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anemia in the elderly

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https://www.readbyqxmd.com/read/27901246/chemotherapy-for-advanced-non-small-cell-lung-cancer-in-the-elderly-population
#1
Fábio Nasser Santos, Tiago Biachi de Castria, Marcelo Rocha Souza Cruz, Rachel Riera
BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these patients are controversial, and the role of single-agent or combination therapy is unclear. In this setting, a critical systematic review of RCTs in this group of patients is warranted. OBJECTIVES: To assess the effectiveness and safety of different cytotoxic chemotherapy regimens for previously untreated elderly patients with advanced (stage IIIB and IV) NSCLC...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27889956/red-blood-cell-function-and-dysfunction-redox-regulation-nitric-oxide-metabolism-anemia
#2
Viktoria Kuhn, Lukas Diederich, T C Stevenson Keller Iv, Christian M Kramer, Wiebke Lückstädt, Christina Panknin, Tatsiana Suvorava, Brant Isakson, Malte Kelm, Miriam Margherita Cortese-Krott
SIGNIFICANCE: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease such as bleeding, thromboembolic events, stroke, hypertension, arrhythmias, as well as inflammation, particularly in elderly patients. The underlying mechanisms of these complications are largely unidentified. Recent Advances: Previously, red blood cells (RBCs) were considered exclusively as transporters of oxygen and nutrients to the tissues. More recent experimental evidence indicates that RBCs are important inter-organ communication systems with additional functions, including participation in control of systemic NO metabolism, redox regulation, blood rheology and viscosity...
November 27, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27872759/impact-of-moderate-intensity-aerobic-exercise-on-chemotherapy-induced-anemia-in-elderly-women-with-breast-cancer-a-randomized-controlled-clinical-trial
#3
Heba M Mohamady, Hany F Elsisi, Yasser M Aneis
Exercises are often recommended for patients suffering from anemia to improve physical conditioning and hematologic parameters. Hence, the present study aimed to investigate the impact of moderate intensity aerobic exercise on chemotherapy-induced anemia. Thirty elderly women with breast cancer underwent chemotherapy and were randomly assigned into two equal groups; Group A received aerobic exercise for 25-40 min at 50-70% of the maximum heart rate, 3 times/week for 12 weeks in addition to usual daily living activities, medication and nutritional support...
January 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27846276/the-prevalence-of-anemia-and-moderate-severe-anemia-in-the-us-population-nhanes-2003-2012
#4
Chi Huu Hong Le
Since anemia is associated with poor health outcomes, the prevalence of anemia is a significant public health indicator. Even though anemia is primarily caused by iron deficiency, low oxygen-carrying capacity may result from other conditions such as chronic diseases, which remain a relevant health concern in the United States. However, studies examining current rates of anemia in the total US population and in more specific subgroups are limited. Data from five National Health and Nutrition Examination Surveys (NHANES) from 2003 to 2012 were analyzed to assess two outcomes: anemia and moderate-severe anemia, which were based upon serum hemoglobin levels (Hb) as per World Health Organization (WHO) definitions...
2016: PloS One
https://www.readbyqxmd.com/read/27844360/-anemia-in-the-elderly-three-steps-towards-diagnosis
#5
REVIEW
Joachim Zeeh
No abstract text is available yet for this article.
