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https://www.readbyqxmd.com/read/28929075/why-cannot-we-have-an-etiological-classification-for-the-patients-with-granular-myringitis
#1
Mohan Bansal
Though granular myringitis (GM) is not a very rare disease it does not have any classification. Its exact etiology is not known. The granulations on tympanic membrane also occur in association with other lesions of external auditory canal (EAC) and middle ear. The aims of this study were to know the etiological factors of GM and classify the disease according to its etiological factors and associated disorders of EAC and middle ear. Data were retrieved from the search of four electronic databases: PubMed, EMBASE, Cochrane Library, and Google scholar...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928913/quality-of-life-in-elderly-iranian-population-using-leiden-padua-questionnaire-a-systematic-review-and-meta-analysis
#2
REVIEW
Parvin Cheraghi, Zahra Cheraghi, Amin Doosti-Irani, Sima Nedjat, Saharnaz Nedjat
The world population is getting old rapidly; the aging population is the new phenomenon in Iran too. The aim of this meta-analysis was to estimate the overall and subscales mean score of quality of life (QOL) based on the Leiden-Padua (LEIPAD) questionnaire among the elderly population of Iran. The major international and national databases including; Medlin, Scopus, Science Direct, SID, MagIran, IranMedex, and Irandoc was searched. All cross-sectional studies, which measured the QOL among the elderly population in Iran using the LEIPAD questionnaire, were included...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28927393/the-complete-digital-workflow-in-fixed-prosthodontics-a-systematic-review
#3
Tim Joda, Fernando Zarone, Marco Ferrari
BACKGROUND: The continuous development in dental processing ensures new opportunities in the field of fixed prosthodontics in a complete virtual environment without any physical model situations. The aim was to compare fully digitalized workflows to conventional and/or mixed analog-digital workflows for the treatment with tooth-borne or implant-supported fixed reconstructions. METHODS: A PICO strategy was executed using an electronic (MEDLINE, EMBASE, Google Scholar) plus manual search up to 2016-09-16 focusing on RCTs investigating complete digital workflows in fixed prosthodontics with regard to economics or esthetics or patient-centered outcomes with or without follow-up or survival/success rate analysis as well as complication assessment of at least 1 year under function...
September 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28926879/-systematic-evaluation-on-effectiveness-and-safety-of-recombinant-human-growth-hormone-in-treating-adult-patients-with-severe-burn
#4
F Y Tian, B Wu, T Xu, X H Jiang
Objective: To systcmatically evaluate the effectiveness and safety of recombinant human growth hormone (rhGH) in treating adults with severe burn. Methods: Databases including PubMed, Cochrane Library, and Embase were searched using key words " burns, thermal, human growth hormone, growth hormone, hGH, and somatropin (human)" , and China Biology Medicine disc, Chinese Journals Full-text Database, VIP Database, and Wanfang Database were searched using key words in Chinese version "," to obtain the randomized controlled trials about rhGH in the treatment of adults with severe burn from the establishment of each database to December 2016...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28926282/bacterial-and-archaeal-lipids-recovered-from-subsurface-evaporites-of-dalangtan-playa-on-the-tibetan-plateau-and-their-astrobiological-implications
#5
Ziye Cheng, Long Xiao, Hongmei Wang, Huan Yang, Jingjing Li, Ting Huang, Yi Xu, Nina Ma
Qaidam Basin (Tibetan Plateau) is considered an applicable analogue to Mars with regard to sustained extreme aridity and abundant evaporites. To investigate the possibility of the preservation of microbial lipids under these Mars analog conditions, we conducted a mineralogical and organic geochemistry study on samples collected from two Quaternary sections in Dalangtan Playa, northwestern Qaidam Basin, which will enhance our understanding of the potential preservation of molecular biomarkers on Mars. Two sedimentary units were identified along two profiles: one salt unit characterized by a predominance of gypsum and halite, and one detrital unit with a decrease of gypsum and halite and enrichment in siliciclastic minerals...
September 19, 2017: Astrobiology
https://www.readbyqxmd.com/read/28925860/pharmacologic-and-perioperative-considerations-for-antihypertensive-medications
#6
Sher-Lu Pai, Ryan M Chadha, Joan M Irizarry Alvarado, Johnathan Ross Renew, Stephen Aniskevich
BACKGROUND: As the prevalence of hypertension continues to increase, physicians routinely encounter patients preoperatively receiving one or more cardiovascular medications to manage hypertension. Thus, the physician's knowledge of perioperative antihypertensive medication management is crucial to ensure patient safety. OBJECTIVE: We discuss the decisions to continue or stop antihypertensive medications to reduce the risk of perioperative complications. METHOD: We conducted a review of the original research studies, review articles, and editorials present on PubMed within the past 60 years...
