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https://www.readbyqxmd.com/read/29781539/intermittent-resistance-exercise-and-obesity-considered-separately-or-combined-impair-spermatic-parameters-in-adult-male-wistar-rats
#1
Ana Paula Franco Punhagui, Giovana Rampazzo Teixeira, Marcelo Conrado de Freitas, Patricia Monteiro Seraphim, Glaura Scantamburlo Alves Fernandes
Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high-fat diet...
May 21, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29779836/-correlations-between-insulin-sensitivity-with-anthropometric-and-metabolic-parameters-in-type-2-diabetics
#2
H Abdesselem, I Sebai, M Jemal, K Ounaissa, H Kandara, I Kammoun, C Amrouche, L Ben Salem
AIM: The aim of the study was to evaluate correlations between insulin sensitivity and insulinosecretion with anthropometric and metabolic parameters in type 2 diabetics. MATERIALS AND METHODS: We conducted a cross-sectional study among patients with type 2 diabetes mellitus treated with oral antidiabetic medications. The evaluation of insulin resistance and insulinosecretion was based on the calculation of the HOMA-IR and HOMA-β indices. RESULTS: The mean age for the 100diabetes recruited was 56...
May 17, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29778021/the-homing-of-human-umbilical-cord-derived-mesenchymal-stem-cells-and-the-subsequent-modulation-of-macrophage-polarization-in-type-2-diabetic-mice
#3
Yaqi Yin, Haojie Hao, Yu Cheng, Jieqing Gao, Jiejie Liu, Zongyan Xie, Qi Zhang, Li Zang, Weidong Han, Yiming Mu
Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are associated with increased M2 macrophages, but no systemic evaluation of M2 macrophages has been performed in T2DM individuals...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29774305/multi-slice-mri-reveals-heterogeneity-in-disease-distribution-along-the-length-of-muscle-in-duchenne-muscular-dystrophy
#4
Stephen M Chrzanowski, Celine Baligand, Rebecca J Willcocks, Jasjit Deol, Ilona Schmalfuss, Donovan J Lott, Michael J Daniels, Claudia Senesac, Glenn A Walter, Krista Vandenborne
Background: Duchenne muscular dystrophy (DMD) causes progressive pathologic changes to muscle secondary to a cascade of inflammation, lipid deposition, and fibrosis. Clinically, this manifests as progressive weakness, functional loss, and premature mortality. Though insult to whole muscle groups is well established, less is known about the relationship between intramuscular pathology and function. Objective: Differences of intramuscular heterogeneity across muscle length were assessed using an ordinal MRI grading scale in lower leg muscles of boys with DMD and correlated to patient's functional status...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29772027/association-between-different-combination-of-measures-for-obesity-and-new-onset-gallstone-disease
#5
Tong Liu, Wanchao Wang, Yannan Ji, Yiming Wang, Xining Liu, Liying Cao, Siqing Liu
BACKGROUND: Body mass index(BMI) is a calculation index of general obesity. Waist circumference(WC) is a measure of body-fat distribution and always used to estimate abdominal obesity. An important trait of general obesity and abdominal obesity is their propensity to coexist. Using one single measure of obesity could not estimate persons at risk for GSD precisely. OBJECTIVES: This study aimed to compare the predictive values of various combination of measures for obesity(BMI, WC, waist to hip ratio) for new-onset GSD...
2018: PloS One
https://www.readbyqxmd.com/read/29769528/a-joint-view-on-genetic-variants-for-adiposity-differentiates-subtypes-with-distinct-metabolic-implications
#6
Thomas W Winkler, Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth Jf Loos, Zoltán Kutalik, Iris M Heid
The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in ~322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P < 5 × 10-8 , into four classes based on the direction of their effects on BMI and WHR. Our classes help differentiate adiposity genetics with respect to anthropometry, fat depots, and metabolic health...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29765930/effect-of-fennel-on-the-health-status-of-menopausal-women-a-systematic-and-meta-analysis
#7
Talat Khadivzadeh, Mona Najaf Najafi, Leila Kargarfard, Masumeh Ghazanfarpour, Fatemeh Rajab Dizavandi, Imaneh Khorsand
Objectives: The aim of the present study is the systematic and critical investigation of the effectiveness of fennel on the climacteric symptoms among menopausal females. Methods: A search of the trials studying the effect of fennel on menopausal females was conducted in 2017 using the MEDLINE and Scopus databases and the Cochrane Library with the following keywords: fennel, Foeniculum vulgare , and menopause. Results: Fennel combined with officinalis is more effective in the attenuating of sleep disorders compared to Citalopram...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29764450/evaluation-of-target-dose-inhomogeneity-in-breast-cancer-treatment-due-to-tissue-elemental-differences
#8
A Fogliata, F De Rose, A Stravato, G Reggiori, S Tomatis, M Scorsetti, L Cozzi
BACKGROUND: Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. METHODS: CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system...
