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Myocardial Infarction

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https://www.readbyqxmd.com/read/28735302/autopsy-interrogation-of-emergency-medicine-dispute-cases-how-often-are-clinical-diagnoses-incorrect
#1
Danyang Liu, Rongchang Gan, Weidi Zhang, Wei Wang, Hexige Saiyin, Wenjiao Zeng, Guoyuan Liu
AIMS: Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, and sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses and postmortem autopsy findings concerning emergency medicine dispute cases and to figure out the most common major missed diagnoses. METHODS: Clinical files and autopsy reports were retrospectively analysed and interpreted...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735289/prolonged-fever-after-st-segment-elevation-myocardial-infarction-and-long-term-cardiac-outcomes
#2
Chika Kawashima, Yasushi Matsuzawa, Eiichi Akiyama, Masaaki Konishi, Hiroyuki Suzuki, Katsutaka Hashiba, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Kengo Tsukahara, Noriaki Iwahashi, Nobuhiko Maejima, Kentaro Sakamaki, Satoshi Umemura, Kazuo Kimura, Kouichi Tamura
BACKGROUND: The biphasic inflammation after ST-segment elevation myocardial infarction (STEMI) plays an important role in myocardial healing and progression of systemic atherosclerosis. The purpose of this study is to investigate the impact of fever during the first and second phases of post-STEMI inflammation on long-term cardiac outcomes. METHODS AND RESULTS: A total of 550 patients with STEMI were enrolled in this study. Axillary body temperature (BT) was measured and maximum BTs were determined for the first (within 3 days: max-BT1-3d) and second (from 4 to 10 days after admission: max-BT4-10d) phases, respectively...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28735151/do-air-pollution-and-neighborhood-greenness-exposures-improve-the-predicted-cardiovascular-risk
#3
Maayan Yitshak-Sade, Itai Kloog, Victor Novack
BACKGROUND: Numerous studies show associations between exposure to Particulate Matter and Cardiovascular disease (CVD). Current cardiovascular equations incorporate the major risk factors for CVD. The patients' environment, however, is not incorporated in these equations. METHODS: In a retrospective analysis, we assessed the contribution of neighborhood greenness and particulate matter (coarse-PM and PM<2.5μm-PM2.5) to the development of CVD by analyzing the change in prediction abilities...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28735014/initial-clinical-experience-with-testosterone-undecanoate-therapy-aveed-%C3%A2-in-testosterone-deficient-men-in-the-united-states
#4
Abraham Morgentaler, Yonah Krakowsky, William Conners, Emily Davidson, Alex Rawji
OBJECTIVE: To report our initial experiences with TU 750mg in testosterone-deficient men. METHODS: All patients receiving TU 750mg at our center between July 1 2014 to August 1 2016 were identified. Clinical response was assessed via structured interviews and laboratory evaluations. Adverse events were documented, including increases in prostate specific antigen (PSA), hematocrit (Hct), and the development of post-injection cough. RESULTS: More than two injections were received by 147 men, with mean age 63...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28734926/derivation-and-evaluation-of-age-specific-multivariate-reference-regions-to-aid-in-identification-of-abnormal-filling-patterns-the-hunt-and-vamis-studies
#5
Jonas Selmeryd, Egil Henriksen, Håvard Dalen, Pär Hedberg
OBJECTIVES: This study aimed to derive age-specific multivariate reference regions (MVRs) able to classify subjects into those having normal or abnormal filling patterns and to evaluate the prognostic impact of this classification. BACKGROUND: The integration of several parameters is necessary to diagnose disorders of left ventricular (LV) filling because no single measurement accurately describes the complexity of diastolic function. However, no generally accepted validated multiparametric algorithm currently exists...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734921/imaging-ischemic-and-reperfusion-injury-in-acute-myocardial-infarction-putting-the-pieces-together-with-cmr
#6
Jan Bogaert, Davide Curione, Pedro Morais, Manuel Barreiro-Perez, Sofie Tilborghs, Frederik Maes, Tom Dresselaers
No abstract text is available yet for this article.
