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https://www.readbyqxmd.com/read/29668117/development-of-molecular-therapies-for-venous-malformations
#1
Jaakko Kangas, Marjut Nätynki, Lauri Eklund
Vascular anomalies are localized defects of morphogenesis that can affect lymphatic and blood vessels. They are generally called birthmarks, typically observed soon after birth and occurring in up to 10% of children. Based on their clinical and histological characteristics, they are classified into vascular tumours and vascular malformations. The most common malformations are venous malformations (VMs) resulting in chronic vascular diseases that can be associated with significant morbidity necessitating often demanding and repeating clinical management...
April 18, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29667952/useful-pharmacodynamic-endpoints-in-children-selection-measurement-and-next-steps
#2
REVIEW
Lauren E Kelly, Yashwant Sinha, Charlotte I S Barker, Joseph F Standing, Martin Offringa
Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research. We identified several considerations relevant to the selection and measurement of PD endpoints in pediatric clinical trials, including the use of biomarkers, modeling, compliance, scoring systems, and validated measurement tools...
April 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29667739/maternal-depressive-symptoms-during-and-after-pregnancy-and-child-developmental-milestones
#3
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Jari Lahti, Kati Heinonen, Rebecca M Reynolds, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Anu-Katriina Pesonen, Pia M Villa, Katri Räikkönen
BACKGROUND: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear. METHODS: A total of 2,231 mothers of the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy...
April 18, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29667722/acute-myelogenous-leukemia-in-adolescents-and-young-adults
#4
REVIEW
Ursula Creutzig, Matthew A Kutny, Ronald Barr, Richard F Schlenk, Raul C Ribeiro
The incidence of acute myelogenous leukemia (AML) increases progressively with age. Favorable genetic mutations are most prevalent in children, and unfavorable profiles increase proportionately in adolescents and young adults (AYA) and into later adulthood. Survival rates of AYA have improved over recent decades to 50-60%, but their accrual to clinical trials remains poor. In contrast to AYA with acute lymphoblastic leukemia, the prognostic benefit for AYA with AML enrolled in pediatric compared with adult trials is minor and only seen when different protocols are used...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667705/intellectual-disability-in-cerebral-palsy-a-population-based-retrospective-study
#5
Susan M Reid, Elaine M Meehan, Sarah J Arnup, Dinah S Reddihough
AIM: A population-based observational study design was used to describe the epidemiology of intellectual disability in cerebral palsy (CP) in terms of clinical and neuroimaging associations, and to report the impact of intellectual disability on utilization of health services and length of survival. METHOD: Population CP registry data were used to retrospectively assess the frequency of intellectual disability and strength of associations between intellectual disability and mobility, epilepsy, vision, hearing, communication, and neuroimaging patterns (n=1141)...
April 18, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29667562/caregiver-perceptions-of-a-fruit-and-vegetable-prescription-programme-for-low-income-paediatric-patients
#6
Amy Saxe-Custack, Heather Claire Lofton, Mona Hanna-Attisha, Colleen Victor, Gwendolyn Reyes, Tiffany Ceja, Jenny LaChance
OBJECTIVE: The physical and social environments that surround children should support good health. However, challenges with food security and access prevent many children from consuming a healthy diet, which is critical to proper growth and development. The present study sought to gain a better understanding of primary care initiatives to address these issues in a low-income setting. DESIGN: Following the relocation of a paediatric clinic to a farmers' market building and the implementation of a fruit and vegetable prescription programme, researchers conducted thirty-two semi-structured interviews with caregivers...
April 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29667543/assessment-of-parents-guardians-initial-comprehension-and-1-day-recall-of-elements-of-informed-consent-within-a-mozambican-study-of-pediatric-bacteremia
#7
Ezequiel B Ossemane, Troy D Moon, Jahit Sacarlal, Esperança Sevene, Darlene Kenga, Wu Gong, Elizabeth Heitman
Participants' understanding of key elements of a research protocol is essential to their ethical enrollment in the study. Ongoing participation should be based on continued comprehension and consent, which presumes a high degree of recall. Many obstacles can prevent full understanding of information about the research protocol. This study's aim was to evaluate the comprehension and 1-day recall of the elements of informed consent by the parents/guardians of children enrolled in a clinical study in Mozambique...
