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https://www.readbyqxmd.com/read/29334236/wb-mri-and-oncology-recent-major-advances
#1
Vassiliki Pasoglou, Nicolas Michoux, Ahmed Larbi, Van Nieuwenhove Sandy, Frédéric Lecouvet
Magnetic Resonance Imaging (MRI) is a very attractive approach for tumor detection and oncological staging with its absence of ionizing radiation, high soft tissue contrast and spatial resolution. Less than ten years ago the use of Whole Body MRI (WB-MRI) protocols was uncommon due to many limitations, such as the long acquisition times and limited availability. This decade has marked substantial progress in WB-MRI protocols. This very promising technique is rapidly arising from the research world and is becoming a commonly used exam for tumor detection, due to recent technological developments and validation of WB-MRI by multiple studies and consensus papers...
January 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29333013/comparative-study-of-imprint-cytology-and-histopathology-of-soft-tissue-tumors
#2
Sujit Kumar Dutta, Senjuti Dasgupta, Nirmal Kumar Bhattacharyya, Parul Jain, Debdas Bose, Pranab Kumar Biswas
Background: The components of soft tissue are fibroblasts, collagen, vascular structures, fatty tissue, skeletal muscles, smooth muscles, and neural tissue. The real incidence of soft tissue tumors (STTs) is difficult to estimate because most of them are benign (Benign: Malignant-100:1). Aims: The aim of the present study was undertaken to note the patterns of presentation of patients with STTs and to evaluate the findings of imprint cytology (IC) and histopathological examination (HPE) of STTs...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332928/optical-coherence-tomography-for-precision-brain-imaging-neurosurgical-guidance-and-minimally-invasive-theranostics
#3
Yingwei Fan, Yan Xia, Xinran Zhang, Yu Sun, Jie Tang, Liwei Zhang, Hongen Liao
This review focuses on optical coherence tomography (OCT)-based neurosurgical application for imaging and treatment of brain tumors. OCT has emerged as one of the most innovative and successful translational biomedical-diagnostic techniques. It is a useful imaging tool for noninvasive, in vivo, in situ and real-time imaging in soft biological tissues, such as brain tumor imaging. OCT can detect the structure of biological tissue in a micrometer scale, and functional OCT has some clinical researches and applications, such as nerve fiber tracts and neurovascular imaging...
January 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29330550/a-metabolomics-pilot-study-on-desmoid-tumors-and-novel-drug-candidates
#4
Kelly A Mercier, Mushriq Al-Jazrawe, Raymond Poon, Zachery Acuff, Benjamin Alman
Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1). Using broad spectrum metabolomics, differences were investigated between paired normal fibroblast and desmoid tumor cells from affected patients...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327709/insm1-expression-and-its-diagnostic-significance-in-extraskeletal-myxoid-chondrosarcoma
#5
Akihiko Yoshida, Naohiro Makise, Susumu Wakai, Akira Kawai, Nobuyoshi Hiraoka
Extraskeletal myxoid chondrosarcoma is a rare subtype of sarcoma that affects the soft tissue and bones in middle-aged and elderly adults. Its diagnosis can be challenging, with the differential diagnoses including a wide variety of mesenchymal tumors. The line of differentiation of extraskeletal myxoid chondrosarcoma has been controversial, but recent evidence suggests a neuroendocrine phenotype. INSM1 is a zinc-finger transcription factor that plays a pivotal role in neuroendocrine differentiation, and has been proposed as a promising immunohistochemical marker of neuroendocrine carcinoma...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29325948/spinal-metastasis-resulting-from-atypical-thymic-carcinoid-a-case-report
#6
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#7
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29324470/fibroma-like-pecoma-a-tuberous-sclerosis-complex-related-lesion
#8
Ana B Larque, Richard L Kradin, Ivan Chebib, G Petur Nielsen, Martin K Selig, Elizabeth A Thiele, Anat Stemmer-Rachamimov, Miriam A Bredella, Pawel Kurzawa, Vikram Deshpande
Perivascular epithelioid cell tumor (PEComa), mesenchymal tumors morphologically characterized by epithelioid cells, coexpress melanocytic and muscle markers. Herein, we describe a heretofore-undescribed tuberous sclerosis complex (TSC)-related neoplasm, morphologically resembling a soft tissue fibroma-like lesion, but showing an immunophenotype resembling PEComa. We identified 3 soft tissue fibroma-like lesions in individuals with TSC. We also evaluated 6 TSC-related periungual fibroma as well as a range of non-TSC fibroma-like lesions (n=19)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29322209/infiltrating-angiolipoma-of-the-foot-magnetic-resonance-imaging-features-and-review-of-the-literature
#9
Eui Dong Yeo, Bo Mi Chung, Eun Ju Kim, Wan Tae Kim
Angiolipoma is a benign soft tissue tumor with two subtypes: non-infiltrating and infiltrating. Although histologically benign, infiltrating angiolipoma can invade surrounding structures. The foot is a very rare location for angiolipoma, with only four cases reported in the English literature, including one infiltrating type. Here, we report a very rare case of infiltrating angiolipoma of the foot with magnetic resonance imaging (MRI) and ultrasonography (US) findings. A 7-year-old boy presented with a slowly growing foot mass...
