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https://www.readbyqxmd.com/read/28811732/exposure-to-and-use-of-electronic-cigarettes-does-language-matter
#1
Paul Wada, Chun Nok Lam, Elizabeth Burner, Sophie Terp, Michael Menchine, Sanjay Arora
OBJECTIVES: To determine whether patients who are English proficient become aware of e-cigarettes through different marketing tactics and have dissimilar patterns of use than patients who are non-English speaking. DESIGN: This was a cross-sectional study surveying adult English- and Spanish-speaking patients. ANOVA and chi-squared tests were used to examine differences between groups. SETTING: A large public, safety-net hospital in Los Angeles County, California...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28807665/a-comparative-study-of-care-practices-for-young-boys-with-duchenne-muscular-dystrophy-between-japan-and-european-countries-implications-of-early-diagnosis
#2
Fumi Takeuchi, Hirofumi Komaki, Zentaro Yamagata, Kazushi Maruo, Sunil Rodger, Janbernd Kirschner, Takeo Kubota, En Kimura, Shin'ichi Takeda, Kathrin Gramsch, Julia Vry, Kate Bushby, Hanns Lochmüller, Keiji Wada, Harumasa Nakamura
Early diagnosis of Duchenne muscular dystrophy (DMD) is widely advocated to initiate proactive interventions and genetic counselling. Genetic testing now allows the diagnosis of DMD even prior to the onset of symptoms. However, little is known about care practices and their impact on young DMD boys and families after receiving an early diagnosis. We analysed 64 young boys (Japan, 19; the United Kingdom, 10; Germany, 18; Hungary, 6; Poland, 5; and the Czech Republic, 6) aged <5 years and diagnosed at ≤2 years old among the participants of the cross-sectional study about care practice in DMD...
July 6, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28801989/determination-of-higenamine-and-coclaurine-levels-in-human-urine-after-the-administration-of-a-throat-lozenge-containing-nandina-domestica-fruit
#3
Masato Okano, Mitsuhiko Sato, Shinji Kageyama
Higenamine is a key component of traditional Chinese herbal medicine. The fruit of Nandina domestica (which contains this component) is available as an ingredient in the so-called Nanten-nodo-ame throat lozenge found on the Japanese market, which is an over-the-counter pharmaceutical and is easy to purchase for Japanese athletes. However, higenamine is a non-selective β2-agonist, which is exemplified in the prohibited list of the World Anti-Doping Agency (WADA). Therefore, some have raised a concern regarding the potential cause of increased unintentional higenamine doping cases in the Asian region...
August 12, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28777462/generation-of-realistic-virtual-nodules-based-on-three-dimensional-spatial-resolution-in-lung-computed-tomography-a-pilot-phantom-study
#4
Akihiro Narita, Masaki Ohkubo, Kohei Murao, Toru Matsumoto, Shinichi Wada
PURPOSE: The aim of this feasibility study using phantoms was to propose a novel method for obtaining computer-generated realistic virtual nodules in lung computed tomography (CT). METHODS: In the proposed methodology, pulmonary nodule images obtained with a CT scanner are deconvolved with the point spread function (PSF) in the scan plane and slice sensitivity profile (SSP) measured for the scanner; the resultant images are referred to as nodule-like object functions...
August 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28767748/hop-powdery-mildew-podosphaera-macularis-spore-cryopreservation
#5
S Wada, B M Reed
BACKGROUND: Hop powdery mildew (HPM), Podosphaera macularis, an important disease organism for hops, is an obligate parasite, requiring constant culture on living plant tissue for strain maintenance. OBJECTIVE: This study determined the parameters required to successfully cryopreserve HPM spores for the first time and reduce the need for constant culture. MATERIALS AND METHODS: Spores of an Oregon HPM strain, OSU C-100 were desiccated over silica gel for 2-10 h to determine the spore moisture content (MC)...
May 2017: Cryo Letters
https://www.readbyqxmd.com/read/28767209/preventive-effects-of-suvorexant-on-delirium-a-randomized-placebo-controlled-trial
#6
Kotaro Hatta, Yasuhiro Kishi, Ken Wada, Takashi Takeuchi, Shigeo Ito, Akiko Kurata, Kazunori Murakami, Manabu Sugita, Chie Usui, Hiroyuki Nakamura
OBJECTIVE: No highly effective pharmacologic interventions to prevent delirium have been identified. We examined whether suvorexant, a potent and selective orexin receptor antagonist, is effective for the prevention of delirium. METHODS: We conducted a multicenter, rater-blinded, randomized, placebo-controlled clinical trial in intensive care units and regular acute wards between April 2015 and March 2016. Eligible patients were 65 to 89 years old, newly admitted due to emergency, and able to take medicine orally and had an expected stay or life expectancy of 48 hours or more...