November 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27835718/low-hemoglobin-levels-and-risk-of-developing-depression-in-the-elderly-results-from-the-prospective-pro-v-a-study
#6
Caterina Trevisan, Nicola Veronese, Francesco Bolzetta, Marina De Rui, Christoph U Correll, Sabina Zambon, Estella Musacchio, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Marco Solmi, Enzo Manzato, Giuseppe Sergi
OBJECTIVE: Low hemoglobin negatively affects health in the elderly, but research about the association with risk for depression is limited. We investigated the association between baseline hemoglobin concentrations and incident depression in a cohort of nondepressed elderly individuals. METHODS: As part of the Northern Italian Progetto Veneto Anziani (PRO.V.A.) study, randomly drawn, community-dwelling subjects aged ≥ 65 years underwent prospective clinical and laboratory assessments between October 1995 and December 2002...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27830968/patterns-of-use-and-survival-outcomes-of-positron-emission-tomography-for-initial-staging-in-elderly-follicular-lymphoma-patients
#7
Ashish Rai, Loretta J Nastoupil, Jessica N Williams, Joseph Lipscomb, Kevin C Ward, David H Howard, Daniel Lee, Christopher R Flowers
The role of positron emission tomography (PET) in the initial assessment of follicular lymphoma (FL) has been a topic of debate. We examined the patterns of utilization of PET staging in FL and assessed the association of PET with survival. Using the SEER-Medicare database, we identified 5712 patients diagnosed with first primary FL between 2000 and 2009. Older age, African-American race, poor performance status, B-symptoms and history of anemia were negatively associated with PET staging. Receipt of PET staging was positively associated with treatment at institutions affiliated with research networks and with residence in areas with higher concentrations of nuclear medicine specialists...
November 10, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27826252/unexplained-anemia-in-the-elderly-potential-role-of-arterial-stiffness
#8
David Montero, Candela Diaz-Cañestro, Andreas Flammer, Carsten Lundby
No abstract text is available yet for this article.
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27825182/practical-aspects-of-monitoring-of-antiplatelet-therapy
#9
Ljubica Jovanovic, Nebojsa Antonijevic, Tina Novakovic, Nebojsa Savic, Branka Terzic, Ivana Zivkovic, Nebojsa Radovanovic, Milika Asanin
Despite the application of new antiplatelet drugs (prasugrel and ticagrelor), dual antiplatelet therapy with clopidogrel and aspirin remains the standard for patients with acute coronary syndrome undergoing percutaneous coronary intervention, especially in countries of low socioeconomic status. Regardless of the proven benefits, numerous studies have shown that certain groups of patients who receive standard doses of clopidogrel and aspirin do not respond adequately, and many of them also exhibit adverse cardiovascular events...
November 8, 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27822071/biosimilar-epoetin-for-the-management-of-chemotherapy-induced-anemia-in-elderly-patients
#10
Jean-Emmanuel Kurtz, Pierre Soubeyran, Mauricette Michallet, Elisabeth Luporsi, Hélène Albrand
INTRODUCTION: Chemotherapy-induced anemia (CIA) is a frequent complication among cancer patients, with elderly patients more likely to suffer severe effects. Biosimilar erythropoiesis-stimulating agents lower costs of supportive cancer treatment, and thus are particularly relevant in the elderly cancer population, which is growing rapidly worldwide. The goal of this subanalysis was to compare the tolerability and effectiveness of an epoetin biosimilar for treating CIA in patients <70 years old vs patients ≥70 years old...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27818982/total-hip-arthroplasty-complications-in-patients-with-or-without-controlled-diabetes-mellitus-during-hospitalization
#11
Fernanda Rezende Campos Falcão, Bruno Anderson Gomes Dias, Liz Araujo Wolfovitch, David Sadigursky
INTRODUCTION: Total hip arthroplasty (THA) is a procedure that aims to restore the function of the hip joint. Diabetes mellitus (DM) is one of the most prevalent comorbidities among patients undergoing THA. DM involves various immunological and metabolic aspects, which lead to limitations and surgical complications. OBJECTIVE: To evaluate the association between THA complications and controlled DM during hospitalization period. METHODS: Cross-sectional research through the analysis of retrospective records of a private hospital in Salvador, Bahia...
September 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27812118/identification-of-hemoglobin-levels-based-on-anthropometric-indices-in-elderly-koreans
#12
Bum Ju Lee, Jong Yeol Kim
OBJECTIVES: Anemia is independently and strongly associated with an increased risk of mortality in older people and is also strongly associated with obesity. The objectives of the present study were to examine the associations between the hemoglobin level and various anthropometric indices, to predict low and normal hemoglobin levels using combined anthropometric indices, and to assess differences in the hemoglobin level and anthropometric indices between Korean men and women. METHODS: A total of 7,156 individuals ranging in age from 53-90 years participated in this retrospective cross-sectional study...
