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https://www.readbyqxmd.com/read/28634461/sensitivity-to-acceleration-in-the-human-early-visual-system
#1
Ryohei Nakayama, Isamu Motoyoshi
It is widely believed that the human visual system is insensitive to acceleration in moving stimuli. This notion is supported by evidence that detection sensitivity for velocity modulation in moving stimuli is a lowpass function of the velocity modulation's temporal frequency. However, the lowpass function might be a mixture of detection by attention-based tracking and low-level mechanisms sensitive to acceleration. To revisit the issue of acceleration perception in relation to attentive tracking, we measured detection sensitivities for velocity modulations at various temporal frequencies (0...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28634260/did-the-suicide-barrier-work-after-all-revisiting-the-bloor-viaduct-natural-experiment-and-its-impact-on-suicide-rates-in-toronto
#2
Mark Sinyor, Ayal Schaffer, Donald A Redelmeier, Alex Kiss, Yasunori Nishikawa, Amy H Cheung, Anthony J Levitt, Jane Pirkis
OBJECTIVE: This research aims to determine the long-term impact of the Bloor Street Viaduct suicide barrier on rates of suicide in Toronto and whether media reporting had any impact on suicide rates. DESIGN: Natural experiment. SETTING: City of Toronto, Canada; records at the chief coroner's office of Ontario 1993-2003 (11 years before the barrier) and 2004-2014 (11 years after the barrier). PARTICIPANTS: 5403 people who died by suicide in the city of Toronto...
June 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28634181/outcomes-after-observation-stays-among-older-adult-medicare-beneficiaries-in-the-usa-retrospective-cohort-study
#3
Kumar Dharmarajan, Li Qin, Maggie Bierlein, Jennie E S Choi, Zhenqiu Lin, Nihar R Desai, Erica S Spatz, Harlan M Krumholz, Arjun K Venkatesh
Objective To characterize rates and trends over time of emergency department treatment-and-discharge stays, repeat observation stays, inpatient stays, any hospital revisit, and death within 30 days of discharge from observation stays.Design Retrospective cohort study.Setting 4750 hospitals in the USA.Participants Nationally representative sample of Medicare fee for service beneficiaries aged 65 or over discharged after 363 037 index observation stays, 2 540 000 index emergency department treatment-and-discharge stays, and 2 667 525 index inpatient stays from 2006-11...
June 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28634051/revisiting-interdialytic-weight-gain-and-mortality-association-with-serum-albumin-interactions-the-japanese-dialysis-outcomes-and-practice-pattern-study
#4
Noriaki Kurita, Yasuaki Hayashino, Shin Yamazaki, Tadao Akizawa, Takashi Akiba, Akira Saito, Shunichi Fukuhara
BACKGROUND: The dialysis practice guideline in Japan sets a limit on the allowed interdialytic weight gain (IDWG) <6%. However, the effects of relative gain of fluid volume to body weight may differ in presence of morbid conditions. Here, we examined whether or not the associations between IDWG and mortality differ by serum albumin (sAlb), a nutritional and illness marker. DESIGN: The study type used was prospective cohort study. SUBJECTS: Patients who participated in the Japan Dialysis Outcomes and Practice Pattern Study (phase 1-4 [1999-2011]) and received thrice-weekly hemodialysis...
June 17, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28633955/the-microbiome-and-transfusion-in-cancer-patients
#5
REVIEW
Hadi Goubran, Jerard Seghatchian, Julia Radosevic, Gaafar Ragab, Thierry Burnouf
Our microbiota is determined by many variables including ABO blood groups. The microbiota is not only confined to the gut and skin but is also recoverable from blood of healthy donors. The microbiota shape our immune system through cross reactivity with antigens, the expression of direct molecular patterns, the release of cytokines, the effects on nutrients and micronutrients and even through an interplay with epigenetics. It is likely, therefore, that a donor's microbiota could alter the antigenicity of blood and its components and potentially contribute to transfusion-related immune modulation [TRIM]...
June 3, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28633875/rational-drug-loading-of-liposomes-revisited
#6
EDITORIAL
Kinam Parak
No abstract text is available yet for this article.
