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Behavioral traits and biology

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https://www.readbyqxmd.com/read/28098394/use-of-asian-samples-in-genetic-research-of-alcohol-use-disorders-genetic-variation-of-alcohol-metabolizing-enzymes-and-the-effects-of-acetaldehyde
#1
Sachio Matsushita, Susumu Higuchi
BACKGROUND AND OBJECTIVES: Epidemiological studies consistently find that Asian populations report lower rates of alcohol use disorders (AUD) compared with other racial groups. These differences result from a variety of biological, genetic, and environmental influences, some of which are related to the metabolism of alcohol. We will review several studies of these metabolic factors, including several alcohol clamping studies conducted in our laboratory, that provide further insight into the role of the alcohol metabolizing genes and drinking behavior among Japanese drinkers...
January 18, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28076762/a-leptin-analog-locally-produced-in-the-brain-acts-via-a-conserved-neural-circuit-to-modulate-obesity-linked-behaviors-in-drosophila
#2
Jennifer Beshel, Josh Dubnau, Yi Zhong
Leptin, a typically adipose-derived "satiety hormone," has a well-established role in weight regulation. Here we describe a functionally conserved model of genetically induced obesity in Drosophila by manipulating the fly leptin analog unpaired 1 (upd1). Unexpectedly, cell-type-specific knockdown reveals upd1 in the brain, not the adipose tissue, mediates obesity-related traits. Disrupting brain-derived upd1 in flies leads to all the hallmarks of mammalian obesity: increased attraction to food cues, increased food intake, and increased weight...
January 10, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28069897/impact-of-estrogen-receptor-%C3%AE-gene-and-oxytocin-receptor-gene-polymorphisms-on-female-sexuality
#3
Anastasia K Armeni, Konstantinos Assimakopoulos, Dimitra J Marioli, Vasiliki Koika, Eftychia Michailidou, Niki Mourtzi, Gregoris Iconomou, Neoklis A Georgopoulos
Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behaviour. The aim of the present study was to investigate the correlation of estrogen receptor α (ERα) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism (rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hundred thirty-three Greek heterosexual women, students in higher education institutions, 20-25 years of age, sexually active, with normal menstrual cycles (28-35 days), were recruited in the study...
January 9, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28051947/early-life-effects-on-adult-physical-activity-concepts-relevance-and-experimental-approaches
#4
Theodore Garland, Marcell D Cadney, Robert A Waterland
Locomotion is a defining characteristic of animal life and plays a crucial role in most behaviors. Locomotion involves physical activity, which can have far-reaching effects on physiology and neurobiology, both acutely and chronically. In human populations and in laboratory rodents, higher levels of physical activity are generally associated with positive health outcomes, although excessive exercise can have adverse consequences. Whether and how such relationships occur in wild animals is unknown. Behavioral variation among individuals arises from genetic and environmental factors and their interactions as well as from developmental programming (persistent effects of early-life environment)...
January 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28039074/caffeine-stimulates-voluntary-wheel-running-in-mice-without-increasing-aerobic-capacity
#5
Gerald C Claghorn, Zoe Thompson, Kristianna Wi, Lindsay Van, Theodore Garland
The "energy drink" Red Bull and the "sports drink" Gatorade are often marketed to athletes, with claims that they cause performance gains. However, both are high in sugars, and also consumed by non-athletes. Few studies have addressed the effects of these drinks or their biologically active components in rodent exercise models. We used three experiments to test effects on both voluntary exercise behavior and maximal aerobic capacity in lines of mice known to differ in "athletic" traits. Mice from four replicate High Runner (HR) lines have been selectively bred for voluntary running on wheels, and run approximately three times as many revolutions per day as do mice from four non-selected Control (C) lines...
December 28, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28027852/analyses-of-differentially-expressed-genes-after-exposure-to-acute-stress-acute-ethanol-or-a-combination-of-both-in-mice
#6
Jessica A Baker, Jingxin Li, Diana Zhou, Ming Yang, Melloni N Cook, Byron C Jones, Megan K Mulligan, Kristin M Hamre, Lu Lu
Alcohol abuse is a complex disorder, which is confounded by other factors, including stress. In the present study, we examined gene expression in the hippocampus of BXD recombinant inbred mice after exposure to ethanol (NOE), stress (RSS), and the combination of both (RSE). Mice were given an intraperitoneal (i.p.) injection of 1.8 g/kg ethanol or saline, and subsets of both groups were exposed to acute restraint stress for 15 min or controls. Gene expression in the hippocampus was examined using microarray analysis...
