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https://www.readbyqxmd.com/read/28929639/surgical-approach-selection-for-total-spondylectomy-for-the-treatment-of-giant-cell-tumors-in-the-lumbar-spine-a-retrospective-analysis-of-12-patients-from-a-single-center
#1
Hua Zhou, Liang Jiang, Feng Wei, Miao Yu, Feng-Liang Wu, Xiao-Guang Liu, Zhong-Jun Liu
AIM: To describe the selection of the surgical approach used for total spondylectomy in the treatment of giant cell tumors of the lumbar spine. METHODS: This retrospective study included 12 patients with giant cell tumors of the lumbar spine who underwent total spondylectomy. The effect of the Weinstein-Boriani-Biagini surgical staging and tumor location on the approach selected was evaluated. RESULTS: Two tumors were treated using the posterior approach: one located in L1, extending into layers A∼D and involving sectors 2∼6, and the other located in L4, extending into layers B∼D and involving sectors 4∼11...
September 20, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28928879/-18-f-fdg-pet-ct-as-an-indicator-of-survival-in-ewing-sarcoma-of-bone
#2
Usama Salem, Behrang Amini, Hubert H Chuang, Najat C Daw, Wei Wei, Tamara Miner Haygood, John E Madewell, Colleen M Costelloe
Objective: The existing literature of 18 F-FDG PET/CT in Ewing sarcoma investigates mixed populations of patients with both soft tissue and bone primary tumors. The aim of our study was to evaluate whether the maximum standardized uptake value (SUVmax) obtained with 18F-FDG PET/CT before and after induction chemotherapy can be used as an indicator of survival in patients with Ewing sarcoma originating exclusively in the skeleton. Materials and Methods: A retrospective database search from 2004-2011 identified 28 patients who underwent 18 F-FDG PET/CT before (SUV1, n= 28) and after (SUV2, n=23) induction chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927153/clinicoradiological-characteristics-management-and-prognosis-of-primary-myeloid-sarcoma-of-the-central-nervous-system-a-report-of-four-cases
#3
Bao Yang, Chenlong Yang, Jingyi Fang, Jun Yang, Yulun Xu
Myeloid sarcoma (MS) is a localized tumor composed of premature precursors of granulocytic cells, which may occur in any organ and most commonly involves the soft tissue and musculoskeletal system. This malignancy may occur in the presence or absence of hematological disorders. Primary MS involving the central nervous system (CNS-MS) is rare, and has only been described in a small number of isolated case reports. The diagnosis of CNS-MS is challenging and strategies for its management are undefined. The present study describes 4 cases of CNS-MS...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927090/downregulation-of-pdcd4-by-mir-21-suppresses-tumor-transformation-and-proliferation-in-a-nude-mouse-renal-cancer-model
#4
Haixin Yuan, Shiyong Xin, Yaoping Huang, Yingfan Bao, Hao Jiang, Liqing Zhou, Xiaoqiang Ren, Liang Li, Qian Wang, Jianguo Zhang
Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 in a nude mouse renal cancer model. A total of 24 BALB/c male nude mice were randomly assigned into the following three groups: Negative control (NC; n=8), miR-21 inhibitor (n=8) and miR-21 mimic (n=8)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926683/salvage-rates-and-prognostic-factors-after-relapse-in-children-and-adolescents-with-malignant-peripheral-nerve-sheath-tumors
#5
Luca Bergamaschi, Gianni Bisogno, Carla Manzitti, Paolo D'Angelo, Giuseppe Maria Milano, Angela Scagnellato, Mirko Cappelletti, Stefano Chiaravalli, Patrizia Dall'Igna, Rita Alaggio, Antonio Ruggiero, Martina Di Martino, Maria Carmen Affinita, Marta Pierobon, Alberto Garaventa, Michela Casanova, Andrea Ferrari
BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients. MATERIALS AND METHODS: This study considered 73 patients <21 years of age with relapsing MPNST observed among 120 patients enrolled in Italian pediatric protocols from 1979 to 2004. With the aim of possibly establishing a risk-adapted stratification, patients' outcome was examined using univariate and multivariate analysis based on clinical features at onset, first-line treatments, clinical findings at the time of first relapse, and second-line treatments...
September 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28923841/a-novel-notch-yap-circuit-drives-stemness-and-tumorigenesis-in-embryonal-rhabdomyosarcoma
#6
Katherine K Slemmons, Lisa E S Crose, Stefan Riedel, Manuela Sushnitha, Brian C Belyea, Corinne M Linardic
Rhabdomyosarcoma (RMS), a cancer characterized by skeletal muscle features, is the most common soft tissue sarcoma of childhood. While low and intermediate-risk groups have seen improved outcomes, high-risk patients still face a 5-year survival of <30%, a statistic that has not changed in over 40 years. Understanding the biologic underpinnings of RMS is critical. The developmental pathways of Notch and YAP have been identified as potent but independent oncogenic signals that support the embryonal variant of RMS (eRMS)...
