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Chronic disease in elderly

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https://www.readbyqxmd.com/read/28811872/current-and-emerging-treatment-options-for-mantle-cell-lymphoma
#1
REVIEW
Bita Fakhri, Brad Kahl
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with typically aggressive behavior. The genetic signature is the chromosomal translocation t(11;14)(q13;q32) resulting in overexpression of cyclin D1. Asymptomatic newly diagnosed MCL patients with low tumor burden can be closely observed, deferring therapy to the time of disease progression. Although MCL classically responds to upfront chemotherapy, it remains incurable with standard approaches. For patients in need of frontline therapy, the initial decision is whether to proceed with an intensive treatment strategy or a non-intensive treatment strategy...
August 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/28810869/-evolution-and-financial-cost-of-socioeconomic-inequalities-in-ambulatory-care-sensitive-conditions-an-ecological-study-for-portugal-2000-2014
#2
Klára Dimitrovová, Cláudia Costa, Paula Santana, Julian Perelman
BACKGROUND: Hospitalizations for Ambulatory Care Sensitive Conditions (ACSC) are specific conditions for which hospitalization is thought to be avoidable through patient education, health promotion initiatives, early diagnosis and by appropriate chronic disease management, and have been shown to be greatly influenced by socioeconomic (SE) characteristics. We examined the SE inequalities in hospitalization rates for ACSC in Portugal, their evolution over time (2000-2014), and their associated financial burden...
August 16, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28805075/validity-and-reliability-of-accelerometry-in-identification-of-lying-sitting-standing-or-purposeful-activity-in-adult-hospital-inpatients-recovering-from-acute-or-critical-illness-a-systematic-review
#3
Jayne L Anderson, Angela J Green, L Samantha Yoward, Howard K Hall
OBJECTIVE: To investigate the validity and reliability of accelerometers to detect lying, sitting and standing postures or purposeful activity in hospitalized adults recovering from acute or critical illness. DATA SOURCES: CINAHL, MEDLINE, EMBASE, AMED, Cochrane Library, PEDro, PsycINFO and SPORTDiscuss were searched from inception to June 2017. Professional networks and reference lists of relevant articles were also searched. The main selection criteria were hospitalized adults with acute or critical illness and studies investigating the validity or reliability of accelerometers to identify body position or purposeful activity...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28802772/effectiveness-of-a-combined-exercise-training-and-home-based-walking-programme-on-physical-activity-compared-with-standard-medical-care-in-moderate-copd-a-randomised-controlled-trial
#4
P de Roos, C Lucas, J H Strijbos, E van Trijffel
OBJECTIVE: To estimate the effectiveness of a 10-week combined exercise training and home-based walking programme on daily physical activity (PA) compared with standard medical care in patients with moderate chronic obstructive pulmonary disease (COPD). DESIGN: Randomised controlled trial. SETTING: Primary care physiotherapy. PARTICIPANTS: Consecutive patients with stable COPD at Gold Stage II with a score of two or more on the Medical Research Council Dyspnoea Scale...
July 14, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28799782/effects-of-nutrient-and-bioactive-food-components-on-alzheimer-s-disease-and-epigenetic
#5
Elİf Celİk, Nevİn Sanlİer
Alzheimer's disease (AD) is the most common form of dementia in the elderly and is a chronic neurodegenerative disease that is becoming widespread. For this reason, in recent years factors affecting the development, progression and cognitive function of the AD have been emphasized. Nutrients and other bioactive nutrients are among the factors that are effective in AD. In particular, vitamins A, C and E, vitamins B1, B6 and B12, folate, magnesium, choline, inositol, anthocyanins, isoflavones etc. nutrients and bioactive nutrients are known to be effective in the development of AD...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28796600/interoperable-end-to-end-remote-patient-monitoring-platform-based-on-ieee-11073-phd-and-zigbee-health-care-profile
#6
Malcolm Clarke, Joost de Folter, Vivek Verma, Hulya Gokalp
This paper describes the implementation of an end-to-end remote monitoring platform based on the IEEE 11073 standards for Personal Health Devices (PHD). It provides an overview of the concepts and approaches and describes how the standard has been optimized for small devices with limited resources of processor, memory and power and that use short range wireless technology. It explains aspects of IEEE 11073, including the Domain Information Model, state model and nomenclature, and how these support its plug-and-play architecture...
August 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28796199/markers-of-t-cell-senescence-in-humans
#7
REVIEW
Weili Xu, Anis Larbi
Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults...
