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JOURNAL ARTICLE
Andrea Baudo, Mattia Luca Piccinelli, Reha-Baris Incesu, Simone Morra, Lukas Scheipner, Francesco Barletta, Stefano Tappero, Cristina Cano Garcia, Anis Assad, Zhe Tian, Pietro Acquati, Ottavio de Cobelli, Nicola Longo, Alberto Briganti, Carlo Terrone, Felix K H Chun, Derya Tilki, Sascha Ahyai, Fred Saad, Shahrokh F Shariat, Luca Carmignani, Pierre I Karakiewicz
INTRODUCTION: In soft tissue pelvic liposarcoma and leiomyosarcoma, it is unknown whether a specific tumor size cut-off may help to better predict prognosis, defined as cancer-specific survival (CSS). We tested whether different tumor size cut-offs, could improve CSS prediction. MATERIALS AND METHODS: Surgically treated non-metastatic soft tissue pelvic sarcoma patients were identified (Surveillance, Epidemiology, and End Results 2004-2019). Kaplan-Meier plots, univariable and multivariable Cox-regression models and receiver operating characteristic-derived area under the curve (AUC) estimates were used...
April 9, 2024: Surgical Oncology
#22
REVIEW
Xinpeng Dai, Bingxin Zhao, Jiangnan Zang, Xinying Wang, Zongjie Liu, Tao Sun, Hong Yu, Xin Sui
RATIONALE AND OBJECTIVES: To systematically evaluate the application value of radiomics and deep learning (DL) in the differential diagnosis of benign and malignant soft tissue tumors (STTs). MATERIALS AND METHODS: A systematic review was conducted on studies published up to December 11, 2023, that utilized radiomics and DL methods for the diagnosis of STTs. The methodological quality and risk of bias were evaluated using the Radiomics Quality Score (RQS) 2.0 system and Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool, respectively...
April 13, 2024: Academic Radiology
#23
Christoffer Vannas, Mandy Escobar, Tobias Österlund, Daniel Andersson, Pia Mouhanna, Amanda Soomägi, Claes Molin, David Wennergren, Henrik Fagman, Anders Ståhlberg
Angiosarcoma is a rare and aggressive type of soft-tissue sarcoma with high propensity to metastasize. For patients with metastatic angiosarcoma, prognosis is dismal and treatment options are limited. To improve the outcomes, identifying patients with poor treatment response at an earlier stage is imperative, enabling alternative therapy. Consequently, there is a need for improved methods and biomarkers for treatment monitoring. Quantification of circulating tumor-DNA (ctDNA) is a promising approach for patient-specific monitoring of treatment response...
April 4, 2024: International Journal of Molecular Sciences
#24
JOURNAL ARTICLE
Sara Soto, Sohvi Blatter, Stefan Hobi, Marco Steck, Julia Lechmann, Silvia Rüfenacht, Nicolas Kühn, Maja Ruetten, Nataliia Ignatenko, Christiane Krudewig
Soft tissue tumors/sarcomas (STSs) in felines, encompassing a variety of mesenchymal tumors with similar histomorphological features, present diagnostic challenges due to their diverse cellular origins and the overlap with other tumor types such as feline sarcoid. This study aimed to delineate the clinical, histomorphological, and immunohistochemical characteristics of 34 feline facial spindle cell tumors affecting 29 cats, including testing for bovine papillomavirus type 14 (BPV14), the virus causing feline sarcoids...
April 4, 2024: Animals: An Open Access Journal From MDPI
#25
JOURNAL ARTICLE
Francois Gouin, Audrey Michot, Mehrdad Jafari, Charles Honoré, Jean Camille Mattei, Alexandre Rochwerger, Mickael Ropars, Dimitri Tzanis, Philippe Anract, Sébastien Carrere, Dimitri Gangloff, Agnès Ducoulombier, Céleste Lebbe, Jérôme Guiramand, Denis Waast, Frédéric Marchal, François Sirveaux, Sylvain Causeret, Pierre Gimbergues, Fabrice Fiorenza, Brice Paquette, Pauline Soibinet, Jean-Marc Guilloit, Louis R Le Nail, Franck Dujardin, David Brinkert, Claire Chemin-Airiau, Magali Morelle, Pierre Meeus, Marie Karanian, François Le Loarer, Gualter Vaz, Jean-Yves Blay
BACKGROUND: Whether re-excision (RE) of a soft tissue sarcoma (STS) of limb or trunk should be systematized as adjuvant care and if it would improve metastatic free survival (MFS) are still debated. The impact of resection margins after unplanned macroscopically complete excision (UE) performed out of a NETSARC reference center or after second resection was further investigated. METHODS: This large nationwide series used data from patients having experienced UE outside of a reference center from 2010 to 2019, collected in a French nationwide exhaustive prospective cohort NETSARC...
