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https://www.readbyqxmd.com/read/29053909/impact-of-ledipasvir-sofosbuvir-on-the-work-productivity-of-genotype-1-chronic-hepatitis-c-patients-in-asia
#1
Zobair M Younossi, Henry Lik Yuen Chan, Yock Young Dan, Mei Hsuan Lee, Young-Suk Lim, Eliza Kruger, Seng Chuen Tan
Chronic, untreated hepatitis C virus (HCV) infection is associated with a poor clinical prognosis and a detrimental impact on patients' lives, including on work productivity. To estimate the value of productivity losses due to genotype 1 (GT1) HCV infection in Hong Kong, Singapore, South Korea and Taiwan and to estimate the potential productivity gains associated with treating patients with ledipasvir/sofosbuvir (LDV/SOF) therapy,an economic model was developed with a time horizon of one year. HCV patients entered the model at 12 weeks post-treatment, having achieved or not achieved sustained virological response (SVR)...
October 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29052566/analysis-on-inpatient-health-expenditures-of-renal-cell-carcinoma-in-a-grade-a-tertiary-hospital-in-beijing
#2
Xin Liu, Yong-Hui Mao, Xue-Mei He, Yan-Jing Zhang, Ying Sun
BACKGROUND: Renal cell carcinoma (RCC) is the most common type of malignant renal tumors with a growing incidence in the recent years. This study aimed to investigate the influencing factors and variation trend of hospitalization expenditures among RCC patients in a single-centered hospital in Beijing during 5 consecutive years and to find the major cost items and fluctuation tendency of inpatient medical expenditures. METHODS: The information of medical expenditures among RCC patients in a Grade-A tertiary hospital during the years 2012-2016 was investigated to find the main cost items and changes affecting the medical cost structure...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052159/recommended-methods-for-the-collection-of-health-state-utility-value-evidence-in-clinical-studies
#3
REVIEW
Roberta Ara, John Brazier, Tracey Young
A conceptual model framework and an initial literature review are invaluable when considering what health state utility values (HSUVs) are required to populate health states in decision models. They are the recommended starting point early within a research and development programme, and before development of phase III trial protocols. While clinical trials can provide an opportunity to collect the required evidence, their appropriateness should be reviewed against the requirements of the model structure taking into account population characteristics, time horizon and frequency of clinical events...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29051771/prevalence-predictors-and-economic-burden-of-morbidities-among-waste-pickers-of-mumbai-india-a-cross-sectional-study
#4
Praveen Chokhandre, Shrikant Singh, Gyan Chandra Kashyap
BACKGROUND: The occupation of waste-picking characterised as 3Ds - dangerous, drudgery and demanding. In this context, the study aimed to assess occupational morbidities among the waste-pickers and attempts to identify potential individual level risk factors enhancing health risks. Additionally, economic burden of morbidities has been assessed. METHODS: The burden of the morbidities was assessed and compared with a comparison group through a cross-sectional survey...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29048726/trends-in-inequalities-in-child-stunting-in-south-asia
#5
Aditi Krishna, Iván Mejía-Guevara, Mark McGovern, Victor Aguayo, S V Subramanian
We analysed socio-economic inequalities in stunting in South Asia and investigated disparities associated with factors at the individual, caregiver, and household levels (poor dietary diversity, low maternal education, and household poverty). We used time-series analysis of data from 55,459 children ages 6-23 months from Demographic and Health Surveys in Bangladesh, India, Nepal, and Pakistan (1991-2014). Logistic regression models, adjusted for age, sex, birth order, and place of residency, examined associations between stunting and multiple types of socio-economic disadvantage...
October 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29048520/pain-acceptance-as-a-predictor-of-medical-utilization-and-school-absenteeism-in-adolescents-with-chronic-pain
#6
Michelle A Clementi, Grace S Kao, Evelyn Monico
Objective: Identifying factors contributing to high medical utilization and productivity loss is important, given the high cost of pediatric chronic pain. The current study examined chronic pain acceptance as a predictor of medical utilization and school absenteeism in adolescents with chronic pain. Methods: In all, 122 adolescents (aged 12-21 years) with chronic pain and their parents/guardians completed questionnaires assessing medical visits (past 6 months), medication usage, and number of school absences (past month)...
