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https://www.readbyqxmd.com/read/27912995/rehabilitation-strategies-and-outcomes-of-the-sarcoma-patient
#1
REVIEW
Sean Robinson Smith
Sarcomas are a relatively rare cancer that, depending on the location, can cause significant neuromusculoskeletal dysfunction and require rehabilitation interventions to reduce pain, restore function, and improve quality of life. This review focuses on sarcoma subtypes that frequently cause these complications: bony and soft tissue sarcomas leading to limb salvage or amputation, desmoid tumors, and malignant peripheral nerve sheath tumors. Rehabilitation approaches and outcomes are discussed, as well as considerations for childhood sarcoma survivors transitioning to adulthood...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27912929/survival-failure-modes-and-function-of-combined-distal-femur-and-proximal-tibia-reconstruction-following-tumor-resection
#2
F Sevelda, W Waldstein, J Panotopoulos, C Stihsen, A Kaider, P T Funovics, R Windhager
BACKGROUND: Tumor spread to the knee joint or skip metastasis to the adjacent bones of the knee require reconstruction with combined distal femur and proximal tibia replacements. The literature on implant survival and failure modes with this type of reconstruction is sparse. The goals of this study were to determine the implant survival, the different failure modes and the functional outcome of this megaendoprosthetic reconstruction. PATIENTS AND METHODS: Thirty-nine patients with combined distal femur and proximal tibia reconstruction were retrospectively reviewed...
November 23, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27912846/new-insights-and-evolving-role-of-pegylated-liposomal-doxorubicin-in-cancer-therapy
#3
REVIEW
Alberto A Gabizon, Yogita Patil, Ninh M La-Beck
We herein review various pharmacological and clinical aspects of pegylated liposomal doxorubicin (PLD), the first nanomedicine to be approved for cancer therapy, and discuss the gap between its potent antitumor activity in preclinical studies and its comparatively modest achievements in clinical studies and limited use in clinical practice. PLD is a complex formulation of doxorubicin based on pharmaceutical nanotechnology with unique pharmacokinetic and pharmacodynamic properties. Its long circulation time with stable retention of the payload and its accumulation in tumors with high vascular permeability both result in important advantages over conventional chemotherapy...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27909467/invasive-squamous-cell-carcinoma-of-the-scalp-and-calvarium-a-multidisciplinary-approach
#4
Jennifer Stark, Silvio Podda, Karen Szymanski
Objective: The correlation between immunosuppression-associated skin cancer and lymphoma has been well established. This includes squamous cell carcinoma and chronic lymphocytic leukemia. When a lesion requires excision, reconstruction can be challenging based on the depth and size of the tumor. We present a patient with chronic lymphocytic leukemia and invasive squamous cell carcinoma of the scalp that extended through the calvarium to the dura mater. His tumors were badly neglected for a long period of time and presented at an advanced stage...
2016: Eplasty
https://www.readbyqxmd.com/read/27908187/dosimetric-characterization-of-mri-only-treatment-planning-for-brain-tumors-in-atlas-based-pseudo-ct-images-generated-from-standard-t1-weighted-mr-images
#5
Benjamin Demol, Christine Boydev, Juha Korhonen, Nick Reynaert
PURPOSE: Magnetic resonance imaging (MRI)-only radiotherapy treatment planning requires accurate pseudo-CT (pCT) images for precise dose calculation. The current work introduced an atlas-based method combined with MR intensity information. pCT analyses and Monte Carlo dose calculations for intracranial stereotactic treatments were performed. METHODS: Twenty-two patients, representing 35 tumor targets, were scanned using a 3D T1-weighted MRI sequence according to the clinical protocol...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908157/volumetry-of-low-contrast-liver-lesions-with-ct-investigation-of-estimation-uncertainties-in-a-phantom-study
#6
Qin Li, Yongguang Liang, Qiao Huang, Min Zong, Benjamin Berman, Marios A Gavrielides, Lawrence H Schwartz, Binsheng Zhao, Nicholas Petrick
PURPOSE: To evaluate the performance of lesion volumetry in hepatic CT as a function of various imaging acquisition parameters. METHODS: An anthropomorphic abdominal phantom with removable liver inserts was designed for this study. Two liver inserts, each containing 19 synthetic lesions with varying diameter (6-40 mm), shape, contrast (10-65 HU), and both homogenous and mixed-density were designed to have background and lesion CT values corresponding to arterial and portal-venous phase imaging, respectively...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27906470/retrospective-evaluation-of-whole-body-computed-tomography-for-tumor-staging-in-dogs-with-primary-appendicular-osteosarcoma
