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Human bone scaffold

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https://www.readbyqxmd.com/read/28803478/biomimetic-bone-like-hydroxyapatite-by-mineralization-on-supramolecular-porous-fiber-networks
#1
Bo Li, Lei Kan, Xinyue Zhang, Jie Li, Ruiting Li, Qinyuan Gui, Dengli Qiu, Fei He, Ning Ma, Yapei Wang, Hao Wei
The hydroxyapatite (HA), main inorganic component of bone tissue, is mineralized with collagen fibril scaffolds during bone formation. Inspired by the process, self-assembled porous networks architecture was designed and synthesized by using the 2-ureido-4[1H]-pyrimidone (UPy) modified glycerol molecule UPy-Gly, which was further utilized as a template for biomimetic mineralization. When incubated in simulated body fluid (SBF), the HA nucleus firstly formed in the holes of the template by the induction of hydroxyls on the surface, grew along the nanofibers and fused with the template to fabricate the hydroxyapatite composites (UPy-Gly/HA)...
August 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28803246/biofunctional-ionic-doped-calcium-phosphates-silk-fibroin-composites-for-bone-tissue-engineering-scaffolding
#2
S Pina, R F Canadas, G Jiménez, M Perán, J A Marchal, R L Reis, J M Oliveira
The treatment and regeneration of bone defects caused by traumatism or diseases have not been completely addressed by current therapies. Lately, advanced tools and technologies have been successfully developed for bone tissue regeneration. Functional scaffolding materials such as biopolymers and bioresorbable fillers have gained particular attention, owing to their ability to promote cell adhesion, proliferation, and extracellular matrix production, which promote new bone growth. Here, we present novel biofunctional scaffolds for bone regeneration composed of silk fibroin (SF) and β-tricalcium phosphate (β-TCP) and incorporating Sr, Zn, and Mn, which were successfully developed using salt-leaching followed by a freeze-drying technique...
August 12, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28800464/accelerated-biomineralization-of-graphene-oxide-incorporated-cellulose-acetate-nanofibrous-scaffolds-for-mesenchymal-stem-cell-osteogenesis
#3
Xiaoyun Liu, He Shen, Saijie Song, Wei Chen, Zhijun Zhang
For bone tissue engineering, it requires that the scaffolds have excellent biocompatibility, proper mechanical and osteoinductive properties. Electrospun nanofibers with extracellular matrices mimicking structure have proven to be good scaffolds for bone tissue repairing. Hybrid nanofibers in particular, endow the nanofibers with specific and multiple functionalities, and therefore have attracted increasing interests in the recent years. In this study, we fabricated graphene oxide (GO)-incorporated cellulose acetate (CA) nanofibrous scaffolds by electrospinning technique for enhancement of biomineralization and osteogenic differentiation of human mesenchymal stem cells (hMSCs)...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28777694/a-dual-application-poly-dl-lactic-co-glycolic-acid-plga-chitosan-composite-scaffold-for-potential-use-in-bone-tissue-engineering
#4
Yamina Boukari, Omar Qutachi, David J Scurr, Andrew P Morris, Stephen W Doughty, Nashiru Billa
The development of patient-friendly alternatives to bone-graft procedures is the driving force for new frontiers in bone tissue engineering. Poly (DL-lactic-co-glycolic acid), (PLGA) and chitosan are well-studied and easy-to-process polymers from which scaffolds can be fabricated. In this study, a novel dual-application scaffold system was formulated from porous PLGA and protein-loaded PLGA/chitosan microspheres. Physicochemical and in vitro protein release attributes were established. The therapeutic relevance, cytocompatibility with primary human mesenchymal stem cells (hMSCs) and osteogenic properties were tested...
August 4, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28774494/scaffold-design-for-artificial-tissue-with-bone-marrow-stem-cells
#5
Aurelija Noreikaitė, Ieva Antanavičiūtė, Valeryia Mikalayeva, Adas Darinskas, Tomas Tamulevičius, Erika Adomavičiūtė, Linas Šimatonis, Dalia Akramienė, Edgaras Stankevičius
OBJECTIVE: The aim of this study was to test polymeric materials (collagen, fibrin, polyimide film, and polylactic acid) for single- and multi-layer scaffold formation. MATERIALS AND METHODS: In our study, we used rabbit bone marrow stem cells (rBMSCs) and human mesenchymal stem cells (hMSCs) with materials of a different origin for the formation of an artificial scaffold, such as a collagen scaffold, fibrin scaffold produced from clotted rabbit plasma, electrospun poly(lactic acid) (PLA) mats, polyimide film (PI), and the combination of the latter two...
