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Se Hyun Oh, Hui Dong Kang, Sang Ku Jung, Sangchun Choi
Cerebral arterial gas embolism (CAGE) shows various manifestations according to the quantity of gas and the brain areas affected. The symptoms range from minor motor weakness, headache, and confusion to disorientation, convulsions, hemiparesis, unconsciousness, and coma. A 46-year-old man was transferred to our emergency department due to altered sensorium. Immediately after a controlled ascent from 33 m of seawater, he complained of shortness of breath and rigid extremities, lapsing into unconsciousness...
July 17, 2018: Therapeutic Hypothermia and Temperature Management
Masaki Nakamura, Satoshi Katagiri, Takaaki Hayashi, Mayumi Yoshioka, Tadashi Nakano
PURPOSE: To describe two cases of paracentral acute middle maculopathy (PAMM) that occurred unilaterally after endovascular coil embolization. METHODS: Medical records including ophthalmic examinations of two PAMM cases were retrospectively reviewed. RESULTS: The first case was a 64-year-old woman with hyperlipidemia and chronic sinusitis. The second case was a 49-year-old man with hypertension, hyperlipidemia, tension headache, and vertigo...
July 13, 2018: Retinal Cases & Brief Reports
Marjie L Hard, Angela Y Wehr, Yangchun Du, Peter J Weiden, David Walling, Lisa von Moltke
BACKGROUND: Aripiprazole lauroxil (AL), a long-acting injectable antipsychotic for the treatment of schizophrenia, requires 21 days of oral aripiprazole supplementation upon initiation. We report findings from a phase 1 study investigating a nanocrystalline milled dispersion of AL (ALNCD) as a potential 1-day initiation regimen. The 1-day initiation regimen is designed to enable rapid achievement of plasma aripiprazole concentrations that are comparable with the 21-day oral initiation regimen...
July 13, 2018: Journal of Clinical Psychopharmacology
Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay, Jonathon M Read, Paul J Steptoe, Nicholas A V Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F Deen, Tom Solomon, Malcolm G Semple, Janet T Scott
We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions...
August 2018: Emerging Infectious Diseases
Qing-Qing Fang, Wei Jiang, Ping Feng, Li-Yu Chen
OBJECTIVE: To compare clinical characteristics and therapeutic outcomes between HIV and non-HIV patients with Cryptococcus neoformans meningitis (CNM). METHODS: A total of 73 patients with CNM (30 patients without HIV and 43 with HIV) were admitted from January 2012 to January 2017. The clinical manifestations,biochemical and microbiological characteristics of cerebrospinal fluid (CSF) were collected and analyzed. RESULTS: The patients in the two group displayed non-specific symptoms such as headache,fever,nausea and vomiting...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Tadej Battelino, Larry C Deeb, Magnus Ekelund, Ona Kinduryte, Georgeanna J Klingensmith, Mirjana Kocova, Margarita Kovarenko, Naim Shehadeh
BACKGROUND: Insulin degludec/insulin aspart (IDegAsp) is a fixed soluble co-formulation of basal and bolus insulin. OBJECTIVE: To evaluate efficacy and safety of IDegAsp in pediatric patients with type 1 diabetes (T1D). SUBJECTS: Children and adolescents (aged 1-<18 years) with T1D. METHODS: A 16-week, phase 3b, treat-to-target, parallel-group, open-label, non-inferiority trial was conducted at 63 sites in 14 countries from October 2013-November 2014...
July 16, 2018: Pediatric Diabetes
Dana P Turner, Adriana D Lebowitz, Ivana Chtay, Timothy T Houle
PURPOSE OF REVIEW: This review synthesizes the utility of measuring migraine triggers for the purpose of forecasting future headache attacks. The nature of forecasting models, headache triggers as inputs to such models, and how these trigger exposures can be measured for forecasting are reviewed. A critical evaluation of the existing forecasting models in the context of their potential application for preemptive treatment is considered. RECENT FINDINGS: A substantial pool of candidate trigger factors could be considered in the creation of forecasting models...
