between the hemoglobin level and various anthropometric indices, to predict low and normal hemoglobin levels using combined anthropometric indices, and to assess differences in the hemoglobin level and anthropometric indices between Korean men and women. METHODS: A total of 7,156 individuals ranging in age from 53-90 years participated in this retrospective cross-sectional study...
2016: PloS One
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