July 13, 2017: Medicina
https://www.readbyqxmd.com/read/28773000/influence-of-controlled-cooling-in-bimodal-scaffold-fabrication-using-polymers-with-different-melting-temperatures
#6
Hernan Lara-Padilla, Christian Mendoza-Buenrostro, Diego Cardenas, Aida Rodriguez-Garcia, Ciro A Rodriguez
The combination of different materials and capabilities to manufacture at several scales open new possibilities in scaffold design for bone regeneration. This work is focused on bimodal scaffolds that combine polylactic acid (PLA) melt extruded strands with polycaprolactone (PCL) electrospun fibers. This type of bimodal scaffold offers better mechanical properties, compared to the use of PCL for the extruded strands, and provides potential a means for controlled drug and/or growth factor delivery through the electrospun fibers...
June 11, 2017: Materials
https://www.readbyqxmd.com/read/28772425/laser-sintered-magnesium-calcium-silicate-poly-%C3%AE%C2%B5-caprolactone-scaffold-for-bone-tissue-engineering
#7
Kuo-Yang Tsai, Hung-Yang Lin, Yi-Wen Chen, Cheng-Yao Lin, Tuan-Ti Hsu, Chia-Tze Kao
In this study, we manufacture and analyze bioactive magnesium-calcium silicate/poly-ε-caprolactone (Mg-CS/PCL) 3D scaffolds for bone tissue engineering. Mg-CS powder was incorporated into PCL, and we fabricated the 3D scaffolds using laser sintering technology. These scaffolds had high porosity and interconnected-design macropores and structures. As compared to pure PCL scaffolds without an Mg-CS powder, the hydrophilic properties and degradation rate are also improved. For scaffolds with more than 20% Mg-CS content, the specimens become completely covered by a dense bone-like apatite layer after soaking in simulated body fluid for 1 day...
January 13, 2017: Materials
https://www.readbyqxmd.com/read/28769083/human-adipose-derived-mesenchymal-stem-cells-seeded-into-a-collagen-hydroxyapatite-scaffold-promote-bone-augmentation-after-implantation-in-the-mouse
#8
Giovanna Calabrese, Raffaella Giuffrida, Stefano Forte, Claudia Fabbi, Elisa Figallo, Lucia Salvatorelli, Lorenzo Memeo, Rosalba Parenti, Massimo Gulisano, Rosario Gulino
Traumatic injury or surgical excision of diseased bone tissue usually require the reconstruction of large bone defects unable to heal spontaneously, especially in older individuals. This is a big challenge requiring the development of biomaterials mimicking the bone structure and capable of inducing the right commitment of cells seeded within the scaffold. In particular, given their properties and large availability, the human adipose-derived stem cells are considered as the better candidate for autologous cell transplantation...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763610/bone-regeneration-by-means-of-a-three-dimensional-printed-scaffold-in-a-rat-cranial-defect
#9
Doo Yeon Kwon, Ji Hoon Park, So Hee Jang, Joon Yeong Park, Ju Woong Jang, Byoung Hyun Min, Wan-Doo Kim, Hai Bang Lee, Junhee Lee, Moon Suk Kim
Recently, computer-designed three-dimensional (3D) printing techniques have emerged as an active research area with almost unlimited possibilities. In this study, we used a computer-designed 3D scaffold to drive new bone formation in a bone defect. Poly-L-lactide (PLLA) and bioactive β-tricalcium phosphate (TCP) were simply mixed to prepare ink. PLLA+TCP showed good printability from the micronozzle and solidification within few seconds, indicating that it was indeed printable ink for layer-by-layer printing...