April 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#8
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667311/how-japanese-nurses-participate-in-decision-making-infants-with-congenital-life-threatening-conditions
#9
Sohei Shitaya, Nobue Nakamura, Naho Sato
BACKGROUND: In Japan, owing to the progress in medical technology, more children with congenital life-threatening conditions survive than ever before. Nurses who care for these children may also influence decision making in difficult situations. AIM: We aimed to describe Japanese nurses' approach toward medical decision making when caring for families of infants with congenital life-threatening conditions. Frequently, these nurses must care for and support parents with ambivalent feelings...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667272/different-brain-networks-underlying-intelligence-in-autism-spectrum-disorders
#10
Emmanuel Peng Kiat Pua, Charles B Malpas, Stephen C Bowden, Marc L Seal
There has been sustained clinical and cognitive neuroscience research interest in how network correlates of brain-behavior relationships might be altered in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders. As previous work has mostly focused on adults, the nature of whole-brain connectivity networks underlying intelligence in pediatric cohorts with abnormal neurodevelopment requires further investigation. We used network-based statistics (NBS) to examine the association between resting-state functional Magnetic Resonance Imaging (fMRI) connectivity and fluid intelligence ability in male children (n = 50) with Autism Spectrum Disorders (ASD; M = 10...
April 17, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29667036/understanding-men-s-self-reported-sexual-interest-in-children
#11
Sandy K Wurtele, Dominique A Simons, Leah J Parker
A few studies have found that even in the general population, a minority of adults-men as well as women-report some sexual interest in a young age group. The purpose of the present study was to identify factors associated with self-reported sexual interest in children among a community-based sample of men. Using an online survey methodology, we examined the extent to which different types of childhood adversities (witnessing parental violence, sexual, physical, and emotional abuse), atypical childhood sexual experiences, and participants' self-reported likelihood of engaging in a variety of sexual behaviors (heightened sexual interest) were related to sexual interest in children (SIC) reported by a non-forensic/non-clinical sample of 173 men...
April 17, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29666976/do-youth-with-separation-anxiety-disorder-differ-in-anxiety-sensitivity-from-youth-with-other-anxiety-disorders
#12
Dagmar Kr Hannesdottir, Sandra Bjorg Sigurjonsdottir, Urdur Njardvik, Thomas H Ollendick
Studies on the relationship between separation anxiety disorder (SAD) in childhood and panic disorder (PD) in adolescence and adulthood have yielded results which suggest a common underlying vulnerability for both disorders. In this study, we examined whether one such possible vulnerability-anxiety sensitivity-differed for youth diagnosed with SAD versus other anxiety disorders. Anxiety sensitivity was assessed using the Childhood Anxiety Sensitivity Index (CASI) in 315 clinic-referred youth (ages 6-17, 113 girls)...
April 17, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29666887/reversible-lesions-of-the-corpus-callosum-with-initially-restricted-diffusion-in-a-series-of-caucasian-children
#13
Anthony Le Bras, Maia Proisy, Mathieu Kuchenbuch, Constantin Gomes, Catherine Tréguier, Sylvia Napuri, Emmanuel Quehen, Bertrand Bruneau
BACKGROUND: Reversible lesions of the corpus callosum with initial restricted diffusion on diffusion-weighted imaging (DWI) are rare and mainly described in the south Asiatic population. OBJECTIVE: The purpose of this study was to describe the clinical presentation, imaging findings, prognosis and etiology of transient restricted diffusion lesions of the corpus callosum in a series of Caucasian children. MATERIALS AND METHODS: Seven children presenting with a transient restricted DWI lesion of the corpus callosum were included...