July 16, 2018: Current Pain and Headache Reports
Wesley Chan, Si Xi Zhao, Aaron Winter, Hesham Lakosha, R Rishi Gupta
Purpose: Hypertensive emergency usually presents to ophthalmologists in the form of hypertensive retinopathy. We present a case of hypertensive emergency that presented as bilateral transient myopic shift due to ciliary body detachment in the absence of any retinal pathology. The purpose of this paper is to showcase another ocular manifestation of hypertensive emergency. Observations: A 35 year-old female with a blood pressure of 192/114 mmHg presented to the emergency department with headache and acute onset blurry vision...
September 2018: American Journal of Ophthalmology Case Reports
Bill Zhou, Catherine Yim, Soni Chawla
Background . Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a diagnosis of exclusion in the clinical scenario of increased intracranial pressure without an identifiable cause. This case report provides a brief review of current literature on IIH, important differential considerations to rule out prior to diagnosis, and relevant imaging findings of IIH. Case Presentation . An 18-year-old male presenting with headache and blurry vision was found to have signs of increased intracranial pressure on imaging without other abnormalities to explain the cause, suggesting IIH as a diagnosis...
2018: Global Pediatric Health
Eliza Szuch, Jeanna Auriemma
Acute onset of encephalopathy is often due to infections or intoxications, but a high index of suspicion should exist for metabolic or autoimmune causes particularly in recurrent cases. A 6-year-old previously healthy Caucasian male presented with confusion and somnolence. He had several days of fever, myalgia, headaches, and rhinorrhea and was influenza-A positive. He was noted to have new urinary incontinence, inability to follow commands, and was responsive only to noxious stimuli. His neurological examination revealed bilateral ankle clonus...
2018: Global Pediatric Health
Josef Finsterer, Sinda Zarrouk-Mahjoub
There is no comprehensive overview concerning the phenotypic variability in patients carrying SLC25A4 mutations available. Therefore, the aim of the present review was to summarise and discuss recent findings concerning the clinical presentation and phenotypic heterogeneity of SLC25A4 mutations. The study was conducted by systematically reviewing the literature using the search terms 'mitochondrial', "myopathy', 'nuclear DNA', 'mitochondrial DNA', in combination with 'SLC25A4' or 'AAC1'. The results indicated that the phenotypic heterogeneity in patients carrying a SLC25A4 mutation is broader than so far anticipated...
August 2018: Biomedical Reports
Iraj Derakhshan
No abstract text is available yet for this article.
April 2018: Middle East Journal of Digestive Diseases
Chun-Shuo Shan, Qing-Qing Xu, Yi-Hua Shi, Yong Wang, Zhang-Xin He, Guo-Qing Zheng
Objective: Migraine is a complex, prevalent and disabling neurological disorder characterized by recurrent episodes of headache without ideal treatment. We aim to assess the current available evidence of herbal Chuanxiong (Ligusticum chuanxiong Hort. root) formulae for the treatment of migraine according to the high-quality randomized controlled trials (RCTs). Methods: English and Chinese electronic databases were searched from their inceptions until March 2017. The methodological quality of included study was assessed by the Cochrane Collaboration risk of bias tool...
2018: Frontiers in Pharmacology
Harsh Bhatt, Gulam Zilani, Caroline Hayhurst
A 75-year-old man with type 2 diabetes mellitus presented with complete loss of vision in his right eye and severe headaches for the past 24 hours. He had been treated for suspected giant cell arteritis (GCA) with high-dose corticosteroids which were being tapered to stop after an inconclusive right temporal artery biopsy and an erythrocyte sedimentation rate (ESR) value of 8. His current acute presentation, however, raised further concern for partially treated GCA and precipitated treatment with pulsed methylprednisolone...
