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https://www.readbyqxmd.com/read/27093913/ebv-positive-diffuse-large-b-cell-lymphoma-of-the-elderly-2016-update-on-diagnosis-risk-stratification-and-management
#1
REVIEW
Jorge J Castillo, Brady E Beltran, Roberto N Miranda, Ken H Young, Julio C Chavez, Eduardo M Sotomayor
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is a provisional entity included in the 2008 WHO classification of lymphoid neoplasms. It is a disease typically seen in the elderly and thought to be associated with chronic EBV infection and severe immunosuppression with a component of immunosenescence. Recent research, however, has suggested that EBV-positive DLBCL can be seen in younger, immunocompetent patients. The diagnosis of EBV-positive DLBCL of the elderly is made through a careful pathological evaluation...
May 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27031317/approach-to-the-underperforming-athlete
#2
Mary L Solomon, Amanda K Weiss Kelly
Children and adolescents who participate in intense sports training may face physical and psychologic stresses. The pediatric health care provider can play an important role in monitoring an athlete's preparation by obtaining a proper sports history, assessing sleep hygiene, discussing nutrition and hydration guidelines, and evaluating physiologic causes of fatigue. Educating parents and athletes on the potential risks of high-intensity training, inadequate rest and sleep, and a poor diet may improve the athlete's performance and prevent symptoms of overtraining syndrome...
March 2016: Pediatric Annals
https://www.readbyqxmd.com/read/26882912/clinical-practice-guideline-tonsillitis-ii-surgical-management
#3
Jochen P Windfuhr, Nicole Toepfner, Gregor Steffen, Frank Waldfahrer, Reinhard Berner
In 2013, a total of 84,332 patients had undergone extracapsular tonsillectomies (TE) and 11,493 a tonsillotomy (TT) procedure in Germany. While the latter is increasingly performed, the number of the former is continually decreasing. However, a constant number of approximately 12,000 surgical procedures in terms of abscess-tonsillectomies or incision and drainage are annually performed in Germany to treat patients with a peritonsillar abscess. The purpose of this part of the clinical guideline is to provide clinicians in any setting with a clinically focused multi-disciplinary guidance through the surgical treatment options to reduce inappropriate variation in clinical care, improve clinical outcome and reduce harm...
April 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/25906501/return-to-play-a-primary-care-physician-s-guide-to-management
#4
REVIEW
Mark List, Zach Nolz, Wesley Nord, Mark Huntington
BACKGROUND: In the primary care clinic, allowing young athletes to return to play following injuries and illnesses can be a challenging balancing act between promoting speed of recovery while still allowing for full recovery and prevention of future injuries or complications. METHODS: A literature review of relevant return-to-play articles was performed for musculoskeletal injuries, concussions, and infectious mononucleosis. RESULTS: We identified several evidence-based approaches to allowing athletes to return to activity following injuries and illnesses...
March 2015: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/25334310/immunological-warfare-two-cases-of-hemophagocytic-lymphohistiocytosis-in-young-adults
#5
Ryan Sugarman, Yonatan Greenstein, Seth Koenig
Critical Care Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Hemophagocytic lymphohistiocystosis (HLH), a syndrome of pathologic immune system activation, results in a severe systemic inflammatory response. Rare in adults, it is well-described in the pediatric population. If unrecognized it is uniformly fatal; with prompt treatment mortality remains high. We present two cases of Epstein-Barr virus (EBV) associated HLH in young adults admitted to the medical intensive care unit (MICU)...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/24790693/return-to-play-after-infectious-mononucleosis
#6
Jonathan A Becker, Julie Anne Smith
CONTEXT: Infectious mononucleosis is a disease primarily of adolescence and early adulthood. The risk of splenic injury and chronic fatigue make return-to-play decisions a challenge for the clinician caring for athletes with infectious mononucleosis. EVIDENCE ACQUISITION: Data were obtained from the PubMed and MEDLINE databases through December 2012 by searching for epidemiology, diagnosis, clinical manifestations, management, and the role of the spleen in infectious mononucleosis...
May 2014: Sports Health
https://www.readbyqxmd.com/read/24629153/-spontaneous-rupture-of-the-spleen-after-infectious-mononucleosis
#7
Mikkel Bak Gulstad, Henrik Thomsen
Non-traumatic rupture of the spleen (NRS) is a rare but serious complication to infectious mononucleosis (IM) and it is important to have in mind, when patients have IM. Although splenectomy has been advocated as the appropriate treatment for this problem, the trend goes towards conservative treatment of the haemodynamically stable patients, but because of its rarity no clear guidelines have been suggested. We present a case of a 18-year-old boy with IM who had NRS with subcapsular haematoma and was treated conservatively...