March 30, 2024: Cancers
#26
JOURNAL ARTICLE
Zeynep Tastan Eroglu, Dilek Ozkan Sen, Elif Oncu
Objective: The objective of this study was to evaluate the effects of keratinized mucosa width (KMW) and mucosal thickness (MT) around dental implants on marginal bone loss (MBL). The evaluation was performed one year after loading by comparing clinical, radiographic, and biochemical parameters. Methods: The study included 87 implants in 87 patients undergoing regular follow-ups without hard or soft tissue augmentation one year after loading. Clinical measurements included plaque index (PI), gingival index (GI), bleeding on probing (BoP), probing depth (PD), KMW, and MT...
March 27, 2024: Journal of Clinical Medicine
#27
JOURNAL ARTICLE
Alexandra R Richards, Gayathri Vijayakumar, Ankica Braun, Steven Gitelis, Alan T Blank
CASE: A 40-year-old man was evaluated for a painful mass on his right calf, and a 36-year-old woman presented with a painless mass on her right foot. Final pathology revealed marked nuclear atypia and positivity for S100/SOX10 and AE1/AE3 confirming diagnoses of myoepithelial carcinoma. Both patients underwent surgical resection and are without evidence of local recurrence or metastatic disease at 1-year follow-up. CONCLUSION: Soft-tissue tumors presenting in the extremities warrant careful evaluation and timely histopathologic diagnosis...
April 1, 2024: JBJS Case Connector
#28
JOURNAL ARTICLE
Kyung Tae Hong, Seung Bin Park, Dhiraj P Murale, Jung Hoon Lee, Jangsun Hwang, Woo Young Jang, Jun-Seok Lee
Cancer stem cells are pivotal players in tumors initiation, growth, and metastasis. While several markers have been identified, there remain challenges particularly in heterogeneous malignancies like adult soft tissue sarcomas, where conventional markers are inherently overexpressed. Here, we designed BODIPY scaffold fluorescence probes (BD-IMC-1, BD-IMC-2) that activate via disaggregation targeting for cyclooxygenase (COX), a potential marker for CSCs in sarcoma in clinical pathology. Based on their structures, BD-IMC-1 showcased higher susceptibility to disaggregation compared to BD-IMC-2, consistent with their selective interaction with COX...
April 12, 2024: Angewandte Chemie
#29
REVIEW
Anastasios G Roustemis, Markos Liontos, Ioannis Trikoupis, Vasileios Karampikas, Stavros Goumenos, Panagiotis Gavriil, Vasileios A Kontogeorgakos, Olga Savvidou, Panayiotis J Papagelopoulos
Periacetabular defects following tumor resection present formidable challenges in reconstruction and continue to pose clinical difficulties. Historically, treatment approaches leaned towards hindquarter amputation; however, due to associated morbidities and functional limitations, limb-sparing procedures gained prominence in the 1980s. Nevertheless, the intricacies of pelvic anatomy and the imperative of achieving wide surgical margins while preserving essential structures make pelvic tumor resection and subsequent reconstruction inherently complex...
March 2024: Curēus
#30
JOURNAL ARTICLE
Ioannis M Stavrakakis, Vasiliki Georgopoulou, George E Magarakis, Maria S Katsafarou
Lipomas are the most common soft-tissue tumors in the human body, but their location in the hand is rare. Symptomatic hand lipomas, due to nerve compression, are even rarer. We present a case of median nerve neuropathy as a result of a giant palm lipoma, located on the thenar and hypothenar areas of the hand. The patient had typical symptoms of carpal tunnel syndrome, along with compromised thumb motion. Intraoperatively, the recurrent motor branch of the median nerve was sitting on the lipoma under a great tension...