October 12, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29048386/leveraging-the-domain-of-work-to-improve-migrant-health
#7
Michael A Flynn, Kolitha Wickramage
Work is a principal driver of current international migration, a primary social determinant of health, and a fundamental point of articulation between migrants and their host society. Efforts by international organizations to promote migrant health have traditionally focused on infectious diseases and access to healthcare, while international labor organizations have largely focused on issues of occupational health. The underutilization of the domain of work in addressing the health of migrants is truly a missed opportunity for influencing worker well-being and reducing societal economic burden...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29047336/a-qualitative-exploration-of-work-related-head-injury-vulnerability-at-the-intersection-of-workers-decision-making-and-organizational-values
#8
P Kontos, A Grigorovich, B Nowrouzi, B Sharma, J Lewko, T Mollayeva, A Colantonio
BACKGROUND: Work-related head injury is a critical public health issue due to its rising prevalence; the association with profound disruption of workers' lives; and significant economic burdens in terms of medical costs and lost wages. Efforts to understand and prevent these types of injuries have largely been dominated by epidemiological research and safety science, which has focused on identifying risk at the level of the individual worker, population group, or organizational sector...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29047317/varicella-and-herpes-zoster-vaccine-development-lessons-learned
#9
Charlotte Warren-Gash, Harriet Forbes, Judith Breuer
Introduction Before vaccination, varicella zoster virus (VZV), which is endemic worldwide, led to almost universal infection. This neurotropic virus persists lifelong by establishing latency in sensory ganglia, where its reactivation is controlled by VZV-specific T-cell immunity. Lifetime risk of VZV reactivation (zoster) is around 30%. Vaccine development was galvanised by the economic and societal burden of VZV, including debilitating zoster complications that largely affect older individuals. Areas covered We describe the story of development, licensing and implementation of live attenuated vaccines against varicella and zoster...
October 19, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29047174/pediatric-allergy-and-immunology-in-china
#10
REVIEW
Gary Wk Wong, Jing Li, Yi-Xiao Bao, Jiu-Yao Wang, Ting Fan Leung, Luan-Luan Li, Jie Shao, Xin-Yuan Huang, En-Mei Liu, Shen Kun-Ling, Chen Yu-Zhi
Over the past thirty years, China has enjoyed rapid economic development along with urbanization at a massive scale that the world has not experienced before. Such development has also been associated with a rapid rise in the prevalence of allergic disorders. Because of the large childhood population in the country, the burden of childhood allergic disorders has become one of the major challenges in the health care system. Among the Chinese centers participating in the International Study of Asthma and Allergies in Childhood clearly, the data showed a continuing rise in the prevalence of asthma, allergic rhinitis and atopic eczema...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047020/rotavirus-epidemiology-and-vaccine-demand-considering-bangladesh-chapter-through-the-book-of-global-disease-burden
#11
REVIEW
Abdullah Mahmud-Al-Rafat, Abdul Muktadir, Hasneen Muktadir, Mahbubul Karim, Arpan Maheshwari, Mohammad Mainul Ahasan
BACKGROUND: Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infection. The situation leads to severe economic loss and constitutes a major public health problem. METHODS: We searched electronic databases including PubMed and Google scholar using the following words: "features of rotavirus," "epidemiology of rotavirus," "rotavirus serotypes," "rotavirus in Bangladesh," "disease burden of rotavirus," "rotavirus vaccine," "low efficacy of rotavirus vaccine," "inactivated rotavirus vaccine"...
October 19, 2017: Infection
https://www.readbyqxmd.com/read/29047008/pastoralists-knowledge-and-practices-towards-clinical-bovine-dermatophilosis-in-cattle-herds-of-north-central-nigeria-the-associated-factors-burden-and-economic-impact
#12
Nma Bida Alhaji, Tajudeen Opeyemi Isola
Dermatophilosis is a contagious disease of high economic importance. The study assessed knowledge/awareness and clinical burden of and mitigation measures practised against clinical bovine dermatophilosis in pastoral herds of North-Central Nigeria and associated socio-cultural factors that predisposed to its occurrence in herds. A cross-sectional survey was conducted between October 2015 and September 2016. Questionnaires were administered on pastoralists and clinical assessment of cattle with gross pathological lesions indicative of dermatophilosis conducted...
October 18, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29046149/schizophrenia-and-nicotine-dependence-what-psychopharmacological-treatment-options-are-available-for-the-duo-perturbationes
#13
Yoong Mei Theng, Suzaily Wahab, Noor Alaudin Wahab, Hatta Sidi, Srijit Das
Nicotine dependence has progressively become a foremost community health interest in the both developed and developing nations due to the economic burden and health-related problem. Smoking was significantly higher among patients with schizophrenia in comparison to the general population. Nicotine dependence is not only associated with public stress, but among patients with schizophrenia, smoking brings major challenges to the management. Nicotine may diminish the therapeutic efficacy of the bioavailability of the psychopharmacological agents in-vivo...