January 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29320751/uterine-rhabdomyosarcoma-in-adults
#10
Andre Pinto, Ryan M Kahn, Andrew E Rosenberg, Brian Slomovitz, Charles Matthew Quick, Michella K Whisman, Marilyn Huang
Rhabdomyosarcoma (RMS) is an aggressive mesenchymal tumor most commonly diagnosed in the pediatric population, and when occurring in adults, tends to develop in the deep soft tissue of the limbs. Primary uterine RMS comprises an even more restricted subset, with little known or reported when compared to most other gynecologic sarcomas. Our goal with this study was to retrospectively evaluate cases from two academic institutions and describe the main histopathologic findings of this rare gynecologic malignancy...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29320333/prostate-specific-membrane-antigen-pet-clinical-utility-in-prostate-cancer-normal-patterns-pearls-and-pitfalls
#11
Michael S Hofman, Rodney J Hicks, Tobias Maurer, Matthias Eiber
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is overexpressed in prostate cancer. Radiolabeled small molecules that bind with high affinity to its active extracellular center have emerged as a potential new diagnostic standard of reference for prostate cancer, resulting in images with extraordinary tumor-to-background contrast. Currently, gallium 68 (68Ga)-PSMA-11 (or HBED-PSMA) is the most widely used radiotracer for PSMA positron emission tomography (PET)/computed tomography (CT) or PSMA PET/magnetic resonance (MR) imaging...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29318761/suitability-of-the-cellienttm-cell-block-method-for-diagnosing-soft-tissue-and-bone-tumors
#12
W Song, B M van Hemel, A J H Suurmeijer
BACKGROUND: The diagnosis of tumors of soft tissue and bone (STB) heavily relies on histological biopsies, whereas cytology is not widely used. CellientTM cell blocks often contain small tissue fragments. In addition to Hematoxylin and Eosin (H&E) interpretation of histological features, immunohistochemistry (IHC) can be applied after optimization of protocols. The objective of this retrospective study was to see whether this cytological technique allowed us to make a precise diagnosis of STB tumors...
January 10, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29318350/-benign-mesenchymal-tumors-of-the-abdomen
#13
REVIEW
P A Kupczyk, G M Kukuk
BACKGROUND: Benign mesenchymal tumors of the abdomen are-except for hemangiomas-rare neoplasms that are associated with potentially life-threatening complications. Thus, awareness of the most important entities and knowledge of their imaging characteristics is fundamental for the radiologist. OBJECTIVES: An overview of the most frequent benign abdominal soft tissue tumors and their common imaging features is given. Furthermore, other facts concerning the individual entities that are relevant to radiologic practice are outlined...
January 9, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29315173/factors-associated-with-acute-and-chronic-wound-complications-in-patients-with-soft-tissue-sarcoma-with-long-term-follow-up
#14
Naveen Karthik, Matthew C Ward, Aditya Juloori, Jacob Scott, Nathan Mesko, Chirag Shah
OBJECTIVES: To identify the rates of acute and chronic wound complications and factors associated in a cohort of patients treated for soft tissue sarcoma (STS) with modern radiotherapy (RT) and surgical techniques. MATERIALS AND METHODS: An Institutional Review Board-approved database was used to identify all adult nonmetastatic patients treated for STS at a single institution between 2006 and 2015 with a minimum follow-up of 1 year. Factors associated with acute and chronic wound complications were analyzed using binomial logistic regression including interaction terms...
