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Orthopedic oncology

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https://www.readbyqxmd.com/read/27904933/-metastatic-disease-in-long-bones-review-of-surgical-treatment-options
#1
Franz Liska, Philipp Schmitz, Norbert Harrasser, Peter Prodinger, Hans Rechl, Rüdiger von Eisenhart-Rothe
Surgery in metastatic bone disease is currently the most frequent type of surgery in orthopedic oncology. Improved survival rates and an increasing incidence of bone metastasis have led to an increase in complications caused by metastatic disease, such as pathological fractures or hardware failure after operative treatment. Although surgery of metastatic lesions remains a palliative therapy concept, because of sufficient therapy for the primary carcinomas, tumor-specific-oriented follow-up protocols and a variation in the prognosis for the individual entities, an individually adapted treatment strategy is necessary...
November 30, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27867823/the-burden-of-metastatic-disease-of-the-femur-on-the-medicare-system
#2
Kirollos Gendi, David Hennessy, John Heiner
BACKGROUND: In the United States, over 1,650,000 new cases of cancer are being diagnosed yearly with almost 50 % of them being the top five bone-seeking cancers. Since cancer risk increases with age, this suggests that orthopedic oncology services may be a strain on the Medicare system. The femur is the most common site of long bone metastases. Prophylactic fixation techniques prevent pathologic fractures, reduce morbidities, and enhance the quality of life of patients with femoral metastases...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27843593/diagnosis-and-treatment-of-bone-metastasis-comprehensive-guideline-of-the-japanese-society-of-medical-oncology-japanese-orthopedic-association-japanese-urological-association-and-japanese-society-for-radiation-oncology
#3
REVIEW
H Shibata, S Kato, I Sekine, K Abe, N Araki, H Iguchi, T Izumi, Y Inaba, I Osaka, S Kato, A Kawai, S Kinuya, M Kodaira, E Kobayashi, T Kobayashi, J Sato, N Shinohara, S Takahashi, Y Takamatsu, K Takayama, K Takayama, U Tateishi, H Nagakura, M Hosaka, H Morioka, T Moriya, T Yuasa, T Yurikusa, K Yomiya, M Yoshida
Diagnosis and treatment of bone metastasis requires various types of measures, specialists and caregivers. To provide better diagnosis and treatment, a multidisciplinary team approach is required. The members of this multidisciplinary team include doctors of primary cancers, radiologists, pathologists, orthopaedists, radiotherapists, clinical oncologists, palliative caregivers, rehabilitation doctors, dentists, nurses, pharmacists, physical therapists, occupational therapists, medical social workers, etc. Medical evidence was extracted from published articles describing meta-analyses or randomised controlled trials concerning patients with bone metastases mainly from 2003 to 2013, and a guideline was developed according to the Medical Information Network Distribution Service Handbook for Clinical Practice Guideline Development 2014...
2016: ESMO Open
https://www.readbyqxmd.com/read/27745864/long-term-outcome-following-treatment-of-adamantinoma-and-osteofibrous-dysplasia-of-long-bones
#4
S E Puchner, R Varga, G M Hobusch, M Kasparek, J Panotopoulos, S Lang, R Windhager, P T Funovics
INTRODUCTION: Adamantinoma (AD) is an ultimately rare, low-grade malignant bone tumor. In most cases it occurs in the tibia of young adults. Osteofibrous dysplasia (OFD) is a rare, benign, lesion that is typically seen in children. Histopathology, ultrastructure, and cytogenetics indicate that these lesions are closely related. Yet, etiology remains a matter of debate. Local recurrence rates are high for both entities as published in literature and long-term outcomes are scarce, due to the rarity of the disease...
October 10, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27741957/where-teachers-are-few-documenting-available-faculty-in-five-tanzanian-medical-schools
#5
Charles A Mkony, Ephata E Kaaya, Alex J Goodell, Sarah B Macfarlane
BACKGROUND: Faced with one of the lowest physician-to-population ratios in the world, the Government of Tanzania is urging its medical schools to train more physicians. The annual number of medical students admitted across the country rose from 55 in the 1990s to 1,680 approved places for the 2015/16 academic year. These escalating numbers strain existing faculty. OBJECTIVE: To describe the availability of faculty in medical schools in Tanzania. DESIGN: We identified faculty lists published on the Internet by five Tanzanian medical schools for the 2011/12 academic year and analyzed the appointment status, rank, discipline, and qualifications of faculty members...
