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https://www.readbyqxmd.com/read/28212249/one-delirium-tool-revisited-a-reply
#1
Jan N M Schieveld, Jurjen J van Zwieten
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28212030/revisiting-silicalite-1-nucleation-in-clear-solution-by-electrochemical-impedance-spectroscopy
#2
Gert Brabants, Maxim Hubin, Erwin Konrad Reichel, Bernhard Jakoby, Eric Breynaert, Francis Taulelle, Johan A Martens, Christine E A Kirschhock
EIS was used to detect and investigate nucleation in silicalite-1 clear solutions. Whereas zeolite nucleation was previously assumed to be a step event, inducing a sharp discontinuity around a Si/OH ratio of 1, complex bulk conductivity measurements at elevated temperatures reveal a gradual decay of the conductivity with increased silicon concentrations. Inverse Laplace transformation of the complex conductivity allows to observe the chemical exchange phenomena governing nano-aggregate formation. At low temperatures, the fast exchange between dissociated ions and ion pairs leads to a gradual decay of the conductivity with increasing silicon content...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28211517/edge-currents-shunt-the-insulating-bulk-in-gapped-graphene
#3
M J Zhu, A V Kretinin, M D Thompson, D A Bandurin, S Hu, G L Yu, J Birkbeck, A Mishchenko, I J Vera-Marun, K Watanabe, T Taniguchi, M Polini, J R Prance, K S Novoselov, A K Geim, M Ben Shalom
An energy gap can be opened in the spectrum of graphene reaching values as large as 0.2 eV in the case of bilayers. However, such gaps rarely lead to the highly insulating state expected at low temperatures. This long-standing puzzle is usually explained by charge inhomogeneity. Here we revisit the issue by investigating proximity-induced superconductivity in gapped graphene and comparing normal-state measurements in the Hall bar and Corbino geometries. We find that the supercurrent at the charge neutrality point in gapped graphene propagates along narrow channels near the edges...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28211452/early-onset-and-delayed-onset-poststroke-dementia-revisiting-the-mechanisms
#4
REVIEW
Vincent C T Mok, Bonnie Y K Lam, Adrian Wong, Ho Ko, Hugh S Markus, Lawrence K S Wong
Incident stroke has long been recognized to cause dementia shortly after the event. Patients who survive stroke without early-onset poststroke dementia (PSD) are at a high risk of developing dementia months to years after the initial stroke incident, which has generated enthusiasm for exploring treatments to prevent delayed-onset PSD in survivors of stroke. However, results from clinical trials completed in the past 10-15 years have been disappointing. In light of these results, the present Review revisits the mechanisms of both early-onset and delayed-onset PSD and proposes preventive strategies and directions for future clinical trials...
February 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28210796/optogenetic-switches-for-light-controlled-gene-expression-in-yeast
#5
REVIEW
Francisco Salinas, Vicente Rojas, Verónica Delgado, Eduardo Agosin, Luis F Larrondo
Light is increasingly recognized as an efficient means of controlling diverse biological processes with high spatiotemporal resolution. Optogenetic switches are molecular devices for regulating light-controlled gene expression, protein localization, signal transduction and protein-protein interactions. Such molecular components have been mainly developed through the use of photoreceptors, which upon light stimulation undergo conformational changes passing to an active state. The current repertoires of optogenetic switches include red, blue and UV-B light photoreceptors and have been implemented in a broad spectrum of biological platforms...
February 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28210770/the-reset-button-revisited-why-high-activity-131-i-therapy-of-advanced-differentiated-thyroid-cancer-after-dosimetry-is-advantageous-for-patients
#6
EDITORIAL
Frederik A Verburg, Markus Luster, Luca Giovanella, Michael Lassmann, Carlo Chiesa, Nicolas Chouin, Glenn Flux
No abstract text is available yet for this article.
February 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28209763/revisiting-suppression-of-interspecies-hybrid-male-lethality-in-caenorhabditis-nematodes
#7
Lauren E Ryan, Eric S Haag
Within the nematode genus Caenorhabditis, C. briggsae and C. nigoni are among the most closely related species known. They differ in sexual mode, with C. nigoni retaining the ancestral XO male-XX female outcrossing system, while C. briggsae recently evolved self-fertility and an XX-biased sex ratio. Wild-type C. briggsae and C. nigoni can produce fertile hybrid XX female progeny, but XO progeny are either 100% inviable (when C. briggsae is the mother) or viable but sterile (when C. nigoni is the mother). A recent study provided evidence suggesting that loss of the Cbr-him-8 meiotic regulator in C...
