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https://www.readbyqxmd.com/read/29792503/revisiting-carroll-s-survey-of-factor-analytic-studies-implications-for-the-clinical-assessment-of-intelligence
#1
Nicholas F Benson, A Alexander Beaujean, Ryan J McGill, Stefan C Dombrowski
John Carroll's three-stratum theory (and the decades of research behind its development) is foundational to the contemporary practice of intellectual assessment. The present study addresses some limitations of Carroll's work: specification, reproducibility with more modern methods, and interpretive relevance. We reanalyzed select data sets from Carroll's survey of factor analytic studies using confirmatory factor analysis as well as modern indices of interpretive relevance. For the majority of data sets, we found that Carroll likely extracted too many factors representing Stratum II abilities...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792431/the-o-no-v-vibrational-relaxation-processes-revisited
#2
Pedro J S B Caridade, Jing Li, Vinícius C Mota, António J C Varandas
We have carried out a quasi-classical trajectory study of the $\mathrm{O}+\mathrm{NO}(v)$ energy transfer process using DMBE potential energy surfaces for the ground-states of the $^2A'$ and $^2A''$ manifolds. State-to-state vibrational relaxation rate constants have been computed over the temperature range $298\rm \,K$ and $3000\,\rm K$ and initial vibrational states between $v=1$ and 9. The momentum-Gaussian binning approach has been employed to calculate the probability of the vibrational transitions. A comparison of the calculated state-to-state rate coefficients with the results from experimental studies and previous theoretical calculations shows the relevance of the $1\,^2A''$ potential energy surface to the title vibrational relaxation process...
May 24, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29791854/nup133-is-required-for-proper-nuclear-pore-basket-assembly-and-dynamics-in-embryonic-stem-cells
#3
Benoit Souquet, Ellen Freed, Alessandro Berto, Vedrana Andric, Nicolas Audugé, Bernardo Reina-San-Martin, Elizabeth Lacy, Valérie Doye
Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC) proliferation. Using single-pore detection and average NE-fluorescence intensity, we find that Nup133 is dispensable for interphase and postmitotic NPC scaffold assembly in pluripotent mESCs. However, loss of Nup133 specifically perturbs the formation of the nuclear basket as manifested by the absence of Tpr in about half of the NPCs combined with altered dynamics of Nup153...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791799/oxidation-of-microcystins-by-permanganate-ph-and-temperature-dependent-kinetics-effect-of-dom-characteristics-and-oxidation-mechanism-revisited
#4
Min Sik Kim, Hye-Jin Lee, Ki-Myeong Lee, Jiwon Seo, Changha Lee
Oxidative degradation of six representative microcystins (MCs) (MC-RR, -LR, -YR, -LF, -LW and -LA) by potassium permanganate (KMnO4; Mn(VII)) was investigated, focusing on the temperature- and pH-dependent reaction kinetics, the effect of dissolved organic matter (DOM), and the oxidation mechanisms. Second-order rate constants for the reactions of the six MCs with Mn(VII) (kMn(VII),MC) were determined to be 160.4-520.1 M-1 s-1 (MC-RR > -LR  -YR > -LF  -LW > -LA) at pH 7.2 and 21°C. The kMn(VII),MC values exhibited activation energies ranging from 15...
May 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29790529/dimethylmagnesium-revisited
#5
Christoph Stuhl, Reiner Anwander
A compilation of solvent-free homometallic methyl compounds of the type MMex (x = 1-6) is provided and categorised according to their method of characterisation (powder or single crystal X-ray diffraction, gas electron diffraction (GED), reactivity, unconfirmed). Recrystallisation of polymeric [MgMe2]n from excess GaMe3 led to the formation of highly pure [MgMe2]n suitable for single crystal X-ray crystallographic studies. Transient Mg(GaMe4)2 could be detected in excess GaMe3 by NMR spectroscopy, but its isolation as Mg(GaMe4)2 failed...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29790167/beware-of-memes-in-the-interpretation-of-your-results-lessons-from-gene-disrupted-mice-in-fertilization-research
#6
Masaru Okabe
For decades, researchers in the fertilization field reported various candidate factors involved in sperm-egg interaction through experiments using enzyme inhibitors and/or antibodies. However, almost all of these factors have been shown to be nonessential by gene-disruption experiments. Recently, attention has focused on the low reproducibility of papers in many research fields. In this Review, I retrospectively revisit how fertilization factors were misinterpreted and led to wrong hypotheses in relation to the reportedly low reproducibility of scientific papers...
May 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29789479/anandamide-revisited-how-cholesterol-and-ceramides-control-receptor-dependent-and-receptor-independent-signal-transmission-pathways-of-a-lipid-neurotransmitter
#7
REVIEW
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J Barrantes, Henri Chahinian
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for the neurotransmitter compared with the fatty acid. In this review, we first analyze the conformational flexibility of anandamide in aqueous and membrane phases. We next study the interaction of the neurotransmitter with membrane lipids and discuss the molecular basis of the unexpected selectivity of anandamide for cholesterol and ceramide from among other membrane lipids...