July 15, 2018: BMJ Case Reports
Kristin Huntoon, Sophia Shaddy, Norman Lehman, James Bradley Elder
A 55-year-old man with a history of Benign Paroxysmal Positional Vertigo unalleviated by Epley manoeuvre presented to an otolaryngologist for dizziness, right ear fullness and headache. MRI of the brain showed numerous marrow-replacing lesions throughout the calvarium, skull base and upper cervical spine which were hypointense on T1-weighted images, hyperintense on T2-weighted images and avidly enhanced following contrast, concerning for a malignant process such as metastatic disease or multiple myeloma (figure 1)...
July 15, 2018: BMJ Case Reports
Eunju Seo, Eunhee Hong, Jiyeon Choi, Younglee Kim, Cheryl Brandt, Sookbin Im
PURPOSE: To investigate the impact of length of autogenic training (AT) use, alone and with the addition of adjunct treatments, on intensity and duration of primary headache in adults age 19 and older. METHODS: We searched articles published in English and Korean from 1926 to 2016. A search of seven domestic and foreign databases was conducted from September 25, 2016 to December 30, 2016 using the search terms "autogenic training," "autogen," "relaxation," and "headache...
August 2018: Complementary Therapies in Medicine
Alyssa M Falise, Isabel Griffin, Danielle Fernandez, Xeniamaria Rodriguez, Emily Moore, Anne Barrera, Juan Suarez, Lidice Cutie, Guoyan Zhang
OBJECTIVE: The Florida Department of Health in Miami-Dade County (DOH-Miami-Dade) investigated 106 reported carbon monoxide (CO) exposures over a 9-day timeframe after Hurricane Irma. This report evaluates risk factors for CO poisoning and the importance of heightened surveillance following natural disasters. METHODS: Data on CO poisoning cases from September 9 to 18, 2017 were extracted from Merlin, the Florida Department of Health Surveillance System. Medical records were obtained and follow-up interviews were conducted to collect data on the confirmed CO poisoning cases...
July 17, 2018: Disaster Medicine and Public Health Preparedness
Jing Ma, Chunjiang Li, Mei-Po Kwan, Yanwei Chai
With rapid urbanization and increase in car ownership, ambient noise pollution resulting from diversified sources (e.g., road traffic, railway, commercial services) has become a severe environmental problem in the populated areas in China. However, research on the spatial variation of noise pollution and its potential effects on urban residents' mental health has to date been quite scarce in developing countries like China. Using a health survey conducted in Beijing in 2017, we for the first time investigated the spatial distributions of multiple noise pollution perceived by residents in Beijing, including road traffic noise, railway (or subway) noise, commercial noise, and housing renovation (or construction) noise...
July 13, 2018: International Journal of Environmental Research and Public Health
Todd D Rozen
INTRODUCTION: To propose a hypothesis theory to establish a linkage between cigarette smoking and cluster headache pathogenesis. BACKGROUND: Cluster headache is a primary headache syndrome grouped under the trigeminal autonomic cephalalgias. What distinguishes cluster headache from all other primary headache conditions is its inherent connection to cigarette smoking. It is undeniable that tobacco exposure is in some manner related to cluster headache. The connection to tobacco exposure for cluster headache is so strong that even if an individual sufferer never smoked, then that individual typically had significant secondary smoke exposure as a child from parental smoking behavior and in many instances both scenarios exist...
July 16, 2018: Headache
Chelsea M Hesterman, Christina L Szperka, Dana P Turner
OBJECTIVE: To identify and characterize the reasons manuscripts are rejected after peer review from the journal Headache. BACKGROUND: Numerous editorials, reviews, and research manuscripts have been published on the topic of manuscript rejection. However, few of these papers evaluate the reasons for rejection after peer review systematically. None are specific to the field of neurology or headache medicine. METHODS: A retrospective analysis of all submissions to Headache from January 1, 2014 through December 31, 2016 was performed...
July 16, 2018: Headache
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