2016: Global Health Action
https://www.readbyqxmd.com/read/27732721/clinical-practice-guidelines-from-the-aabb-red-blood-cell-transfusion-thresholds-and-storage
#6
Jeffrey L Carson, Gordon Guyatt, Nancy M Heddle, Brenda J Grossman, Claudia S Cohn, Mark K Fung, Terry Gernsheimer, John B Holcomb, Lewis J Kaplan, Louis M Katz, Nikki Peterson, Glenn Ramsey, Sunil V Rao, John D Roback, Aryeh Shander, Aaron A R Tobian
Importance: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. Objective: To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. Evidence Review: Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27716330/survival-rate-and-perioperative-data-of-patients-who-have-undergone-hemipelvectomy-a-retrospective-case-series
#7
Alfredo Guilherme Haack Couto, Bruno Araújo, Roberto André Torres de Vasconcelos, Marcos José Renni, Clóvis Orlando Da Fonseca, Ismar Lima Cavalcanti
BACKGROUND: Hemipelvectomy is a major orthopedic surgical procedure indicated in specific situations. Although many studies discuss surgical techniques for hemipelvectomy, few studies have presented survival data, especially in underdeveloped countries. Additionally, there is limited information on anesthesia for orthopedic oncologic surgeries. The primary aim of this study was to determine the survival rate after hemipelvectomy, and the secondary aims were to evaluate anesthesia and perioperative care associated with hemipelvectomy and determine the influence of the surgical technique (external hemipelvectomy [amputation] or internal hemipelvectomy [limb sparing surgery]) on anesthesia and perioperative care in Brazil...
October 7, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27686768/-association-of-exposure-to-environmental-chemicals-with-risk-of-childhood-acute-lymphocytic-leukemia
#8
W C Jiang, S Y Wu, Y B Ke
Objective: This study aimed to investigate the association between exposure to environmental chemicals and the risk of childhood acute lymphocytic leukemia(cALL). Methods: A case-controlled study was conducted in Shenzhen Children's Hospital, China from January 2015 to January 2016. The cases were selected from the section of Hematology and Oncology, and the controls were selected from Orthopedics by 1∶2 matching of cases according to sex and age. A questionnaire including population data and chemical exposure characteristics was conducted on the children's parents, and urine and EDTA-blood were collected from the children...
October 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27676853/pediatric-rehabilitation-and-pediatric-oncology-a-winner-association-the-experience-of-grenoble-pediatric-hospital
#9
Véronique Bourg, Anne Descotes, Anne Pagnier, Jacques Griffet, Dominique Plantaz
The Child and Family Hospital of Grenoble is one of the rare university hospitals in France to benefit from the presence of a physician specializing in rehabilitation medicine. This hospital includes both inpatient and outpatient units. During the temporary closure of one department, certain members of the rehabilitation unit were reassigned to the acute care wards of the pediatric department, including physical therapists, occupational therapists, and speech therapists. Over the course of one year, these therapists completed more than 150 interventions in this department, more than half of which were in the hematology and oncology ward...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27650452/treatment-for-long-bone-metastases-based-on-a-systematic-literature-review
#10
Costantino Errani, Andreas F Mavrogenis, Luca Cevolani, Silvia Spinelli, Andrea Piccioli, Giulio Maccauro, Nicola Baldini, Davide Donati
PURPOSE: To provide treatment guidelines for patients with long bone metastatic disease based on a systematic review of the literature and to propose an algorithm to guide orthopedic surgeons in decision-making for these patients. MATERIALS AND METHODS: We performed a computerized literature search in MEDLINE, EMBASE and Scopus for studies on patients with long bone metastases. We used the key words "long bones", "metastasis" and "treatment" for published studies that evaluated any treatment for long bone metastases...
September 20, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27636683/applied-nanotechnology-and-nanoscience-in-orthopedic-oncology
#11
Olga D Savvidou, Ioanna K Bolia, George D Chloros, Stavros D Goumenos, Vasileios I Sakellariou, Evanthia C Galanis, Panayiotis J Papagelopoulos
Nanomedicine is based on the fact that biological molecules behave similarly to nanomolecules, which have a size of less than 100 nm, and is now affecting most areas of orthopedics. In orthopedic oncology, most of the in vitro and in vivo studies have used osteosarcoma or Ewing sarcoma cell lineages. In this article, tumor imaging and treatment nanotechnology applications, including nanostructure delivery of chemotherapeutic agents, gene therapy, and the role of nano-selenium-coated implants, are outlined. Finally, the potential role of nanotechnology in addressing the challenges of drug and radiotherapy resistance is discussed...
September 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27604159/perceptions-of-medical-doctors-on-bisphosphonate-related-osteonecrosis-of-the-jaw
#12
Jin-Woo Kim, Su-Ra Jeong, Sun-Jong Kim, YeonSoo Kim
BACKGROUND: This study aimed to investigate medical doctors' awareness of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the status of dental referrals. METHODS: Self-administered questionnaires were distributed to medical doctors practicing internal medicine, family medicine, and orthopedics at the 6 tertiary medical centers located in Seoul, Korea. The survey consisted of 22 questions regarding the general characteristics, bisphosphonate therapy, awareness of BRONJ, and implementation of dental referrals...
