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Dimuthu C Senevirathna, Victoria L Blair, Melissa V Werrett, Philip C Andrews
Eight novel bismuth(III) sulfonato compounds have been synthesized and characterized using the sonochemical reaction of Bi2O3 with a range of sulfonic acids, including 2,5-dimethylbenzenesulfonic acid (2,5-DMSH), 2,4-dinitrobenzenesulfonic acid (2,4-DNSH), 2,5-dichlorobenzenesulfonic acid (2,5-DCSH), 1,2-benzenedisulfonic acid (1,2-BDSH2), 1,3-benzenedisulfonic acid (1,3-BDSH2), 2-sulfobenzoic acid (2-SBH2), 3-sulfobenzoic acid (3-SBH2), and 2-naphthalenesulfonic acid (NPSH). Six of the complexes (1, 2, 4, and 6-8) were structurally characterized through single-crystal X-ray crystallography...
October 14, 2016: Inorganic Chemistry
Qingqing Sun, Yanchao Lü, Lingling Liu, Kaiqiang Liu, Rong Miao, Yu Fang
Supramolecular approach plays pivotal role in the construction of smart and functional materials due to the reversible nature of noncovalent interactions. In the present work, two compounds, cholesterol-functionalized calix[4]pyrrole (CCP) and perylene bisimide diacid (PDA), were synthesized. Little fluorescence is observed in the ethanol solution of the mixture of CCP and PDA, while the solution turns fluorescent upon introduction of ammonia, which is attributed to the formation of a supramolecular ensemble, PDA/(CCP)2/NH3...
October 5, 2016: ACS Applied Materials & Interfaces
A Gorski, A Starukhin, S Stavrov, S Gawinkowski, J Waluk
Resonance Raman microscopy was used to study the resonance Raman scattering of the diacid (diprotonated form) of free-base porphyrin (21H,23H-porphine) in a crystal powder and KBr pellets. Intensive lines in the spectral range between 100÷1000cm(-1) have been detected and assigned as spectral manifestation of out-of-plane modes. The Raman spectra were simulated by means of DFT methods and compared with the experimental data. It is evident from experimental and theoretical results that the activation of out-of-plane modes arises from saddle distortion of the porphyrin macrocycle upon formation of its diprotonated form...
September 21, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Guillermo Schmeda-Hirschmann, Cristina Quispe, Gabriel Vargas Arana, Cristina Theoduloz, Félix A Urra, César Cárdenas
Little is known on the composition of Peruvian Amazon toad venoms. The large toad Rhinella marina is common in the cleared tropical forests of the Iquitos region and is regarded as poisonous. The venom from two different populations of R. marina was collected in the Departamento de Loreto, Perú. The samples were assessed for antiproliferative effect and composition. Some 29 compounds were identified or tentatively identified from the venom by spectroscopic and spectrometric means. The main free bufadienolide was marinobufagin 7 while marinobufotoxin 15 and bufalitoxin 9 were the main bufadienolide argininyl diacid derivatives...
October 2016: Toxicon: Official Journal of the International Society on Toxinology
Janeni Natarajan, Queeny Dasgupta, Shreya N Shetty, Kishor Sarkar, Giridhar Madras, Kaushik Chatterjee
Designing biomaterials for bone tissue regeneration that are also capable of eluting drugs is challenging. Poly(ester amide)s are known for their commendable mechanical properties, degradation, and cellular response. In this regard, development of new poly(ester amide)s becomes imperative to improve the quality of lives of people affected by bone disorders. In this framework, a family of novel soybean oil based biodegradable poly(ester amide)s was synthesized based on facile catalyst-free melt-condensation reaction...
September 28, 2016: ACS Applied Materials & Interfaces
Roger Verdaguer, Marçal Soler, Olga Serra, Aïda Garrote, Sandra Fernández, Dolors Company-Arumí, Enriqueta Anticó, Marisa Molinas, Mercè Figueras
Suberin and wax deposited in the cork (phellem) layer of the periderm form the lipophilic barrier that protects mature plant organs. Periderm lipids have been widely studied for their protective function with regards to dehydration and for how they respond to environmental stresses and wounding. However, despite advances in the biosynthetic pathways of suberin and associated wax, little is known about the regulation of their deposition. Here, we report on a potato NAC transcription factor gene, StNAC103, induced in the tuber phellem (skin)...
October 2016: Journal of Experimental Botany
Gregory M Treich, Shamima Nasreen, Arun Mannodi Kanakkithodi, Rui Ma, Mattewos Tefferi, James Flynn, Yang Cao, Rampi Ramprasad, Gregory A Sotzing
Recently, there has been a growing interest in developing wide band gap dielectric materials as the next generation insulators for capacitors, photovoltaic devices, and transistors. Organotin polyesters have shown promise as high dielectric constant, low loss, and high band gap materials. Guided by first-principles calculations from density functional theory (DFT), in line with the emerging codesign concept, the polymer poly(dimethyltin 3,3-dimethylglutarate), p(DMTDMG), was identified as a promising candidate for dielectric applications...
