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Behavioral traits and biology

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https://www.readbyqxmd.com/read/29162172/cumulative-prenatal-exposure-to-adversity-reveals-associations-with-a-broad-range-of-neurodevelopmental-outcomes-that-are-moderated-by-a-novel-biologically-informed-polygenetic-score-based-on-the-serotonin-transporter-solute-carrier-family-c6-member-4-slc6a4
#1
Patrícia P Silveira, Irina Pokhvisneva, Carine Parent, Shirong Cai, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Anne Rifkin-Graboi, Michael Pluess, Kieran J O'Donnell, Michael J Meaney
While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29150295/paternal-transmission-of-early-life-traumatization-through-epigenetics-do-fathers-play-a-role
#2
Enrique d'Harcourt Rowold, Lara Schulze, Sandra Van der Auwera, Hans Jörgen Grabe
Traumatizing events are known to have consequences for the victim which may lead to the development of several well-known mental disorders. Recent research has shown that traumatic events may affect not only the victims' lives, but also that of their progeny. It is generally accepted that this transmission of trauma occurs through parental behavior; however as has been recently discovered, the effects of trauma may also be inherited due to induced alterations in gene expression. These changes, so called epigenetic modifications, illuminate the interaction between genes and the environment...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29147618/programmed-cell-death-ligands-expression-in-phaeochromocytomas-and-paragangliomas-relationship-with-the-hypoxic-response-immune-evasion-and-malignant-behavior
#3
David J Pinato, James R Black, Sebastian Trousil, Roberto E Dina, Pritesh Trivedi, Francesco A Mauri, Rohini Sharma
The hypoxic response underlies the pathogenesis and malignant behavior of PCC/PGL. Regulation of PD-1 receptor-ligand signaling, a therapeutically actionable driver of the anti-tumor immune response, is a hypoxic-driven trait across malignancies. We evaluated the prognostic role of PD ligands in association with biomarkers of hypoxia and angiogenesis in patients with PCC/PGL. Tissue microarrays sections including consecutive cases diagnosed between 1983-2011 were stained for PD-L1 and 2, hypoxia inducible factor 1a (Hif-1a), Carbonic Anhydrase IX (CaIX), Vascular Endothelial Growth Factor-A (VEGF-A)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29142334/approaches-to-macroevolution-2-sorting-of-variation-some-overarching-issues-and-general-conclusions
#4
David Jablonski
Approaches to macroevolution require integration of its two fundamental components, within a hierarchical framework. Following a companion paper on the origin of variation, I here discuss sorting within an evolutionary hierarchy. Species sorting-sometimes termed species selection in the broad sense, meaning differential origination and extinction owing to intrinsic biological properties-can be split into strict-sense species selection, in which rate differentials are governed by emergent, species-level traits such as geographic range size, and effect macroevolution, in which rates are governed by organism-level traits such as body size; both processes can create hitchhiking effects, indirectly causing the proliferation or decline of other traits...
2017: Evolutionary Biology
https://www.readbyqxmd.com/read/29130219/-colorectal-cancer-heterogeneity-genotype-phenotype-and-clinical-manifestation
#5
Sanjun Cai, Junjie Peng, Fangqi Liu
Colorectal cancer is the third high-incidence of malignant tumors in the world, and also a kind of tumor with good biological behavior and good efficacy. Colorectal cancer heterogeneity is a very important trait of its biological behavior, which can be reflected in many different aspects, including tumor type, pathogenesis, molecular phenotyping and time-space heterogeneity. Different pathogenesis produces different tumor phenotypes, which are generated in the process of natural evolution and intervention. Various phenotypes show the difference among different individuals of colorectal cancer, in terms of clinical characteristics, treatment response and prognosis...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29129275/how-micronutrients-influence-the-physiology-of-mosquitoes
#6
REVIEW
Crisalejandra Rivera-Pérez, Mark E Clifton, Fernando G Noriega
Micronutrients or non-energetic nutrients (NEN) are needed in reduced amounts, but are essential for many mosquito physiological processes that influence biological traits from vector competence to reproductive capacity. The NEN include amino acids (AA), vitamins, salts, metals and sterols. Free AA plays critical roles controlling most physiological processes, from digestion to reproduction. Particularly proline connects metabolic pathways in energy production, flight physiology and ammonia detoxification. Metal, in particular iron and calcium, salts, sterol and vitamin homeostasis are critical for cell signaling, respiration, metabolism and reproduction...
October 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29109672/towards-a-developmentally-integrative-model-of-personality-change-a-focus-on-three-potential-mechanisms
#7
Elizabeth N Riley, Sarah J Peterson, Gregory T Smith
While the overall stability of personality across the lifespan has been well-documented, one does see incremental changes in a number of personality traits, changes that may impact overall life trajectories in both positive and negative ways. In this chapter, we present a new, developmentally-oriented and integrative model of the factors that might lead to personality change, drawing from the theoretical and empirical work of prior models (e.g. Caspi & Roberts, 2001; Roberts et al., 2005) as well as from our own longitudinal studies of personality change and risky behavior engagement in children, adolescents, and young adults (Boyle et al...
