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https://www.readbyqxmd.com/read/28292514/similarities-and-differences-between-coronary-heart-disease-and-stroke-in-the-associations-with-cardiovascular-risk-factors-the-japan-collaborative-cohort-study
#1
Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi
BACKGROUND AND AIMS: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians. METHODS: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing-risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke)...
March 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28267516/protein-adsorption-of-dialdehyde-cellulose-crosslinked-chitosan-with-high-amino-group-contents
#2
Ung-Jin Kim, Yeong Ro Lee, Tong Ho Kang, Joon Weon Choi, Satoshi Kimura, Masahisa Wada
Crosslinked chitosan was prepared by Schiff base formation between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of chitosan and a subsequent reduction. DAC was obtained through periodate oxidation of cellulose and solubilization in hot water at 100°C for 1h. Three grades of DAC-crosslinked chitosan were prepared by adding various amounts DAC. The degrees of crosslinking as determined by amino group content were 3.8, 8.3, and 12.1%, respectively. DAC-crosslinked chitosan showed higher stability in the pH 2-9 range and no cytotoxicity was identified over the course of a 21-day long-term stability test...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28260369/a-new-generation-of-solid-phase-microextraction-coatings-for-complementary-separation-approaches-a-step-toward-comprehensive-metabolomics-and-multiresidue-analyses-in-complex-matrices
#3
Emanuela Gionfriddo, Ezel Boyaci, Janusz Pawliszyn
In this work, a new generation of SPME coatings based on polytetrafluoroethylene amorphous fluroplastics (PTFE AF 2400) as a particle binder is presented. The developed coating was tested for thermal and solvent-assisted desorption, demonstrat-ing its compatibility with both gas- and liquid-chromatographic platforms. The incorporation of hydrophilic-lipophilic bal-ance (HLB) adsorptive particles provided optimal extraction coverage for analytes bearing a broad range of hydrophobi-cities, molecular weights, and of varied chemical diversity...
March 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28260029/lymphatic-invasion-is-a-significant-indicator-of-poor-patient-prognosis-in-lung-squamous-cell-carcinoma
#4
Ryota Masuda, Hiroshi Kijima, Madoka Nito, Atsushi Wada, Tomohiko Matsuzaki, Yoichiro Ikoma, Kenei Nakazato, Daisuke Masuda, Makiko Tanaka, Hiroyuki Kobayashi, Sadaki Inokuchi, Masayuki Iwazaki
Pathological stage is the most important prognostic factor in patients with lung cancer, and is defined according to the tumor node metastasis classification system. The present study aimed to investigate the clinicopathological significance of lymphatic invasion in 103 patients who underwent surgical resection of lung squamous cell carcinoma (SqCC). The patients were divided into two groups, according to the degree of lymphatic invasion: Those with no or mild lymphatic invasion (ly0‑1) and those with moderate or severe lymphatic invasion (ly2‑3)...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28222125/streptococcus-sanguinis-induces-neutrophil-cell-death-by-production-of-hydrogen-peroxide
#5
Ryuichi Sumioka, Masanobu Nakata, Nobuo Okahashi, Yixuan Li, Satoshi Wada, Masaya Yamaguchi, Tomoko Sumitomo, Mikako Hayashi, Shigetada Kawabata
Streptococcus is the dominant bacterial genus in the human oral cavity and a leading cause of infective endocarditis. Streptococcus sanguinis belongs to the mitis group of streptococci and produces hydrogen peroxide (H2O2) by the action of SpxB, a pyruvate oxidase. In this study, we investigated the involvement of SpxB in survival of S. sanguinis in human blood and whether bacterial H2O2 exhibits cytotoxicity against human neutrophils. Results of a bactericidal test with human whole blood revealed that the spxB mutation in S...