August 24, 2016: ACS Applied Materials & Interfaces
Genyun Tang, Xin Liu, Nan Ma, Xiaojie Huang, Zhen-Long Wu, Wen Zhang, Ying Wang, Bing-Xin Zhao, Zhen-Ya Wang, Fanny C F Ip, Nancy Y Ip, Wen-Cai Ye, Lei Shi, Wei-Min Chen
Neurite outgrowth is crucial during neuronal development and regeneration, and strategies that aim at promoting neuritogenesis are beneficial for reconstructing synaptic connections after neuronal degeneration and injury. Using a bivalent analogue strategy as a successful approach, the current study identifies a series of novel dimeric securinine analogs as potent neurite outgrowth enhancers. Compounds 13, 14, 17-19, 21-23, with different lengths of carbon chain of N,N-dialkyl substituting diacid amide linker between two securinine molecules at C-15 position, exhibited notable positive effects on both neuronal differentiation and neurite extension of neuronal cells...
July 28, 2016: ACS Chemical Neuroscience
Keith Riccardi, Zhenhong Li, Janice A Brown, Matthew F Gorgoglione, Mark Niosi, James Gosset, Kim Huard, Derek M Erion, Li Di
Unbound partition coefficient (Kpuu) is important to an understanding of the asymmetric free drug distribution of a compound between cells and medium in vitro, as well as between tissue and plasma in vivo, especially for transporter-mediated processes. Kpuu was determined for a set of compounds from the SLC13A family that are inhibitors and substrates of transporters in hepatocytes and transporter-transfected cell lines. Enantioselectivity was observed, with (R)-enantiomers achieving much higher Kpuu (>4) than the (S)-enantiomers (<1) in human hepatocytes and SLC13A5-transfected human embryonic 293 cells...
October 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Dhananjay K Deshmukh, Kimitaka Kawamura, Manas K Deb
The size distributions of aerosols can provide evidences for their sources and formation processes in the atmosphere. Size-segregated aerosols (9-sizes) were collected in urban site (Raipur: 21.2°N and 82.3°E) in central India during winter of 2012-2013. The samples were analyzed for dicarboxylic acids (C2-C12), ω-oxocarboxylic acids (ωC2-ωC9), pyruvic acid and α-dicarbonyls (C2-C3) as well as elemental carbon (EC), organic carbon (OC), water-soluble OC (WSOC) and inorganic ions. Diacids showed a predominance of oxalic acid (C2) followed by succinic and azelaic acid whereas ω-oxoacids exhibited a predominance of glyoxylic acid and glyoxal was more abundant than methylglyoxal in all the sizes...
October 2016: Chemosphere
Ben Hanson, John Hofmann, Melissa A Pasquinelli
Copolyesters are a subset of polymers that have the desirable properties of strength and clarity while retaining chemical resistance, and are thus potential candidates for enhancing the impact resistance of soda-lime glass. Adhesion between the polymer and the glass relates to the impact performance of the system, as well as the longevity of the bond between the polymer and the glass under various conditions. Modifying the types of diols and diacids present in the copolyester provides a method for fine-tuning the physical properties of the polymer...
June 1, 2016: ACS Applied Materials & Interfaces
Davinia Salvachúa, Holly Smith, Peter C St John, Ali Mohagheghi, Darren J Peterson, Brenna A Black, Nancy Dowe, Gregg T Beckham
The production of chemicals alongside fuels will be essential to enhance the feasibility of lignocellulosic biorefineries. Succinic acid (SA), a naturally occurring C4-diacid, is a primary intermediate of the tricarboxylic acid cycle and a promising building block chemical that has received significant industrial attention. Basfia succiniciproducens is a relatively unexplored SA-producing bacterium with advantageous features such as broad substrate utilization, genetic tractability, and facultative anaerobic metabolism...
August 2016: Bioresource Technology
Julius N Korley, Sara Yazdi, Kevin McHugh, James Kirk, James Anderson, David Putnam
The one-step synthesis of a polyester family containing dihydroxyacetone is described along with a quantitative analysis of in vitro/in vivo degradation kinetics and initial biocompatibility. Polyesters were synthesized by combining dihydroxyacetone, which is a diol found in the eukaryotic glucose metabolic pathway, with even-carbon aliphatic diacids (adipic, suberic, sebacic) represented in the long-chain alpha carboxylic acid metabolic pathway, by Schӧtten-Baumann acylation. We show that by using a crystalline monomeric form of dihydroxyacetone, well-defined polyesters can be formed in one step without protection and deprotection strategies...