May 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29762256/computed-tomography-perfusion-measurements-in-renal-lesions-obtained-by-bayesian-estimation-advanced-singular-value-decomposition-deconvolution-maximum-slope-and-patlak-models-intermodel-agreement-and-diagnostic-accuracy-of-tumor-classification
#9
Dominik Deniffel, Timothé Boutelier, Aissam Labani, Mickael Ohana, Daniela Pfeiffer, Catherine Roy
OBJECTIVES: The aims of this study were to evaluate the agreement of computed tomography (CT)-perfusion parameter values of the normal renal cortex and various renal tumors, which were obtained by different mathematical models, and to evaluate their diagnostic accuracy. MATERIALS AND METHODS: Perfusion imaging was performed prospectively in 35 patients to analyze 144 regions of interest of the normal renal cortex and 144 regions of interest of renal tumors, including 21 clear-cell renal cell carcinomas (RCC), 6 papillary RCCs, 5 oncocytomas, 1 chromophobe RCC, 1 angiomyolipoma with minimal fat, and 1 tubulocystic RCC...
May 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29761230/ghrelin-receptor-signaling-targets-segregated-clusters-of-neurons-within-the-nucleus-of-the-solitary-tract
#10
María Paula Cornejo, Pablo Nicolás De Francesco, Guadalupe García Romero, Enrique L Portiansky, Jeffrey M Zigman, Mirta Reynaldo, Mario Perello
Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specific actions of the hormone. GHSR is highly expressed in the nucleus of the solitary tract (NTS), which is located in the medulla oblongata and controls essential functions, including orofacial, autonomic, neuroendocrine and behavioral responses...
May 14, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29760084/distinct-macrophage-populations-direct-inflammatory-versus-physiological-changes-in-adipose-tissue
#11
David A Hill, Hee-Woong Lim, Yong Hoon Kim, Wesley Y Ho, Yee Hoon Foong, Victoria L Nelson, Hoang C B Nguyen, Kavya Chegireddy, Jihoon Kim, Andreas Habertheuer, Prashanth Vallabhajosyula, Taku Kambayashi, Kyoung-Jae Won, Mitchell A Lazar
Obesity is characterized by an accumulation of macrophages in adipose, some of which form distinct crown-like structures (CLS) around fat cells. While multiple discrete adipose tissue macrophage (ATM) subsets are thought to exist, their respective effects on adipose tissue, and the transcriptional mechanisms that underlie the functional differences between ATM subsets, are not well understood. We report that obese fat tissue of mice and humans contain multiple distinct populations of ATMs with unique tissue distributions, transcriptomes, chromatin landscapes, and functions...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758737/structural-stability-of-interaction-networks-against-negative-external-fields
#12
S Yoon, A V Goltsev, J F F Mendes
We explore structural stability of weighted and unweighted networks of positively interacting agents against a negative external field. We study how the agents support the activity of each other to confront the negative field, which suppresses the activity of agents and can lead to collapse of the whole network. The competition between the interactions and the field shape the structure of stable states of the system. In unweighted networks (uniform interactions) the stable states have the structure of k-cores of the interaction network...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756965/visceral-adiposity-index-associated-with-behavioral-and-inflammatory-parameters-in-adults-a-population-based-study
#13
Fabrícia Geralda Ferreira, Wellington Segheto, Danielle Cristina Guimarães Da Silva, Patricia Feliciano Pereira, Giana Zarbato Longo
INTRODUCTION: the visceral adiposity index (VAI) is an indicator of fat distribution and function which is considered a predictor of cardiometabolic risk. OBJECTIVE: analyze the factors associated with VAI in Brazilian adults. METHODS: a cross-sectional population-based study was conducted with 854 adults, in Viçosa, MG, Brazil. A questionnaire was applied and anthropometric measurements, body composition and biochemical data were collected...