May 22, 2018: Biomolecules
https://www.readbyqxmd.com/read/29788352/revisiting-the-low-birthweight-paradox-using-sibling-data-with-implications-for-the-classification-of-low-birthweight
#8
M Tabet, L H Flick, H Xian, J J Chang
Background: We examined the birthweight threshold for increased odds of neonatal death among second births based on their elder sibling's birthweight category. Methods: This population-based cohort study included 190 575 women who delivered their first two non-anomalous singleton live births in Missouri (1989-2005). We examined the birthweight distribution and neonatal mortality curves of second births whose elder sibling had low versus adequate/high birthweight...
May 19, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29787983/circuit-filling-factor-cff-for-multiply-tuned-probes-revisited
#9
Mark S Conradi, Albert P Zens
The concept of circuit filling factor (CFF) is re-examined for multi-tuned, multi-inductor probe circuits. The CFF is the fraction of magnetic stored energy residing in the NMR coil. The CFF theorem states that the CFF sums to unity across all the resonant normal modes. It dictates that improved performance from a large CFF in one mode comes at the expense of CFF (and performance) at the other mode(s). Simple analytical calculations of two-mode circuits are used to demonstrate and confirm the CFF theorem. A triple-resonance circuit is calculated to show the large trade-offs involved there...
May 17, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29787421/the-impact-of-saphenous-vein-sparing-during-inguinal-lymphadenectomy-on-postoperative-morbidity-in-women-with-vulval-cancer-an-updated-per-groin-meta-analysis-of-short-term-outcomes
#10
Anastasios Tranoulis, Alexandros Laios, George Theophilou, Konstantinos Bramis, Sean Kehoe
OBJECTIVE: Inguinofemoral lymphadenectomy (IFL) is included in the standard surgical management of early-stage vulval cancer (VC) but is often accompanied by surgical complications. Efforts have been made to limit the postoperative morbidity by adopting more conservative IFL techniques without compromising the surgical outcomes. Saphenous vein (SV) preservation during IFL for VC appears to reduce the incidence of postoperative complications including lymphedema. To ascertain the efficacy of SV preservation, we aimed to revisit the impact of SV preservation on short-term per groin complications by updating on a previous meta-analysis to further guide current clinical practice...
May 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29786913/new-insights-into-the-anion-transport-selectivity-and-mechanism-of-tren-based-tris-thio-ureas
#11
Laura Jowett, Ethan Howe, Xin Wu, Nathalie Busschaert, Philip Alan Gale
The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29786564/developing-defined-substrates-for-stem-cell-culture-and-differentiation
#12
REVIEW
Louise Hagbard, Katherine Cameron, Paul August, Christopher Penton, Malin Parmar, David C Hay, Therése Kallur
Over the past few decades, a variety of different reagents for stem cell maintenance and differentiation have been commercialized. These reagents share a common goal in facilitating the manufacture of products suitable for cell therapy while reducing the amount of non-defined components. Lessons from developmental biology have identified signalling molecules that can guide the differentiation process in vitro , but less attention has been paid to the extracellular matrix used. With the introduction of more biologically relevant and defined matrices, that better mimic specific cell niches, researchers now have powerful resources to fine-tune their in vitro differentiation systems, which may allow the manufacture of therapeutically relevant cell types...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29785033/identification-and-characterization-of-diverse-coherences-in-the-fenna-matthews-olson-complex
#13
Erling Thyrhaug, Roel Tempelaar, Marcelo J P Alcocer, Karel Žídek, David Bína, Jasper Knoester, Thomas L C Jansen, Donatas Zigmantas
The idea that excitonic (electronic) coherences are of fundamental importance to natural photosynthesis gained popularity when slowly dephasing quantum beats (QBs) were observed in the two-dimensional electronic spectra of the Fenna-Matthews-Olson (FMO) complex at 77 K. These were assigned to superpositions of excitonic states, a controversial interpretation, as the strong chromophore-environment interactions in the complex suggest fast dephasing. Although it has been pointed out that vibrational motion produces similar spectral signatures, a concrete assignment of these oscillatory signals to distinct physical processes is still lacking...
