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https://www.readbyqxmd.com/read/27798673/identification-and-expression-profiling-of-mirnaome-in-goat-longissimus-dorsi-muscle-from-prenatal-stages-to-a-neonatal-stage
#1
Jiazhong Guo, Wei Zhao, Siyuan Zhan, Li Li, Tao Zhong, Linjie Wang, Yao Dong, Hongping Zhang
Skeletal muscle development is a complex biological process regulated by numerous genes and non-coding RNAs, such as microRNAs (miRNAs). In the current study, we made use of the deep sequencing data from Jianzhou Da'er goat longissimus dorsi sampled on days 45, 60, and 105 of gestation, as well as day three after birth to identify miRNAs that regulate goat skeletal myogenesis, and examine their temporal expression profiles. A total of 410 known goat miRNAs, 752 miRNA homologs and 88 novel miRNAs were identified across four stages...
2016: PloS One
https://www.readbyqxmd.com/read/27671199/chronic-alcohol-exposure-induces-muscle-atrophy-myopathy-in-zebrafish-and-alters-the-expression-of-micrornas-targeting-the-notch-pathway-in-skeletal-muscle
#2
Andrew Khayrullin, Lauren Smith, Dhwani Mistry, Amy Dukes, Y Albert Pan, Mark W Hamrick
Muscle wasting is estimated to affect 40-60% of alcoholics, and is more common than cirrhosis among chronic alcohol abusers. The molecular and cellular mechanisms underlying alcohol-related musculoskeletal dysfunction are, however, poorly understood. Muscle-specific microRNAs (miRNAs) referred to as myoMirs are now known to play a key role in both myogenesis and muscle atrophy. Yet, no studies have investigated a role for myoMirs in alcohol-related skeletal muscle damage. We developed a zebrafish model of chronic ethanol exposure to better define the mechanisms mediating alcohol-induced muscle atrophy...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27569217/deep-sequencing-reveals-a-novel-mir-22-regulatory-network-with-therapeutic-potential-in-rhabdomyosarcoma
#3
Francesca Bersani, Marcello Francesco Lingua, Deborah Morena, Valentina Foglizzo, Silvia Miretti, Letizia Lanzetti, Giovanna Carrà, Alessandro Morotti, Ugo Ala, Paolo Provero, Roberto Chiarle, Samuel Singer, Marc Ladanyi, Thomas Tuschl, Carola Ponzetto, Riccardo Taulli
Current therapeutic options for the pediatric cancer rhabdomyosarcoma have not improved significantly, especially for metastatic rhabdomyosarcoma. In the current work, we performed a deep miRNA profiling of the three major human rhabdomyosarcoma subtypes, along with cell lines and normal muscle, to identify novel molecular circuits with therapeutic potential. The signature we determined could discriminate rhabdomyosarcoma from muscle, revealing a subset of muscle-enriched miRNA (myomiR), including miR-22, which was strongly underexpressed in tumors...
October 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27503950/epigenetic-control-of-exercise-training-induced-cardiac-hypertrophy-by-mir-208
#4
Ursula Paula Renó Soci, Tiago Fernandes, Valerio Garrone Barauna, Nara Yumi Hashimoto, Gloria de Fátima Alves Mota, Kaleizu Teodoro Rosa, Maria Claudia Irigoyen, Michael Ian Phillips, Edilamar Menezes de Oliveira
: Aerobic exercise-induced cardiac hypertrophy is a physiological response involving accurate orchestration of gene and protein expression of contractile and metabolic components. The microRNAs: miR-208a, miR-208b and miR-499 are each encoded by a myosin gene and thus are also known as "MyomiRs", regulating several mRNA targets that in turn regulate cardiac hypertrophy and metabolic pathways. AIMS: To understand the role of myomiRs in the fine-tuning of cardiac MHC isoform expression by exercise training-induced physiological hypertrophy...
