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https://www.readbyqxmd.com/read/28440570/mass-spectrometric-characterization-of-the-selective-androgen-receptor-modulator-sarm-yk-11-for-doping-control-purposes
#1
Mario Thevis, Thomas Piper, Josef Dib, Andreas Lagojda, Dirk Kuehne, Lars Packschies, Hans Geyer, Wilhelm Schaenzer
RATIONALE: Selective androgen receptor modulators (SARMs) represent an emerging class of therapeutics targeting inter alia conditions referred to as cachexia and sarcopenia. Due to their anabolic properties, the use of SARMs is prohibited in sports as regulated by the World Anti-Doping Agency (WADA), and doping control laboratories test for these anabolic agents in blood and urine. In order to accomplish and maintain comprehensive test methods, the characterization of new drug candidates is critical for efficient sports drug testing...
April 25, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28433263/memory-assessment-in-patients-with-temporal-lobe-epilepsy-to-predict-memory-impairment-after-surgery-a-systematic-review
#2
P Parra-Díaz, N García-Casares
INTRODUCTION: Given that surgical treatment of refractory mesial temporal lobe epilepsy may cause memory impairment, determining which patients are eligible for surgery is essential. However, there is little agreement on which presurgical memory assessment methods are best able to predict memory outcome after surgery and identify those patients with a greater risk of surgery-induced memory decline. OBJECTIVE: We conducted a systematic literature review to determine which presurgical memory assessment methods best predict memory outcome...
April 19, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28430819/estimating-optimal-sparseness-of-developmental-gene-networks-using-a-semi-quantitative-model
#3
Natsuhiro Ichinose, Tetsushi Yada, Hiroshi Wada
To estimate gene regulatory networks, it is important that we know the number of connections, or sparseness of the networks. It can be expected that the robustness to perturbations is one of the factors determining the sparseness. We reconstruct a semi-quantitative model of gene networks from gene expression data in embryonic development and detect the optimal sparseness against perturbations. The dense networks are robust to connection-removal perturbation, whereas the sparse networks are robust to misexpression perturbation...
2017: PloS One
https://www.readbyqxmd.com/read/28426527/us-antibiotic-stewardship-and-penicillin-allergy
#4
Kara J Wada, Karen H Calhoun
PURPOSE OF REVIEW: The purpose of this review is to improve otolaryngologists' antibiotic stewardship by detailing current approaches to penicillin allergy. RECENT FINDINGS: Although up to 15% of hospitalized patients in the United States have a penicillin allergy recorded on their charts, fewer than 10% of these have a true penicillin allergy. SUMMARY: Using a combination of a detailed allergy history, skin testing and graded-dose administration, many patients whose charts say 'penicillin-allergic' can safely be treated with penicillin and cross-reacting antibiotics...
April 19, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28416987/importance-of-exercise-testing-shortly-after-subcutaneous-implantable-cardioverter-defibrillator-implantation-in-patients-with-brugada-syndrome-the-first-case-of-associated-inappropriate-shock-in-japan
#5
Kohei Ishibashi, Takashi Noda, Tsukasa Kamakura, Mitsuru Wada, Yuko Inoue, Hideo Okamura, Kengo Kusano
We report the case of a 51-year-old patient with Brugada syndrome (BrS) who experienced inappropriate shock due to T-wave oversensing (TWOS) during exercise when the optimal sensing vector was selected based on the automatic analysis by a subcutaneous implantable cardioverter-defibrillator (S-ICD). After selecting another vector during exercise testing, TWOS did not re-occur. Selection of appropriate sensing vector based on analyses under various conditions, including during exercise after S-ICD implantation, should be considered for patients with BrS...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28403894/antibiotic-resistant-airborne-bacteria-and-their-multidrug-resistance-pattern-at-university-teaching-referral-hospital-in-south-ethiopia
#6
Fithamlak Bisetegen Solomon, Fiseha Wada Wadilo, Amsalu Amache Arota, Yishak Leka Abraham
BACKGROUND: Hospitals provide a reservoir of microorganisms, many of which are multi-resistant to antibiotics. Emergence of multi-drug resistant strains in a hospital environment, particularly in developing countries is an increasing problem to infection treatment. This study aims at assessing antibiotic resistant airborne bacterial isolates. METHODS: A cross-sectional study was conducted at Wolaita Sodo university teaching and referral Hospital. Indoor air samples were collected by using passive air sampling method...
