keyword
MENU ▼
Read by QxMD icon Read
search

wada testing

keyword
https://www.readbyqxmd.com/read/29336201/poor-motor-function-recovery-after-spinal-cord-injury-in-anxiety-model-mice-with-phospholipase-c-related-catalytically-inactive-protein-type-1-knockout
#1
Taku Fujita, Gentaro Kumagai, Xizhe Liu, Kanichiro Wada, Toshihiro Tanaka, Hitoshi Kudo, Toru Asari, Tatsuhiro Fukutoku, Ayako Sasaki, Yohshiro Nitobe, Yoshikazu Nikaido, Ken-Ichi Furukawa, Masato Hirata, Takashi Kanematsu, Shinya Ueno, Yasuyuki Ishibashi
Mice with a knockout of phospholipase C (PLC)-related inactive protein type 1 (PRIP1-/- mice) display anxiety-like behavior and altered GABAA-receptor pharmacology. Here we examined associations between anxiety and motor-function recovery in PRIP1-/- mice after a spinal-cord injury (SCI) induced by a moderate contusion injury at the 10th thoracic level. Uninjured PRIP1-/- mice spent less distance than wild-type (WT) mice in the center 25% in an open field test (OFT), indicating anxiety-like behavior. Anxiety behavior increased in both WT and PRIP1-/- mice after SCI...
January 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29318416/air-bubble-sign-a-new-screening-method-for-anastomotic-leakage-after-esophagectomy-for-esophageal-cancer
#2
Yoshiaki Shoji, Hiroya Takeuchi, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Hirofumi Kawakubo, Yuko Kitagawa
BACKGROUND: Contrast esophagography often is performed to screen for anastomotic leakage (AL) after esophagectomy. However, its sensitivity remains low. Adverse events also have been reported. This report describes a new screening method to detect AL on computed tomography (CT) after esophagectomy. METHODS: From January 2012 to December 2015, 185 patients with esophageal cancer underwent surgical resection at the authors' institution. The study comparatively reviewed patient characteristics, surgical outcomes, and findings from postoperative CT images and contrast esophagrams of 142 patients who underwent esophagectomy followed by primary gastric conduit reconstruction through a posterior mediastinum route...
January 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29278456/growth-hormone-isoform-differential-mass-spectrometry-for-doping-control-purposes
#3
Cristian G Arsene, Dirk Schulze, Anita Röthke, Mario Thevis, André Henrion
Mass spectrometry (MS) allows for monitoring growth-hormone (GH) isoform compositions at high specificity. It is demonstrated, that this capability can be used to reliably detect alterations as elicited by (putative) doping with 22 kDa-GH. Sample treatment consists in enzymatic protein cleavage, followed by two-step liquid chromatography clean-up, prior to analysis by MS. The protocol does not depend on antibodies for analyte extraction, at any stage. Therefore, MS opens an opportunity to independent confirmation, if combined with the antibody-based isoform differential test presently used in practice...
December 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29248418/evaluation-of-the-modified-carbapenem-inactivation-method-for-the-detection-of-carbapenemase-producing-enterobacteriaceae
#4
Tomokazu Kuchibiro, Masaru Komatsu, Katsutoshi Yamasaki, Tatsuya Nakamura, Hisaaki Nishio, Isao Nishi, Keigo Kimura, Makoto Niki, Tamotsu Ono, Noriyuki Sueyoshi, Machiko Kita, Kaneyuki Kida, Masanobu Ohama, Kaori Satoh, Hirofumi Toda, Tetsu Mizutani, Nozomi Fukuda, Kana Sawa, Isako Nakai, Tomomi Kofuku, Tamaki Orita, Hideo Watari, Satoshi Shimura, Saori Fukuda, Akihiro Nakamura, Yasunao Wada
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing worldwide. Rapid and accurate detection of CPE is necessary for appropriate antimicrobial treatment and hospital infection control. However, CPE contains some strains that are difficult to detect depending on genotype and MIC value of carbapenem, and a detection method has not been established. The recently reported modified carbapenem inactivation method (mCIM) has been developed in CLSI M100-S27 as a phenotypic technique for detecting carbapenemase activity...