2017: PloS One
https://www.readbyqxmd.com/read/28215314/the-reduced-oxidized-state-of-plasma-albumin-is-modulated-by-dietary-protein-intake-partly-via-albumin-synthesis-rate-in-rats
#6
Yasuaki Wada, Yoshiyasu Sato, Keisuke Miyazaki, Yasuhiro Takeda, Masashi Kuwahata
The reduced/oxidized state of plasma albumin is influenced by many factors, including chronic diseases and strenuous training. Recently, the reduced/oxidized state has also been shown to be associated with dietary protein and energy intakes in rats. We hypothesized that dietary protein intake may modulate the reduced/oxidized state of plasma albumin by altering the rate of albumin synthesis and that the reduced/oxidized state could therefore serve as a novel marker of protein undernutrition. We tested this hypothesis by examining male growing rats placed on a low-protein or energy-restriction diet...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28158227/beneficial-effects-of-metformin-on-energy-metabolism-and-visceral-fat-volume-through-a-possible-mechanism-of-fatty-acid-oxidation-in-human-subjects-and-rats
#7
Ichiro Tokubuchi, Yuji Tajiri, Shimpei Iwata, Kento Hara, Nobuhiko Wada, Toshihiko Hashinaga, Hitomi Nakayama, Hiroharu Mifune, Kentaro Yamada
OBJECTIVE: Metformin is known to have a beneficial effect on body weight and body composition, although the precise mechanism has not been elucidated yet. The aim of this study is to investigate the effects of metformin on energy metabolism and anthropometric factors in both human subjects and rats. METHODS: In human studies, metformin (1500mg/day) was administered to 23 healthy subjects and 18 patients with type 2 diabetes for 2 weeks. Metabolic parameters and energy metabolism were measured during a meal tolerance test in the morning before and after the treatment of metformin...
2017: PloS One
https://www.readbyqxmd.com/read/28144875/development-of-plastic-disks-containing-flame-retardants-for-elucidating-changes-in-their-concentrations-due-to-simulated-weathering-and-the-application-of-these-disks-to-weathering-tests
#8
Nobuyasu Hanari, Takamitsu Otake, Nobuyasu Itoh, Ayaka Wada, Masaki Ohata
Flame retardants (FRs) are useful because they can prevent combustion and delay the spread of fire after the ignition on commercial products containing plastics. However, such commercial products could be a primary source of environmental contamination with FRs. Plastic disks containing FRs were prepared to elucidate changes in the concentrations of the FRs after weathering tests. Acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) resin were separately kneaded with a combination of three organic FRs [Dechlorane plus (DP), tetrabromobisphenol A (TBBPA), and triphenyl phosphate (TPhP)] and one inorganic FR [antimony trioxide (Sb2O3)]...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28139665/vitamin-d-receptor-activator-use-and-cause-specific-death-among-dialysis-patients-a-nationwide-cohort-study-using-coarsened-exact-matching
#9
Yoshitsugu Obi, Takayuki Hamano, Atsushi Wada, Yoshiharu Tsubakihara
Vitamin D receptor activators (VDRA) may exert pleiotropic effects on cardiovascular disease, malignancy, and infections among dialysis patients, but recent studies have mainly focused on cardiovascular outcomes. Among 8,675 patients who started dialysis in 2007 and who survived until January 1, 2010, listed in the Renal Data Registry of the Japanese Society for Dialysis Therapy, 5,365 VDRA users were matched to 3,203 non-users based on clinically relevant variables at the end of 2009 using the coarsened exact matching procedure...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137616/detection-of-sarms-in-doping-control-analysis
#10
Mario Thevis, Wilhelm Schänzer
The class of selective androgen receptor modulators (SARMs) has been the subject of intense and dedicated clinical research over the past two decades. Potential therapeutic applications of SARMs are manifold and focus particularly on the treatment of conditions manifesting in muscle loss such as general sarcopenia, cancer-associated cachexia, muscular dystrophy, etc. Consequently, based on the substantial muscle- and bone-anabolic properties of SARMs, these agents constitute substances with significant potential for misuse in sport and have therefore been added to the Word Anti-Doping Agency's (WADA's) Prohibited List in 2008...
