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Insterstitial nephritis

Èlia Ripoll, Ana Merino, Immaculada Herrero-Fresneda, Josep M Aran, Montse Goma, Nuria Bolaños, Laura de Ramon, Oriol Bestard, Josep M Cruzado, Josep M Grinyó, Juan Torras
Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cholesterol-conjugated-anti-CD40-siRNA in dendritic cells (DC) in vitro and in a model of LPS to check its potency and tissue distribution. Then, we report the effects of Chol-siRNA in an experimental model of mice with established lupus nephritis. Our in vitro studies in DC show a 100% intracellular delivery of Chol-siRNA, with a significant reduction in CD40 after LPS stimuli. In vivo in ICR mice, the CD40-mRNA suppressive effects of our Chol-siRNA on renal tissue were remarkably sustained over a 5 days after a single preliminary dose of Chol-siRNA...
2013: PloS One
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