April 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28633422/-research-on-infertility-definition-makes-a-difference-revisited
#7
Melanie H Jacobson, Helen B Chin, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards
In a 1989 paper (Am J Epidemiol. 1989;130(2):259-67), Marchbanks et al. noted inconsistent definitions of infertility across research and clinical practice and examined differences in prevalence estimates across definitions. Since their study, there have been substantial changes in society, technology, and clinical practice related to female reproductive health. In response, we revisited the original paper using data from a recent study among reproductive-aged women. Internal comparisons across various definitions of infertility were made by assessing how many and which women were classified as infertile, their age at infertility, and probability of spontaneous pregnancy after infertility; results were also compared with Marchbanks et al...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28632976/succession-planning-a-case-for-revisiting-the-process-in-critical-care
#8
EDITORIAL
Julie Scholes, Josef Trapani
No abstract text is available yet for this article.
July 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28632657/role-of-computed-tomography-in-the-classification-of-pediatric-pelvic-fractures-revisited
#9
Melissa A Bent, William L Hennrikus, Johan E Latorre, Douglas G Armstrong, Brian Shaw, Kerwyn C Jones, Lee S Segal
OBJECTIVES: To determine the need for computerized tomography (CT) scans in the assessment of pediatric pelvic fractures. DESIGN: Retrospective Chart Review. SETTING: Level-1 Pediatric Trauma Center. PATIENTS/PARTICIPANTS: Thirty pediatric trauma patients with pelvic fractures who have obtained both a radiograph and CT scan. MAIN OUTCOME MEASUREMENTS: Fleiss Kappa coefficient to compare interreliability...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28632629/evaluation-of-nitrous-oxide-in-the-gas-mixture-for-anesthesia-ii-enigma-ii-revisited-patients-still-vomiting
#10
Edmond C K Li, Lloyd D Balbuena, Jonathan J Gamble
No abstract text is available yet for this article.
July 2017: Anesthesiology
https://www.readbyqxmd.com/read/28631043/erratum-to-formula-see-text-revisited-local-stability-and-bifurcation-theory-for-physiologically-structured-population-models-explained-by-way-of-an-example
#11
Odo Diekmann, Mats Gyllenberg, J A J Metz, Shinji Nakaoka, André M de Roos
No abstract text is available yet for this article.
June 19, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28630644/isometric-gene-tree-reconciliation-revisited
#12
Broňa Brejová, Askar Gafurov, Dana Pardubská, Michal Sabo, Tomáš Vinař
BACKGROUND: Isometric gene tree reconciliation is a gene tree/species tree reconciliation problem where both the gene tree and the species tree include branch lengths, and these branch lengths must be respected by the reconciliation. The problem was introduced by Ma et al. in 2008 in the context of reconstructing evolutionary histories of genomes in the infinite sites model. RESULTS: In this paper, we show that the original algorithm by Ma et al. is incorrect, and we propose a modified algorithm that addresses the problems that we discovered...
2017: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/28630095/antibody-dependent-nk-cell-activation-differentially-targets-ebv-infected-cells-in-lytic-cycle-and-bystander-b-lymphocytes-bound-to-viral-antigen-containing-particles
#13
María López-Montañés, Elisenda Alari-Pahissa, Jordi Sintes, José E Martínez-Rodríguez, Aura Muntasell, Miguel López-Botet
NK cells have been reported to respond against EBV-infected B cells in the lytic cycle and to control the viral infection involving IFN-γ secretion. Early reports proposed a role for NK cell Ab-dependent cellular cytotoxicity (ADCC) triggered via FcγR-IIIA (CD16) in the response to EBV. In the current study, we revisited this issue, showing that serum from EBV(+) individuals triggered vigorous NK cell degranulation and cytokine production (i.e., TNF-α and IFN-γ) against EBV-infected cells, enhancing NK cell activation...
June 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28629897/a-unified-pathophysiological-construct-of-diabetes-and-its-complications
#14
REVIEW
Stanley S Schwartz, Solomon Epstein, Barbara E Corkey, Struan F A Grant, James R Gavin Iii, Richard B Aguilar, Mary E Herman
Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives the diabetic state throughout its natural history and across its varied clinical presentations, a pathophysiology involving metabolic insults, oxidative damage, and vicious cycles that aggravate and intensify organ dysfunction and damage. This new understanding of the disease requires that we revisit existing diagnostics and treatment approaches, which were built upon outmoded assumptions...