October 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29045291/devices-for-autonomic-regulation-therapy-in-heart-failure-with-reduced-ejection-fraction
#14
Benjamin R Wagner, William H Frishman
Heart failure is associated with significant morbidity and mortality as well as an increasing economic burden. The persistence of heart failure's risk factors, coupled with an aging population, also leads to an increase in its incidence and prevalence. It is well established that sympathetic hyperactivity and parasympathetic withdrawal are instrumental in the development and worsening of heart failure. Therefore, restoring autonomic balance to the cardiovascular system is an attractive therapeutic approach...
October 17, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29044584/direct-medical-costs-associated-with-the-extrahepatic-manifestations-of-hepatitis-c-virus-infection-in-france
#15
P Cacoub, M Vautier, A C Desbois, D Saadoun, Z Younossi
BACKGROUND: The economic impact of extrahepatic manifestations of hepatitis C virus (HCV) infection remains unknown for France. AIM: To estimate the prevalence of extrahepatic manifestations of HCV and the direct medical costs associated with them. METHODS: Estimates of 13 extrahepatic manifestations prevalence were obtained from (1) a retrospective data analysis of HCV-infected patients in a specialised centre and the baseline prevalence in the general French population and (2) an international systematic review...
October 18, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29044372/should-we-be-treating-animal-schistosomiasis-in-africa-the-need-for-a-one-health-economic-evaluation-of-schistosomiasis-control-in-people-and-their-livestock
#16
Charlotte M Gower, Louise Vince, Joanne P Webster
A One Health economic perspective allows informed decisions to be made regarding control priorities and/or implementation strategies for infectious diseases. Schistosomiasis is a major and highly resilient disease of both humans and livestock. The zoonotic component of transmission in sub-Saharan Africa appears to be more significant than previously assumed, and may thereby affect the recently revised WHO vision to eliminate schistosomiasis as a public health problem by 2025. Moreover, animal schistosomiasis is likely to be a significant cost to affected communities due to its direct and indirect impact on livelihoods...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29043001/effect-of-pingchuan-guben-decoction-on-patients-with-chronic-obstructive-pulmonary-disease-results-from-a-randomized-comparative-effectiveness-research-trial
#17
Cheng-Liang Qian, Rong Fan
Chronic obstructive pulmonary disease (COPD) is known to be a systemic low-grade ongoing inflammation exerting major health and economic burden worldwide. Complementary and alternative medicines, such as Traditional Chinese Medicine, are widely used for the treatment of patients with COPD. The present study was designed to investigate the efficacy of Pingchuan Guben decoction on patients with COPD through a double-blinded, open-labeled, randomized controlled trial. A total of 86 patients were randomly assigned to two groups, with 43 patients in the intervention group and 43 cases in the control group...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042396/differentiated-thyroid-cancer-millions-spent-with-no-tangible-gain
#18
Luis Furuya-Kanamori, Art Sedrakyan, Adedayo A Onitilo, Nasser Bagheri, Paul Glasziou, Suhail A R Doi
The incidence of differentiated thyroid cancer (DTC) has rapidly increased worldwide over the last decades. It is unknown if the increase in diagnosis has been mirrored by an increase in thyroidectomy rates with the concomitant economic impact that this would have on the healthcare system. DTC and thyroidectomy incidence as well as DTC specific mortality were modelled using Poisson regression in New South Wales (NSW), Australia per year and by sex. The incidence of 2002 was the point from which the increase in rates were assessed cumulatively over the subsequent decade...
October 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29041941/disentangling-the-effects-of-a-multiple-behaviour-change-intervention-for-diarrhoea-control-in-zambia-a-theory-based-process-evaluation
#19
Katie Greenland, Jenala Chipungu, Joyce Chilekwa, Roma Chilengi, Val Curtis
BACKGROUND: Diarrhoea is a leading cause of child death in Zambia. As elsewhere, the disease burden could be greatly reduced through caregiver uptake of existing prevention and treatment strategies. We recently reported the results of the Komboni Housewives intervention which tested a novel strategy employing motives including affiliation and disgust to improve caregiver practice of four diarrhoea control behaviours: exclusive breastfeeding; handwashing with soap; and correct preparation and use of oral rehydration salts (ORS) and zinc...
October 17, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29041940/state-of-inequality-in-malaria-intervention-coverage-in-sub-saharan-african-countries
#20
Katya Galactionova, Thomas A Smith, Don de Savigny, Melissa A Penny
BACKGROUND: Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS: Using Demographic and Health Surveys we computed equity metrics to characterize the distribution of malaria interventions in 30 endemic countries proxying economic position with an asset-wealth index...
October 18, 2017: BMC Medicine
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