April 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28397603/masculinization-related-genes-and-cell-mass-structures-during-early-gonadal-differentiation-in-the-african-clawed-frog-xenopus-laevis
#7
Mikako Wada, Kazuko Fujitani, Kei Tamura, Shuuji Mawaribuchi, Yosuke Kamata, Nobuhiko Takamatsu, Michihiko Ito
The African clawed frog Xenopus laevis has a female heterogametic ZZ/ZW-type sex-determining system. We previously discovered a W-linked female sex-determining gene dm-W that is involved in ovary formation, probably through the up-regulation of the estrogen synthesis genes cyp19a1 and foxl2. We also reported that a unique "mass-in-line structure", which disappears from ZZ gonads during early testicular development, might serve as the basis for ovary differentiation in ZW gonads. However, the molecular mechanisms underlying early masculinization are poorly understood...
April 2017: Zoological Science
https://www.readbyqxmd.com/read/28378453/lmplementation-of-the-prolyl-hydroxylase-inhibitor-roxadustat-fg-4592-and-its-main-metabolites-into-routine-doping-controls
#8
Daniel Eichner, Ryan M Van Wagoner, Mitch Brenner, James Chou, Scott Leigh, Lee R Wright, Lee A Flippin, Michael Martinelli, Oliver Krug, Wilhelm Schänzer, Mario Thevis
The utility of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors as therapeutic means for the treatment of patients suffering from anemia has been demonstrated for various different clinical settings. However, besides this intended use, HIF stabilizers can be the subject of misuse in amateur and elite sports due to their erythropoietic properties as recently proven by several cases of adverse analytical findings in doping control testing. Consequently, in order to allow for adequate and comprehensive test methods, knowledge about the drug candidates' metabolism and analytical options enabling appropriate detection windows in sports drug testing samples (i...
April 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28367849/acute-heart-failure-triggered-by-coronary-spasm-with-transient-left-ventricular-dysfunction
#9
Yusuke Adachi, Kenichi Sakakura, Tatsuro Ibe, Nanae Yoshida, Hiroshi Wada, Hideo Fujita, Shin-Ichi Momomura
Coronary spasm is abnormal contraction of an epicardial coronary artery resulting in myocardial ischemia. Coronary spasm induces not only depressed myocardial contractility, but also incomplete myocardial relaxation, which leads to elevated ventricular filling pressure. We herein report the case of a 55-year-old woman who had repeated acute heart failure caused by coronary spasm. Acetylcholine provocation test with simultaneous right heart catheterization was useful for the diagnosis of elevated ventricular filling pressure as well as coronary artery spasm...
March 27, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28353607/specimen-acquisition-training-with-a-new-biosimulator-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#10
Takahiro Nakajima, Taiki Fujiwara, Fumie Saegusa, Terunaga Inage, Yuichi Sakairi, Hironobu Wada, Hidemi Suzuki, Takekazu Iwata, Shigetoshi Yoshida, Yukio Nakatani, Ichiro Yoshino
Training for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has focused on the procedure itself; however, the techniques for obtaining adequate sample are also important for achieving a pathological diagnosis as well as for molecular testing. The aim of this study was to evaluate the feasibility and efficacy of a biosimulator for training subjects in adequate sample acquisition during EBUS-TBNA.A total of 19 bronchoscopists voluntarily participated in this study. A biosimulator (ArtiCHEST, HARADA Corporation, Tokyo, Japan) was used for the training...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28292514/similarities-and-differences-between-coronary-heart-disease-and-stroke-in-the-associations-with-cardiovascular-risk-factors-the-japan-collaborative-cohort-study
#11
Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi
BACKGROUND AND AIMS: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians. METHODS: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing-risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke)...