June 16, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28628705/time-to-appendectomy-and-risk-of-complicated-appendicitis-and-adverse-outcomes-in-children
#15
Stephanie K Serres, Danielle B Cameron, Charity C Glass, Dionne A Graham, David Zurakowski, Mahima Karki, Seema P Anandalwar, Shawn J Rangel
Importance: Management of appendicitis as an urgent rather than emergency procedure has become an increasingly common practice in children. Controversy remains as to whether this practice is associated with increased risk of complicated appendicitis and adverse events. Objective: To examine the association between time to appendectomy (TTA) and risk of complicated appendicitis and postoperative complications. Design, Setting, and Participants: In this retrospective cohort study using the Pediatric National Surgical Quality Improvement Program appendectomy pilot database, 2429 children younger than 18 years who underwent appendectomy within 24 hours of presentation at 23 children's hospitals from January 1, 2013, through December 31, 2014, were studied...
June 19, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28627943/the-efficacy-and-safety-of-adjuvant-interferon-alfa-therapy-in-the-evolving-treatment-landscape-for-resected-high-risk-melanoma
#16
Van Anh Trinh, Chrystia Zobniw, Wen-Jen Hwu
Patients with resected stage II or III melanoma are at high risk of recurrence, with 5-year mortality rate of 40-60%. Adjuvant interferon-alfa has demonstrated a small RFS and OS benefit versus observation in this patient population. However, the adjuvant treatment landscape is evolving rapidly. Areas covered: This review aims to summarize the safety and efficacy profiles of adjuvant IFNα/PEG-IFNα, revisit the controversy surrounding its application, and reappraise its position in the rapidly changing treatment landscape of resected melanoma...
June 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28627430/kinetic-of-eosinophil-count-during-bacterial-infection-revisiting-an-old-marker-to-assess-the-efficacy-of-antimicrobial-therapy
#17
B Davido, S Makhloufi, M Matt, R Calin, O Senard, C Perronne, A Dinh, J Salomon
INTRODUCTION: Eosinopenia has been in the centre of debates for decades as a criterion of sepsis. Depending on authors, different cut-off values are proposed. METHODS: We conducted a prospective study, from February to August 2016, of hospitalized adults suffering from bacterial infection with eosinopenia defined by an eosinophil count <100/mm(3). Patients were divided into 2 groups considering the first day of effective antimicrobial therapy. They were observed during 5days (D) in order to evaluate whether recovery from eosinopenia was predictive of an appropriate antibiotic regimen...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28627420/distinct-neural-processes-supports-post-success-and-post-error-slowing-in-the-stop-signal-task
#18
Yihe Zhang, Jaime S Ide, Sheng Zhang, Sien Hu, Nikola S Valchev, Xiaoying Tang, Chiang-Shan R Li
Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the right-hemispheric ventrolateral prefrontal cortex, in the area of inferior frontal gyrus, pars opercularis (IFGpo) and anterior insula (AI), during post-error slowing (PES). However, in similar analyses we were not able to identify regional activities during post-success slowing (PSS)...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627015/small-proteins-encoded-by-unannotated-orfs-are-rising-stars-of-the-proteome-confirming-shortcomings-in-genome-annotations-and-current-vision-of-an-mrna
#19
REVIEW
Vivian Delcourt, Antanas Staskevicius, Michel Salzet, Isabelle Fournier, Xavier Roucou
Short ORF-encoded peptides and small proteins in eukaryotes have been hiding in the shadow of large proteins for a long time. Recently, improved identifications in MS-based proteomics and ribosome profiling resulted in the detection of large numbers of small proteins. The variety of functions of small proteins is also emerging. It seems to be the right time to reflect on why small proteins remained invisible. In addition to the obvious technical challenge of detecting small proteins, they were mostly forgotten from annotations and they escaped detection because they were not sought...
June 19, 2017: Proteomics
https://www.readbyqxmd.com/read/28626276/standing-and-travelling-waves-in-a-spherical-brain-model-the-nunez-model-revisited
#20
S Visser, R Nicks, O Faugeras, S Coombes
The Nunez model for the generation of electroencephalogram (EEG) signals is naturally described as a neural field model on a sphere with space-dependent delays. For simplicity, dynamical realisations of this model either as a damped wave equation or an integro-differential equation, have typically been studied in idealised one dimensional or planar settings. Here we revisit the original Nunez model to specifically address the role of spherical topology on spatio-temporal pattern generation. We do this using a mixture of Turing instability analysis, symmetric bifurcation theory, centre manifold reduction and direct simulations with a bespoke numerical scheme...
June 15, 2017: Physica D. Nonlinear Phenomena
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