May 3, 2016: Biomaterials
Min-Chen Liu, Lin Liu, Xia-Rong Wang, Wu-Ping Shuai, Ying Hu, Min Han, Jian-Qing Gao
The diacid metabolite of norcantharidin (DM-NCTD) is clinically effective against hepatocellular carcinoma (HCC), but is limited by its short half-life and high incidence of adverse effects at high doses. We developed a DM-NCTD-loaded, folic acid (FA)-modified, polyethylene glycolated (DM-NCTD/FA-PEG) liposome system to enhance the targeting effect and antitumor potency for HCC at a moderate dose based on our previous study. The DM-NCTD/FA-PEG liposome system produced liposomes with regular spherical morphology, with mean particle size approximately 200 nm, and an encapsulation efficiency >80%...
2016: International Journal of Nanomedicine
Autchara Pangon, Somsak Saesoo, Nattika Saengkrit, Uracha Ruktanonchai, Varol Intasanta
Biomimetic nanofibrous scaffolds derived from natural biopolymers for bone tissue engineering applications require good mechanical and biological performances including biomineralization. The present work proposes the utility of chitin whisker (CTWK) to enhance mechanical properties of chitosan/poly(vinyl alcohol) (CS/PVA) nanofibers and to offer osteoblast cell growth with hydroxyapatite (HA) mineralization. By using diacid as a solvent, electrospun CS/PVA nanofibrous membranes containing CTWK can be easily obtained...
June 25, 2016: Carbohydrate Polymers
Divyavani Gowda, Kimitaka Kawamura, Eri Tachibana
RATIONALE: The identification of hydroxy- and keto-dicarboxylic acids (diacids) in remote marine aerosol samples is important for a better understanding of the composition of organic particulate matter, as this chemical composition is essential for predicting the effects on climate, air quality, and human health. Molecular characterization of these compounds provides insights into sources and formation pathways of organic aerosols. METHODS: The method of chemical derivatization followed by gas chromatography-flame ionization detection (GC-FID), gas chromatography/quadruple mass spectrometry (GC/QMS) and gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) was used to identify hydroxy- and keto-diacids in remote marine aerosols...
April 15, 2016: Rapid Communications in Mass Spectrometry: RCM
Elisabeth Darrouzet, Fanny Graslin, Didier Marcellin, Iulia Tcheremisinova, Charles Marchetti, Lisa Salleron, Philippe Pognonec, Thierry Pourcher
The sodium-iodide symporter (NIS) is an integral membrane protein that plays a crucial role in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its intracellular sorting and distribution have a tremendous effect on its function, and constitute an important aspect of its regulation. Many short sequences have been shown to contribute to protein trafficking along the sorting or endocytic pathways. Using bioinformatics tools, we identified such potential sites on human NIS [tyrosine-based motifs, SH2-(Src homology 2), SH3- and PDZ (post-synaptic density-95/discs large tumour suppressor/zonula occludens-1)-binding motifs, and diacidic, dibasic and dileucine motifs] and analysed their roles using mutagenesis...
April 1, 2016: Biochemical Journal
Queeny Dasgupta, Kaushik Chatterjee, Giridhar Madras
Salicylic acid (SA) based biodegradable polyanhydrides (PAHs) are of great interest for drug delivery in a variety of diseases and disorders owing to the multi-utility of SA. There is a need for the design of SA-based PAHs for tunable drug release, optimized for the treatment of different diseases. In this study, we devised a simple strategy for tuning the release properties and erosion kinetics of a family of PAHs. PAHs incorporating SA were derived from related aliphatic diacids, varying only in the chain length, and prepared by simple melt condensation polymerization...
January 21, 2016: Physical Chemistry Chemical Physics: PCCP
Soo-Keun Lee, Daeic Chang, Seung Dae Yang, Sang Wook Kim
Indium oxide (In2O3) is an extreme wide band-gap oxide material with unique electronic and optical properties that is used widely in solar cells, gas sensors and optoelectronic devices. In this study, two types of In2O3 nanostructures were prepared by a simple hydrothermal method using succinic acid (SA) or malonic acid (MA) as the assistant agents. The products were characterized by powder X-ray diffractions and scanning electron microscopy (SEM). SEM of the products showed that the In2O3 nanostructures prepared in the presence of SA have a typical cubic morphology with a length and height of -30 nm, whereas the In2O3 nanostructures synthesized in the presence of MA has an atypical rock shape, length and height of 30 -300 nm...
December 2015: Journal of Nanoscience and Nanotechnology
Min-Chen Liu, Xiao-Qiong Ma, Yong Xu, Li-Hua Peng, Min Han, Jian-Qing Gao
A previous study has reported diacid metabolite (DM) as the stable form of norcantharidin (NCTD), which is almost 100% metabolized to DM-NCTD. However, the unreliable pharmacokinetic characteristics of DM-NCTD could result in low bioavailability, hindering the clinical use of DM-NCTD in the treatment of diseases. A liposomal drug delivery system could overcome the shortcomings of DM-NCTD by improving the relative bioavailability (Fr), reducing drug toxicity, and increasing the therapeutic efficacy. However, there are no data concerning the pharmacokinetics of a DM-NCTD-loaded liposomal drug delivery system in animals, which is required for assessing its safety profile...
February 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
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