#7
Jessica L Talbott, Sarah E Boston, Rowan J Milner, Amandine Lejeune, Carlos H de M Souza, Kelvin Kow, Nicholas J Bacon, Jorge A Hernandez
OBJECTIVE: To evaluate whole body computed tomography (CT) for staging canine appendicular osteosarcoma. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs diagnosed with appendicular osteosarcoma (n=39). METHODS: Medical records for client-owned dogs diagnosed with appendicular osteosarcoma from August 2008 to July 2014 were reviewed. Dogs were included if they had a confirmed diagnosis of appendicular osteosarcoma and were staged using whole body CT...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27905671/long-term-survivors-of-childhood-bone-and-soft-tissue-sarcomas-are-at-risk-of-hospitalization
#8
Cristian D Gonzalez, R Lor Randall, Jennifer Wright, Holly Spraker-Perlman, Jian Ying, Carol Sweeney, Ken R Smith, Anne C Kirchhoff
BACKGROUND: Childhood cancer survivors can have a high burden of chronic conditions related to cancer treatment, some of which are debilitating or potentially life-threatening. Much remains to be learned about late effects in bone and soft tissue sarcoma survivors. PROCEDURES: The Utah Cancer Registry was used to identify survivors of bone (N = 71) and soft tissue sarcomas (N = 98) who were diagnosed at ages 0-20 years between 1973 and 2007 and were alive at least 5 years after diagnosis...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27905051/seom-clinical-guideline-of-management-of-soft-tissue-sarcoma-2016
#9
A López-Pousa, J Martin Broto, J Martinez Trufero, I Sevilla, C Valverde, R Alvarez, J A Carrasco Alvarez, J Cruz Jurado, N Hindi, X Garcia Del Muro
Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease...
November 29, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27904207/primary-cutaneous-synovial-sarcoma-an-extremely-rare-report-of-superficial-synovial-sarcoma
#10
Nastaran Namazi, Morteza Ghassemipour, Azadeh Rakhshan, Ata Abbasi
Synovial sarcoma is a type of malignancy which usually occurs near the joints of the arm, neck, or leg. It is a sarcoma of soft tissue and accounts for 5-10% of all adult soft tissue sarcomas in the world. We present a case with primary superficial cutaneous synovial sarcoma without involvement of the underlying knee joint. It is a very rare condition, and to the best of our knowledge, it is the second report of this topic. Although it is rare among soft tissue tumors, the dermatologists should have precise attention to this skin tumor, as early diagnosis is associated with lower metastatic rate and therefore better prognosis...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27904013/clinical-benefit-of-eribulin-halaven-%C3%A2-in-the-treatment-of-advanced-soft-tissue-sarcoma-patients-and-the-novel-anti-tumor-mechanisms
#11
Noriyuki Koyama, Shigeru Taniguchi, Kotaro Kodama, Osamu Tohyama, Hiroki Hasegawa, Taro Semba
No abstract text is available yet for this article.
2016: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/27902593/angiosarcoma-in-the-chest-radiologic-pathologic-correlation-case-report
#12
Sara Piciucchi, Alessandra Dubini, Sara Tomassetti, Stefano Sanna, Claudia Ravaglia, Angelo Carloni, Christian Gurioli, Carlo Gurioli, Thomas V Colby, Venerino Poletti
RATIONALE: Angiosarcomas are rare, malignant vascular tumors. PATIENT CONCERNS: They represents about 2% of all soft tissue sarcoma, which can often metastasize through the hematogenous route. The radiological features have been analyzed in 4 patients with metastatic angiosarcoma in the chest. DIAGNOSES: The main radiologic findings included nodules, cysts, nodules with halo sign, and vascular tree-in-bud. Morphologic features, as observed in the histologic specimen, have been correlated with radiologic appearance...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27900663/mir-152-down-regulation-is-associated-with-met-up-regulation-in-leiomyosarcoma-and-undifferentiated-pleomorphic-sarcoma
#13
Laura Pazzaglia, Chiara Novello, Amalia Conti, Serena Pollino, Piero Picci, Maria Serena Benassi
PURPOSE: Highly aggressive adult soft tissue sarcomas (STS), i.e., leiomyosarcomas (LMS) and undifferentiated pleomorphic sarcomas (UPS), present complex genomic anomalies and overall 5-year survival rates of 20 to 40%. Here, we aimed to identify new biomarkers that may be employed to improve the treatment of non-translocation STS patients. We validated 12 miRNAs implicated in tumor development using primary STS samples and selected miR-152 for further analysis in STS-derived cell lines...