August 8, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27466195/selective-release-of-muscle-specific-extracellular-micrornas-during-myogenic-differentiation
#5
Anna M L Coenen-Stass, Corinne A Betts, Yi F Lee, Imre Mäger, Mikko P Turunen, Samir El Andaloussi, Jennifer E Morgan, Matthew J A Wood, Thomas C Roberts
MyomiRs are muscle-specific microRNAs (miRNAs) that regulate myoblast proliferation and differentiation. Extracellular myomiRs (ex-myomiRs) are highly enriched in the serum of Duchenne Muscular Dystrophy (DMD) patients and dystrophic mouse models and consequently have potential as disease biomarkers. The biological significance of microRNAs present in the extracellular space is not currently well understood. Here we demonstrate that ex-myomiR levels are elevated in perinatal skeletal muscle, during the regenerative phase that follows exercise-induced myoinjury, and concomitant with myoblast differentiation in culture...
July 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27445979/myomirs-as-markers-of-insulin-resistance-and-decreased-myogenesis-in-skeletal-muscle-of-diet-induced-obese-mice
#6
Flávia de Toledo Frias, Mariana de Mendonça, Amanda Roque Martins, Ana Flávia Gindro, Bruno Cogliati, Rui Curi, Alice Cristina Rodrigues
High-fat diet (HFD) feeding causes insulin resistance (IR) in skeletal muscle of mice, which affects skeletal muscle metabolism and function. The involvement of muscle-specific microRNAs in the evolution of skeletal muscle IR during 4, 8, and 12 weeks in HFD-induced obese mice was investigated. After 4 weeks in HFD, mice were obese, hyperglycemic, and hyperinsulinemic; however, their muscles were responsive to insulin stimuli. Expressions of MyomiRs (miR-1, miR-133a, and miR-206) measured in soleus muscles were not different from those found in control mice...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27429962/prospective-and-therapeutic-screening-value-of-non-coding-rna-as-biomarkers-in-cardiovascular-disease
#7
REVIEW
Albert Busch, Suzanne M Eken, Lars Maegdefessel
Non-coding RNA (ncRNA) is a class of genetic, epigenetic and translational regulators, containing short and long transcripts with intriguing abilities for use as biomarkers due to their superordinate role in disease development. In the past five years many of these have been investigated in cardiovascular diseases (CVD), mainly myocardial infarction (MI) and heart failure. To extend this view, we summarize the existing data about ncRNA as biomarker in the whole entity of CVDs by literature-based review and comparison of the identified candidates...
June 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27262998/evolution-and-distribution-of-teleost-myomirnas-functionally-diversified-myomirs-in-teleosts
#8
Bhuiyan Sharmin Siddique, Shigeharu Kinoshita, Chaninya Wongkarangkana, Shuichi Asakawa, Shugo Watabe
Myosin heavy chain (MYH) genes belong to a multigene family, and the regulated expression of each member determines the physiological and contractile muscle properties. Among these, MYH6, MYH7, and MYH14 occupy unique positions in the mammalian MYH gene family because of their specific expression in slow/cardiac muscles and the existence of intronic micro(mi) RNAs. MYH6, MYH7, and MYH14 encode miR-208a, miR-208b, and miR-499, respectively. These MYH encoded miRNAs are designated as myomiRs because of their muscle-specific expression and functions...
June 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27170302/identification-in-grmd-dog-muscle-of-critical-mirnas-involved-in-pathophysiology-and-effects-associated-with-mustem-cell-transplantation
#9
Florence Robriquet, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Mireille Ledevin, Hélicia Goubin, Karl Rouger, Laëtitia Guével
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked muscle disease that leads to fibre necrosis and progressive paralysis. At present, DMD remains a lethal disease without any effective treatment, requiring a better understanding of the pathophysiological processes and comprehensive assessment of the newly identified therapeutic strategies. MicroRNAs including members of the muscle-specific myomiR family have been identified as being deregulated in muscle of DMD patients and in mdx mice used as a model for DMD...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27038912/depleting-extracellular-vesicles-from-fetal-bovine-serum-alters-proliferation-and-differentiation-of-skeletal-muscle-cells-in-vitro
#10
Hala Aswad, Audrey Jalabert, Sophie Rome
BACKGROUND: Fetal bovine serum (FBS) contains a wide range of growth factors, hormones, vitamins, amino acids, fatty acids and trace elements required for cell growth. It was shown that animal sera contain also extracellular vesicles (EVs) with important biological properties; thus we wondered whether EVs present in FBS would influence muscle cell phenotype. EVs were removed from sera by ultracentrifugation (18 h). C2C12, L6 and human primary myoblasts, were grown either in classical media (CM) or in EVs-depleted media...
