keyword
https://read.qxmd.com/read/38547511/operating-properties-of-disease-activity-indices-in-pediatric-inflammatory-bowel-disease-a-systematic-review
#1
JOURNAL ARTICLE
Ruben J Colman, Virginia Solitano, John K MacDonald, Christopher Ma, Anne M Griffiths, Vipul Jairath, Eileen Crowley
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched on December 6, 2022, to identify studies evaluating clinical, endoscopic, imaging, or patient-reported outcome measures (PROMs) in pIBD including Crohn's disease (CD) and ulcerative colitis (UC)...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547499/epidemiological-and-clinical-insights-into-the-enterovirus-d68-upsurge-in-europe-2021-22-and-the-emergence-of-novel-b3-derived-lineages-enpen-multicentre-study
#2
JOURNAL ARTICLE
Margarida Pires Simoes, Emma B Hodcroft, Peter Simmonds, Jan Albert, Enagon K Alidjinou, Katia Ambert-Balay, Cristina Andrés, Andrés Antón, Christelle Auvray, Jean-Luc Bailly, Fausto Baldanti, Capser Bastings, Stuart Beard, Carla Berengua Pereira, Natasa Berginc, Mandy Bloemen, Soile Blomqvist, Froukje Bosma, Sindy Böttcher, Laura Bubba, Stafan Buderus, Maria Cabrerizo, Christina Calvo, Christina Celma, Ferruccio Ceriotti, Gemma Clark, Inës Costa, Marianne Coste-Burel, Karen Couderé, Jeroen Cremer, Margarita Del Cuerpo Casas, Theo Daehne, Jessica de Beer, Maria de Ceano-Vivas, Cillian De Gascun, Alexis de Rougemont, Johnathan Dean, Jennifer L Dembinski, Sabine Diedrich, Javier Diez-Domingo, Lena Dillner, Dagny H Dorenberg, Alexandra Ducancelle, Susanne Dudman, Robert Dyrdak, Anna-Maria Eis-Huebinger, Iker Falces-Romero, Agnes Farkas, Susan Feeney, Maria D Fernandez-Garcia, Jacky Flipse, Kristina T Franck, Cristina Galli, Isabelle Garrigue, Felix Geeraedts, Irina Georgieva, Federica Giardina, Raquel Guiomar, Elenor Hauzenberger, Esther Heikens, Cécille Henquell, Didier Hober, Amrio Hönemann, Hannah Howson-Wells, Željka Hruškar, Niina Ikonen, Berthemarie Imbert, Arjan R Jansz, Marion Jeannoël, Helena Jiřincová, Laurence Josset, Kathrin Keeren, Naomie Kramer-Lindhout, Sidsel Krokstad, Mouna Lazrek, Hélène Le Guillou-Guillemette, Caroline Lefeuvre, Andreas Lind, Maja M Lunar, Melanie Maier, Stéphanie Marque-Juillet, C Patrick McClure, James McKenna, Adam Meijer, Ana Menasalvas Ruiz, Beatriz Mengual-Chuliá, Sofie Midgley, Audrey Mirand, Richard Molenkamp, Milagrosa Montes, Antonio Moreno-Docón, Ursula Morley, Jean-Luc Murk, Ana Navascués-Ortega, Roel Nijhuis, Lubomira Nikolaeva-Glomb, Svein A Nordbø, Sanela Numanovic, Massimo Oggioni, Eider Oñate Vergara, Jordi Pacaud, Marie L Pacreau, Marcus Panning, Elena Pariani, Lili Pekova, Laura Pellegrinelli, Miroslav Petrovec, Corinna Pietsch, Léa Pilorge, Luis Piñeiro, Antonio Piralla, Mario Poljak, Birgit Prochazka, Nuria Rabella, Janette C Rahamat-Langendoen, Petra Rainetova, Marijke Reynders, Annelies Riezebos-Brilman, Lieuwe Roorda, Carita Savolainen-Kopra, Isabelle Schuffenecker, Leo C Smeets, Ayse Stoyanova, Karl Stefic, Caroline Swanink, Irena Tabain, Jeroen Tjhie, Luc Thouault, Camille Tumiotto, Sara Uceda Renteria, Tina Uršič, Sophie Vallet, Marc Van Ranst, Peter Van Wunnik, Jaco J Verweij, Jorgina Vila, Bas Wintermans, Elke Wollants, Katja C Wolthers, F Xavier López-Labrado, Thea Kolsen Fischer, Heli Harvala, Kimberley S M Benschop
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases...