2016: PloS One
https://www.readbyqxmd.com/read/27803723/cognitive-impairment-among-elderly-patients-with-chronic-heart-failure-and-related-factors
#13
Zohreh Taraghi, Ahmad-Ali Akbari Kamrani, Mahshid Foroughan, Jamshid Yazdani, Ali Mahdavi, Seied Kazem Baghernejad
BACKGROUND: Patients with heart failure (HF) older than 65 years have a two-fold increased risk of cognitive impairment than elders without HF. Identifying factors affecting cognitive impairment in HF may present targets for intervention. OBJECTIVES: The aim of the present study was to determine cognitive function and related factors among elderly patients with heart failure. PATIENTS AND METHODS: In this cross-sectional study, 184 elderly patients with heart failure were selected from four Mazandaran University of Medical Sciences teaching hospitals using convenience sampling...
June 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27789224/effectiveness-and-safety-of-sofosbuvir-plus-ribavirin-for-hcv-genotype-2-patients-65-and-over-with-or-without-cirrhosis
#14
Eiichi Ogawa, Norihiro Furusyo, Hideyuki Nomura, Kazuhiro Takahashi, Nobuhiko Higashi, Akira Kawano, Kazufumi Dohmen, Takeaki Satoh, Koichi Azuma, Makoto Nakamuta, Toshimasa Koyanagi, Masaki Kato, Shinji Shimoda, Eiji Kajiwara, Jun Hayashi
Older patients with chronic hepatitis C virus (HCV) infection have historically been designated difficult-to-treat. We evaluated the efficacy and safety of sofosbuvir (nucleotide NS5B polymerase inhibitor) plus ribavirin for patients with HCV genotype 2 infection in a real-world clinical setting, with the focus on elderly patients aged ≥ 65. This large, multicenter study consisted of 446 Japanese HCV genotype 2 patients (303 treatment-naïve and 143 treatment-experienced), including 190 (42.6%) aged ≥ 65 and 90 (20...
October 24, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27782373/efficacy-and-safety-of-sofosbuvir-simeprevir-plus-flat-dose-ribavirin-in-genotype-1-elderly-cirrhotic-patients-a-real-life-study
#15
Adriano M Pellicelli, Valeria Pace Palitti, Pascal Vignally, Francesca Ceccherini-Silberstain, Massimo Siciliano, Valerio Giannelli, Alessandra Moretti, Pierluigi Tarquini, Gaetano Scifo, Vincenzo Messina, Antonio Ascione, Antonio Izzi, Massimo Marignani, Cecilia D'Ambrosio, Lucia Fondacaro, Giuseppe M Ettorre, Pasquale Ialongo, Rodolfo Sacco, Carlo Federico Perno, Giorgio Barbarini
BACKGROUND AND AIMS: The proportion of HCV infected patients over age 65 years in Western countries is increasing. This growth and the advent of new antiviral therapy bring into the question the real world efficacy and safety of the combination of Sofosbuvir (SOF) and Simeprevir (SMV) plus a flat dose of 800 mg/d ribavirin (RBV) in elderly patients with liver cirrhosis compared to younger patients. METHODS: Retrospective observational multicenter real life investigation study of SOF/SMV/RBV for a duration of 12 weeks in HCV genotype 1-infected patients with liver cirrhosis...