February 16, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28209759/revisiting-seed-and-soil-examining-the-primary-tumor-and-cancer-cell-foraging-in-metastasis
#8
Amber E de Groot, Sounak Roy, Joel S Brown, Kenneth J Pienta, Sarah R Amend
Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels throughout the body, and invades and colonizes a distant site.  Based on Paget's 1889 hypothesis, the majority of modern metastasis research focuses on the properties of the metastatic "seed and soil," but the implications of the primary tumor "soil" have been largely neglected. The rare lethal metastatic "seed" arises as a result of the selective pressures in the primary tumor. Optimal foraging theory describes how cancer cells adopt a mobile foraging strategy to balance predation risk and resource reward...
February 16, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28209057/saturated-fatty-acid-analogues-of-cell-penetrating-peptide-pepfect14-role-of-fatty-acid-modification-in-complexation-and-delivery-of-splice-correcting-oligonucleotides
#9
Tõnis Lehto, Luis Vasconcelos, Helerin Margus, Ricardo Figueroa, Margus Pooga, Mattias Hällbrink, Ulo Langel
Modifying cell-penetrating peptides (CPPs) with fatty acids has long been used to improve peptide-mediated nucleic acid delivery. In this study we have revisited this phenomenon with a systematic approach where we developed a structure-activity relationship to describe the role of the acyl chain length in the transfection process. For that we took a well-studied CPP, PepFect14, as the basis and varied its N-terminal acyl chain length from 2 to 22 carbons. To evaluate the delivery efficiency, the peptides were non-covalently complexed with a splice-correcting oligonucleotide (SCO) and tested in the HeLa pLuc705 reporter cell line...
February 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28208724/assessing-the-knowledge-level-attitudes-risky-behaviors-and-preventive-practices-on-sexually-transmitted-diseases-among-university-students-as-future-healthcare-providers-in-the-central-zone-of-malaysia-a-cross-sectional-study
#10
Adigun Temiloluwa Folasayo, Afolayan John Oluwasegun, Suhailah Samsudin, Siti Nor Sakinah Saudi, Malina Osman, Rukman Awang Hamat
This study was done to assess the knowledge, attitudes, risky behaviors and preventive practices related to sexually-transmitted diseases (STDs) among health and non-health sciences university students as future healthcare providers in Malaysia. A total of 700 health and non-health sciences university students (255 male; 445 female) aged between 17 and 30 years were surveyed by using a self-administered questionnaire. The majority (86.6%) had heard of STDs, and 50.4% knew STDs could present without symptoms...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207296/gambit-a-parameterless-model-based-evolutionary-algorithm-for-mixed-integer-problems
#11
Krzysztof L Sadowski, Dirk Thierens, Peter A N Bosman
Learning and exploiting problem structure is one of the key challenges in optimization. This is especially important for black-box optimization (BBO) where prior structural knowledge of a problem is not available. Existing model-based Evolutionary Algorithms (EAs) are very efficient at learning structure in both the discrete, and in the continuous domain. In this paper, discrete and continuous model-building mechanisms are integrated for the Mixed-Integer (MI) domain, comprising discrete and continuous variables...
February 16, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/28205444/revisiting-the-corrosion-of-aluminum-current-collector-in-lithium-ion-batteries
#12
Tianyuan Ma, Gui-Liang Xu, Yan Li, Li Wang, Xiangming He, Jianming Zheng, Jun Liu, Mark H Engelhard, Peter Zapol, Larry A Curtiss, Jacob Jorne, Khalil Amine, Zonghai Chen
The corrosion of aluminum current collectors and the oxidation of solvents at a relatively high potential have been widely investigated with an aim to stabilize the electrochemical performance of lithium-ion batteries using such components. The corrosion behavior of aluminum current collectors was revisited using a home-build high-precision electrochemical measurement system, and the impact of electrolyte components and the surface protection layer on aluminum foil was systematically studied. The electrochemical results showed that the corrosion of aluminum foil was triggered by the electrochemical oxidation of solvent molecules, like ethylene carbonate, at a relative high potential...