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734913/uncovered-culprit-plaque-ruptures-in-patients-with-st-segment-elevation-myocardial-infarction-assessed-by-optical-coherence-tomography-and-intravascular-ultrasound-with-imap
#7
Mikkel Hougaard, Henrik Steen Hansen, Per Thayssen, Lisbeth Antonsen, Lisette Okkels Jensen
OBJECTIVES: This study assessed the incidence and course of healing of uncovered plaque ruptures (PR) following primary percutaneous coronary intervention. BACKGROUND: The infarct-related occlusion is frequently located at the lesion site with maximum thrombus burden, whereas the culprit PR may be situated more proximally or distally. METHODS: Uncovered PR in segments adjacent to the stent were identified by optical coherence tomography and intravascular ultrasound using iMap (Boston Scientific, Marlborough, Massachusetts) within 48 h and after 12 months...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734911/plaque-rupture-in-coronary-atherosclerosis-is-associated-with-increased-plaque-structural-stress
#8
Charis Costopoulos, Yuan Huang, Adam J Brown, Patrick A Calvert, Stephen P Hoole, Nick E J West, Jonathan H Gillard, Zhongzhao Teng, Martin R Bennett
OBJECTIVES: The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. BACKGROUND: Plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound-virtual histology studies indicate that <10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734575/outcomes-associated-to-serum-phosphate-levels-in-patients-with-suspected-acute-coronary-syndrome
#9
Hong Xu, Marie Evans, Alessandro Gasparini, Karolina Szummer, Jonas Spaak, Johan Ärnlöv, Bengt Lindholm, Tomas Jernberg, Juan Jesús Carrero
BACKGROUND: We investigated the association between phosphate and the risk of adverse clinical outcomes in patients with manifest cardiovascular disease (CVD). METHODS: Observational study of patients hospitalized during 2006-2011 in Stockholm, Sweden, because of suspected acute coronary syndrome (ACS). The exposure was serum phosphate during the hospitalization. We modeled the association between phosphate and in-hospital death or in-hospital events (composite of myocardial infarction, cardiogenic shock, resuscitated cardiac arrest, atrial fibrillation, or atrioventricular block) as well as the one-year post-discharge risk of death or cardiovascular event (composite of myocardial re-infarction, heart failure and stroke)...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734463/usefulness-of-elevated-levels-of-growth-differentiation-factor-15-to-classify-patients-with-acute-coronary-syndrome-having-percutaneous-coronary-intervention-who-would-benefit-from-high-dose-statin-therapy
#10
Ioannis Tentzeris, Serdar Farhan, Matthias Karl Freynhofer, Miklos Rohla, Rudolf Jarai, Birgit Vogel, Sabina Baumgartner-Parzer, Michael Nürnberg, Alexander Geppert, Emil Wessely, Johann Wojta, Kurt Huber, Alexandra Kautzky-Willer
The aim of this study was to evaluate whether growth differentiation factor-15 (GDF-15) plasma concentration at the time of percutaneous coronary intervention (PCI) might help identify those patients with acute coronary syndrome (ACS), who benefit most from high-dose statin treatment. Two hundred eighty-four consecutive patients, who underwent percutaneous coronary intervention (PCI) for ACS, were included in a prospective registry. The combined end point at 3 months after PCI consisted of cardiovascular death, nonfatal myocardial infarction, and unstable angina...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28733995/incidence-predictors-and-clinical-outcomes-of-early-stent-thrombosis-in-acute-myocardial-infarction-patients-treated-with-primary-percutaneous-coronary-angioplasty-insights-from-the-university-of-ottawa-heart-institute-stemi-registry
#11
Kuljit Singh, Mohammed Rashid, Derek Y So, Christopher A Glover, Michael Froeschl, Benjamin Hibbert, Aun-Yeong Chong, Alexander Dick, Marino Labinaz, Michel Le May
BACKGROUND: Early stent thrombosis (ST) remains an important complication of primary percutaneous intervention (PCI). To date, our information on angiographic and clinical predictors of early ST in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI is limited. METHODS: We tried to evaluate the incidence, predictors, and outcomes of early ST in real-world patients treated with primary PCI. We identified all the patients presenting with STEMI between June 2004 and January 2011 who underwent primary PCI as the primary mode of revascularization...
July 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28733974/impact-of-diabetes-mellitus-on-procedural-and-one-year-clinical-outcomes-following-treatment-of-severely-calcified-coronary-lesions-with-the-orbital-atherectomy-system-a-subanalysis-of-the-orbit-ii-study
#12
Michael S Lee, Brad J Martinsen, Arthur C Lee, Ann N Behrens, Richard A Shlofmitz, Christopher Y Kim, Jeffrey W Chambers
OBJECTIVES: The goal of the study was to investigate the safety and efficacy of the coronary orbital atherectomy system to treat severe coronary artery calcification (CAC) prior to stent placement in diabetic and non-diabetic patients. BACKGROUND: The ORBIT II study reported the safety and efficacy of orbital atherectomy treatment in 443 patients with severe CAC. Percutaneous coronary intervention in diabetic patients is associated with an increased risk of major adverse cardiac events (MACE) compared with non-diabetics...
July 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28733630/plasma-dipeptidyl-peptidase-4-activity-is-associated-with-left-ventricular-systolic-function-in-patients-with-st-segment-elevation-myocardial-infarction
#13
Jing Wei Li, Yun Dai Chen, Yu Qi Liu, Jin Da Wang, Wei Ren Chen, Ying Qian Zhang, Qiang Ma
Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied this association in 584 consecutive STEMI patients at a tertiary referral center from July 2014 to October 2015. DPP4a and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels were quantified by enzymatic assays...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733467/acromegaly-at-diagnosis-in-3173-patients-from-the-li%C3%A3-ge-acromegaly-survey-las-database
#14
Patrick Petrossians, Adrian F Daly, Emil Natchev, Luigi Maione, Karin Blijdorp, Mouna Sahnoun Fathallah, Renata Auriemma, Alpha M Diallo, Anna-Lena Hulting, Diego Ferone, Vaclav Hana, Silvia Filipponi, Caroline Sievers, Claudia Nogueira, Carmen Fajardo Montañana, Davide M C Carvalho, Vaclav Hana, Günter K Stalla, Marie-Lise Jaffrain-Réa, Brigitte Delemer, Annamaria A L Colao, Thierry Brue, Sebastian J C M M Neggers, Sabina Zacharieva, Philippe Chanson, Albert Beckers
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female...