December 16, 2016: Alcohol
https://www.readbyqxmd.com/read/28004894/explanations-for-adaptations-just-so-stories-and-limitations-on-evidence-in-evolutionary-biology
#7
Richard J Smith
Explanations of the historical origin of specific individual traits are a key part of the research program in paleontology and evolutionary biology. Why did bipedalism evolve in the human lineage? Why did some dinosaurs and related species have head crests? Why did viviparity evolve in some reptiles? Why did the common ancestor of primates evolve stereoscopic vision, grasping hands and feet, nails instead of claws, and large brains? These are difficult questions. To varying degrees, an explanation must grapple with (1) judgments about changes in fitness that might follow from a change in morphology - without actually observing behavior or measuring reproductive success, (2) the relationship between genes and traits, (3) limitations on doing relevant experiments, (4) the interpretation of causes that are almost certainly contingent, multifactorial, interactive, hierarchical, nonlinear, emergent, and probabilistic rather than deterministic, (5) limited information about variation and ontogeny, (6) a dataset based on the random fortunes of the historical record, including only partial hard-tissue morphology and no soft-tissue morphology, (7) an equally partial and problematic (for example, time-averaged) record of the environment, (8) the compression of all data into a geological time scale that is likely to miss biologically important events or fluctuations, (9) dependence on a process that can only be inferred ("form and even behavior may leave fossil traces, but forces like natural selection do not", (1:130) ) and finally, (10) the assumption of the "adaptationist programme"(2) that the trait in question is in fact an adaptation rather than a consequence of genetic drift, correlated evolution, pleiotropy, exaptation, or other mechanisms...
November 2016: Evolutionary Anthropology
https://www.readbyqxmd.com/read/27990277/biting-the-hand-that-feeds-current-opinion-on-the-interpersonal-causes-correlates-and-consequences-of-borderline-personality-disorder
#8
REVIEW
Sheila E Crowell
Borderline personality disorder (BPD) is a complex psychiatric diagnosis characterized by dysregulated behaviors, emotions, cognitions, and interpersonal relationships. In recent years, developmental psychopathologists have sought to identify early origins of BPD, with the ultimate goal of developing and providing effective preventative interventions for those at highest risk. In addition to heritable biological sensitivities, many scholars assert that environmental and interpersonal risk factors contribute to the emergence and maintenance of key borderline traits...
2016: F1000Research
https://www.readbyqxmd.com/read/27982108/high-maltose-sensitivity-of-sweet-taste-receptors-in-the-japanese-macaque-macaca-fuscata
#9
Emiko Nishi, Kei Tsutsui, Hiroo Imai
Taste sensitivity differs among animal species depending on feeding habitat. To humans, sucrose is one of the sweetest natural sugars, and this trait is expected to be similar in other primates. However, previous behavioral tests have shown that some primate species have equal preferences for maltose and sucrose. Because sweet tastes are recognized when compounds bind to the sweet taste receptor Tas1R2/Tas1R3, we evaluated the responses of human and Japanese macaque Tas1R2/Tas1R3 to various natural sugars using a heterologous expression system...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27965696/modeling-rice-metabolism-from-elucidating-environmental-effects-on-cellular-phenotype-to-guiding-crop-improvement
#10
REVIEW
Meiyappan Lakshmanan, C Y Maurice Cheung, Bijayalaxmi Mohanty, Dong-Yup Lee
Crop productivity is severely limited by various biotic and abiotic stresses. Thus, it is highly needed to understand the underlying mechanisms of environmental stress response and tolerance in plants, which could be addressed by systems biology approach. To this end, high-throughput omics profiling and in silico modeling can be considered to explore the environmental effects on phenotypic states and metabolic behaviors of rice crops at the systems level. Especially, the advent of constraint-based metabolic reconstruction and analysis paves a way to characterize the plant cellular physiology under various stresses by combining the mathematical network models with multi-omics data...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27965368/environmental-and-hormonal-control-of-cambial-stem-cell-dynamics
#11
REVIEW
Rishikesh P Bhalerao, Urs Fischer
Perennial trees have the amazing ability to adjust their growth rate to both adverse and favorable seasonally reoccurring environmental conditions over hundreds of years. In trunks and stems, the basis for the tuning of seasonal growth rate is the regulation of cambial stem cell activity. Cambial stem cell quiescence and dormancy protect the tree from potential physiological and genomic damage caused by adverse growing conditions and may permit a long lifespan. Cambial dormancy and longevity are both aspects of a tree's life for which the study of cambial stem cell behavior in the annual model plant Arabidopsis is inadequate...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27956745/altered-brain-processing-of-decision-making-in-healthy-first-degree-biological-relatives-of-suicide-completers
#12
Y Ding, F Pereira, A Hoehne, M-M Beaulieu, M Lepage, G Turecki, F Jollant
Suicidal behavior is heritable, with the transmission of risk being related to the transmission of vulnerability traits. Previous studies suggest that risky decision-making may be an endophenotype of suicide. Here, we aimed at investigating brain processing of decision-making in relatives of suicide completers in order to shed light on heritable mechanisms of suicidal vulnerability. Seventeen healthy first-degree biological relatives of suicide completers with no personal history of suicidal behavior, 16 relatives of depressed patients without any personal or family history of suicidal behavior, and 19 healthy controls were recruited...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27951454/kamikazes-and-cultural-evolution
#13
Sean Allen-Hermanson
Is cultural evolution needed to explain altruistic selfsacrifice? Some contend that cultural traits (e.g. beliefs, behaviors, and for some "memes") replicate according to selection processes that have "floated free" from biology. One test case is the example of suicide kamikaze attacks in wartime Japan. Standard biological mechanisms-such as reciprocal altruism and kin selection-might not seem to apply here: The suicide pilots did not act on the expectation that others would reciprocate, and they were supposedly sacrificing themselves for country and emperor, not close relatives...