September 18, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#7
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28920443/four-fallacies-and-an-oversight-searching-for-martian-life
#8
J D Rummel, C A Conley
While it is anticipated that future human missions to Mars will increase the amount of biological and organic contamination that might be distributed on that planet, robotic missions continue to grow in capability and complexity, requiring precautions to be taken now to protect Mars, and particularly areas of Mars that might be Special Regions. Such precautionary cleanliness requirements for spacecraft have evolved over the course of the space age, as we have learned more about planetary environments, and are the subject of regular deliberations and decisions sponsored by the Committee on Space Research (COSPAR)...
September 16, 2017: Astrobiology
https://www.readbyqxmd.com/read/28918671/long-term-outcomes-of-severe-combined-immunodeficiency-therapy-implications
#9
Jennifer Heimall, Morton J Cowan
Newborn screening has led to a better understanding of the prevalence of Severe Combined Immunodeficiency (SCID) overall and in terms of specific genotypes. Survival has improved following hematopoietic stem cell transplantation (HCT) with the best outcomes seen following use of a matched sibling donor. However, questions remain regarding the optimal alternative donor source, appropriate use of conditioning and the impact of these decisions on immune reconstitution and other late morbidities. Areas covered: The currently available literature reporting late effects after HCT for SCID and use of alternative therapies including enzyme replacement, alternative donors and gene therapy are reviewed...
September 18, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28915088/abiotic-and-biotic-formation-of-amino-acids-in-the-enceladus-ocean
#10
Elliot L Steel, Alfonso Davila, Christopher P McKay
The active plume at Enceladus' south pole makes the indirect sampling of its global ocean possible. The partially resolved chemistry of the plume, which points to conditions that are seemingly compatible with life, has made orbital sampling missions a priority. We present a conceptual model of energy flux, hydrothermal H2 production, and both abiotic and biotic production of amino acids. Based on the energy flux observed at the south pole and the inferred internal hydrothermal activity, we estimate an H2 production of 0...
September 2017: Astrobiology
https://www.readbyqxmd.com/read/28915087/feasibility-of-detecting-bioorganic-compounds-in-enceladus-plumes-with-the-enceladus-organic-analyzer
#11
Richard A Mathies, Md Enayet Razu, Jungkyu Kim, Amanda M Stockton, Paul Turin, Anna Butterworth
Enceladus presents an excellent opportunity to detect organic molecules that are relevant for habitability as well as bioorganic molecules that provide evidence for extraterrestrial life because Enceladus' plume is composed of material from the subsurface ocean that has a high habitability potential and significant organic content. A primary challenge is to send instruments to Enceladus that can efficiently sample organic molecules in the plume and analyze for the most relevant molecules with the necessary detection limits...
September 2017: Astrobiology
https://www.readbyqxmd.com/read/28914501/andrology-of-male-to-female-transsexuals-influence-of-cross-sex-hormone-therapy-on-testicular-function
#12
REVIEW
F Schneider, S Kliesch, S Schlatt, N Neuhaus
Patients with gender dysphoria are offered cross-sex hormone therapy and sex reassignment surgery to achieve the transition between the sex assigned at birth and gender identity. According to international guidelines, cross-sex hormone therapy in trans-women should lead to a psychologically and physiologically healthy body with feminized serum hormone levels, resulting in suppression of spermatogenesis. However, in a recently published multi-center study, we discovered a high proportion of patients with male serum hormone levels and qualitatively intact spermatogenesis on the day of sex reassignment surgery...