September 7, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27602251/can-imaging-put-the-advanced-back-in-advanced-wound-care
#13
Ralph S DaCosta, Kathryn Ottolino-Perry, Jaideep Banerjee
An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27528845/staged-soft-tissue-reconstruction-following-sarcoma-excision-with-anticipated-large-cutaneous-defects-an-oncologically-safe-alternative
#14
Geoffrey W Siegel, William M Kuzon, Jill M Hasen, J Sybil Biermann
BACKGROUND: We hypothesized that select patients undergoing planned soft tissue sarcoma (STS) excision with anticipated skin and soft tissue deficits could be treated with a two stage surgical procedure which would allow some flexibility in coverage options while not significantly increasing local recurrence rate or wound complication rate. METHODS: A retrospective review was undertaken in a series of consecutive patients with a minimum 2-year follow-up treated by a single orthopedic oncologist and a single reconstructive plastic surgeon who were managed with a staged approach STS excision and reconstruction...
2016: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/27517027/epidemiological-study-on-giant-cell-tumor-recurrence-at-the-brazilian-national-institute-of-traumatology-and-orthopedics
#15
Roberto Clayton Lima Oliveira Júnior, Marcelo Glauber da Silva Pereira, Pedro Braga Linhares Garcia, Patrícia Albuquerque Dos Santos, Amanda Dos Santos Cavalcanti, Walter Meohas
OBJECTIVE: Giant cell tumors are benign bone neoplasms that are relatively rare in adults and their biological behavior is still unpredictable. The incidence of local recurrence has presented variation between 0% and 65% in studies conducted worldwide, but few data are available on this complication in the Brazilian population. METHODS: Information on 155 patients with confirmed histological diagnoses of giant cell tumor who were treated in our institution's orthopedic oncology service between January 2000 and July 2014 was gathered...
July 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27516036/the-interdisciplinary-approach-of-an-aggressive-giant-cell-tumor-of-bone-complicated-with-a-fracture-of-the-distal-femur
#16
Iulian Daniel Vîlcioiu, Dragoş George Zamfirescu, Ioan Cristescu, Andrei Ursache, Şerban Arghir Popescu, Cosmin Antoniu Creangă, Ioan Lascăr
Giant cell tumor of bone (GCTB) represents one of the commonest bone tumors encountered by an orthopedic surgeon. The giant-cell tumor is generally classified as benign but the fast growing rhythm and the aggressive soft-tissue invasion may in some cases demonstrate a malign potential of the tumor. We present the case of an aggressive giant cell tumor in a young patient that was first diagnosed in our emergency department with a fracture of the distal femur after a low energy trauma. With further examinations, we discovered that the tumor was invading the both femoral condyles and was vascularized by three major arterial pedicles...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27509485/spontaneous-healing-of-fractures-and-osteotomy-within-intercalary-allograft-reconstruction-after-distal-femur-osteosarcoma-resection-in-a-child
#17
Bart Kowalczyk, Krzysztof Miklaszewski, Jarosław Feluś
Intercalary biologic reconstructions using allogenic bone grafts remain a useful option in orthopedic oncology; however, these reconstructions are prone to fractures, and treatment is usually required involving surgical interventions. Biologic activity of the implanted allografts remains minimal, but in some cases, spontaneous healing of the graft may occur. We present a report and discussion on two fractures and corrective osteotomy within the implanted allograft that healed with abundant callus without the need for additional surgery...
August 8, 2016: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/27448611/orthopedic-oncology-caseload-among-orthopedic-surgery-residents
#18
Richard M Hinds, Timothy B Rapp, John T Capo
Despite educational focus regarding orthopedic oncology during residency, assessment of resident orthopedic oncology caseload has not been performed. The purpose of this study was to evaluate orthopedic oncology caseload trends and variation among residents. The Accreditation Council for Graduate Medical Education case log reports for orthopedic surgery residents were reviewed for graduating years 2007 to 2013. Trends in orthopedic oncology cases and variation in the median number of cases performed by residents in the 90th, 50th, and 10th percentiles of caseload were evaluated...
July 23, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27270831/evaluation-of-clinical-pharmacists-interventions-in-the-czech-republic
#19
Jitka Rychlíčková, Jan Šaloun, Jana Gregorová
STUDY OBJECTIVES: To determine the frequency of interventions, categorized by type of intervention and therapeutic class, made by a team of four clinical pharmacists over a 1-year period, and to assess the potential economic impact of these interventions. DESIGN: Prospective analysis. SETTING: Large medical center in Prague, Czech Republic. PATIENTS: A total of 9153 adults who were admitted to the general surgery, infectious diseases, oncology, orthopedics, and thoracic surgery and respiratory medicine services between January 1, 2014, and December 31, 2014...
July 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27266236/characteristics-and-demographic-distributions-of-toxigenic-clostridium-difficile-strains-in-rajavithi-hospital-2009-2015
#20
Prakaithip Thongkoom, Suwattana Kanchanahareutai, Suriwan Chantrakooptungkul, Somsak Rahule
BACKGROUND: In recent years, toxigenic Clostridium difficile infection (CDI) has been the cause of C. difficile-associated diseases (CDAD), resulting in increasing hospitalization, community infection outbreak and mortality all over the world. OBJECTIVE: To investigate the prevalence of toxigenic C. difficile strains in Rajavithi Hospital. MATERIAL AND METHOD: This was a retrospective study of data from C. difficile toxin tests at Rajavithi Hospital's microbiology laboratory from January 1, 2009 to June 30, 2015...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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