March 28, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38547363/paediatric-voice-disorder-who-to-refer-and-how-to-assess-a-summary-of-recent-literature
#3
JOURNAL ARTICLE
Wendy Cohen, David M Wynne
PURPOSE OF REVIEW: The purpose of this review is to update the reader with recent advances and current opinion on the assessment and management of paediatric voice disorders. RECENT FINDINGS: Access to advanced multidisciplinary paediatric voice clinics has increased over the last decade. Often the assessment is combined between speech therapy/pathology and ENT surgery. Vocal fold nodules remain the most prevalent diagnosis at a paediatric voice clinic, but significant diseases will also present, for example laryngeal papilloma...
March 5, 2024: Current Opinion in Otolaryngology & Head and Neck Surgery
https://read.qxmd.com/read/38547335/impact-of-iodine-supply-in-infancy-and-childhood
#4
JOURNAL ARTICLE
Dominique Turck
PURPOSE OF REVIEW: To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women. RECENT FINDINGS: The 2022 Iodine Global Network Annual Report confirmed the dramatic decrease of severe iodine deficiency over the last 30 years, thanks to universal iodine iodization. However, mild to moderate deficiency is still present in many countries, where recent data showed a decrease of iodine intake and an impairment of iodine status...
March 28, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547138/safety-and-efficacy-of-antioxidant-therapy-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-systematic-review-and-network-meta-analysis
#5
JOURNAL ARTICLE
Peike Zhou, Xiaohui Yu, Tao Song, Xiaoli Hou
OBJECTIVE: To systematically evaluate the safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder (ADHD). METHODS: Randomized controlled trials and prospective studies on antioxidant therapy in children and adolescents with ADHD were searched in PubMed, Embase, and Cochrane Library from the inception of databases to November 12, 2022. Two investigators independently screened the literature, extracted data, and evaluated the quality of the included studies...
2024: PloS One
https://read.qxmd.com/read/38547087/human-myiasis-in-sub-saharan-africa-a-systematic-review
#6
JOURNAL ARTICLE
Binta J J Jallow, Goudja Gassara, Ousman Bajinka, Yifei Luo, Mandie Liu, Jifeng Cai, Jingjing Huang, Fanming Meng
BACKGROUND: Human myiasis is a parasitic dipteran fly infestation that infects humans and vertebrates worldwide. However, the disease is endemic in Sub-Saharan Africa and Latin America. In Sub-Saharan Africa, it is under-reported and therefore its prevalence is unknown. This systematic review aims to elucidate the prevalence of human myiasis, factors that influence the infection, and myiasis-causing fly species in SSA. The review also dwelled on the common myiasis types and treatment methods of human myiasis...
March 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38546926/depression-and-personality-traits-across-adolescence-within-person-analyses-of-a-birth-cohort
#7
JOURNAL ARTICLE
Ida Sund Morken, Lars Wichstrøm, Silje Steinsbekk, Kristine Rensvik Viddal
Depressive symptoms and personality traits covary in adolescents, but our understanding of the nature of this relation is limited. Whereas a predisposition explanation posits that specific personality traits increase the vulnerability for developing depression, a scar explanation proposes that depression may alter premorbid personality. Attempts to test these explanatory models have relied on analyses that conflate within-person changes and between-person differences, which limits the implications that can be drawn...
March 28, 2024: Research on child and adolescent psychopathology
https://read.qxmd.com/read/38546875/-congenital-pulmonary-malformations-diagnosis-and-treatment
#8
REVIEW
M Dohna, W F Hirsch, J Dingemann, D Gräfe
PERFORMANCE: Congenital pulmonary malformations (CPM) are rare and can be associated with high morbidity. Clinical presentation, diagnostic procedures, imaging, and therapy of CPM are discussed. ACHIEVEMENTS: Today, most CPM can be diagnosed prenatally by ultrasound. Postnatally, respiratory symptoms up to respiratory failure and recurrent lower respiratory tract infection are typical findings. Due to low diagnostic accuracy of chest x‑ray in CPM, all children with prenatal diagnosis of CPM or postnatally suspected CPM should undergo cross-sectional imaging...
March 28, 2024: Radiologie (Heidelb)
https://read.qxmd.com/read/38546815/assessment-of-autism-spectrum-disorders-in-children-with-visual-impairment-and-blindness-a-scoping-review
#9
JOURNAL ARTICLE
Moire Stevenson, Emmanuela Tedone
There is a higher incidence of diagnosed Autism Spectrum Disorder (ASD) in children with visual impairment and blindness (VIB) than in typically sighted children. However, we currently lack appropriate assessment measures to fully understand the neurodevelopment of children with VIB. Numerous factors, such as common characteristics between children with VIB and ASD and the reliance of visual behaviours in assessments of ASD, complicate the clinical and diagnostic understanding of these children. This scoping review aims to describe the published knowledge on ASD assessment in children with VIB...