April 2024: Revista Brasileira de Ortopedia
#31
Jinfeng Sun, Xiuli Gu, Liangjun Wang
INTRODUCTION: This systematic review and meta-analysis aimed to examine the risk of second primary cancers (SPCs) among retinoblastoma (Rb) patients, both hereditary and nonhereditary. Previous studies have reported on the long-term risk of SPCs in these patient populations, but a comprehensive synthesis of the existing evidence is lacking. METHODS: A systematic search was conducted in PubMed, EMBASE, and Cochrane Library from inception to 12 March 2023, supplemented by manual screening...
2024: Frontiers in Oncology
#32
JOURNAL ARTICLE
Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, Amelia L Parker, Kendelle J Murphy, Kaitlin Wyllie, Gretel S Major, Osvaldo Contreras, Ellie T Y Mok, Ronaldo F Enriquez, Suzanne McGowan, Kristen Feher, Lake-Ee Quek, Sarah E Hancock, Michelle Yam, Emmi Tran, Yordanos F I Setargew, Joanna N Skhinas, Jessica L Chitty, Monica Phimmachanh, Jeremy Z R Han, Antonia L Cadell, Michael Papanicolaou, Hadi Mahmodi, Beata Kiedik, Simon Junankar, Samuel E Ross, Natasha Lam, Rhiannon Coulson, Jessica Yang, Anaiis Zaratzian, Andrew M Da Silva, Michael Tayao, Ian L Chin, Aurélie Cazet, Maya Kansara, Davendra Segara, Andrew Parker, Andrew J Hoy, Richard P Harvey, Ozren Bogdanovic, Paul Timpson, David R Croucher, Elgene Lim, Alexander Swarbrick, Jeff Holst, Nigel Turner, Yu Suk Choi, Irina V Kabakova, Andrew Philp, Thomas R Cox
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter stages of the metastatic cascade, such as metastatic seeding of secondary sites and outgrowth remains underappreciated. This work sought to address this in the context of triple negative breast cancer (TNBC), a cancer type known to aggressively disseminate at all stages of disease progression. Using mechanically tuneable model systems, mimicking the range of stiffness's typically found within breast tumors, it is found that, contrary to expectations, cancer cells exposed to softer microenvironments are more able to colonize secondary tissues...
April 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#33
María Álvaro-Martinez, Carolina Cuesta-Urquía, Luis Ortiz-Peces, Jorge Noguera-Tomás, Teresa González-Otero, José-Luis Cebrián-Carretero
Venous malformations (VMs) are aberrant venous vessel angiogenesis present at birth. However, they can become apparent later in life, debuting in early childhood. This poses a clinical quest for surgeons, dentists, and pediatricians, as they might appear as a compressible mass in the head and neck region, not uncommonly mistaking them for odontogenic abscesses or other soft tissue tumors. The differential diagnosis can be challenging and imaging techniques are often needed. Ultrasounds are extremely useful initially as other diagnostic tools can be potentially harmful in the context of a VM...
March 2024: Journal of Clinical and Experimental Dentistry
#34
JOURNAL ARTICLE
X Y Feng, M J Chen, Y Xu, W Zhong, X Y Liu, X X Gao, J Zhao, M Z Wang
Objective: To summarize the clinical characteristics, treatment, and outcomes of patients with pulmonary sarcomatoid carcinoma (PSC) in order to improve clinicians' understanding of this disease. Methods: The clinical data of patients diagnosed with PSC in our hospital from January 1, 2015 to November 30, 2023 were retrospectively analyzed. According to whether radical resection was performed, the patients were divided into resectable group and unresectable group. The characteristics and treatments of PSC in different groups were compared...