August 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28795337/the-reverse-metabolic-syndrome-in-the-elderly-is-it-a-catabolic-syndrome
#8
REVIEW
Francesco Curcio, Giuseppe Sasso, Ilaria Liguori, Gaetana Ferro, Gennaro Russo, Michele Cellurale, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
Traditional risk factors of cardiovascular death in the general population, including body mass index (BMI), serum cholesterol, and blood pressure are also found to relate to outcomes in the geriatric population, but in a differing direction. A higher body mass index, hypercholesterolemia and hypertension are not harmful but even permit better survival at advancing age. This phenomenon is called "reverse epidemiology" or "risk factor paradox" and is also detected in a variety of chronic disease states such as chronic heart failure...
August 9, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28793118/quality-of-life-of-elderly-people-with-chronic-kidney-disease-in-conservative-treatment
#9
Roberta Maria de Pina Pereira, Marcelo Aparecido Batista, Aline de Sousa Meira, Marília Pilotto de Oliveira, Luciana Kusumota
Objective: To describe the quality of life (QOL) of elderly people with Chronic Kidney Disease (CKD) in conservative treatment, correlating it with sociodemographic and health-related aspects. Method: This is a quantitative, cross-sectional, and descriptive study that used: a previously validated instrument for data collection; the WHOQOL-BREF and WHOQOL-OLD QOL scales; and the Mini-Mental State Examination. Results: Thirty-five elderly people (54...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28792995/-attention-to-elderly-individuals-with-hypertension-the-brazilian-national-health-survey-2013
#10
Rosália Garcia Neves, Suele Manjourany Silva Duro, Thaynã Ramos Flores, Bruno Pereira Nunes, Caroline Dos Santos Costa, Andrea Wendt, Fernando César Wehrmeister, Elaine Tomasi
This study aimed to assess the attention paid by health professionals to elderly individuals with hypertension and related inequalities in Brazil, using level of schooling as the socioeconomic indicator. This was a cross-sectional study with data from the Brazilian National Health Survey, 2013. Attention was assessed according to the following indicators: recommendations for healthy eating, maintaining adequate weight, less salt, regular exercise, prevention of smoking and excessive drinking, and regular medical checkups with blood and urine tests, ECG, and stress test...
August 7, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28792992/-trends-in-alcohol-abuse-in-brazilian-state-capitals-from-2006-to-2013-an-analysis-of-data-from-the-vigitel-survey
#11
Tiago N Munhoz, Iná S Santos, Bruno P Nunes, Christian Loret de Mola, Inácio Crochemore Mohnsam da Silva, Alicia Matijasevich
The aim of this study was to evaluate the trend in alcohol abuse in Brazil from 2006 to 2013 according to demographic, socioeconomic, and regional characteristics. This was an analysis of cross-sectional studies (VIGITEL, the Risk and Protective Factors Surveillance for Chronic Non-Communicable Diseases through Telephone Interview) that evaluated the Brazilian adult population (≥ 18 years) in the country's state capitals. Sampling was two-stage probabilistic (telephone line and adult resident). Alcohol abuse was defined as ≥ 5 drinks for men and ≥ 4 drinks for women on a single occasion, at least once in the 30 days prior to the interview...
August 7, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28791071/periorbital-and-mediastinal-emphysema-after-upper-gastrointestinal-endoscopy-case-report-of-a-rare-complication
#12
Thankappan Lekha, Leelakrishnan Venkatakrishnan, Karuppannasamy Divya, Perumal Lavanya
PURPOSE: To report a rare case of periorbital emphysema concurrent with cervicofacial and mediastinal emphysema in an elderly woman who underwent upper gastrointestinal endoscopy for chronic liver disease. CASE REPORT: An elderly woman with decompensated chronic liver disease presented with features of periorbital, facial, and mediastinal emphysema, characterized with crepitant swelling over the right periorbital area, face, neck, and mediastinum after undergoing upper gastrointestinal endoscopy...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28782884/chronic-lymphocytic-leukemia-2017-update-on-diagnosis-risk-stratification-and-treatment
#13
REVIEW
Michael Hallek
DISEASE OVERVIEW: Chronic lymphocytic leukemia (CLL) is the commonest leukemia in western countries. The disease typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that impair apoptosis of clonal B cells. DIAGNOSIS: The diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B lymphocytes, which identify a clonal B-cell population carrying the CD5 antigen and B-cell markers...
September 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28782588/impact-of-aging-immune-system-on-neurodegeneration-and-potential-immunotherapies
#14
REVIEW
Zhanfeng Liang, Yang Zhao, Linhui Ruan, Linnan Zhu, Kunlin Jin, Qichuan Zhuge, Dong-Ming Su, Yong Zhao
The interaction between the nervous and immune systems during aging is an area of avid interest, but many aspects remain unclear. This is due, not only to the complexity of the aging process, but also to a mutual dependency and reciprocal causation of alterations and diseases between both the nervous and immune systems. Aging of the brain drives whole body systemic aging, including aging-related changes of the immune system. In turn, the immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution that are sources of chronic inflammation in the elderly (termed inflammaging), potentially induces brain aging and memory loss in a reciprocal manner...