September 18, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28922244/fibular-graft-effective-panorama-for-prosthetic-rehabilitation-of-resected-mandible
#7
Pankaj Kharade, Saidul Islam, Mahesh Verma, Swati Sharma, Ranjeet Bodh
Surgical management of extensive tumors in the mandibular region leads to massive disfigurement of the face. Also the prosthetic outcome of such patients rehabilitated with free soft tissue flaps is very poor. Reconstruction of extensive defects to overcome the disfigurement is a challenging procedure and can be achieved with free fibula flap. Free fibula graft provides sufficient length of bone for the reconstruction of the postsurgical defects. Excellent vascularity of fibula flap allows for easy uptake of the graft and osseointegration of the dental implants...
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28921170/comparison-of-novel-multi-level-otsu-mo-pet-and-conventional-pet-segmentation-methods-for-measuring-fdg-metabolic-tumor-volume-in-patients-with-soft-tissue-sarcoma
#8
Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan, Steve Y Cho
BACKGROUND: We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conventional PET segmentation methods for measuring (18)F-FDG (FDG) PET metabolic tumor volume (MTV) in patients with soft tissue sarcoma (STS). Clinical and imaging data were obtained from the Cancer Imaging Archive. Forty-eight STS patients with FDG PET/CT and MR prior to therapy were analyzed...
September 18, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28919293/correlation-between-histological-and-ultrasonographic-findings-of-soft-tissue-tumors-to-verify-the-possibility-of-cell-like-resolution-in-ultrasonography
#9
Ching-Lan Wu, Yi-Chen Lai, Hsin-Kai Wang, Paul Chih-Hsueh Chen, Hong-Jen Chiou
BACKGROUND: The purpose of this study is to test the possibility of obtained cell-like resolution in soft tissue tumors on the basis of ultrasound echotexture. METHODS: This is a prospective study consisting of 57 patients (29 females and 28 males, age range: 9-83 years, average age: 44.5 years) with palpable soft tissue mass, referred from the Departments of Orthopedics and Oncology for ultrasound (US)-guided biopsy. The study was approved by the institutional review board (IRB) of our hospital...
September 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#10
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28910916/-primary-tracheal-malignant-glomus-tumor-with-lung-metastasis-diagnosed-by-pathological-analysis-a-case-report-and-literature-review
#11
B Huang, F G Chen, J Zhuang, W C Zheng, W Y Zhu, Q C Zhang, S H Wang, C M Guo, C M Xie
Objective: To study the clinical manifestations, pathological features, diagnosis, differential diagnosis, treatment and prognosis of primary tracheobronchial or pulmonary malignant glomus tumor (MGT). Methods: A case of primary tracheal MGT with lung metastasis diagnosed by pathological analysis admitted to Affiliated Shantou Hospital of Sun Yat-sen University in May. 2015 was analyzed, and the related literatures were reviewed. We searched databases including PubMed, Embase, Ovid, Cochrane, Wanfang and Chinese National Knowledge infrastructure (CNKI), using the keyword "tracheal or bronchial or pulmonary malignant glomus tumor" from Jan...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28906125/imaging-of-rare-appendicular-non-acral-soft-tissue-chondromas-in-adults-with-histopathologic-correlation
#12
Mohamed Ragab Nouh, Hanan Abd El-Aziz Amr, Rola H Ali
Background Soft-tissue chondroma (STC) is a rare benign soft tissue tumor that arises primarily in acral extra-skeletal locations. Occasionally, STCs may arise in more proximal non-acral locations, accompanied by non-classic features that label them as indeterminate lesions and pose diagnostic challenge for both radiologists and pathologists alike. Purpose To explicate the potential of diagnostic imaging in the identification and characterization of appendicular non-acral STCs with emphasis on their morphologic magnetic resonance imaging (MRI) enhancement...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28905843/orbital-dermatofibrosarcoma-protuberans-with-frontal-and-ethmoid-sinus-involvement-a-case-report-and-brief-review-of-literature
#13
Deepti Sharma, Garima Singh, Neha Kakkar, Vidya Jha
Dermatofibrosarcoma protuberans is a soft tissue sarcoma that is dermal in origin. The incidence is <0.1% of all malignancies and 1% of soft tissue sarcoma. Most commonly, it involves trunk (62%) followed by extremities (25%) and head and neck (13%). It is a slow growing tumor with locally aggressive behavior. Here, a 50-year-old female diagnosed with orbital dermatofibrosarcoma developed extra-axial component in right frontal region even on chemotherapy. Hence, the bad prognostic factors are yet to be established in dermatofibrosarcoma protuberans...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28904301/a-case-of-gastric-lipoma-resected-by-endoscopic-submucosa-dissection-with-difficulty-in-preoperative-diagnosis
#14
Mizue Ichinose, Takuto Hikichi, Yukiko Kanno, Naohiko Gunji, Masashi Fujita, Masahito Kuroda, Kumiko Terashima, Yoshinori Sato, Satoshi Kawana, Yuko Hashimoto, Hiromasa Ohira, Masayuki Miyata
A 66-year-old man was referred to our hospital with an increasing subepithelial lesion in the gastric antrum. Using esophagogastroduodenoscopy, a tumor with a steep, 20-mm-high rise protruding in the lumen was observed. The mucosal surface of the tumor was reddish, with ulcers forming at the base. Moreover, the tumor was mobile and soft. A biopsy specimen was taken from the ulcer, but tumor tissue was not collected from the submucosa. Endoscopic ultrasonography (EUS) showed a high echoic mass in the submucosa...