July 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28733433/intensive-exercise-training-improves-cardiac-electrical-stability-in-myocardial-infarcted-rats
#15
Horesh Dor-Haim, Chaim Lotan, Michal Horowitz, Moshe Swissa
BACKGROUND: Moderate exercise training has been shown to decrease sudden cardiac death post myocardial infarction. However, the effects of intensive exercise are still controversial. METHODS AND RESULTS: Fourteen myocardial-infarcted rats were divided into sedentary (n=8) and intensive training groups (n=6) and 18 sham control rats to sedentary (n=10) and intensive training groups (n=8). Heart rate variability was obtained at weeks 1 and 8. The inducibility of ventricular tachycardia/fibrillation was assessed in a Langendorff system...
July 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28733432/should-bilateral-internal-thoracic-artery-grafting-be-used-in-patients-after-recent-myocardial-infarction
#16
Dan Loberman, Dmitry Pevni, Rephael Mohr, Yosef Paz, Nahum Nesher, Mohamad Khaled Midlij, Yanai Ben-Gal
BACKGROUND: Bilateral internal thoracic artery grafting (BITA) is associated with improved survival. However, surgeons do not commonly use BITA in patients after myocardial infarction (MI) because survival is good with single internal thoracic artery grafting (SITA). We aimed to compare the outcomes of BITA with those of SITA and other approaches in patients with multivessel disease after recent MI. METHODS AND RESULTS: In total, 938 patients with recent MI (<3 months) who underwent BITA between 1996 and 2011 were compared with 682 who underwent SITA...
July 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28733364/magnetic-resonance-imaging-of-myocardial-strain-after-acute-st-segment-elevation-myocardial-infarction-a-systematic-review
#17
Kenneth Mangion, Christie McComb, Daniel A Auger, Frederick H Epstein, Colin Berry
The purpose of this systematic review is to provide a clinically relevant, disease-based perspective on myocardial strain imaging in patients with acute myocardial infarction or stable ischemic heart disease. Cardiac magnetic resonance imaging uniquely integrates myocardial function with pathology. Therefore, this review focuses on strain imaging with cardiac magnetic resonance. We have specifically considered the relationships between left ventricular (LV) strain, infarct pathologies, and their associations with prognosis...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28733122/the-effect-of-eosinopenia-on-mortality-in-patients-with-intracerebral-hemorrhage
#18
Asli Bolayir, Burhanettin Cigdem, Seyda Figul Gokce, Hasan Ata Bolayir, Ozlem Kayim Yildiz, Ertugrul Bolayir, Suat Ahmet Topaktas
INTRODUCTION: Inflammation may determine the prognosis of intracerebral hemorrhage (ICH), which has high mortality and morbidity rates. Recent studies have increasingly demonstrated eosinopenia as a prognostic factor, particularly in bacteremia, chronic obstructive pulmonary disease, and myocardial and cerebral infarction. Nonetheless, its significance regarding the determination of prognosis in patients with ICH has not yet been clarified. MATERIALS AND METHODS: Our study included 296 patients who presented to our clinic within 24 hours of the onset of symptoms and who were diagnosed with ICH between January 2008 and June 2016, along with 180 age- and sex-matched controls...
July 19, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28733072/early-myocardial-edema-after-acute-myocardial-infarction-is-stable-and-not-bimodal-in-humans-evidence-from-a-large-cmr-multicenter-study
#19
Thomas Stiermaier, Holger Thiele, Ingo Eitel
BACKGROUND: Experimental data reported a temporal pattern of myocardial edema following acute myocardial infarction (AMI). Therefore, the aim of this study was to assess the time course of myocardial edema in a large population of patients with ST-segment elevation myocardial infarction (STEMI). METHODS: Myocardium at risk (MAR), infarct size (IS) and myocardial salvage index (MSI) were compared according to the time between infarction and cardiovascular magnetic resonance (CMR) imaging in a large multicenter STEMI cohort (n=795)...
July 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28733067/hospital-quality-variation-matters-a-time-trend-and-cross-section-analysis-of-outcomes-in-german-hospitals-from-2006-to-2014
#20
Christoph Pross, Reinhard Busse, Alexander Geissler
Awareness of care variation and associated differences in outcome quality is important for patients to recognize and leverage the benefits of hospital choice and for policy makers, providers, and suppliers to adapt initiatives to improve hospital quality of care. We examine panel data on outcome quality in German hospitals between 2006 and 2014 for cholecystectomy, pacemaker implantation, hip replacement, percutaneous coronary intervention (PCI), stroke, and acute myocardial infarction (AMI). We use risk-adjusted and unadjusted outcomes based on 16 indicators...
July 8, 2017: Health Policy
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