January 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28105335/detection-of-stanozolol-in-the-urine-of-athletes-at-a-pg-level-the-possibility-of-passive-exposure
#11
Christina Tsitsimpikou, Konstantinos Tsarouhas, Demetrios A Spandidos, Aristides M Tsatsakis
Stanozolol is a synthetic heterocyclic steroid with anabolic and androgenic properties, which has been abused by several high-profile professional athletes. Stanozolol is also used in veterinary medicine to increase appetite, cause weight gain and treat certain types of anemia. The detection of stanozolol metabolites in human urine for doping control purposes depends on the analytical method applied. The most commonly applied methods in the World Anti-Doping Agency (WADA)-accredited doping control laboratories are gas chromatography/high-resolution mass spectrometry (GC/HRMS) or gas chromatography-mass spectrometry (GC/MS/MS)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28065795/rational-identification-of-a-novel-soy-derived-anxiolytic-like-undecapeptide-acting-via-gut-brain-axis-after-oral-administration
#12
Ami Ota, Akane Yamamoto, Saeko Kimura, Yukiha Mori, Takafumi Mizushige, Yoshiki Nagashima, Masaru Sato, Hideyuki Suzuki, Saori Odagiri, Daisuke Yamada, Masayuki Sekiguchi, Keiji Wada, Ryuhei Kanamoto, Kousaku Ohinata
Here we found that the chymotryptic digest of soy β-conglycinin, a major storage protein, exhibited anxiolytic-like effects in mice. We then searched for anxiolytic-like peptides in the digest. Based on a comprehensive peptide analysis of the chymotryptic digest by high performance liquid chromatograph connected to an LTQ Orbitrap mass spectrometer and the structure-activity relationship of known peptides, we explored anxiolytic-like peptides present in the digest. FLSSTEAQQSY, which corresponds to 323-333 of the β-conglycinin α subunit [βCGα(323-333)] emerged as a candidate...
January 6, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28063399/sleep-quality-among-elderly-high-altitude-dwellers-in-ladakh
#13
Ryota Sakamoto, Kiyohito Okumiya, Tsering Norboo, Norboo Tsering, Takayoshi Yamaguchi, Mitsuhiro Nose, Shinya Takeda, Toshihiro Tsukihara, Motonao Ishikawa, Shun Nakajima, Taizo Wada, Michiko Fujisawa, Hissei Imai, Yasuko Ishimoto, Yumi Kimura, Eriko Fukutomi, Wenling Chen, Kuniaki Otsuka, Kozo Matsubayashi
It has been already known that people who temporarily stay at high altitude may develop insomnia as a symptom of acute mountain sickness. However, much less is known about people living at high altitude. The aim of this study was to determine the effect of high altitude environment on sleep quality for the elderly who have been living at high altitude for their whole lives. A cross-sectional study was conducted in Domkhar valley at altitudes of 2800-4200m, Ladakh. Sleep quality was assessed using Insomnia Severity Index (ISI)...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28028188/feasibility-of-a-respiratory-movement-evaluation-tool-to-quantify-thoracoabdominal-movement-for-neuromuscular-diseases
#14
Fumio Liu, Michiyuki Kawakami, Kimimasa Tamura, Yoshihito Taki, Katsumi Shimizu, Tomoyoshi Otsuka, Tetsuya Tsuji, Chieko Miyata, Syoichi Tashiro, Ayako Wada, Katsuhiro Mizuno, Yoshimitsu Aoki, Meigen Liu
BACKGROUND: An objective method to evaluate thoracoabdominal movement is needed in daily clinical practice to detect patients at risk of hypoventilation and to allow for timely interventions in neuromuscular diseases. The clinical feasibility, reliability, and validity of a newly developed method for quantifying respiratory movement using fiber grating sensors, called the Respiratory Movement Evaluation Tool (RMET), was evaluated. METHODS: The time needed to measure respiratory movement and the usability of the measurement were determined by 5 clinicians using the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) 2...
December 27, 2016: Respiratory Care
https://www.readbyqxmd.com/read/28017223/parent-vessel-occlusion-for-treatment-of-cerebral-aneurysms-is-there-still-an-indication-a-series-of-17-patients
#15
Nishant Ganesh Kumar, Travis R Ladner, Imad S Kahn, Scott L Zuckerman, Christopher B Baker, Marybess Skaletsky, Deborah Cushing, Matthew R Sanborn, J Mocco, Robert D Ecker
INTRODUCTION/PURPOSE: Flow diversion has allowed cerebrovascular neurosurgeons and neurointerventionalists to treat complex, large aneurysms, previously treated with trapping, bypass, and/or parent vessel sacrifice. However, a minority of aneurysms remain that cannot be treated endovascularly, and microsurgical treatment is too dangerous. However, balloon test occlusion (macro and micro), micro WADA testing, ICG, intra-angiography and intra-operative monitoring are all available to clinically test the hypothesis that vessel sacrifice is safe...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28011352/clinical-characteristics-and-predictive-factors-for-mortality-in-coryneform-bacteria-bloodstream-infection-in-hematological-patients
#16
Shun-Ichi Kimura, Ayumi Gomyo, Jin Hayakawa, Yu Akahoshi, Naonori Harada, Tomotaka Ugai, Yusuke Komiya, Kazuaki Kameda, Hidenori Wada, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Miki Sato, Kiriko Terasako-Saito, Misato Kikuchi, Hideki Nakasone, Junya Kanda, Shinichi Kako, Aki Tanihara, Yoshinobu Kanda
BACKGROUND: We examined the clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients. METHODS: We searched for hematological patients who had positive blood cultures for coryneform bacteria at our center between April 2007 and January 2016. Patients with definite bloodstream infections were included. We started species identification in April 2014. RESULTS: Twenty of twenty-eight cases with a positive blood culture for coryneform bacteria were regarded as definite infections...