August 1, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28738670/antidoping-program-an-important-factor-in-the-promotion-and-protection-of-the-integrity-of-sport-and-athlete-s-health
#7
Filomena Mazzeo, Vincenzo Monda, Stefania Santamaria, Ersilia Nigro, Anna Valenzano, Ines Villano, Giuseppe Cibelli, Antonietta Messina, Giovanni Messina
Use of performance-enhancing drugs concern not only elite Olympic and Paralympic Games' athletes but also amateur athletes, who are making increasing use of substances and/or methods. Furthermore, a new frontier reached by the doping is the use of genes. World Anti- Doping Agency (WADA), expressly prohibited the participation in competitive sports by the athlete in case of taking banned substances to treat disease in the event that the above assumption implies an excessive improvement of performance. This study aims to analyze and show the doping control as an essential part of the anti-doping program to promote and protect the integrity of sport and athlete's health...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28707095/chronic-administration-of-myristic-acid-improves-hyperglycaemia-in-the-nagoya-shibata-yasuda-mouse-model-of-congenital-type-2-diabetes
#8
Tamae Takato, Kai Iwata, Chiaki Murakami, Yuko Wada, Fumio Sakane
AIMS/HYPOTHESIS: Previously, we demonstrated that myristic acid (14:0) increases levels of diacylglycerol kinase (DGK) δ, a key enzyme involved in type 2 diabetes exacerbation, and enhances glucose uptake in C2C12 myotube cells. Moreover, results from a population-based cohort study suggest that consumption of high-fat dairy products, which contain high amounts of myristic acid, is associated with a lower risk of developing type 2 diabetes. Taken together, we hypothesised that intake of myristic acid reduces type 2 diabetes risk in vivo...
July 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28674351/azathioprine-intolerance-in-japanese-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#9
Michiko Morishita, Haruki Watanabe, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Keiji Ohashi, Yoshia Miyawaki, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano Narazaki, Noriko Toyota Tatebe, Katsue Sunahori Watanabe, Tomoko Kawabata, Ken-Ei Sada, Jun Wada
Objective To assess the safety of azathioprine (AZA) in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods We retrospectively enrolled 67 consecutive AAV patients who had initiated AZA treatment from January 2006 to August 2014 at Okayama University Hospital. We evaluated the development of severe adverse events (AEs), AZA discontinuation due to total AEs (severe AEs included) within 1 year, and AZA-associated risk factors. Results The patients' median age was 70 years old...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28669567/nationwide-surveillance-of-bacterial-respiratory-pathogens-conducted-by-the-surveillance-committee-of-japanese-society-of-chemotherapy-the-japanese-association-for-infectious-diseases-and-the-japanese-society-for-clinical-microbiology-in-2012-general-view-of
#10
Katsunori Yanagihara, Akira Watanabe, Nobuki Aoki, Tetsuya Matsumoto, Masaki Yoshida, Junko Sato, Tomotaro Wakamura, Keisuke Sunakawa, Junichi Kadota, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Ohsaki, Satoru Fujiuchi, Manabu Takahashi, Kenichi Takeuchi, Hiroaki Takeda, Hideki Ikeda, Makoto Miki, Susumu Nakanowatari, Hiroshi Takahashi, Mutsuko Utagawa, Hajime Nishiya, Sayoko Kawakami, Eriko Morino, Jin Takasaki, Kazuhisa Mezaki, Naohiko Chonabayashi, Chie Tanaka, Hideko Sugiura, Hajime Goto, Takeshi Saraya, Daisuke Kurai, Yasuhiro Katono, Rika Inose, Yoshihito Niki, Takahiro Takuma, Makoto Kudo, Shigeru Ehara, Yoshimi Sato, Hiroki Tsukada, Nobuei Watabe, Yasuo Honma, Hiroshige Mikamo, Yuka Yamagishi, Atsushi Nakamura, Minoru Ohashi, Masafumi Seki, Shigeto Hamaguchi, Masahiro Toyokawa, Yasunori Fujikawa, Noriko Mitsuno, Akira Ukimura, Takayuki Miyara, Takahito Nakamura, Keiichi Mikasa, Kei Kasahara, Koji Ui, Saori Fukuda, Akihiro Nakamura, Mika Morimura, Mikio Yamashita, Yoshio Takesue, Yasunao Wada, Keisuke Sugimoto, Nobuchika Kusano, Motoko Nose, Eiichirou Mihara, Masao Kuwabara, Masao Doi, Yaeko Watanabe, Hirokazu Tokuyasu, Satoshi Hino, Kiyoshi Negayama, Hiroshi Mukae, Toshinori Kawanami, Toshiyuki Ota, Masaki Fujita, Junichi Honda, Kazufumi Hiramatsu, Yosuke Aoki, Mami Fukuoka, Hiroki Magarifuchi, Zenzo Nagasawa, Norihito Kaku, Jiro Fujita, Futoshi Higa, Masao Tateyama
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, Japanese association for infectious diseases and Japanese society for Clinical Microbiology in 2012. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January and December in 2012 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standard Institutes...