October 26, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27766023/lower-body-mass-index-is-a-risk-factor-for-in-hospital-mortality-of-elderly-japanese-patients-treated-with-ampicillin-sulbactam
#16
Makoto Miura, Akiko Kuwahara, Akinori Tomozawa, Naoki Omae, Motohiro Yamamori, Kaori Kadoyama, Toshiyuki Sakaeda
Objectives: A retrospective examination was conducted to identify risk factors for in-hospital mortality of elderly patients (65 years or older) treated with the beta-lactam/beta-lactamase inhibitor combination antibiotic, ampicillin/sulbactam (ABPC/SBT). Methods: Clinical data from 96 patients who were hospitalized with infectious diseases and treated with ABPC/SBT (9 g/day or 12 g/day) were analyzed. Risk factors examined included demographic and clinical laboratory parameters. Parameter values prior to treatment and changes after treatment were compared between survivors and non-survivors...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27750230/safety-tolerability-and-efficacy-of-sofosbuvir-plus-ribavirin-in-elderly-patients-infected-with-hepatitis-c-virus-genotype-2
#17
Naoshi Nishida, Masashi Kono, Tomohiro Minami, Hirokazu Chishina, Tadaaki Arizumi, Masahiro Takita, Norihisa Yada, Hiroshi Ida, Satoru Hagiwara, Yasunori Minami, Kazuomi Ueshima, Tashiharu Sakurai, Masatoshi Kudo
BACKGROUND: An interferon-free regimen including sofosbuvir and ribavirin (RBV) for patients with hepatitis C virus (HCV) genotype 2 (G2) infection leads to a drastic improvement of sustained virological response (SVR). However, the safety, tolerability, and efficacy in patients aged 75 or older have not been completely understood. SUMMARY: Fifty-six patients with HCV G2 infection who were treated with sofosbuvir and weight-based dose of RBV were enrolled. Thirty-seven patients aged ≥75 and 19 patients aged ≤74 were classified as the aged and non-aged groups, respectively...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27742261/predictors-and-causes-of-long-term-mortality-in-elderly-patients-with-acute-venous-thromboembolism-a-prospective-cohort-study
#18
Nicolas Faller, Andreas Limacher, Marie Méan, Marc Righini, Markus Aschwanden, Jürg Hans Beer, Beat Frauchiger, Josef Osterwalder, Nils Kucher, Bernhard Lämmle, Jacques Cornuz, Anne Angelillo-Scherrer, Christian M Matter, Marc Husmann, Martin Banyai, Daniel Staub, Lucia Mazzolai, Olivier Hugli, Nicolas Rodondi, Drahomir Aujesky
BACKGROUND: Long-term predictors and causes of death are understudied in elderly patients with acute venous thromboembolism. METHODS: We prospectively followed up 991 patients aged ≥65 years with acute venous thromboembolism in a multicenter Swiss cohort study. The primary outcome was overall mortality. We explored the association between patient baseline characteristics and mortality, adjusting for other baseline variables and periods of anticoagulation as a time-varying covariate...
October 11, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27735087/multiplicative-interaction-between-mean-corpuscular-volume-and-red-cell-distribution-width-with-target-organ-damage%C3%A2-in-hypertensive-patients
#19
Yu-Liang Zhan, Bin Zou, Ting Kang, Ling-Bing Xiong, Jin Zou, Yun-Feng Wei
BACKGROUND: Accumulating evidence suggests that increased red cell distribution width (RDW) and mean corpuscular volume (MCV) were both poor prognostic factors for patients with cardiovascular diseases. Recently, the multiplicative interaction between RDW and MCV has been observed for predicting mortality in elderly patients without anemia; however, the relationship between the product of RDW-MCV and hypertension-induced target organ damage (TOD) has not been evaluated. METHODS: We performed a cross-sectional study in 1115 hypertensive patients...
October 13, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27716841/trajectories-of-risk-for-specific-readmission-diagnoses-after-hospitalization-for-heart-failure-acute-myocardial-infarction-or-pneumonia
#20
Harlan M Krumholz, Angela Hsieh, Rachel P Dreyer, John Welsh, Nihar R Desai, Kumar Dharmarajan
BACKGROUND: The risk of rehospitalization is elevated in the immediate post-discharge period and declines over time. It is not known if the extent and timing of risk vary across readmission diagnoses, suggesting that recovery and vulnerability after discharge differ by physiologic system. OBJECTIVE: We compared risk trajectories for major readmission diagnoses in the year after discharge among all Medicare fee-for-service beneficiaries hospitalized with heart failure (HF), acute myocardial infarction (AMI), or pneumonia from 2008-2010...
2016: PloS One
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