January 18, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29755576/cold-pressed-minke-whale-oil-reduces-circulating-ldl-vldl-cholesterol-lipid-oxidation-and-atherogenesis-in-apolipoprotein-e-deficient-mice-fed-a-western-type-diet-for-13-weeks
#14
Mari Johannessen Walquist, Svein Kristian Stormo, Bjarne Østerud, Edel O Elvevoll, Karl-Erik Eilertsen
Background: Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29755575/waist-hip-ratio-related-genetic-loci-are-associated-with-risk-of-impaired-fasting-glucose-in-chinese-children-a-case-control-study
#15
Qi-Ying Song, Xiang-Rui Meng, Anke Hinney, Jie-Yun Song, Tao Huang, Jun Ma, Hai-Jun Wang
Background: The meta-analyses of genome-wide association studies identified several waist-hip ratio (WHR) related loci in individuals of European ancestry. Since the pattern of fat distribution and the relationship between fat distribution and glucose metabolism disturbance in Chinese are different from those in Europeans, the present study aimed to explore the individual and cumulative effects of WHR-related loci on glycemic phenotypes in Chinese children. Methods: A total of 2030 children were recruited from two independent studies...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29754392/fto-m-6-a-m-and-the-hypothesis-of-reversible-epitranscriptomic-mrna-modifications
#16
REVIEW
Jan Mauer, Samie R Jaffrey
The fate of mRNA is regulated by epitranscriptomic nucleotide modifications, the most abundant of which is N6 -methyladenosine (m6 A). Although the pattern and distribution of m6 A in mRNA is mediated by specific methyltransferases, a recent hypothesis is that specific demethylases or "erasers" allow m6 A to be dynamically reversed by signaling pathways. In this Review, we discuss the data in support and against this model. New insights into the function of FTO (fat mass and obesity-associated protein), the original enzyme thought to be an m6 A eraser, reveal that its physiologic target is not m6 A, but instead is N6 ,2'-O-dimethyladenosine (m6 Am )...
May 12, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29754194/loss-of-p2x7-receptor-function-dampens-whole-body-energy-expenditure-and-fatty-acid-oxidation
#17
Giacomo Giacovazzo, Savina Apolloni, Roberto Coccurello
The established role of ATP-responsive P2X7 receptor in inflammatory, neurodegenerative, and immune diseases is now expanding to include several aspects of metabolic dysregulation. Indeed, P2X7 receptors are involved in β cell function, insulin secretion, and liability to diabetes, and loss of P2X7 function may increase the risk of hepatic steatosis and disrupt adipogenesis. Recently, body weight gain, abnormal lipid accumulation, adipocyte hyperplasia, increased fat mass, and ectopic fat distribution have been found in P2X7 KO mice...
May 12, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29753471/effects-of-processing-conditions-on-the-texture-and-rheological-properties-of-model-acid-gels-and-cream-cheese
#18
M Brighenti, S Govindasamy-Lucey, J J Jaeggi, M E Johnson, J A Lucey
Manufacture of cream cheese involves the formation of an initial acid-induced gel made from high-fat milk, followed by a series of processing steps including shearing, heating, and dewatering that complete the conversion of the acid gel into a complex cheese product. We investigated 2 critical parameters for their effect on the initial gel: homogenization pressure (HP) of the high-fat cheese milk, and fermentation temperature (FT). The impact of a low (10 MPa) and high (25 MPa) HP, and low (20°C) and high (26°C) FT were investigated for their effects on rheological and textural properties of acid-induced gels...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29750646/circulating-steroid-levels-as-correlates-of-adipose-tissue-phenotype-in-premenopausal-women
#19
Geneviève B Marchand, Anne-Marie Carreau, Sofia Laforest, Julie-Anne Côté, Marleen Daris, Katherine Cianflone, Cornelia Prehn, Jerzy Adamski, André Tchernof
Background Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal women. Materials and methods In a sample of 42 premenopausal women [age 46 ± 3 years; body mass index (BMI) 27.1 ± 4.2 kg/m2], 19 plasma steroids were quantified by electrospray ionization-liquid chromatography-tandem mass spectroscopy (ESI-LC-MS/MS). Body composition and fat distribution were assessed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively...
May 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29749466/upregulated-14%C3%A2-3%C3%A2-3%C3%AE-aggravates-restenosis-by-promoting-cell-migration-following-vascular-injury-in-diabetic-rats-with-elevated-levels-of-free-fatty-acids
#20
Lishuai Feng, Chaoran Dou, Jianbo Wang, Chunyu Jiang, Xu Ma, Jingjing Liu
Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the levels of tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein β (YWHAB; also known as 14‑3‑3β), in vascular smooth muscle cells (VSMCs) treated with different concentrations of oleic acid (OA) were examined by reverse transcription‑quantitative polymerase chain reaction and western blot analyses...
May 11, 2018: International Journal of Molecular Medicine
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