November 29, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27900363/integration-of-genomics-and-histology-revises-diagnosis-and-enables-effective-therapy-of-refractory-cancer-of-unknown-primary-with-pdl1-amplification
#14
Stefan Gröschel, Martin Bommer, Barbara Hutter, Jan Budczies, David Bonekamp, Christoph Heining, Peter Horak, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Christina Geörg, Daniela Richter, Nicole Pfarr, Katrin Pfütze, Stephan Wolf, Peter Schirmacher, Dirk Jäger, Christof von Kalle, Benedikt Brors, Hanno Glimm, Wilko Weichert, Albrecht Stenzinger, Stefan Fröhling
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage malignancy initially mimicking poorly differentiated soft-tissue sarcoma that did not respond to multiagent chemotherapy...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27900101/neoplastic-fever-in-patients-with-bone-and-soft-tissue-sarcoma
#15
Tomoki Nakamura, Akihiko Matsumine, Takao Matsubara, Kunihiro Asanuma, Akihiro Sudo
The development of fever is a common complication in the clinical course of cancer. If all other potential causes of fever are excluded, the possibility of neoplastic fever should be considered. The aim of the present study was to determine the incidence of neoplastic fever in patients with bone and soft tissue sarcomas. Between January 2009 and December 2014, 195 patients with bone and soft tissue sarcoma (111 men and 84 women; mean age, 55 years) were admitted to the Department of Orthopaedic Surgery of Mie University Graduate School of Medicine (Tsu, Japan)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27900091/fibular-juxta-articular-ganglion-a-rare-case-report-and-literature-review
#16
Xiaobo Yan, Zhengliang Zhang, Nong Lin, Tao Xie, Zhaoming Ye
This is the case report of a 65-year-old man who experienced left calf pain after spraining his left ankle. On magnetic resonance imaging (MRI), a well-defined fluid collection was identified, with low intensity on T1-weighted images and very high intensity on T2-weighted images. On certain slices, a soft tissue mass in the proximal fibula was identified. Following resection of the fibular lesion, histological examination confirmed a benign tumor with cystic elements, described in the current pathology and radiology literature as juxta-articular myxoma...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27900036/management-of-pediatric-head-and-neck-rhabdomyosarcoma-a-case-series-of-36-patients
#17
Joanna Radzikowska, Wojciech Kukwa, Andrzej Kukwa, Anna M Czarnecka, Maciej Kawecki, Fei Lian, Cezary Szczylik, Antoni Krzeski
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric population. In 35% of cases, RMS develops in the head and neck (H&N) region, and only combined therapy is recognized as a curative treatment. However, recent advances in skull base and reconstructive surgery, along with microsurgery and endoscopic surgery, have strengthened the role of surgery as an important part of RMS treatment. In the present study, 36 pediatric RMS cases (24 males and 12 females) were analyzed after surgical treatment...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898357/catastrophic-metallosis-after-tumoral-knee-prosthesis-failure-a-case-report
#18
Luca La Verde, Domenico Fenga, Maria Silvia Spinelli, Francesco Rosario Campo, Michela Florio, Michele Attilio Rosa
INTRODUCTION: Metallosis is a condition characterized by an infiltration of periprosthetic soft tissues and bone by metallic debris resulting from wear or failure of joint arthroplasties. PRESENTATION OF CASE: Authors describe a case of a 45-year-old man treated for an osteosarcoma of the distal femur with a modular prosthesis when he was 18 years old, he developed massive metallosis with skin dyspigmentation after 17 years. His medical\surgical history was remarkable for a left tumoral knee prosthesis implanted 21 years ago...
November 18, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27896676/what-is-the-incidence-of-suicide-in-patients-with-bone-and-soft-tissue-cancer-suicide-and-sarcoma
#19
Brianna L Siracuse, George Gorgy, Jeremy Ruskin, Kathleen S Beebe
BACKGROUND: Patients with cancer in the United States are estimated to have a suicide incidence that is approximately twice that of the general population. Patients with bone and soft tissue cancer often have physical impairments and activity limitations develop that reduce their quality of life, which may put them at high risk for depression, anxiety, and suicidal ideation. To our knowledge, there have been no large studies determining incidence of suicide among patients with bone and soft tissue cancer; this information might allow screening of certain high-risk groups...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27895862/cutaneous-angiosarcoma-metastatic-to-small-bowel-with-nodal-involvement
#20
Vidya A Fleetwood, Jamie C Harris, Minh B Luu
A 77-year-old male with a history of metastatic scalp angiosarcoma presented with intractable gastrointestinal bleeding from a jejunal mass detected on capsule endoscopy. He underwent laparoscopic-assisted resection of the mass. Intraoperatively, an isolated small bowel mass with bulky lymphadenopathy was seen and resected en bloc. Pathology showed a 6.8cm high-grade metastatic angiosarcoma with nodal involvement and negative margins. Angiosarcoma is a sarcoma with a grim prognosis. The incidence is 2% of all soft tissue sarcomas; cutaneous lesions comprise 27% of manifestations and usually appear on head and neck...
2016: Gastroenterology and Hepatology From Bed to Bench
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