December 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29245083/concordance-between-the-wada-test-and-neuroimaging-lateralization-influence-of-imaging-modality-fmri-and-meg-and-patient-experience
#5
Steven Kemp, Garreth Prendergast, Theodoros Karapanagiotidis, Gus Baker, Thomas P Kelly, Tufail Patankar, Simon S Keller
The Wada test remains the traditional test for lateralizing language and memory function prior to epilepsy surgery. Functional imaging, particularly functional MRI (fMRI), has made progress in the language domain, but less so in the memory domain. Magnetoencephalography (MEG) has received less research attention, but shows promise, particularly for language lateralization. We recruited a consecutive sample of 19 patients with epilepsy who had completed presurgical work-up, including the Wada test, and compared fMRI (memory) and MEG (language and memory) with Wada test results...
December 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29237349/administration-of-oral-contraceptives-could-alleviate-age-related-fertility-decline-possibly-by-preventing-ovarian-damage-in-a-mouse-model
#6
Wataru Isono, Osamu Wada-Hiraike, Yumiko Kawamura, Tomoyuki Fujii, Yutaka Osuga, Hiroki Kurihara
Age-related fertility decline is hypothesized to occur mainly by the spontaneous exhaustion and deterioration of the ovarian follicle, and the accumulation of ovarian tissue damage resulting from the ovulation cycle may play roles in the process. In this study, we hypothesized that suppressing ovulation would exert protective effects against age-related fertility decline. To test this hypothesis, we established a mouse model in which oral contraceptives (OCs) were administered daily. Female C57BL/6N mice were administered OCs daily from the age of 2 months to 12 months as an ovulation suppression mouse model...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29229107/clinical-characterization-of-52-patients-with-immunoglobulin-g4-related-disease-in-a-single-tertiary-center-in-japan-special-reference-to-lung-disease-in-thoracic-high-resolution-computed-tomography
#7
Takeshi Saraya, Kosuke Ohkuma, Masachika Fujiwara, Chika Miyaoka, Shoko Wada, Takayasu Watanabe, Sunao Mikura, Manami Inoue, Miku Oda, Mitsuru Sada, Yukari Ogawa, Kojiro Honda, Masaki Tamura, Takuma Yokoyama, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a rare multi-organ disorder. Physicians rarely encounter patients with IgG4-RD and its range of symptoms. METHODS: To elucidate the clinical characterization of IgG4-RD, along with the clinical significance of lung involvement, we retrospectively reviewed the medical records of patients who satisfied the comprehensive diagnostic criteria for IgG4-RD. RESULTS: We identified 52 patients with IgG4-RD...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29191650/cortical-language-areas-and-plasticity-in-pediatric-patients-with-epilepsy-a-review
#8
REVIEW
Naomi Chou, Sandra Serafini, Carrie R Muh
Chronic injury to the brain from seizure activity is associated with decreased language skills in pediatric patients, as measured on neuropsychological tests for language function and academic achievement. This makes the study of language in patients with epilepsy clinically necessary. Functional magnetic resonance imaging and direct electrical cortical stimulation have been used to evaluate aspects of cortical language processing in healthy adults and in adults with epilepsy or other neurological insults. Results of these studies help to locate cortical language areas that are involved with modality-specific language processing (visual naming, auditory naming, sentence-completion, and repetition) and the neuroplasticity of language areas in the setting of neurological injury and reorganization...
October 12, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29169082/the-safety-and-efficacy-of-propofol-as-a-replacement-for-amobarbital-in-intracarotid-wada-testing-of-presurgical-patients-with-epilepsy
#9
Kaci McCleary, Joseph Barrash, Mark Granner, Kenneth Manzel, Audrey Greider, Robert Jones
OBJECTIVE: The intracarotid sodium amytal procedure (the "Wada test") has for many years been the gold standard for language and memory lateralization and remains an important part of presurgical analysis for patients with medically intractable seizures. Due to shortages in the key sedative (amobarbital), neuropsychologists have turned to alternatives such as propofol. Our aim was to investigate the safety and efficacy of propofol relative to amobarbital in the Wada test. METHODS: We performed a retrospective review of the 97 Wada procedures performed at University of Iowa Hospitals and Clinics from 2007 through mid-2015...