March 28, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38546733/high-flow-humidified-oxygen-as-an-early-intervention-in-children-with-acute-severe-asthma-protocol-for-a-feasibility-randomized-controlled-trial
#10
JOURNAL ARTICLE
Hector Rojas-Anaya, Akshat Kapur, Graham Roberts, Damian Roland, Atul Gupta, Michaela Lazner, Jane Bayreuther, John Pappachan, Christina Jones, Stephen Bremner, Fleur Cantle, Paul Seddon
BACKGROUND: Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to first-line therapy is problematic: the use of intravenous agents is inconsistent, and side effects are frequent. High-flow humidified oxygen (HiFlo) is widely used in respiratory conditions and is increasingly being used in ASA, but with little evidence for its effectiveness...
March 28, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38546662/-travel-burden-to-acpa-approved-cleft-and-craniofacial-teams-a-geospatial-analysis
#11
JOURNAL ARTICLE
Madyson I Brown, Boris K Kuyeb, Laura I Galarza, Katherine C Benedict, Ian C Hoppe, Laura S Humphries
BACKGROUND: Despite the existence of American Cleft Palate and Craniofacial Association (ACPA)-approved Cleft and Craniofacial Teams, access to multidisciplinary team-based care remains challenging for patients from rural areas, leading to disparities in care. We investigated the geospatial relationship between U.S. counties and ACPA-approved centers. METHODS: The geographic location of all ACPA-approved cleft and craniofacial centers in the U.S. was identified...
March 25, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546643/germline-genetic-testing-and-survival-outcomes-among-children-with-rhabdomyosarcoma-a-report-from-the-children-s-oncology-group
#12
JOURNAL ARTICLE
Bailey A Martin-Giacalone, He Li, Michael E Scheurer, Dana L Casey, Shannon Dugan-Perez, Deborah A Marquez-Do, Donna Muzny, Richard A Gibbs, Donald A Barkauskas, David Hall, Douglas R Stewart, Joshua D Schiffman, Matthew T McEvoy, Javed Khan, David Malkin, Corinne M Linardic, Brian D Crompton, Jack F Shern, Stephen X Skapek, Rajkumar Venkatramani, Douglas S Hawkins, Aniko Sabo, Sharon E Plon, Philip J Lupo
IMPORTANCE: Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma. OBJECTIVE: To assess whether CPVs are associated with outcome among children with rhabdomyosarcoma. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, data were obtained for individuals, aged 0.01-23.23 years, newly diagnosed with rhabdomyosarcoma who were treated across 171 Children's Oncology Group sites from March 15, 1999, to December 8, 2017...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546621/what-works-better-1-year-outcomes-of-an-effectiveness-trial-comparing-online-telehealth-and-group-based-formats-of-a-military-parenting-program
#13
JOURNAL ARTICLE
Abigail H Gewirtz, David S DeGarmo, Susanne Lee
OBJECTIVE: The present study, conducted with a population of military families, examined the comparative effectiveness of three program formats of Adaptive Parenting Tools (ADAPT), a parenting program for families of school-aged children in which a National Guard or Reserve (NG/R) parent had returned from deployment to the post-9/11 conflicts. Despite well-documented need, parenting programs for NG/R families are scarce and often inaccessible. We predicted that both facilitator-delivered conditions (i...
March 28, 2024: Journal of Consulting and Clinical Psychology
https://read.qxmd.com/read/38546544/true-incidence-of-marginal-mandibular-nerve-palsy-following-neonatal-mandibular-distraction-osteogenesis
#14
JOURNAL ARTICLE
Sarah Myers, Justin W Beiriger, Madeleine K Bruce, Sayna Matinrazm, Lucas Dvoracek, Anjali Raghuram, Zhazira Irgebay, Anne E Glenney, Joseph Mocharnuk, Nicolás M Kass, John Smetona, Joseph E Losee, Jesse A Goldstein
INTRODUCTION: In children with PRS, MDO is routinely performed to alleviate airway obstruction; however, it involves risk of injury to the MMN. We hypothesize that MMN palsy incidence following MDO, reported at 1-15%, is underestimated. This study investigates the true incidence of MMN palsy after MDO to better guide follow-up care and improve treatment of this complication. METHODS: A retrospective review of PRS patients who underwent MDO at a single, tertiary pediatric hospital between September 2007 and March 2021 was conducted...