January 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29314300/low-grade-fibromyxoid-sarcoma-arising-within-the-median-nerve
#15
Amy A Swanson, Caterina Giannini, Andrew L Folpe, Daniel L Van Dyke, Kimberly K Amrami, William A Michalak, Rachael A Vaubel
We report a case of low-grade fibromyxoid sarcoma arising within the median nerve. A 31-year-old woman presented with symptoms of carpal tunnel syndrome and an enlarging mass in her right palm over 1 year. MRI demonstrated a mass associated with the right median nerve with solid and cystic components. At surgery, the mass was located within the epineurium, could be bluntly dissected from the nerve fascicles, and was suspected to be a schwannoma. A 3.4 cm, tan-pink, glistening, smooth, homogenous mass was submitted to pathology...
January 3, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29313104/-imaging-and-biopsy-of-soft-tissue-tumors
#16
L Fenzl, K Bubel, M Mehrmann, G Schneider
Soft tissue tumors represent a special challenge in interdisciplinary cooperation. Malignant tumors require a multimodal therapy concept so that patient treatment in a specialized tumor center is recommended. The task of the surgeon in close cooperation with the radiologist is the resection of the tumor in sano with the required safety margin. The aim of diagnostic imaging is to describe the primary expansion of the tumor size and a possible tumor infiltration of adjacent compartments. The most important diagnostic imaging for this purpose is magnetic resonance imaging (MRI), especially T1-weighted fat-suppressed gadolinium-enhanced sequences...
January 8, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29313091/intradural-cervical-chordoma-with-diffuse-spinal-leptomeningeal-spread-case-report-and-review-of-the-literature
#17
Jing Zhang, Chuan-Ping Gao, Xue-Jun Liu, Wen-Jian Xu
PURPOSE: Chordoma is a low-grade malignant bone tumor derived from embryonic notochord remnants along the axial skeleton. About 50% of chordomas occur in the sacral vertebrae and 35% in the skull base. Most chordomas are extradural and cause extensive bone destruction. Intradural spinal tumors without bone involvement are rare. METHODS: We herein describe the clinical features of a patient with a chordoma as well as the imaging and pathological manifestations of the tumor...
January 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29310457/pediatric-ganglion-cysts-a-retrospective-review
#18
Joseph Meyerson, Yangshu L Pan, Maya Spaeth, Gregory Pearson
BACKGROUND: Ganglion cysts are the most common type of soft tissue tumors of the hand. In the pediatric population, monitoring may be appropriate unless cysts are painful, interfering with range of motion or parental concerns exist. Reported recurrence rates after surgical removal of pediatric ganglion cysts vary widely in the literature. Notably, recurrence rates are higher for children than adults, ranging from as low as 6% to as high as 35%. METHODS: A retrospective review was performed of a single pediatric hand surgeon's patients undergoing excision of primary and recurrent ganglion cysts from 2010 to 2015...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29310397/massive-rare-desmoplastic-fibroma-of-the-ilium-and-ischium-in-a-young-adult-a-case-report
#19
Xin-Nan Ma, Shuai Qiang, Tian-Yi Liu, Mei-Yu Cao, Song-Cen Lv
RATIONALE: Desmoplastic fibroma (DF) is a rare, locally invasive but benign bone tumor. It represents one of the rarest bone diseases, with an incidence of only 0.11% of all primary bone tumors. PATIENT CONCERNS: Herein, a case of massive and unusual DF, with simultaneous involvement of ilium and ischium, is described. A 29-year-old man suffered minor pain in his right hip for 2 years. It worsened after sudden movements, which prevented him from walking normally...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305965/pediatric-granular-cell-tumors-of-the-vulva-a-report-of-four-cases-and-a-review-of-the-literature
#20
Beryl L Manning-Geist, Antonio R Perez-Atayde, Marc R Laufer
BACKGROUND: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. While malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multi-site development. CASES: Four cases of pediatric vulvar GCT are presented, including one atypical and three benign tumors. The atypical lesion occurred in a 3-year-old girl, the youngest reported patient with GCT of the vulva...
January 3, 2018: Journal of Pediatric and Adolescent Gynecology
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