November 20, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29151544/-creation-and-evaluation-of-educational-programs-for-additional-delayed-scan-of-fdg-pet-ct
#10
Ryota Wada, Takashi Kamiya, Kouichi Fujino, Junpei Ueda, Kayako Isohashi, Mitsuaki Tatsumi, Jun Hatazawa
Generally, FDG-PET/CT image is acquired at the 60th minute after tracer administration. Depending on the clinical case, additional delayed scans may be useful. However, it is difficult to judge whether additional delayed scan is useful or not. The purposes of this study were creation and evaluation of educational programs to help radiological technologists to decide the usefulness of additional delayed scan of FDG-PET/CT. METHODS: Educational programs consisted of the instructional materials and the judgment test of clinical cases...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29150907/sensitivity-of-doping-biomarkers-after-administration-of-a-single-dose-testosterone-gel
#11
Jenny Mullen, Annica Börjesson, Oscar Hopcraft, Jenny J Schulze, Magnus Ericsson, Anders Rane, Mikael Lehtihet, Lena Ekström
Micro-doping with testosterone (T) is challenging to detect with the current doping tests. Today, the methods available to detect T are longitudinally monitoring of urine biomarkers in the Athlete Biological Passport (ABP) and measuring the isotopic composition of excreted biomarkers to distinguish the origin of the molecule. In this study, we investigated the detectability of a single dose of 100 mg T gel in 8 healthy male subjects. We also studied which biomarkers were most sensitive to T gel administration, including blood biomarkers...
November 18, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29149502/annual-banned-substance-review-analytical-approaches-in-human-sports-drug-testing
#12
Mario Thevis, Tiia Kuuranne, Hans Geyer
A number of high profile revelations concerning anti-doping rule violations over the past 12 months has outlined the importance of tackling prevailing challenges and reducing the limitations of the current anti-doping system. At this time, the necessity to enhance, expand and improve analytical test methods in response to the substances outlined in the World Anti-Doping Agency's (WADA) Prohibited List represents an increasingly crucial task for modern sports drug testing programs. The ability to improve analytical testing methods often relies on the expedient application of novel information regarding superior target analytes for sports drug testing assays, drug elimination profiles, alternative test matrices, together with recent advances in instrumental developments...
November 17, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29148891/hyperventilation-and-breath-holding-test-with-indocyanine-green-kinetics-predicts-cerebral-hyperperfusion-after-carotid-artery-stenting
#13
Ichiro Nakagawa, Shohei Yokoyama, Daisuke Wajima, Fumihiko Nishimura, Shuichi Yamada, Hiroshi Yokota, Yasushi Motoyama, Young Su Park, Takeshi Wada, Kimihiko Kichikawa, Hiroyuki Nakase
Cerebral hyperperfusion syndrome (CHS) is a serious complication following carotid artery stenting (CAS), but definitive early prediction of CHS has not been established. Here, we evaluated whether indocyanine green kinetics and near-infrared spectroscopy (ICG-NIRS) with hyperventilation (HV) and the breath-holding (BH) test can predict hyperperfusion phenomenon after CAS. The blood flow index (BFI) ratio during HV and BH was prospectively monitored using ICG-NIRS in 66 patients scheduled to undergo CAS. Preoperative cerebrovascular reactivity (CVR) and the postoperative asymmetry index (AI) were also assessed with single-photon emission computed tomography before and after CAS and the correlation with the BFI HV/rest ratio, BFI BH/rest ratio was evaluated...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29148228/evaluation-of-markers-out-of-the-steroid-profile-for-the-screening-of-testosterone-misuse-part-i-transdermal-administration
#14
Aristotelis Kotronoulas, Àlex Gomez-Gómez, Andreu Fabregat, Jordi Segura, Sheng Yang, Yanyi Xing, Wu Moutian, Josep Marcos, Jesús Joglar, Rosa Ventura, Oscar J Pozo
Although the introduction by WADA of the steroid module of the athlete biological passport (ABP) marked an important step forward in the screening of testosterone (T) misuse, it still remains one of the most difficult challenges in doping control analysis. The urinary determination of alternative markers has been recently reported as a promising tool for improving the screening of T oral administration. However, their evaluation for other, commonly used, administration routes is still required. The main goal of this study is the evaluation of the potential of two groups of metabolites (cysteinyl conjugated and glucuronoconjugated) after transdermal and intramuscular administration of T...