September 2017: Andrology
https://www.readbyqxmd.com/read/28914070/effect-of-the-vaginal-pessaries-melanizol%C3%A2-and-klimedeks%C3%A2-on-the-glycogen-level-in-the-vaginal-tissue-of-rats-on-the-background-of-experimental-vaginitis
#13
Olena V Dolzhykova, Ludmyla M Maloshtan, Rimma F Yeriomenko, Volodymyr A Maloshtan
The experimental studies of the new vaginal pessaries Melanizol® and Klimedeks® have been carried out on the model of experimental vaginitis induced in rats by a mixture of terebenthine oil and dimethyl sulfoxide. The obtained experimental data indicate that the vaginal pessaries Melanizol® and Klimedeks® on the background of experimental vaginitis have a therapeutic effect on the 5th and 8th days of the experiment, significantly surpassing the group of animals of control pathology and placebo in its ability to restore physiological functions and accumulate glycogen by the vaginal epithelium...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914069/the-role-of-a%C3%A2-hospital-pharmacist-in-the-management-of-asthma-in-great-britain
#14
Inka Sembol, Božena Macešková
The role of the pharmacist in the asthma management is well established. However, there is still a considerable number of patients with suboptimal asthma control affecting patients quality of life and resulting in poor outcomes, morbidity and mortality. The aim was to identify patients factors, explore the hospital pharmacists role in the asthma management and identify any areas for improvement in Great Britain. Qualitative data collection was selected. Patients case studies and semi-structured open interviews with the hospital multi-disciplinary team (MDT) were applied...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914068/-the-extent-of-the-burnout-syndrome-among-pharmacists-partial-study
#15
Markéta Saligerová, Jozef Kolář
The paper deals with the possibilities of investigating the susceptibility to burnout syndrome in pharmacists and pharmaceutical assistants working in pharmacies. By using the Maslach Burnout Inventory, between November 2015 and January 2016, 53 healthcare professionals were contacted in 11 pharmacies (Brno, Vyškov). The results of the research show that with an increasing length of practice the average EE factor (emotional exhaustion) increases. The DP (depersonalization) factor does not increase significantly with the increase in the length of practice...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914067/-drugs-and-dosage-forms-as-risk-factors-for-dental-caries
#16
Petra Bořilová Linhartová, Lydie Izakovičová Hollá
Dental caries is a multifactorial disease which, despite a series of preventive measures, remains the most common infectious disease worldwide. Susceptibility or resistance to caries may be a result of the presence of risk or protective factors, genetic predisposition, inappropriate lifestyle associated with education, behavioural and socioeconomic factors. The aim of this review is to highlight the risks associated with the use of some drugs and dosage forms in relation to the formation and development of dental caries...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914066/-herpes-simplex-virus-infection-an-overview-of-the-problem-pharmacologic-therapy-and-dietary-measures
#17
Sherif T S Hassan, Miroslava Šudomová, Radka Masarčíková
Treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. Herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. The worldwide disease burden of HSV is substantial, and acyclovir and related nucleoside analogues (viral DNA polymerase inhibitors) as therapies have led to significantly increased treatment efficacy of HSV infections...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914065/-the-image-of-a%C3%A2-good-pharmacist-in-the-works-of-saladin-di-ascoli-and-valerius-cordus
#18
Anton Bartunek, František Šimon
Separation of pharmacy from medicine induced the requirements formulation for an ideal pharmacist. Two prominent authors did so, Saladin di Ascoli (the first half of the XVth century) in the work Compendium aromatariorum (1488) and Valerius Cordus (1515-1544) in the work Dispensatorium pharmacopolarum (1546). Both of them formulate similar postulates of both professional and ethical nature, namely a knowledge of Latin, good education, experience, good character traits, need of satisfied marriage; both say that the pharmacist is required to be a good Christian, they condemn alcohol, relationships with women, poisons and abortifacients, remember right relationship to money...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914064/-targeted-drug-delivery-system-potential-application-to-resveratrol
#19
Hassan Farghali, Ludmila Kameníková
Drug delivery system (DDS) is intended to increasing effectiveness of drugs through targeted distribution and to reducing of unwanted effects. In this mini-review, the basic principles of nanotechnology that were developed for DDS were reported including sections on the present research in key areas that are important for future investigations. Attention is paid on resveratrol as a model phytochemical with interesting pharmacologic profile which was demonstrated in great numbers of studies and for its wide use as supplemental therapy...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28914063/identifying-the-interprofessional-agreement-between-community-pharmacists%C3%A2-and-general-practitioners%C3%A2-views-on-collaborative-practice-in-slovakia
#20
Ladislav Dubán, Tomáš Fazekaš, Magdaléna Fulmeková, Miroslava Snopková, Anna Oleárová, Magdaléna Kuželová
BACKGROUND: The collaboration of community pharmacists (CPs) and general practitioners (GPs) has a positive effect on healthcare outcomes. There are still many countries, where no efforts have been made to enhance this type of teamwork. There is no evidence of how GPs and CPs collaborate in Slovakia. The objective of this study is to identify the current level of GPs and CPs teamwork in Slovakia and to identify the key factors, where these professions agree. METHODS: Two parallel electronic surveys were prepared and sent out by e-mail to CPs and GPs in Slovakia...
2017: Ceská a Slovenská Farmacie
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