April 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
#35
JOURNAL ARTICLE
Gabrielle S Fontes, Hunter J Piegols, Janis M Lapsley, Shay Bracha, Laura E Selmic
OBJECTIVE: To report the survival times in dogs diagnosed with adrenal tumors with vascular or soft tissue invasion that did not undergo adrenalectomy. ANIMALS: Retrospective case series of 32 client-owned dogs. METHODS: The medical records of a referral veterinary hospital were reviewed to identify dogs that were diagnosed with an invasive adrenal mass and did not undergo adrenalectomy between January 2013 and December 2022. Data collected included signalment, examination findings, and diagnostic results from the initial presentation...
April 10, 2024: Journal of the American Veterinary Medical Association
#36
Adil Aziz Khan, Sana Ahuja, Sufian Zaheer
Introduction Rhabdomyosarcoma, though rare in the middle ear, necessitates prompt recognition for optimal management. They are malignant mesenchymal neoplasms arising from the embryonic mesenchymal cells of striated skeletal muscles. Case presentation We present a case of a 5-year-old child with massive right mastoid swelling and bloody ear discharge. Cytological examination via fine needle aspiration biopsy revealed features suggestive of a malignant mesenchymal tumor, confirmed on imaging and subsequent histopathology as embryonal rhabdomyosarcoma (ERMS) FNCLCC grade 2...
April 10, 2024: Acta Cytologica
#37
JOURNAL ARTICLE
Shan Gao, Yu-Tong Wang, Guang-Yu Ma, Min-Qiu Lu, Bin Chu, Lei Shi, Li-Juan Fang, Qiu-Qing Xiang, Yue-Hua Ding, Li Bao
BACKGROUND: A solitary plasmacytoma is classified into a solitary plasmacytoma of the bone (SBP) and a solitary extramedullary (soft tissue mass) plasmacytoma, based on the site of the lesion. Despite the high local control rate with radiotherapy, approximately half of patients' conditions progress to multiple myeloma (MM) within 3-5 years after diagnosis, with SBP having a worse prognosis. PATIENTS AND METHODS: We retrospectively assessed the treatment and outcomes of patients with SBP in a hospital in China from 2008 to 2021...
April 9, 2024: Current Problems in Cancer
#38
Takashi Noguchi, Akio Sakamoto, Kensaku Kakehi, Shuichi Matsuda
BACKGROUND: Tumoral calcinosis is a condition characterized by deposits of calcium phosphate crystals in extra-articular soft tissues, occurring in hemodialysis patients. Calcium phosphate crystals are mainly composed of hydroxyapatite, which is highly infiltrative to tissues, thus making complete resection difficult. An adjuvant method to remove or resolve the residual crystals during the operation is necessary. CASE SUMMARY: A bicarbonate Ringer's solution with bicarbonate ions (28 mEq/L) was used as the adjuvant...
March 18, 2024: World Journal of Orthopedics
#39
JOURNAL ARTICLE
Zachary Alan Wilkinson, Maria Luisa C Policarpio-Nicolas
This report describes the cytologic features of a recently described MXD4::NUTM1-rearranged colonic sarcoma metastatic to the midclavicular soft tissue. Thirteen years ago, a 65-year-old woman presented with a cecal mass and subsequent liver mass. The cecal mass was diagnosed as malignant undifferentiated spindled and epithelioid neoplasm based on morphology and lack of tumor immunoreactivity with a panel of epithelial, smooth muscle, skeletal, melanoma, hematologic, and GIST markers. The liver mass showed morphologic and immunophenotypic similarity to the epithelioid component of the patient's cecal mass, albeit devoid of the spindled component...
April 9, 2024: Diagnostic Cytopathology
#40
JOURNAL ARTICLE
Sebastian Lenart, Oskar Koperek, Anke Scharrer, Eva Comperat
BACKGROUND: Fasciitis ossificans is a rare subtype of nodular fasciitis, a benign soft tissue tumor with reactive characteristics. Due to its rapid growth, it is often misdiagnosed as a malignant tumor. While fasciitis ossificans commonly originates from the subcutaneous tissue and can appear throughout the body, it may also arise from extraordinary sites. CASE PRESENTATION: We report the first-ever documented case of fasciitis ossificans arising from the penis in a male patient who presented with a tumor on the glans penis...
April 9, 2024: BMC Urology
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