May 21, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29784539/revisiting-antithrombin-in-health-and-disease-congenital-deficiencies-and-genetic-variants-and-laboratory-studies-on-%C3%AE-and-%C3%AE-forms
#14
REVIEW
Jean Amiral, Jerard Seghatchian
Antithrombin [AT] is the main inhibitor for activated plasma coagulation serine esterases, inhibiting thrombin, Factors Xa and IXa, but also Factors XIIa, XIa, VIIa, kallicrein, and plasmin. Its activity is highly enhanced by heparin, through binding to the pentasaccharide sequences, for inhibition of all coagulation proteases, except thrombin, which inhibition requires its additional binding to the heparin polysaccharide chain. However, AT is the major inhibitor of thrombin in the blood circulation. Congenital or acquired deficiencies of AT expose affected patients to an increased risk of developing unprovoked and recurrent thrombo-embolic diseases...
April 19, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29783885/pneumomediastinum-revisited-we-should-reconsider-usual-classification
#15
Melanie Dechamps, Lieven De Smedt, Said Hachimi Idrissi
Pneumomediastinum work-up should focus on differentiating mediastinal organ injuries from alveolar rupture since these two causative mechanisms have a different management and prognosis. After an admission at our Emergency Department, we wanted to challenge the current classification into 'spontaneous' or 'secondary' pneumomediastinum, which reflects the clinical rather than the pathophysiological circumstances and is therefore confusing and inappropriate to our view. We propose a new work-up algorithm based on clinical risks factors and chest CT findings...
May 21, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29783736/revisiting-cd28-superagonist-tgn1412-as-potential-therapeutic-for-pediatric-b-cell-leukemia-a-review
#16
REVIEW
Katelyn E Brown
Pediatric acute lymphoblastic leukemia (ALL) represents the most common pediatric cancer diagnosis, with numbers rising gradually every year. This paper proposes a novel therapeutic agent for pediatric ALL on the basis of a failed clinical drug trial in 2006. TGN1412 was a promising therapeutic agent that yielded outstanding results in both in vitro studies and animal trials. It is a CD28 superagonist monoclonal antibody that activates T regulatory (TReg ) cells in the absence of costimulation of the T cell receptor (TCR) by an antigen-presenting cell...
May 19, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29782575/refining-the-maritime-foundations-of-andean-civilization-how-plant-fiber-technology-drove-social-complexity-during-the-preceramic-period
#17
David Beresford-Jones, Alexander Pullen, George Chauca, Lauren Cadwallader, Maria García, Isabel Salvatierra, Oliver Whaley, Víctor Vásquez, Susana Arce, Kevin Lane, Charles French
Moseley's (1975) Maritime Foundations of Andean Civilization hypothesis challenges, in one of humanity's few pristine hearths of civilization, the axiom that agriculture is necessary for the rise of complex societies. We revisit that hypothesis by setting new findings from La Yerba II (7571-6674 Cal bp) and III (6485-5893 Cal bp), Río Ica estuary, alongside the wider archaeological record for the end of the Middle Preceramic Period on the Peruvian coast. The La Yerba record evinces increasing population, sedentism, and "Broad Spectrum Revolution" features, including early horticulture of Phaseolus and Canavalia beans...
2018: Journal of archaeological method and theory
https://www.readbyqxmd.com/read/29782045/revisiting-the-table-2-fallacy-a-motivating-example-examining-preeclampsia-and-preterm-birth
#18
Gretchen Bandoli, Kristin Palmsten, Christina D Chambers, Laura L Jelliffe-Pawlowski, Rebecca J Baer, Caroline A Thompson
BACKGROUND: A "Table Fallacy," as coined by Westreich and Greenland, reports multiple adjusted effect estimates from a single model. This practice, which remains common in published literature, can be problematic when different types of effect estimates are presented together in a single table. The purpose of this paper is to quantitatively illustrate this potential for misinterpretation with an example estimating the effects of preeclampsia on preterm birth. METHODS: We analysed a retrospective population-based cohort of 2 963 888 singleton births in California between 2007 and 2012...
May 21, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29780612/the-sound-of-jacqueline-du-pr%C3%A3-revisiting-her-medical-and-musical-history
#19
REVIEW
Luis Octavio Tierradentro-García, Juan Sebastián Botero-Meneses, Claudia Talero-Gutiérrez
Jacqueline du Pré was a British cellist, famous for her masterful interpretations and her passionate style of playing. Her outstanding musical career was, unfortunately, cut short by multiple sclerosis. In the present paper, we conduct a historical and medical analysis of her life story, discussing a few aspects regarding her illness and treatment options available at the time of her diagnosis.
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29778624/conditioning-of-human-salivary-flow-using-a-visual-cue-for-sour-candy
#20
Jonathan C Kershaw, Cordelia A Running
OBJECTIVE: Although the "mouthwatering" to sight, smell, or thought of food is commonly accepted in food and nutrition research, the concept of mouthwatering and human salivary flow conditioning is not well accepted in salivary research. The objective of this study was to revisit whether human salivary flow could be classically conditioned to a previously neutral stimulus. DESIGN: Sour candy or a non-food control in opaque containers were presented to healthy participants (n = 8)...
May 14, 2018: Archives of Oral Biology
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