August 4, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28781008/-prognostic-value-of-assessment-tools-on-elderly-patients-with-chronic-advanced-disease-and-end-of-life-admitted-to-an-intermediate-care-centre
#15
Elizabeth da Costa, María José Robles, María Dolores Sánchez-Rodríguez, Olga Vázquez-Ibar, Ramón Miralles
OBJECTIVE: To apply 3advanced chronic disease evaluation tools in elderly patients admitted to an intermediate and long-term care centre, and evaluate its relationship with mortality. METHODS: The NECPAL tool, PROFUND prognostic index, and Charlson comorbidity index were applied to 87 patients. RESULTS: The NECPAL tool identified 31 patients (35.6%) in need of palliative care, and according to the PROFUND index, 45 (54.7%) had high/very high risk of mortality (≥7 points), and according to Charlson index, 31 (35...
August 3, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28780792/-analyses-on-relevant-factors-of-the-prognosis-of-elderly-patients-with-acute-poisoning
#16
Y X Wu, L Wang, Z Wu, G L Hong, G J Zhao, M F Li, D Li, B Wu, Q M Qiu, Z Q Lu
Objective: To explore the risk factors influencing the prognosis of elderly patients with acute poisoning. Methods: We retrospected 177 elderly patients with Acute Poisoning who were treated in the emergency department of the first affiliated hospital of wenzhou medical university from July 2009 to May 2015. According to the outcome of patients, we distributed the patients to death group (31 cases) and survival group (146 cases) , compared the clinic data and using multivariate analysis with Logistic regression to prognosis factors...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780255/paget-s-disease-of-bone
#17
Tim Cundy
Paget's disease is a chronic focal high turnover bone disorder that is primarily present in middle-aged or older adults. It seems to be restricted to humans and has no clear parallels with other diseases. Although much has been learnt about its pathology and epidemiology, and treatment is now highly effective we still lack a complete understanding of its etiology and biology. This review focusses on the natural history of the disorder, in particular its changing epidemiology, recent discoveries about its genetic basis and current approaches to diagnosis and treatment...
July 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28779902/-erythropoiesis-stimulating-agents-literature-review-of-uses-and-indications-in-advanced-oncological-and-non-oncological-disease-in-the-elderly
#18
Nieves Fernandez Letamendi, Teresa Fernandez Letamendi, M Angeles Montañes Gracia, Valle Recasens Flores
The aim of this article is to review possible indications and controversies about the most frequent uses of ESAs in the treatment of anaemia in elderly patients with oncological and non-oncological diseases. Using PubMed a systematic review was carried out on articles published from 1985 to September 2016, as well as a review of the main Spanish, European, and American consensus guidelines on each of the following diseases in which could pose the treatment of anaemia associated with ESA. A review was also carried out on the main Spanish, European and American consensus guidelines regarding the management of anaemia related to the diseases outlined in this article...
August 2, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28779823/gastrointestinal-disturbances-in-the-elderly
#19
REVIEW
Natalie R Baker, Kala K Blakely
Gastrointestinal (GI) age-related changes create alterations in the body's ability to digest, absorb, and excrete nutrients, medications, and alcohol and disrupts GI immunity responses. All older adults exhibit some degree of swallowing difficulty, also known as senescent swallowing. The effects of chronic disease and sustained use of alcohol, tobacco, and medications often exacerbate age-related GI dysfunction. Older adults often have nonspecific complaints, warranting a thorough health history and physical examination, including prescription and over-the-counter medications...
September 2017: Nursing Clinics of North America
https://www.readbyqxmd.com/read/28775119/incidence-and-management-of-toxicity-associated-with-ibrutinib-and-idelalisib-a-practical-approach
#20
Iris de Weerdt, Suzanne M Koopmans, Arnon P Kater, Michel van Gelder
The use of novel B cell receptor signaling inhibitors results in high response rates and long progression-free survival in patients with indolent B cell malignancies, such as chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma and Waldenstroms macroglobulinemia. Ibrutinib, the first-in-class inhibitor or Bruton's tyrosine kinase, and idelalisib, the first-in-class inhibitor of phosphatidylinositol 3-kinase δ have recently been approved for several indolent B cell malignancies. These drugs especially foresee in previously unmet needs for patients with relapsed or refractory disease, high-risk cytogenetic or molecular abnormalities or with comorbidities...
August 3, 2017: Haematologica
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