2016: BMC Biotechnology
https://www.readbyqxmd.com/read/26975470/myomir-dysregulation-and-reactive-oxygen-species-in-aged-human-satellite-cells
#11
Ester Sara Di Filippo, Rosa Mancinelli, Tiziana Pietrangelo, Rita Maria Laura La Rovere, Mattia Quattrocelli, Maurilio Sampaolesi, Stefania Fulle
Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to the age-associated decline in muscle mass, known as sarcopenia. The myogenic potential impairment does not depend on a reduced myogenic cell number, but mainly on their difficulty to complete a differentiation program...
April 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26878133/a-selective-screening-platform-reveals-unique-global-expression-patterns-of-micrornas-in-a-cohort-of-human-soft-tissue-sarcomas
#12
Peter Y Yu, Mumtaz Y Balkhi, Katherine J Ladner, Hansjuerg Alder, Lianbo Yu, Xiaokui Mo, William G Kraybill, Denis C Guttridge, O Hans Iwenofu
Sarcomas are malignant heterogenous tumors of mesenchymal derivation. Emerging data suggest that miRNA might have a causal role in sarcomagenesis. Herein, we used a selective miRNA screening platform to study the comparative global miRNA expression signatures in a cohort of human sarcomas with the caveat that comparisons between tumor and non-tumor cells were performed from the same patients using formalin-fixed paraffin-embedded tissue. Five histologic types were examined that included: myxoid liposarcoma, well-differentiated liposarcoma, dedifferentiated liposarcoma, pleomorphic rhabdomyosarcoma, and synovial sarcoma...
April 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26708096/muscle-specific-micrornas-in-skeletal-muscle-development
#13
REVIEW
Martin Horak, Jan Novak, Julie Bienertova-Vasku
Proper muscle function constitutes a precondition for good heath and an active lifestyle during an individual's lifespan and any deviations from normal skeletal muscle development and its functions may lead to numerous health conditions including e.g. myopathies and increased mortality. It is thus not surprising that there is an increasing need for understanding skeletal muscle developmental processes and the associated molecular pathways, especially as such information could find further uses in therapy. The understanding of complex skeletal muscle developmental networks was broadened with the discovery of microRNA (miRNA) molecules...
February 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/26530925/positive-bioluminescence-imaging-of-microrna-expression-in-small-animal-models-using-an-engineered-genetic-switch-expression-system-riles
#14
Patrick Baril, Chantal Pichon
MicroRNAs (miRNAs) are a class of small, noncoding RNAs which regulate gene expression by directing their target mRNA for degradation or translational repression. Since their discovery in the early 1990s, miRNAs have emerged as key components in the posttranscriptional regulation of gene networks, shaping many biological processes from development, morphogenesis, differentiation, proliferation and apoptosis. Although understanding of the molecular basis of miRNA biology is improving, methods to monitor the dynamic and the spatiotemporal aspects of miRNA expression under physiopathological conditions are required...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26472872/influence-of-statins-on-distinct-circulating-micrornas-during-prolonged-aerobic-exercise
#15
Pil-Ki Min, Joseph Park, Stephanie Isaacs, Beth A Taylor, Paul D Thompson, Chris Troyanos, Pierre D'Hemecourt, Sophia Dyer, Stephen Y Chan, Aaron L Baggish
Statins exacerbate exercise-induced skeletal muscle injury. Muscle-specific microRNAs (myomiRs) increase in plasma after prolonged exercise, but the patterns of myomiRs release after statin-associated muscle injury have not been examined. We examined the relationships between statin exposure, in vitro and in vivo muscle contraction, and expression of candidate circulating myomiRs. We measured plasma levels of myomiRs, circulating microRNA-1 (c-miR-1), c-miR-133a, c-miR-206, and c-miR-499-5p from 28 statin-using and 28 nonstatin-using runners before (PRE), immediately after (FINISH), and 24 h after they ran a 42-km footrace (the 2011 Boston marathon) (POST-24)...