September 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28659543/sox2-nonsense-mutation-in-a-patient-clinically-diagnosed-with-non-syndromic-hypogonadotropic-hypogonadism
#11
Hirohito Shima, Akira Ishii, Yasunori Wada, Junya Kizawa, Tadashi Yokoi, Noriyuki Azuma, Yoichi Matsubara, Erina Suzuki, Akie Nakamura, Satoshi Narumi, Maki Fukami
Hypogonadotropic hypogonadism (HH) is a genetically heterogeneous condition that occurs either as an isolated disorder or as a component of congenital malformation syndromes. SOX2 is a causative gene of syndromic HH characterized by anophthalmia, microphthalmia, or coloboma and other neurological defects such as epilepsy. To date, the causal relationship between SOX2 abnormalities and non-syndromic HH remains speculative. Here, we identified a nonsense mutation of SOX2 in a male patient clinically diagnosed with non-syndromic HH...
June 28, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28652553/establishment-of-experimental-models-to-evaluate-the-effectiveness-of-dental-trauma-splints
#12
Takahiro Shirako, Hiroshi Churei, Takahiro Wada, Motohiro Uo, Toshiaki Ueno
The purpose was to describe a novel simple experimental model of injured teeth for developing dental trauma splints (DTS), and to test various splints by combining use of this model and the Periotest(®) device. Rubber O-rings and spring washers were used to simulate and modify injured tooth mobility. Splinting effects were assessed among three kinds of DTS, including a composite splint and two wire-composite splints (1: rectangular orthodontic wire 0.533×0.635 mm, 2: cobalt-chromium alloy wire Φ0.9 mm). The Periotest values were measured three times for each tooth before and after splint insertion...
June 23, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28637046/the-preoperative-composite-physiologic-index-may-predict-mortality-in-lung-cancer-patients-with-combined-pulmonary-fibrosis-and-emphysema
#13
Fumika Ueno, Yoshiaki Kitaguchi, Takayuki Shiina, Shiho Asaka, Kentaro Miura, Masanori Yasuo, Yosuke Wada, Akihiko Yoshizawa, Masayuki Hanaoka
BACKGROUND: It remains unclear whether the preoperative pulmonary function parameters and prognostic indices that are indicative of nutritional and immunological status are associated with prognosis in lung cancer patients with combined pulmonary fibrosis and emphysema (CPFE) who have undergone surgery. OBJECTIVE: The aim of this study is to identify prognostic determinants in these patients. METHODS: The medical records of all patients with lung cancer associated with CPFE who had undergone surgery at Shinshu University Hospital were retrospectively reviewed to obtain clinical data, including the results of preoperative pulmonary function tests and laboratory examinations, chest high-resolution computed tomography (HRCT), and survival...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28634310/-a-case-of-coexistent-glossopharyngeal-neuralgia-and-hemifacial-spasm-successfully-treated-with-transposition-of-the-vertebral-artery
#14
Takashi Fujii, Naoki Otani, Yohei Otsuka, Takashi Matsumoto, Shunsuke Tanoue, Hideaki Ueno, Satoshi Tomura, Arata Tomiyama, Terushige Toyooka, Kojiro Wada, Kentaro Mori
A case of coexistent glossopharyngeal neuralgia and hemifacial spasm was treated by transposition of the vertebral artery. A 60-year-old man was referred to our hospital due to pain in the left posterior part of the tongue that was difficult to control with oral medication at a local hospital. The diagnosis was left glossopharyngeal neuralgia based on the symptoms, imaging findings, and lidocaine test results. Moreover, the patient had left hemifacial spasm. Microvascular decompression was performed, which confirmed that the vertebral artery was compressing the lower cranial nerve and the posterior inferior cerebellar artery was compressing the root exit zone of the facial nerve...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28632647/high-osteogenic-potential-of-adipose-and-muscle-derived-mesenchymal-stem-cells-in-spinal-ossification-model-mice
#15
Xizhe Liu, Gentaro Kumagai, Kanichiro Wada, Toshihiro Tanaka, Toru Asari, Kazuki Oishi, Taku Fujita, Hiroki Mizukami, Ken-Ichi Furukawa, Yasuyuki Ishibashi
STUDY DESIGN: Basic experiments in a mouse model of ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE: To assess the osteogenic potential of mesenchymal stem cells (MSCs) obtained from muscle and adipose tissue in Tiptoe-walking (ttw) mice, in which cervical OPLL compresses the spinal cord and causes motor and sensory dysfunction. SUMMARY OF BACKGROUND DATA: In humans, MSCs have been implicated in the pathogenesis of cervical OPLL...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28626411/dissociated-crossed-speech-areas-in-a-tumour-patient
#16
Jörg Mauler, Irene Neuner, Georg Neuloh, Bruno Fimm, Frank Boers, Martin Wiesmann, Hans Clusmann, Karl-Josef Langen, N Jon Shah
In the past, the eloquent areas could be deliberately localised by the invasive Wada test. The very rare cases of dissociated crossed speech areas were accidentally found based on the clinical symptomatology. Today functional magnetic resonance imaging (fMRI)-based imaging can be employed to non-invasively localise the eloquent areas in brain tumour patients for therapy planning. A 41-year-old, left-handed man with a low-grade glioma in the left frontal operculum extending to the insular cortex, tension headaches, and anomic aphasia over 5 months underwent a pre-operative speech area localisation fMRI measurement, which revealed the evidence of the transhemispheric disposition, where the dominant Wernicke speech area is located on the left and the Broca's area is strongly lateralised to the right hemisphere...