September 14, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28904276/a-case-of-acromegaly-in-which-a-pituitary-gland-tumor-was-reduced-significantly-by-administering-octreotide-long-acting-release-lar-and-could-be-removed-surgically
#15
Tadashi Arao, Yosuke Okada, Fumi Uemura, Shigeru Nishizawa, Yoshiya Tanaka
A 54-year-old woman was admitted to our hospital for detailed examination of acromegaly because she noticed bilateral hand and finger swelling at the age of 43 and plantar thickening, facial changes and unclear articulation at the age of 49. She had prominent brow ridges, mandibular protrusion, and enlargement of the hands, feet, nasal wings, lips and tongue. Her growth hormone (GH) level was 39.8 ng/ml, insulin-like growth factor-1 (IGF-1) level was 717 ng/ml, GH level was not suppressed (22.9 ng/ml) during a 75-g oral glucose tolerance test (OGTT)...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28903344/establishing-a-patient-derived-xenograft-model-of-human-myxoid-and-round-cell-liposarcoma
#16
Yiming Qi, Yu Hu, Hua Yang, Rongyuan Zhuang, Yingyong Hou, Hanxing Tong, Yi Feng, Yuan Huang, Quan Jiang, Qunsheng Ji, Qingyang Gu, Zhixiang Zhang, Xuzhen Tang, Weiqi Lu, Yuhong Zhou
Myxoid and round cell liposarcoma (MRCL) is a common type of soft tissue sarcoma. The lack of patient-derived tumor xenograft models that are highly consistent with human tumors has limited the drug experiments for this disease. Hence, we aimed to develop and validate a patient-derived tumor xenograft model of MRCL. A tumor sample from a patient with MRCL was implanted subcutaneously in an immunodeficient mouse shortly after resection to establish a patient-derived tumor xenograft model. After the tumor grew, it was resected and divided into several pieces for re-implantation and tumor passage...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902468/fine-needle-aspiration-of-lipoblastoma-cytological-molecular-and-clinical-features
#17
Joana Ferreira, Gonçalo Esteves, Ricardo Fonseca, Carmo Martins, Saudade André, Maria Manuel Lemos
BACKGROUND: Lipoblastomas are rare, benign adipocytic tumors that present mostly during infancy. In about 70% of cases, these tumors carry abnormalities in chromosome 8, mainly leading to rearrangements of the PLAG1 gene. METHODS: We report a series of histologically proven lipoblastomas with previous fine-needle aspiration (FNA) cytology from 9 patients (n = 10 samples) and describe their clinical, cytological, and molecular features. RESULTS: Our cohort included 5 boys and 4 girls (median age, 2...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28901729/magnetic-field-dose-effects-on-different-radiation-beam-geometries-for-hypofractionated-partial-breast-irradiation
#18
Anthony Kim, Stephanie Lim-Reinders, Claire McCann, Syed Bilal Ahmad, Arjun Sahgal, Justin Lee, Brian M Keller
PURPOSE: Hypofractionated partial breast irradiation (HPBI) involves treatment to the breast tumor using high doses per fraction. Recent advances in MRI-Linac solutions have potential in being applied to HPBI due to gains in the soft tissue contrast of MRI; however, there are potentially deleterious effects of the magnetic field on the dose distribution. The purpose of this work is to determine the effects of the magnetic field on the dose distribution for HPBI tumors using a tangential beam arrangement (TAN), 5-beam intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT)...
September 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28898987/typical-and-atypical-granular-cell-tumors-of-soft-tissue-a-clinicopathologic-study-of-50-patients
#19
Matthew Stemm, David Suster, Paul E Wakely, Saul Suster
Objectives: Granular cell tumors are rare neoplasms of neural origin. Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. Methods: All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28898423/iterative-volume-of-interest-based-4d-cone-beam-ct
#20
Rachael Martin, Moiz Ahmad, Geoffrey Hugo, Tinsu Pan
PURPOSE: 4D cone-beam CT (CBCT) has potential applications in soft tissue alignment and tumor motion verification at the time of radiation treatment. However, prominent streak artifacts with conventional image reconstructions have limited its clinical use and alternative reconstructions are generally too computationally expensive for the time available. We propose an iterative volume of interest based (I4D VOI) reconstruction technique, where 4D reconstruction is only performed within a VOI, to limit streak artifacts with limited added computation time...
September 12, 2017: Medical Physics
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