December 20, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27990483/identification-of-novel-and-noninvasive-biomarkers-of-acute-cellular-rejection-after-liver-transplantation-by-protein-microarray
#17
Keita Okubo, Hiroshi Wada, Atsushi Tanaka, Hidetoshi Eguchi, Masahide Hamaguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Hiroaki Nagano, Noriko Sakaguchi, Hiroyoshi Nishikawa, Yuichiro Doki, Masaki Mori, Shimon Sakaguchi
BACKGROUND: Acute cellular rejection (ACR) is one of the main factors in transplanted organ failure in liver transplantation. A precise marker for diagnosing or predicting rejection is not currently available; therefore, invasive liver biopsy is standard procedure. To develop a noninvasive method for precise diagnosis of ACR, we evaluated autoantibodies from patient sera as potential biomarkers using protein microarrays (seromics). METHODS: Sera from hepatitis C virus-positive ACR patients were compared to three hepatitis C virus cirrhosis control groups and healthy volunteers...
December 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27980284/roles-of-the-wada-test-and-functional-magnetic-resonance-imaging-in-identifying-the-language-dominant-hemisphere-among-patients-with-gliomas-located-near-speech-areas
#18
Tatsuya Ishikawa, Yoshihiro Muragaki, Takashi Maruyama, Kayoko Abe, Takakazu Kawamata
This study examined the accuracy of functional magnetic resonance imaging (fMRI) in identifying the language-dominant hemisphere and the situations in which the Wada test can be skipped among patients with gliomas located near speech areas. We examined 74 patients [48 men (64.9%); mean ± standard deviation age of 42.7 ± 13.6 years (range: 13 to 70 years); 71 right-handed, 2 left-handed, and 1 ambidextrous] with gliomas located near speech areas. All patients underwent the Wada test and fMRI, and 34 patients underwent awake surgery...
January 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27942243/prevalence-seasonal-variation-and-antibiotic-resistance-pattern-of-enteric-bacterial-pathogens-among-hospitalized-diarrheic-children-in-suburban-regions-of-central-kenya
#19
Mohammad Shah, Cyrus Kathiiko, Akihiro Wada, Erick Odoyo, Martin Bundi, Gabriel Miringu, Sora Guyo, Mohamed Karama, Yoshio Ichinose
BACKGROUND: The epidemiology of enteric pathogens has not been well studied in Kenya because of wide disparities in health status across the country. Therefore, the present study describes the prevalence of enteropathogenic bacteria, their seasonal variation, and antibiotic resistance profiles among hospitalized diarrheic children in a suburban region of central Kenya. METHODS: Fecal samples were collected between July 2009 and December 2013 from a total of 1410 children younger than 5 years, hospitalized with acute diarrhea in Kiambu County Hospital, Kenya...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27940211/fibrin-fibrinogen-degradation-products-fdp-at-hospital-admission-predict-neurological-outcomes-in-out-of-hospital-cardiac-arrest-patients
#20
Yuichi Ono, Mineji Hayakawa, Kunihiko Maekawa, Akira Kodate, Yoshihiro Sadamoto, Naoki Tominaga, Hiromoto Murakami, Tomonao Yoshida, Kenichi Katabami, Takeshi Wada, Hisako Sageshima, Atsushi Sawamura, Satoshi Gando
OBJECTIVE: This study aimed to test the hypothesis that coagulation, fibrinolytic markers and disseminated intravascular coagulation (DIC) score (International Society on Thrombosis and Haemostasis) at hospital admission of out-of-hospital cardiac arrest (OHCA) patients can predict neurological outcomes 1 month after cardiac arrest. METHODS: In this retrospective, observational analysis, data were collected from the Sapporo Utstein Registry and medical records at Hokkaido University Hospital...
February 2017: Resuscitation
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