October 21, 2013: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/23390945/determining-ebv-load-current-best-practice-and-future-requirements
#8
REVIEW
Stephanie Ruf, Hans-Joachim Wagner
EBV, a gammaherpesvirus and the pathogenic agent for infectious mononucleosis, is also associated with a broad spectrum of lymphoid and epithelial malignancies in immunocompetent and immunosuppressed individuals. EBV-DNA-load measurement by PCR has been shown to be a potential tool for the diagnosis of these diseases, a prognostic factor of their outcome and a successful method to monitor immunosuppressed patients. Since the end of 2011, there is an international WHO standard reference for EBV quantification available; however, many questions still remain; for instance about the optimal amplified region of the EBV genome, or the best-used specimen for EBV detection...
February 2013: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/23278656/a-questionnaire-for-multinational-case-control-studies-of-environmental-risk-factors-in-multiple-sclerosis-envims-q
#9
M Pugliatti, I Casetta, J Drulovic, E Granieri, T Holmøy, M T Kampman, A-M Landtblom, K Lauer, K-M Myhr, M Parpinel, T Pekmezovic, T Riise, B Zhu, C Wolfson
OBJECTIVES: The increasing incidence of multiple sclerosis (MS) worldwide, especially in women, points to the crucial role of environmental and lifestyle risk factors in determining the disease occurrence. An international multicentre case-control study of Environmental Risk Factors In Multiple Sclerosis (EnvIMS) has been launched in Norway, Sweden, Italy, Serbia and Canada, aimed to examine MS environmental risk factors in a large study population and disclose reciprocal interactions...
2012: Acta Neurologica Scandinavica. Supplementum
https://www.readbyqxmd.com/read/22897479/hypoalbuminaemia-is-an-independent-predictor-for-hemophagocytic-lymphohistiocytosis-in-childhood-epstein-barr-virus-associated-infectious-mononucleosis
#10
Shu-Ching Huang, Jiann-Shiuh Chen, Chao-Neng Cheng, Yao-Jong Yang
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal condition in children with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). This study aimed to identify commonly available clinical and laboratory predictors that might help clinicians decide to perform the bone marrow and immunological tests for HLH in paediatric EBV-associated IM. METHODS: A retrospective case-control study of patients aged <18 yr diagnosed with EBV-associated IM and HLH from 1991 to 2010 in a tertiary medical centre was conducted...
November 2012: European Journal of Haematology
https://www.readbyqxmd.com/read/21267209/chronic-mononucleosis-syndrome
#11
S E Shortt, E R Haynes
Debilitating illness in patients with only vague symptoms and minimal findings from physical examination and routine laboratory tests is frustrating for both patient and physician. A case of chronic mononucleosis is presented, and the literature describing the clinical and laboratory features of the syndrome is reviewed, with reference to four recent studies. Guidelines for diagnosis are suggested.
May 1986: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/20822055/-upper-respiratory-tract-infections-and-sports
#12
Emmanuelle Boffi El Amari
Upper respiratory tract infections are frequent in athletes. Mainly of viral origin, they are treated symptomatically. Infectious mononucleosis is associated with an estimated 2% per hundred risk of splenic rupture, which occurs between day four and twenty one of the illness. Therefore return to play guidelines recommend avoiding, exercice during the first twenty one days. Physical exercise seems to influence the immune system, depending on the intensity and length of it. But the relationship between physical exercise and risk of infections remains controversial: some articles showing an increase in risk, whereas others suggesting a certain degree of protection, in athletes...
August 11, 2010: Revue Médicale Suisse
https://www.readbyqxmd.com/read/19786768/noncolorectal-malignancies-in-inflammatory-bowel-disease-more-than-meets-the-eye
#13
REVIEW
Laurent Beaugerie, Harry Sokol, Philippe Seksik
In patients with Crohn's disease, the risk of small bowel adenocarcinoma is 20-40 times higher than the low background risk of the general population. In the subset of patients with longstanding small bowel lesions, the absolute risk of small bowel adenocarcinoma exceeds 1 per 100 patient-years after 25 years of follow-up and becomes equivalent to the risk of colorectal cancer. Growing evidence suggests that the pathogenesis of small bowel adenocarcinoma arising in inflammatory lesions of Crohn's disease is similar to that of colorectal cancer complicating chronic colonic inflammation (inflammation-dysplasia-cancer sequence)...