August 1, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28758916/effect-of-a-particulate-and-a-putty-like-tricalcium-phosphate-based-bone-grafting-material-on-bone-formation-volume-stability-and-osteogenic-marker-expression-after-bilateral-sinus-floor-augmentation-in-humans
#10
Christine Knabe, Doaa Adel Khattab, Esther Kluk, Rainer Struck, Michael Stiller
This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P...
July 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28747768/controlling-adult-stem-cell-behavior-using-nanodiamond-reinforced-hydrogel-implication-in-bone-regeneration-therapy
#11
Settimio Pacelli, Ryan Maloney, Aparna R Chakravarti, Jonathan Whitlow, Sayantani Basu, Saman Modaresi, Stevin Gehrke, Arghya Paul
Nanodiamonds (NDs) have attracted considerable attention as drug delivery nanocarriers due to their low cytotoxicity and facile surface functionalization. Given these features, NDs have been recently investigated for the fabrication of nanocomposite hydrogels for tissue engineering. Here we report the synthesis of a hydrogel using photocrosslinkable gelatin methacrylamide (GelMA) and NDs as a three-dimensional scaffold for drug delivery and stem cell-guided bone regeneration. We investigated the effect of different concentration of NDs on the physical and mechanical properties of the GelMA hydrogel network...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747099/in-vivo-models-for-the-evaluation-of-the-osteogenic-potency-of-bone-substitutes-seeded-with-mesenchymal-stem-cells-of-human-origin-a-concise-review-special-issue-animal-models-in-tissue-engineering
#12
Fabian Westhauser, Anne-Sophie Senger, Bruno Reible, Arash Moghaddam
Research concerning bone substitutes is one of the most challenging fields in orthopedic research and has a high clinical relevance, especially since the currently available bone substitutes are limited in their osteostimulative capabilities. In-vitro models for the evaluation of the properties of bone substitutes allow the use of human mesenchymal stem cells (hMSC) seeded onto scaffolds, but suffer from the lack of a physiological environment for those cells. Most in-vivo models include the use of non-human MSC and are therefore lacking in clinical relevance...
July 26, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28747097/tissue-engineering-strategies-to-improve-osteogenesis-in-the-juvenile-swine-alveolar-cleft-model
#13
Montserrat Caballero, Donna C Jones, Zhengyuan Shan, Sajjad Soleimani, John A van Aalst
Alveolar <b>(gumline)</b> clefts are the most common congenital bone defect in humans, affecting 1 in 700 live births. Treatment <b>to repair these bony</b> defects relies on autologous, <b>cancellous</b> bone transfer from the iliac crest. This harvest requires a second surgical site <b>with increased </b>surgical time associated with potential complications, <b>while providing only limited cancellous bone</b>. Improvements in treatment protocols that avoid these limitations would be beneficial to patients with clefts and other craniofacial bone defects...
July 26, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28737897/biogenic-hydroxyapatite-a-new-material-for-the-preservation-and-restoration-of-the-built-environment
#14
Ronald Joseph Turner, Joanna C Renshaw, Andrea Hamilton
Ordinary Portland Cement (OPC) is by weight the world's most produced man-made material, and consequently is used in a variety of applications in environments ranging from buildings, to nuclear wasteforms, and within the human body. In this paper, we present for the first time the direct deposition of biogenic hydroxyapatite onto the surface of OPC, in a synergistic process which relies upon the unique properties of the cement substrate. The synthesised hydroxyapatite is very similar to that found in nature; having a crystallite size, iron and carbonate substitution, and a semi-crystalline structure which identify that this biogenic hydroxyapatite is akin to that found in natural bone and tooth enamel...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28735626/differentiation-of-hmsc-and-hpdlsc-induced-by-pge2-or-bmp-7-in-3d-models
#15
Christina Ern, Tamara Berger, Iris Frasheri, Richard Heym, Reinhard Hickel, Matthias Folwaczny
Regenerative therapies of pathogenic tissue defects are gaining increasing importance in periodontology. Among others, the osteogenic effect of BMP-7 seems to play a major role in the development of teeth and alveolar bone. Human periodontal ligament stem cells (hPDLSC), as well as human mesenchymal stem cells (hMSC), show the ability to differentiate into various types of tissues. Regarding prostaglandin E2, many studies have confirmed that it is involved in the inflammation associated to periodontitis stimulating osteoclasts, which ultimately leads to resorption of tooth supporting bone...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28734258/mechanical-properties-and-biocompatibility-of-porous-titanium-scaffolds-for-bone-tissue-engineering
#16
Yunhui Chen, Jessica Ellen Frith, Ali Dehghan-Manshadi, Hooyar Attar, Damon Kent, Nicolas Dominique Mathieu Soro, Michael J Bermingham, Matthew S Dargusch
Synthetic scaffolds are a highly promising new approach to replace both autografts and allografts to repair and remodel damaged bone tissue. Biocompatible porous titanium scaffold was manufactured through a powder metallurgy approach. Magnesium powder was used as space holder material which was compacted with titanium powder and removed during sintering. Evaluation of the porosity and mechanical properties showed a high level of compatibility with human cortical bone. Interconnectivity between pores is higher than 95% for porosity as low as 30%...
