D Dionysopoulos, K Pavlakis, V Kotoula, E Fountzilas, K Markou, I Karasmanis, N Angouridakis, A Nikolaou, K T Kalogeras, G Fountzilas
INTRODUCTION: EGFR (epidermal growth factor receptor), cyclin D1 and Akt/mTOR pathways are active in head and neck cancer. The aim of this study was to explore biomarker expression, their correlations with clinicopathological parameters and their prognostic utility in a cohort of patients with localized squamous laryngeal carcinoma. PATIENTS AND METHODS: We assessed relative messenger RNA expression of EGFR, Akt1, 2, and 3, mTOR and CCND1, copy number variants of the EGFR and CCND1 genes and immunohistochemical protein expression of EGFR, p-Akt308, p-Akt473, pmTOR, PTEN, p53 and cyclin D1 in paraffin-embedded tissue samples of localized laryngeal carcinomas...
March 2013: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]