March 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26272918/myod-transcription-factor-induces-myogenesis-by-inhibiting-twist-1-through-mir-206
#16
Demetris Koutalianos, Andrie Koutsoulidou, Nikilaos P Mastroyiannopoulos, Denis Furling, Leonidas A Phylactou
Twist-1 is mostly expressed during development and has been previously shown to control myogenesis. Because its regulation in muscle has not been fully exploited, the aim of this project was to identify micro (mi)RNAs in muscle that regulate Twist-1. miR-206, one of the most important muscle-specific miRNAs (myomiRs), was identified as a possible regulator of Twist-1 mRNA. Luciferase assays and transfections in human foetal myoblasts showed that Twist-1 is a direct target of miR-206 and that through this pathway muscle cell differentiation is promoted...
October 1, 2015: Journal of Cell Science
https://www.readbyqxmd.com/read/26071549/aerobic-exercise-training-promotes-physiological-cardiac-remodeling-involving-a-set-of-micrornas
#17
REVIEW
Tiago Fernandes, Valério G Baraúna, Carlos E Negrão, M Ian Phillips, Edilamar M Oliveira
Left ventricular (LV) hypertrophy is an important physiological compensatory mechanism in response to chronic increase in hemodynamic overload. There are two different forms of LV hypertrophy, one physiological and another pathological. Aerobic exercise induces beneficial physiological LV remodeling. The molecular/cellular mechanisms for this effect are not totally known, and here we review various mechanisms including the role of microRNA (miRNA). Studies in the heart, have identified antihypertrophic miRNA-1, -133, -26, -9, -98, -29, -378, and -145 and prohypertrophic miRNA-143, -103, -130a, -146a, -21, -210, -221, -222, -27a/b, -199a/b, -208, -195, -499, -34a/b/c, -497, -23a, and -15a/b...
August 15, 2015: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/25915937/microrna-transcriptome-profile-analysis-in-porcine-muscle-and-the-effect-of-mir-143-on-the-myh7-gene-and-protein
#18
Jianjun Zuo, Fan Wu, Yihua Liu, Juan Xiao, Mei Xu, Qinping Yu, Minhao Xia, Xiaojun He, Shigeng Zou, Huize Tan, Dingyuan Feng
Porcine skeletal muscle fibres are classified based on their different physiological and biochemical properties. Muscle fibre phenotype is regulated by several independent signalling pathways, including the mitogen-activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT), myocyte enhancer factor 2 (MEF2) and peroxisome proliferator-activated receptor (PPAR) signalling pathways. MicroRNAs are non-coding small RNAs that regulate many biological processes. However, their function in muscle fibre type regulation remains unclear...
2015: PloS One
https://www.readbyqxmd.com/read/25881242/temperature-during-early-development-has-long-term-effects-on-microrna-expression-in-atlantic-cod
#19
Teshome Tilahun Bizuayehu, Steinar D Johansen, Velmurugu Puvanendran, Hilde Toften, Igor Babiak
BACKGROUND: Environmental temperature has serious implications in life cycle of aquatic ectotherms. Understanding the molecular mechanisms of temperature acclimation and adaptation of marine organisms is of the uttermost importance for ecology, fisheries, and aquaculture, as it allows modeling the effects of global warming on population dynamics. Regulatory molecules are major modulators of acclimation and adaptation; among them, microRNAs (miRNAs) are versatile and substantial contributors to regulatory networks of development and adaptive plasticity...
2015: BMC Genomics
https://www.readbyqxmd.com/read/25859932/mir-206-a-cerebellum-enriched-mirna-is-downregulated-in-all-medulloblastoma-subgroups-and-its-overexpression-is-necessary-for-growth-inhibition-of-medulloblastoma-cells
#20
Pooja Panwalkar, Aliasgar Moiyadi, Atul Goel, Prakash Shetty, Naina Goel, Epari Sridhar, Neelam Shirsat
Medulloblastoma is the most common and a highly malignant pediatric brain tumor located in the cerebellar region of the brain. Medulloblastomas have recently been shown to consist of four distinct molecular subgroups, viz., WNT, SHH, group 3, and group 4. MiR-206, a miRNA first identified as a myomiR due to its enriched expression in skeletal muscle was found to be expressed specifically in the cerebellum, the site of medulloblastoma occurrence. MiR-206 expression was found to be downregulated in medulloblastomas belonging to all the four molecular subgroups as well as in established medulloblastoma cell lines...
July 2015: Journal of Molecular Neuroscience: MN
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