March 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28267516/protein-adsorption-of-dialdehyde-cellulose-crosslinked-chitosan-with-high-amino-group-contents
#12
Ung-Jin Kim, Yeong Ro Lee, Tong Ho Kang, Joon Weon Choi, Satoshi Kimura, Masahisa Wada
Crosslinked chitosan was prepared by Schiff base formation between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of chitosan and a subsequent reduction. DAC was obtained through periodate oxidation of cellulose and solubilization in hot water at 100°C for 1h. Three grades of DAC-crosslinked chitosan were prepared by adding various amounts DAC. The degrees of crosslinking as determined by amino group content were 3.8, 8.3, and 12.1%, respectively. DAC-crosslinked chitosan showed higher stability in the pH 2-9 range and no cytotoxicity was identified over the course of a 21-day long-term stability test...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28260369/new-generation-of-solid-phase-microextraction-coatings-for-complementary-separation-approaches-a-step-toward-comprehensive-metabolomics-and-multiresidue-analyses-in-complex-matrices
#13
Emanuela Gionfriddo, Ezel Boyacı, Janusz Pawliszyn
In this work, a new generation of solid-phase microextraction (SPME) coatings based on polytetrafluoroethylene amorphous fluoroplastics (PTFE AF 2400) as a particle binder is presented. The developed coating was tested for thermal and solvent-assisted desorption, demonstrating its compatibility with both gas- and liquid-chromatographic platforms. The incorporation of hydrophilic-lipophilic balance (HLB) adsorptive particles provided optimal extraction coverage for analytes bearing a broad range of hydrophobicities and molecular weights and of varied chemical diversity...
March 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28260029/lymphatic-invasion-is-a-significant-indicator-of-poor-patient-prognosis-in-lung-squamous-cell-carcinoma
#14
Ryota Masuda, Hiroshi Kijima, Madoka Nito, Atsushi Wada, Tomohiko Matsuzaki, Yoichiro Ikoma, Kenei Nakazato, Daisuke Masuda, Makiko Tanaka, Hiroyuki Kobayashi, Sadaki Inokuchi, Masayuki Iwazaki
Pathological stage is the most important prognostic factor in patients with lung cancer, and is defined according to the tumor node metastasis classification system. The present study aimed to investigate the clinicopathological significance of lymphatic invasion in 103 patients who underwent surgical resection of lung squamous cell carcinoma (SqCC). The patients were divided into two groups, according to the degree of lymphatic invasion: Those with no or mild lymphatic invasion (ly0‑1) and those with moderate or severe lymphatic invasion (ly2‑3)...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28222125/streptococcus-sanguinis-induces-neutrophil-cell-death-by-production-of-hydrogen-peroxide
#15
Ryuichi Sumioka, Masanobu Nakata, Nobuo Okahashi, Yixuan Li, Satoshi Wada, Masaya Yamaguchi, Tomoko Sumitomo, Mikako Hayashi, Shigetada Kawabata
Streptococcus is the dominant bacterial genus in the human oral cavity and a leading cause of infective endocarditis. Streptococcus sanguinis belongs to the mitis group of streptococci and produces hydrogen peroxide (H2O2) by the action of SpxB, a pyruvate oxidase. In this study, we investigated the involvement of SpxB in survival of S. sanguinis in human blood and whether bacterial H2O2 exhibits cytotoxicity against human neutrophils. Results of a bactericidal test with human whole blood revealed that the spxB mutation in S...