December 9, 2016: Studies in History and Philosophy of Biological and Biomedical Sciences
https://www.readbyqxmd.com/read/27942020/evolutionary-and-functional-diversification-of-the-vitamin-d-receptor-lithocholic-acid-partnership
#14
Erin M Kollitz, Guozhu Zhang, Mary Beth Hawkins, G Kerr Whitfield, David M Reif, Seth W Kullman
The evolution, molecular behavior, and physiological function of nuclear receptors are of particular interest given their diverse roles in regulating essential biological processes. The vitamin D receptor (VDR) is well known for its canonical roles in calcium homeostasis and skeletal maintenance. Additionally, VDR has received an increased amount of attention due to the discovery of numerous non-calcemic functions, including the detoxification of lithocholic acid. Lithocholic acid is a toxic metabolite of chenodeoxycholic acid, a primary bile acid...
2016: PloS One
https://www.readbyqxmd.com/read/27940316/proteomic-analysis-of-the-adaptative-response-of-mucor-spp-to-cheese-environment
#15
Stéphanie Morin-Sardin, Jean-Luc Jany, Sébastien Artigaud, Vianney Pichereau, Benoît Bernay, Emmanuel Coton, Stéphanie Madec
: In the cheese industry context, Mucor species exhibit an ambivalent behavior as some species are essential "technological" organisms of some cheeses while others can be spoiling agents. Previously, we observed that cheese "technological" species exhibited higher optimal growth rates on cheese related matrices than on synthetic media. This growth pattern combined with morphological differences raise the question of their adaptation to cheese. In this study, using a comparative proteomic approach, we described the metabolic pathways of three Mucor strains considered as "technological" or "contaminant" in the cheese environment (M...
December 6, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27933521/genenetwork-a-toolbox-for-systems-genetics
#16
Megan K Mulligan, Khyobeni Mozhui, Pjotr Prins, Robert W Williams
The goal of systems genetics is to understand the impact of genetic variation across all levels of biological organization, from mRNAs, proteins, and metabolites, to higher-order physiological and behavioral traits. This approach requires the accumulation and integration of many types of data, and also requires the use of many types of statistical tools to extract relevant patterns of covariation and causal relations as a function of genetics, environment, stage, and treatment. In this protocol we explain how to use the GeneNetwork web service, a powerful and free online resource for systems genetics...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27923919/quorum-sensing-coordinates-cooperative-expression-of-pyruvate-metabolism-genes-to-maintain-a-sustainable-environment-for-population-stability
#17
Lisa A Hawver, Jennifer M Giulietti, James D Baleja, Wai-Leung Ng
: Quorum sensing (QS) is a microbial cell-cell communication system that regulates gene expression in response to population density to coordinate collective behaviors. Yet, the role of QS in resolving the stresses caused by the accumulation of toxic metabolic by-products at high cell density is not well defined. In response to cell density, QS could be involved in reprogramming of the metabolic network to maintain population stability. Using unbiased metabolomics, we discovered that Vibrio cholerae mutants genetically locked in a low cell density (LCD) QS state are unable to alter the pyruvate flux to convert fermentable carbon sources into neutral acetoin and 2,3-butanediol molecules to offset organic acid production...
December 6, 2016: MBio
https://www.readbyqxmd.com/read/27922606/otto-a-new-strategy-to-extract-mental-disease-relevant-combinations-of-gwas-hits-from-individuals
#18
H Ehrenreich, M Mitjans, S Van der Auwera, T P Centeno, M Begemann, H J Grabe, S Bonn, K-A Nave
Despite high heritability of schizophrenia, genome-wide association studies (GWAS) have not yet revealed distinct combinations of single-nucleotide polymorphisms (SNPs), relevant for mental disease-related, quantifiable behavioral phenotypes. Here we propose an individual-based model to use genome-wide significant markers for extracting first genetic signatures of such behavioral continua. 'OTTO' (old Germanic=heritage) marks an individual characterized by a prominent phenotype and a particular load of phenotype-associated risk SNPs derived from GWAS that likely contributed to the development of his personal mental illness...
December 6, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27911941/copper-oxide-nanoparticles-impact-several-toxicological-endpoints-and-cause-neurodegeneration-in-caenorhabditis-elegans
#19
Michael J Mashock, Tyler Zanon, Anthony D Kappell, Lisa N Petrella, Erik C Andersen, Krassimira R Hristova
Engineered nanoparticles are becoming increasingly incorporated into technology and consumer products. In 2014, over 300 tons of copper oxide nanoparticles were manufactured in the United States. The increased production of nanoparticles raises concerns regarding the potential introduction into the environment or human exposure. Copper oxide nanoparticles commonly release copper ions into solutions, which contribute to their toxicity. We quantified the inhibitory effects of both copper oxide nanoparticles and copper sulfate on C...
2016: PloS One
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#20
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
November 24, 2016: Pain Management
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