May 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28626376/successful-treatment-for-chronic-hepatitis-c-autoimmune-hepatitis-overlap-syndrome-due-to-daclatasvir-and-asunaprevir
#17
Ayumi Sugiura, Shuichi Wada, Hiromitsu Mori, Takefumi Kimura, Yoshiaki Matsuda, Naoki Tanaka, Eiji Tanaka, Kendo Kiyosawa
Persistent hepatitis C virus (HCV) infection may induce autoimmune diseases and chronic hepatitis C is sometimes accompanied by autoimmune hepatitis (AIH). However, we are worried about the treatment for chronic hepatitis C-AIH overlap syndrome because interferon-based antiviral therapies may enhance autoimmunity and immunosuppressive corticosteroid administration may promote viral replication. Here, we report a patient having chronic hepatitis C-AIH overlap syndrome treated with the direct-acting antivirals (DAA), daclatasvir and asunaprevir...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28616638/piriformis-muscle-syndrome-with-assessment-of-sciatic-nerve-using-diffusion-tensor-imaging-and-tractography-a-case-report
#18
Keizo Wada, Tomohiro Goto, Tomoya Takasago, Daisuke Hamada, Koichi Sairyo
Piriformis muscle syndrome (PMS) is difficult to diagnose by objective evaluation of sciatic nerve injury. Here we report a case of PMS diagnosed by diffusion tensor imaging (DTI) and tractography of the sciatic nerve, which can assess and visualize the extent of nerve injury. The patient was a 53-year-old man with a 2-year history of continuous pain and numbness in the left leg. His symptoms worsened when sitting. Physical examination, including sensorimotor neurologic tests, the deep tendon reflex test, and the straight leg raise test, revealed no specific findings...
June 14, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28596984/use-of-a-novel-shorter-minimum-caliber-needle-for-creating-endoscopic-tattoos-for-preoperative-localization-a-comparative-ex-vivo-study
#19
Kenichiro Imai, Kinichi Hotta, Sayo Ito, Yuichiro Yamaguchi, Takeshi Kawakami, Takuya Wada, Kimihiro Igarashi, Yoshihiro Kishida, Yusuke Kinugasa, Noboru Kawata, Masaki Tanaka, Naomi Kakushima, Kohei Takizawa, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND AND STUDY AIMS : In colorectal cancer surgery, inadvertent deep injections during endoscopic tattooing can cause India ink leakage into the peritoneum, leading to complications or to poor visualization of the surgical plane. This ex vivo animal study compared the use of novel shorter, minimum caliber needles versus conventional injection needles for endoscopic tattooing. ANIMALS AND METHODS : Four endoscopists used the novel needles and conventional needles to make ten endoscopic tattoos (five tattoos/needle type/endoscopist) in harvested porcine rectum using a saline test-injection method...
June 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28595352/neuropsychology-outcomes-following-trephine-epilepsy-surgery-the-inferior-temporal-gyrus-approach-for-amygdalohippocampectomy-in-medically-refractory-mesial-temporal-lobe-epilepsy
#20
Mike R Schoenberg, William E Clifton, Ryan W Sever, Fernando L Vale
BACKGROUND: Surgery is indicated in cases of mesial temporal lobe epilepsy(MTLE) that are refractory to medical management. The inferior temporal gyrus (ITG) approach provides access to the mesial temporal lobe (MTL) structures with minimal tissue disruption. Reported neuropsychology outcomes following this approach are limited. OBJECTIVE: To report neuropsychological outcomes using an ITG approach to amygdalohippocampectomy (AH) in patients with medically refractory MTLE based on a prospective design...
June 8, 2017: Neurosurgery
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