2017: PloS One
https://www.readbyqxmd.com/read/28215314/the-reduced-oxidized-state-of-plasma-albumin-is-modulated-by-dietary-protein-intake-partly-via-albumin-synthesis-rate-in-rats
#16
Yasuaki Wada, Yoshiyasu Sato, Keisuke Miyazaki, Yasuhiro Takeda, Masashi Kuwahata
The reduced/oxidized state of plasma albumin is influenced by many factors, including chronic diseases and strenuous training. Recently, the reduced/oxidized state has also been shown to be associated with dietary protein and energy intakes in rats. We hypothesized that dietary protein intake may modulate the reduced/oxidized state of plasma albumin by altering the rate of albumin synthesis and that the reduced/oxidized state could therefore serve as a novel marker of protein undernutrition. We tested this hypothesis by examining male growing rats placed on a low-protein or energy-restriction diet...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28158227/beneficial-effects-of-metformin-on-energy-metabolism-and-visceral-fat-volume-through-a-possible-mechanism-of-fatty-acid-oxidation-in-human-subjects-and-rats
#17
Ichiro Tokubuchi, Yuji Tajiri, Shimpei Iwata, Kento Hara, Nobuhiko Wada, Toshihiko Hashinaga, Hitomi Nakayama, Hiroharu Mifune, Kentaro Yamada
OBJECTIVE: Metformin is known to have a beneficial effect on body weight and body composition, although the precise mechanism has not been elucidated yet. The aim of this study is to investigate the effects of metformin on energy metabolism and anthropometric factors in both human subjects and rats. METHODS: In human studies, metformin (1500mg/day) was administered to 23 healthy subjects and 18 patients with type 2 diabetes for 2 weeks. Metabolic parameters and energy metabolism were measured during a meal tolerance test in the morning before and after the treatment of metformin...
2017: PloS One
https://www.readbyqxmd.com/read/28144875/development-of-plastic-disks-containing-flame-retardants-for-elucidating-changes-in-their-concentrations-due-to-simulated-weathering-and-the-application-of-these-disks-to-weathering-tests
#18
Nobuyasu Hanari, Takamitsu Otake, Nobuyasu Itoh, Ayaka Wada, Masaki Ohata
Flame retardants (FRs) are useful because they can prevent combustion and delay the spread of fire after the ignition on commercial products containing plastics. However, such commercial products could be a primary source of environmental contamination with FRs. Plastic disks containing FRs were prepared to elucidate changes in the concentrations of the FRs after weathering tests. Acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) resin were separately kneaded with a combination of three organic FRs [Dechlorane plus (DP), tetrabromobisphenol A (TBBPA), and triphenyl phosphate (TPhP)] and one inorganic FR [antimony trioxide (Sb2O3)]...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28139665/vitamin-d-receptor-activator-use-and-cause-specific-death-among-dialysis-patients-a-nationwide-cohort-study-using-coarsened-exact-matching
#19
Yoshitsugu Obi, Takayuki Hamano, Atsushi Wada, Yoshiharu Tsubakihara
Vitamin D receptor activators (VDRA) may exert pleiotropic effects on cardiovascular disease, malignancy, and infections among dialysis patients, but recent studies have mainly focused on cardiovascular outcomes. Among 8,675 patients who started dialysis in 2007 and who survived until January 1, 2010, listed in the Renal Data Registry of the Japanese Society for Dialysis Therapy, 5,365 VDRA users were matched to 3,203 non-users based on clinically relevant variables at the end of 2009 using the coarsened exact matching procedure...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137616/detection-of-sarms-in-doping-control-analysis
#20
Mario Thevis, Wilhelm Schänzer
The class of selective androgen receptor modulators (SARMs) has been the subject of intense and dedicated clinical research over the past two decades. Potential therapeutic applications of SARMs are manifold and focus particularly on the treatment of conditions manifesting in muscle loss such as general sarcopenia, cancer-associated cachexia, muscular dystrophy, etc. Consequently, based on the substantial muscle- and bone-anabolic properties of SARMs, these agents constitute substances with significant potential for misuse in sport and have therefore been added to the Word Anti-Doping Agency's (WADA's) Prohibited List in 2008...
January 27, 2017: Molecular and Cellular Endocrinology
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