November 17, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29107706/effects-of-transcranial-direct-current-stimulation-over-the-supplementary-motor-area-body-weight-supported-treadmill-gait-training-in-hemiparetic-patients-after-stroke
#15
Atsushi Manji, Kazu Amimoto, Tadamitsu Matsuda, Yoshiaki Wada, Akira Inaba, Sangkyun Ko
Transcranial direct current stimulation (tDCS) is used in a variety of disorders after stroke including upper limb motor dysfunctions, hemispatial neglect, aphasia, and apraxia, and its effectiveness has been demonstrated. Although gait ability is important for daily living, there were few reports of the use of tDCS to improve balance and gait ability. The supplementary motor area (SMA) was reported to play a potentially important role in balance recovery after stroke. We aimed to investigate the effect of combined therapy body weight-supported treadmill training (BWSTT) and tDCS on gait function recovery of stroke patients...
January 1, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29098788/urine-reference-intervals-for-human-chorionic-gonadotropin-hcg-isoforms-by-immunoextraction-tandem-mass-spectrometry-to-detect-hcg-use
#16
Anthony W Butch, Brian D Ahrens, Nuraly K Avliyakulov
Human chorionic gonadotropin (hCG) stimulates testosterone production by the testicles and can normalize suppressed testosterone concentrations in males following prolonged anabolic steroid use. Because of the potential for abuse by males, hCG is on the World Anti-Doping Agency (WADA) list of prohibited substances. The majority of WADA-accredited laboratories measure urinary hCG using an automated immunoassay. Only immunoassays that recognize the intact alpha and beta heterodimer of hCG (intact hCG) should be used to measure urinary hCG for doping control purposes since intact hCG is the only biologically active molecule...
November 3, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29091250/functional-hemispherectomy-for-adult-rasmussen-encephalitis-a-case-report-and-literature-review
#17
Qun Wang, Zhanpeng Zhu, Guangming Wang, Lichao Sun, Jiqing Qiu
BACKGROUND: Rasmussen encephalitis (RE) is a rare and severe brain disorder associated with unilateral hemispheric atrophy, manifesting as severe refractory epilepsy, hemiplegia, defects of motor and speech functions, and cognitive impairment. Treatment of RE, especially in adult patients, is extremely challenging. Herein, we report the case of an adult patient with RE who was treated with a functional hemispherectomy and achieved a favorable prognosis. CASE REPORT: A 29-year-old woman presented with a 24-year history of epileptic seizures...
September 26, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29076659/cytological-findings-of-ros1-rearranged-lung-adenocarcinoma
#18
Naoto Kuroda, Hiroyuki Tamiya, Kimiko Nakatani, Haruna Ide, Yukari Wada, Kaori Yasuoka, Masahiko Ohara, Keiko Mizuno, Kenji Yorita, Kengo Takeuchi
ROS1-rearranged lung adenocarcinoma has been recently identified. We report a case of ROS1-rearranged lung adenocarcinoma with special emphasis on cytological findings. Here, we report a case of young woman with ROS1-rearranged lung adenocarcinoma diagnosed by cytology and discuss the clinical, cytological, and molecular findings. Cytologically, the tumor consisted of small tight clusters of cells with high nuclear/cytoplasmic ratio. Nuclei were enlarged and small nucleoli were occasionally observed. Signet-ring cells were focally identified...
October 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29034235/coagulofibrinolytic-changes-in-patients-with-post-cardiac-arrest-syndrome
#19
REVIEW
Takeshi Wada
Whole-body ischemia and reperfusion due to cardiac arrest and subsequent return of spontaneous circulation constitute post-cardiac arrest syndrome (PCAS), which consists of four syndromes including systemic ischemia/reperfusion responses and post-cardiac arrest brain injury. The major pathophysiologies underlying systemic ischemia/reperfusion responses are systemic inflammatory response syndrome and increased coagulation, leading to disseminated intravascular coagulation (DIC), which clinically manifests as obstruction of microcirculation and multiple organ dysfunction...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29032611/fast-irms-screening-of-pseudoendogenous-steroids-in-doping-analyses
#20
Xavier de la Torre, Cristiana Colamonici, Davide Curcio, Francesco Botrè
The detection of the abuse of pseudoendogenous steroids (testosterone and/or its precursors) is currently based, when possible, on the application of the steroid module of the World Antidoping Agency (WADA), Athletes' Biological Passport (ABP), implemented through ADAMS. When a suspicious sample is detected, the confirmation by isotope ratio mass spectrometry (IRMS) is required. It is well known that this confirmation procedure is time consuming, expensive and can be only applied on a reduced number of samples...
October 15, 2017: Drug Testing and Analysis
keyword
keyword
56051
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"