February 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28204944/photodissociation-of-fono-an-excited-state-nonadiabatic-dynamics-study
#13
Allaa R Hilal, Rifaat Hilal
The photo dissociation of nitrosyl fluorite, FONO, a potential source of atmospheric fluorine, underlies its active role in ozone depletion and other activities in the troposphere. In the present work, the electronic structure of FONO is revisited at high level of ab initio and density functional theory (DFT) theoretical levels. Several different post SCF methods were used to compute excited states, vertical excitation energies and intensities, namely configuration interaction with single excitations (CIS), equation of motion coupled cluster with single and double excitations (EOM-CCSD), and symmetry adopted cluster configuration interaction (SAC-CI) methods...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28202338/a-new-strategy-for-emergency-department-crowding-high-turnover-utility-bed-intervention
#14
I-Hsin Lee, Chung-Ting Chen, Yi-Tzu Lee, Yueh-Shuang Hsu, Chia-Ling Lu, Hsien-Hao Huang, Teh-Fu Hsu, Chorng-Kuang How, David Hung-Tsang Yen, Ueng-Cheng Yang
BACKGROUND: This study applied a new strategy, termed high-turnover utility bed intervention, to offer early admission chances for emergency department (ED) patients and alleviate ED crowding. METHODS: This before-and-after observational cohort study was conducted at the ED of an urban tertiary hospital. On January 1, 2012, 14 utility beds were prepared exclusively for ED patient use. A strict 48-hour course limit for each patient was formulated to govern these high-turnover beds...
February 12, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28202155/-the-liability-of-newness-revisited-theoretical-restatement-and-empirical-testing-in-emergent-organizations
#15
Tiantian Yang, Howard E Aldrich
The mismatch between Stinchcombe's original propositions regarding "the liability of newness" and subsequent attempts to test those propositions suggests to us that the form and causes of the liability remain open to further investigation. Taking organizational emergence as a process comprising entrepreneurs engaging in actions that produce outcomes, we propose hypotheses about the social mechanisms of organizational construction involved in investing resources, developing routines, and maintaining boundaries...
March 2017: Social Science Research
https://www.readbyqxmd.com/read/28201989/revisiting-phylogenetic-signal-strong-or-negligible-impacts-of-polytomies-and-branch-length-information
#16
Rafael Molina-Venegas, Miguel Á Rodríguez
BACKGROUND: Inaccurate estimates of phylogenetic signal may mislead interpretations of many ecological and evolutionary processes, and hence understanding where potential sources of uncertainty may lay has become a priority for comparative studies. Importantly, the sensitivity of phylogenetic signal indices and their associated statistical tests to incompletely resolved phylogenies and suboptimal branch-length information has been only partially investigated. METHODS: Here, we use simulations of trait evolution along phylogenetic trees to assess whether incompletely resolved phylogenies (polytomic chronograms) and phylogenies with suboptimal branch-length information (pseudo-chronograms) could produce directional biases in significance tests (p-values) associated with Blomberg et al...
February 15, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28201912/free-energy-functionals-for-polarization-fluctuations-pekar-factor-revisited
#17
Mohammadhasan Dinpajooh, Marshall D Newton, Dmitry V Matyushov
The separation of slow nuclear and fast electronic polarization in problems related to electron mobility in polarizable media was considered by Pekar 70 years ago. Within dielectric continuum models, this separation leads to the Pekar factor in the free energy of solvation by the nuclear degrees of freedom. The main qualitative prediction of Pekar's perspective is a significant, by about a factor of two, drop of the nuclear solvation free energy compared to the total (electronic plus nuclear) free energy of solvation...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28201763/the-barrow-neurological-institute-scale-revisited-predictive-capabilities-for-cerebral-infarction-and-clinical-outcome-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#18
Nora F Dengler, Dominik Diesing, Asita Sarrafzadeh, Stefan Wolf, Peter Vajkoczy
No abstract text is available yet for this article.
February 14, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28200072/malignant-hypertension-revisited-does-this-still-exist
#19
Alena Shantsila, Gregory Y H Lip
No abstract text is available yet for this article.
February 12, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28199368/secondary-structure-prediction-revisited-theoretical-%C3%AE-sheet-propensity-and-coil-propensity-represent-structures-of-amyloids-and-aid-in-elucidating-phenomena-involved-in-interspecies-transmission-of-prions
#20
Yuzuru Taguchi, Noriyuki Nishida
Prions are unique infectious agents, consisting solely of abnormally-folded prion protein (PrPSc). However, they possess virus-like features, including strain diversity, the ability to adapt to new hosts and to be altered evolutionarily. Because prions lack genetic material (DNA and RNA), these biological phenomena have been attributed to the structural properties of PrPSc. Therefore, many structural models of the structure of PrPSc have been proposed based on the limited structural information available, regardless of the incompatibility with high-resolution structural analysis...
2017: PloS One
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