2017: Advances in Psychology Research
https://www.readbyqxmd.com/read/29109033/predicting-and-analyzing-early-wake-up-associated-gene-expressions-by-integrating-gwas-and-eqtl-studies
#8
JiaRui Li, Tao Huang
Circadian rhythms are endogenous 24-hour rhythmic oscillations affecting human behaviors, such as sleep, blood pressure and other biological processes, the disturbance of which lead to circadian rhythm sleep disorders (CRSDs). In this study, based on the data from genome-wide association studies (GWASs) and expression quantitative trait loci (eQTLs), we tried to identify novel gene expression patterns in brain tissues that were associated with early wake-up. First, the maximum-relevance-minimum-redundancy (mRMR) method was adopted to analyze the involved gene expression patterns, yielding a feature list...
November 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107202/defining-the-phenotype-of-young-adults-with-family-histories-of-alcohol-and-other-substance-use-disorders-studies-from-the-family-health-patterns-project
#9
Ashley Acheson, Andrea S Vincent, Andrew J Cohoon, William R Lovallo
Individuals with a family history of alcohol and other drug use disorders (FH+) are at increased risk for developing substance use disorders themselves relative to those with no such histories (FH-). Here we sought to identify key characteristics associated with FH+ status and alcohol and other drug use disorder status in a large cohort of FH+ and FH- young adults. We conducted principal component analyses on demographic, temperament, and cognitive measures differentiating 506 FH+ and 528 FH- young adults. Three principal components were identified, and these component scores were then used to predict the odds of being FH+ and the odds of having an alcohol or other drug use disorder...
October 20, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29103063/the-effect-of-biological-rhythms-and-personality-traits-on-the-incidence-of-unsafe-behaviors-among-bus-drivers-in-shiraz-iran
#10
Fatemeh Kamari Ghanavati, Mehdi Jahangiri, Maryam Khalifeh, Sareh Keshavarzi, Mahnaz Shakerian
BACKGROUND: Unsafe behaviors are main causes of accidents mostly influenced by personal characteristics, social environment and also individual biorhythm cycles. This study was carried out to find out whether personality traits and biorhythm could affect the incidence of unsafe behaviors among city bus drivers. METHODS: This cross-sectional study was conducted on 224 bus drivers in Shiraz, Iran, 2014. The data were collected using NEO personality traits questionnaire...
November 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/29096330/why-some-behaviors-spread-while-others-don-t-a-laboratory-simulation-of-dialect-contact
#11
Betsy Sneller, Gareth Roberts
The question of how behavioral variants compete and propagate is of primary importance to the study of cultural evolution; with respect to language, it is also an important focus of the field of sociolinguistics. Variant propagation can occur by neutral means-akin to drift in biological evolution-or through selection, whereby individuals are biased in what variants they adopt. An important bias concerns social meaning, and sociolinguistic theory distinguishes between variants that are primarily associated with a particular social group (such as working-class people or Texans) and variants primarily associated with a perceived trait of the group (such as toughness)...
November 5, 2017: Cognition
https://www.readbyqxmd.com/read/29083079/reproductive-ecology-of-the-carnivorous-plant-pinguicula-moranensis-lentibulariaceae
#12
S G Villegas, R E Alcalá
The interaction of plants with pollinators can be determinant of their reproductive fitness. However, information about the pollination biology of carnivorous plants is scarce. To increase the knowledge about reproductive ecology of carnivorous plant we focused on Pinguicula moranensis. In specific, based on the presence of large, zygomorphic and spurred flowers, we predicted a higher reproductive fitness in cross-pollinated in comparison with self-pollinated flowers. Within a plot of 51 m(2) we characterized the reproductive phenology, including flower span time and stigmatic receptivity...