July 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28730696/cd34-cells-seeded-in-collagen-scaffolds-promote-bone-formation-in-a-mouse-calvarial-defect-model
#17
Jens Hertweck, Ulrike Ritz, Hermann Götz, Patrick C Schottel, Pol Maria Rommens, Alexander Hofmann
Bone tissue engineering (BTE) holds promise for managing the clinical problem of large bone defects. However, clinical adoption of BTE is limited due to limited vascularization of constructs, which could be circumvented by pre-cultivation of osteogenic and endothelial derived cells in natural-based polymer scaffolds. However, until now not many studies compared the effect of mono- and cocultures pre-seeded in collagen before implantation. We utilized a mouse calvarial defect model and compared five groups of collagen scaffolds: a negative control of a collagen scaffold alone, a positive control treated with BMP-7, monocultures of either human osteoblasts (hOBs) or CD34+ cells, and a coculture of hOB and CD34(+) cells...
July 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28718708/enhanced-bone-repair-induced-by-human-adipose-derived-stem-cells-on-osteogenic-extracellular-matrix-ornamented-small-intestinal-submucosa
#18
Chi Zhang, Mei Li, Jinjin Zhu, Fangmiao Luo, Jiyuan Zhao
AIM: Our aim was to design an osteogenic extracellular matrix (ECM) coated bioscaffold and to apply it to critical bone defect repair with adipose-derived stem cells (ADSCs). MATERIALS & METHODS: Morphology of scaffolds was scanned by scanning electron microscope. Cell adhesion, proliferation and osteogenic differentiation of ADSCs on ECM-small intestinal submucosa (SIS) were evaluated by immunofluorescences staining, cell counting kit-8 and real-time qPCR, respectively...
July 18, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28717129/3d-printed-scaffolds-of-calcium-silicate-doped-%C3%AE-tcp-synergize-with-co-cultured-endothelial-and-stromal-cells-to-promote-vascularization-and-bone-formation
#19
Yuan Deng, Chuan Jiang, Cuidi Li, Tao Li, Mingzheng Peng, Jinwu Wang, Kerong Dai
Synthetic bone scaffolds have potential application in repairing large bone defects, however, inefficient vascularization after implantation remains the major issue of graft failure. Herein, porous β-tricalcium phosphate (β-TCP) scaffolds with calcium silicate (CS) were 3D printed, and pre-seeded with co-cultured human umbilical cord vein endothelial cells (HUVECs) and human bone marrow stromal cells (hBMSCs) to construct tissue engineering scaffolds with accelerated vascularization and better bone formation...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714856/use-of-human-aortic-extracellular-matrix-as-a-scaffold-for-construction-of-patient-specific-tissue-engineered-vascular-patch
#20
Liping Gao, Mingjun Du, Jingjing Lv, Sebastian Schmull, Ritai Huang, Jun Li
Abstract Synthetic or biologic materials are usually used to repair vascular malformation in congenital heart defects; however, non-autologous materials show both mismatch compliance and antigenicity, as well as a lack of recellularization on its surface. Here, we constructed a tissue-engineered vascular patch (TEVP) using decellularized extracellular matrix (ECM) scaffold obtained from excised human aorta during surgery, which was seeded with patient-derived bone marrow CD34-positive (CD34+) progenitor cells...
July 17, 2017: Biomedical Materials
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