March 25, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546529/food-insecurity-and-changes-in-diet-quality-and-body-mass-index-z-scores-among-elementary-school-students
#15
JOURNAL ARTICLE
Jiwoo Lee, Erika Helgeson, Melissa L Horning, Kristin M Elgesma, Martha Y Kubik, Jayne A Fulkerson
Background: Previous research has identified food insecurity as a risk factor for obesity but those studies employed cross-sectional designs and were largely focused on adults and young children. In addition, there is a paucity of studies examining the association between food insecurity and changes in children's overall diet quality. This study aimed to assess whether food insecurity is associated with subsequent changes in diet quality and BMI z-scores over 2 years among 7- to 12-year-old children. Methods: We used 2011-2019 secondary data ( n  = 404) from three randomized controlled trials in Minnesota...
March 28, 2024: Childhood Obesity
https://read.qxmd.com/read/38546348/patient-positioning-and-its-impact-on-perioperative-outcomes-in-children-a-narrative-review
#16
REVIEW
Heather Patterson, Jonathan Eady, Aine Sommerfield, David Sommerfield, Neil Hauser, Britta S von Ungern-Sternberg
Patient positioning interacts with a number of body systems and can impact clinically important perioperative outcomes. In this educational review, we present the available evidence on the impact that patient positioning can have in the pediatric perioperative setting. A literature search was conducted using search terms that focused on pediatric perioperative outcomes prioritized by contemporary research in this area. Several key themes were identified: the effects of positioning on respiratory outcomes, cardiovascular outcomes, enteral function, patient and carer-centered outcomes, and soft issue injuries...
March 28, 2024: Paediatric Anaesthesia
https://read.qxmd.com/read/38546301/case-report-pediatric-thyroid-storm-presenting-to-the-emergency-department-with-afebrile-seizure
#17
JOURNAL ARTICLE
Daniel J Klein, Emily Rose
INTRODUCTION: Seizures are a common presenting complaint and account for approximately 1% of total emergency department (ED) visits. Seizures are especially common in children less than five years old as they have a lower seizure threshold as compared to adults. One potentially dangerous etiology that is far less common, especially in children, is thyroid storm, the extreme manifestation of hyperthyroidism. CASE REPORT: We describe the case of a 3-year-old girl who presented to the ED with an afebrile seizure but was found to be in thyroid storm...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546252/inflammatory-myofibroblastic-tumour-in-children-a-report-of-two-cases-and-review-of-literature
#18
JOURNAL ARTICLE
P P Sreepriya, Md Mokarram Ali, Rashi Rashi, Amit Kumar, Amit Kumar Sinha, Surabhi Raj, Bindey Kumar
Inflammatory myofibroblastic tumour in paediatric patients present with a diagnostic dilemma because of its clinical, radiological and histopathological features overlapping with other mesenchymal tumours common in this age. Because of its rarity, the exact features are still unclear. Here, we are reporting clinical, radiological and histopathological appearances of two such cases. In both cases, the exact diagnosis was confirmed only after immunohistochemistry. There is a need for further detailed study to exactly determine the natural course and prognosis of these tumours...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38545761/using-real-world-data-to-externally-evaluate-population-pharmacokinetic-models-of-dexmedetomidine-in-children-and-infants
#19
JOURNAL ARTICLE
Sean McCann, Victória E Helfer, Stephen J Balevic, Chi D Hornik, Stuart L Goldstein, Julie Autmizguine, Marisa Meyer, Amira Al-Uzri, Sarah G Anderson, Elizabeth H Payne, Sitora Turdalieva, Daniel Gonzalez
Dexmedetomidine is a sedative used in both adults and off-label in children with considerable reported pharmacokinetic (PK) interindividual variability affecting drug exposure across populations. Several published models describe the population PKs of dexmedetomidine in neonates, infants, children, and adolescents, though very few have been externally evaluated. A prospective PK dataset of dexmedetomidine plasma concentrations in children and young adults aged 0.01-19.9 years was collected as part of a multicenter opportunistic PK study...
March 28, 2024: Journal of Clinical Pharmacology
https://read.qxmd.com/read/38545757/feasibility-and-effectiveness-of-repeat-laparoscopic-pyeloplasty-for-recurrent-ureteropelvic-junction-obstruction-in-pediatric-patients
#20
JOURNAL ARTICLE
Qike Xie, Congjun Wang, Cheng Su, Bo Shi, Yong Li, Junqiang Huang, Chao Chen
OBJECTIVE: To assess the outcomes of redo laparoscopic pyeloplasty (RLP) in pediatric patients with recurrent ureteropelvic junction obstruction (UPJO) in contrast to redo open pyeloplasty (ROP). Additionally, evaluate the feasibility and efficacy of RLP as a treatment modality for recurrent UPJO in children. MATERIALS AND METHODS: The data of 44 patients from March 2012 to March 2022 who underwent redo pyeloplasty were retrospectively reviewed. In Group RLP, the children underwent RLP, while ROP was attempted in Group ROP...
March 28, 2024: Journal of Endourology
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