October 30, 2017: Plant Biology
https://www.readbyqxmd.com/read/29024902/psychological-and-behavioral-characteristics-of-suicide-attempts-and-non-suicidal-self-injury-in-chinese-adolescents
#13
Zhen-Zhen Liu, Hua Chen, Qi-Gui Bo, Ren-Hong Chen, Feng-Wen Li, Lei Lv, Cun-Xian Jia, Xianchen Liu
BACKGROUND: Suicide attempts (SA) and non-suicidal self-injury (NSSI) are prevalent in adolescents and important risk factors of suicide death. Both SA and NSSI are associated with multiple psychosocial, behavioral, biological and genetic factors. This study examined similarities and differences in psychological vulnerability and internalizing and externalizing problems between adolescents with SA and NSSI. METHODS: Participants consisted of 11,831 students and had a mean age of 14...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28991767/anorexia-anormal-phobia-of-normal-weight
#14
Nada Pop-Jordanova, Tatjana Zorcec, Aneta Demerdzieva
Anorexia nervosa is a disorder of feeding behavior associated with distortion of body image, mood disturbance and a wide variety of hormonal and metabolic abnormalities. It is supposed that the disease could be the consequence of a combination of cultural-social, psychological and biological factors. Our study confirmed that anorexia mentalis is a serious, life threatening disorder which in our country appears earlier than it was expected and that is strongly related to environmental factors (family, school, fashion, society)...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28987450/differing-responses-of-the-estuarine-bivalve-limecola-balthica-to-lowered-water-ph-caused-by-potential-co2-leaks-from-a-sub-seabed-storage-site-in-the-baltic-sea-an-experimental-study
#15
Adam Sokołowski, Dominika Brulińska, Zuzanna Mirny, Dorota Burska, Dorota Pryputniewicz-Flis
Sub-Seabed CCS is regarded as a key technology for the reduction of CO2 emissions, but little is known about the mechanisms through which leakages from storage sites impact benthic species. In this study, the biological responses of the infaunal bivalve Limecola balthica to CO2-induced seawater acidification (pH7.7, 7.0, and 6.3) were quantified in 56-day mesocosm experiments. Increased water acidity caused changes in behavioral and physiological traits, but even the most acidic conditions did not prove to be fatal...
October 4, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28986463/hebbian-learning-in-a-random-network-captures-selectivity-properties-of-prefrontal-cortex
#16
Grace W Lindsay, Mattia Rigotti, Melissa R Warden, Earl K Miller, Stefano Fusi
Complex cognitive behaviors, such as context-switching and rule-following, are thought to be supported by prefrontal cortex (PFC). Neural activity in PFC must thus be specialized to specific tasks while retaining flexibility. Nonlinear 'mixed' selectivity is an important neurophysiological trait for enabling complex and context-dependent behaviors. Here we investigate (1) the extent to which PFC exhibits computationally-relevant properties such as mixed selectivity and (2) how such properties could arise via circuit mechanisms...
October 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28979981/genome-wide-association-studies-of-a-broad-spectrum-of-antisocial-behavior
#17
Jorim J Tielbeek, Ada Johansson, Tinca J C Polderman, Marja-Riitta Rautiainen, Philip Jansen, Michelle Taylor, Xiaoran Tong, Qing Lu, Alexandra S Burt, Henning Tiemeier, Essi Viding, Robert Plomin, Nicholas G Martin, Andrew C Heath, Pamela A F Madden, Grant Montgomery, Kevin M Beaver, Irwin Waldman, Joel Gelernter, Henry R Kranzler, Lindsay A Farrer, John R B Perry, Marcus Munafò, Devon LoParo, Tiina Paunio, Jari Tiihonen, Sabine E Mous, Irene Pappa, Christiaan de Leeuw, Kyoko Watanabe, Anke R Hammerschlag, Jessica E Salvatore, Fazil Aliev, Tim B Bigdeli, Danielle Dick, Stephen V Faraone, Arne Popma, Sarah E Medland, Danielle Posthuma
Importance: Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified. Objectives: To estimate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortium...
October 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28959013/dissecting-genetic-architecture-of-startle-response-in-drosophila-melanogaster-using-multi-omics-information
#18
Angli Xue, Hongcheng Wang, Jun Zhu
Startle behavior is important for survival, and abnormal startle responses are related to several neurological diseases. Drosophila melanogaster provides a powerful system to investigate the genetic underpinnings of variation in startle behavior. Since mechanically induced, startle responses and environmental conditions can be readily quantified and precisely controlled. The 156 wild-derived fully sequenced lines of the Drosophila Genetic Reference Panel (DGRP) were used to identify SNPs and transcripts associated with variation in startle behavior...
September 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28957521/oxytocin-experiments-shed-light-on-mechanisms-shaping-prosocial-and-antisocial-behaviors-in-non-human-mammals
#19
Jennifer E Smith, Matthew B Petelle, Emily L Jerome, Hélène Cristofari, Daniel T Blumstein
Oxytocin has gained a reputation in popular culture as a simple "love drug" or "cuddle hormone", yet emerging biological evidence indicates that the effects of oxytocin are complex, mediating a suite of behavioral traits that range from ultrasocial to antisocial. Here we provide a comprehensive review to assess the salience of oxytocin in the lives of free-living social mammals. We reviewed the literature to understand the potential effects of oxytocin in promoting prosocial and antisocial behaviors in non-human mammals...
September 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28951829/epigenetics-in-formation-function-and-failure-of-the-endocrine-pancreas
#20
REVIEW
Maria L Golson, Klaus H Kaestner
BACKGROUND: Epigenetics, in the broadest sense, governs all aspects of the life of any multicellular organism, as it controls how differentiated cells arrive at their unique phenotype during development and differentiation, despite having a uniform (with some exceptions such as T-cells and germ cells) genetic make-up. The endocrine pancreas is no exception. Transcriptional regulators and epigenetic modifiers shape the differentiation of the five major endocrine cell types from their common precursor in the fetal pancreatic bud...
September 2017: Molecular Metabolism
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