April 17, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29666504/no-prophylactic-antibiotic-use-for-young-children-s-intussusception-with-low-risk-infection-after-successful-air-enema-reduction
#14
Yuan Zhang, Wen Zou, Lemeng Ren, Yinghui Zhang, Zhaohui Sun, Huandi Liu, Qian Liu, Chunfeng Si, Hongying Jia
The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value of prophylactic antibiotics for intussusception with low-risk infections. A retrospective non-randomized comparative study was conducted among 188 young children with intussusception after successful air enema reduction between January 1, 2011 and December 30, 2013...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666137/the-french-prospective-multisite-registry-on-sudden-unexpected-infant-death-omin-rationale-and-study-protocol
#15
Karine Levieux, Hugues Patural, Inge Harrewijn, Elisabeth Briand Huchet, Sophie de Visme, Géraldine Gallot, Martin Chalumeau, Christèle Gras Le Guen, Matthieu Hanf
INTRODUCTION: Even after 'back-to-sleep' campaigns, sudden unexpected infant death (SUID) continues to be the leading cause of death for infants 1 month to 1 year old in developed countries, with devastating social, psychological and legal implications for families. To sustainably tackle this problem and decrease the number of SUIDs, a French SUID registry was initiated in 2015 to (1) inform prevention with standardised data, (2) understand the mechanisms leading to SUID and the contribution of the already known or newly suggested risk factors and (3) gather a multidisciplinary group of experts to coordinate and develop innovative and urgent research in the SUID area...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666035/anemia-and-its-effect-on-cardiovascular-findings-in-obese-adolescents
#16
Öner Yıldırım, Tülay Demircan, Özlem Tüfekçi, Özgür Kızılca, Pınar Kuyum, Mustafa Kır, Ayhan Abacı, Nurettin Ünal, Nur Arslan, Ece Böber, Şebnem Yılmaz, Hale Ören
OBJECTIVE: We assessed the effect of anemia on cardiovascular findings in obese adolescents. MATERIALS AND METHODS: We studied 29 anemic, 33 nonanemic obese adolescents, and 33 nonobese healthy adolescents. These three groups were investigated for clinical and laboratory features of anemia and obesity. Echocardiography was used to examine cardiac functions. RESULTS: The anemia was mild (mean hemoglobin 11.67±0.79g/dL), ferritin level was significantly low, and CRP and fibrinogen levels were significantly high in anemic obese patients...
April 18, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29666001/distal-tibial-triplane-fracture-with-ipsilateral-tibial-shaft-fracture-a-case-series
#17
Timothy S Holland, Christopher P Prior, Roger Dm Walton
BACKGROUND & PURPOSE: Distal tibial Triplane fracture with ipsilateral tibial shaft fracture is a rare but important problem. This rarely reported combination of injuries if not recognised may lead to deleterious consequences. METHODS/PATIENTS: The local database of all emergency admissions was scrutinised to identify subjects before interrogation of the clinical notes and relevant radiographic imaging. FINDINGS: This paper reports a series of five children who were found to have triplane fracture of the distal tibia with concomitant ipsilateral fracture of the tibial shaft...
April 14, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29665952/community-engagement-for-paediatric-mdr-tb-clinical-trials-principles-to-support-ethical-trial-implementation
#18
G Hoddinott, S Staples, R Brown, M Simwinga, C Mubekapi-Musadaidzwa, A C Hesseling, G Hendricks, P De Koker, L McKenna
The paediatric tuberculosis (TB) prevention and treatment landscape is moving into a new and exciting era, with knowledge from clinical trials offering real benefit to children. Community engagement is key to optimising the success of these trials. However, the clinical profile, epidemiology and social perceptions for paediatric multidrug-resistant TB (MDR-TB) complicate the operationalisation of this community engagement. We reflect on a diversity of recent experiences attempting to implement this type of research and the community engagement around it...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665943/-interpretation-of-the-guidance-for-immune-thrombocytopenia-review
#19
Xiao-Yang Yang, Meng-Jie Wan, Fang-Ping Chen
Since the American Medical Association published the 2011 guidelines for immune thrombocytopenia, China has been the first to update the guidelines for immune thrombocytopenia based on evidence-based medicine. Recently, there have been many breakthroughs in clinical research published, especially the Chinese medical workers have made a prominent contribution to the treatment of the immune thrombocytopenia. However, the references of systematic drug introduction for children, adults, aged and pregnant women are still insufficient, and the first or second line treatment for some patients were ineffective...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665901/-clinical-efficacy-of-nopho-aml-2004-regimen-for-treatment-of-children-with-acute-myelocytic-leukemia-non-m3
#20
Kun-Yin Qiu, Xiong-Yu Liao, Ke Huang, Yang Li, Wen-Jun Weng, Hong-Gui Xu, Jian-Pei Fang, Ruo-Hao Wu, Dun-Hua Zhou
OBJECTIVE: To investigate the efficacy and safety of NOPHO-AML 2004 chemotherapy regimen for treatment of children with acute myelocytic leukemia(non-M3). METHODS: Thirty-three patients aged 1-13 with acute myelocytic leukemia (non-M3) were diagnosed from January 2013 to June 2017. FAB typing showed that 1 case in M0, 4 cases in M1, 12 cases in M2, 5 cases in M4, 8 cases in M5, 1 case in M6, and 2 cases in M7; Risk stratification showed that: 19 cases in standard risk, and 14 cases in high risk...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
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