2009: Digestive Diseases
https://www.readbyqxmd.com/read/18817494/a-remote-fuzzy-multicriteria-diagnosis-of-sore-throat
#14
Doraid Dalalah, Sami Magableh
A sore throat (also known as pharyngitis or tonsillitis) is most commonly caused by a contagious viral infection (such as the flu, cold, or mononucleosis), although more serious throat infections can be caused by a bacterial infection (such as strep, mycoplasma, or Haemophilus). Bacterial sore throats respond well to antibiotics, whereas viral ones do not. However, strep throat remains a leading cause for physician visits, and researchers have long struggled to determine how best to treat it. The current practice guidelines offer different management options for adult patients presenting with a sore throat...
September 2008: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/18614881/mononucleosis-and-athletic-participation-an-evidence-based-subject-review
#15
REVIEW
Margot Putukian, Francis G O'Connor, Paul Stricker, Christopher McGrew, Robert G Hosey, Steven M Gordon, James Kinderknecht, Vesna Kriss, Gregory Landry
Infectious mononucleosis (IM) is a common medical condition that afflicts thousands of young athletes each year. Despite the self-limited nature of this disorder, the variability of the clinical presentation and the rare risk of splenic rupture routinely present sports medicine clinicians with difficult return-to-play decisions. Currently there are no evidence-based guidelines regarding the management of the athlete with IM. This review discusses the available research data pertaining to the management of IM in young athletes and develops questions for future clinical research...
July 2008: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/18419486/clinical-and-virological-characteristics-of-15-patients-with-chronic-active-epstein-barr-virus-infection-treated-with-hematopoietic-stem-cell-transplantation
#16
Kensei Gotoh, Yoshinori Ito, Yukiko Shibata-Watanabe, Jun-ichi Kawada, Yoshiyuki Takahashi, Hiroshi Yagasaki, Seiji Kojima, Yukihiro Nishiyama, Hiroshi Kimura
BACKGROUND: Chronic active Epstein-Barr virus (EBV) infection is characterized by recurrent infectious mononucleosis-like symptoms, and infected patients have high viral loads in their peripheral blood. Standard therapy for the disease has not yet been established. Recently, hematopoietic stem cell transplantation (HSCT) has been introduced and has the potential to become a standard treatment, although guidelines for HSCT to treat chronic active EBV infection have not yet been proposed...
May 15, 2008: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/18361191/-summary-of-the-practice-guideline-sore-throat-second-revision-from-the-dutch-college-of-general-practitioners
#17
J S Starreveld, S Zwart, F S Boukes, Tj Wiersma, A N Goudswaard
The second version of the practice guideline 'Sore throat' has been updated from the 1999 version. --Infections of the throat generally cure spontaneously within 7 days. In most cases the sore throat is caused by a virus. Group A beta-haemolytic streptococci (GABHS) are the most important bacterial cause ofa sore throat. --In diagnostics, the main focus is placed on evaluating how sick the patient is in general. --In adolescents who have had a sore throat for more than 7 days, the possibility of mononucleosis infectiosa should be borne in mind...
February 23, 2008: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/18327737/-a-study-of-antibiotic-treatment-of-upper-respiratory-infections-in-primary-care
#18
MULTICENTER STUDY
Zdenka Bazalová, Jirí Benes, Eva Bronská
OBJECTIVE: To assess the antibiotic therapy of and approach to treating pharyngitis/tonsillopharyngitis in primary care physicians, including the trends and rationality. METHODS: In April 2005, a multicentre study was carried out as a sequel to a similar study performed in 1998. The two studies monitored how primary care physicians treated patients subsequently hospitalized in Czech departments of infectious diseases with the diagnosis of acute upper respiratory infection...
February 2008: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/18159380/multiple-sclerosis-and-epstein-barr-virus
#19
Ruth Ann Marrie, Christina Wolfson
OBJECTIVE: To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS). DATA SOURCES: MEDLINE and Cochrane Library searches of the medical literature identified 24 studies. DATA EXTRACTION: Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS...
March 2002: Canadian Journal of Infectious Diseases, Journal Canadien des Maladies Infectieuses
https://www.readbyqxmd.com/read/17392399/post-transplant-lymphoproliferative-disease-in-liver-transplantation
#20
M S Dhillon, J K Rai, B K Gunson, S Olliff, J Olliff
Post-transplant lymphoproliferative disease (PTLD) is a well recognized complication of solid organ transplantation and therapeutic immunosuppression, first reported in 1968. PTLD incorporates a spectrum of abnormalities ranging from a benign infectious mononucleosis-like illness to non-Hodgkin's lymphoma with nodal and extranodal site involvement. The first liver transplant was performed at our institution in January 1982. This retrospective study examined the incidence of PTLD, reason for the original transplants, presenting symptoms, radiological findings, immunosuppression regimens and outcomes of these patients...
May 2007: British Journal of Radiology
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