keyword
https://read.qxmd.com/read/38536670/tyrosinase-modified-uhmw-selp-polymers-as-wet-and-underwater-adhesives-to-achieve-multi-interface-adhesion
#1
JOURNAL ARTICLE
Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
The presence of a hydration layer in humid and underwater environments challenges adhesive-substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#2
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534622/development-of-ph-responsive-thermosensitive-antibacterial-and-anticancer-cs-pva-graphene-blended-hydrogels-for-controlled-drug-delivery
#3
JOURNAL ARTICLE
Saira Mansha, Amna Sajjad, Aneeqa Zarbab, Tahmina Afzal, Zakia Kanwal, Muhammad Javaid Iqbal, Mohsin Ali Raza, Sharafat Ali
Drug delivery techniques based on polymers have been investigated for their potential to improve drug solubility, reduce systemic side effects, and controlled and targeted administration at infection site. In this study, we developed a co-polymeric hydrogel composed of graphene sheets (GNS), polyvinyl alcohol (PVA), and chitosan (CS) that is loaded with methotrexate (MTX) for in vitro liver cancer treatment. Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM) was employed to check the structural properties and surface morphology...
March 18, 2024: Gels
https://read.qxmd.com/read/38531881/silk-fibroin-hydrogel-adhesive-enables-sealed-tight-reconstruction-of-meniscus-tears
#4
JOURNAL ARTICLE
Xihao Pan, Rui Li, Wenyue Li, Wei Sun, Yiyang Yan, Xiaochen Xiang, Jinghua Fang, Youguo Liao, Chang Xie, Xiaozhao Wang, Youzhi Cai, Xudong Yao, Hongwei Ouyang
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38529002/superior-oblique-muscle-extramedullary-plasmacytoma-in-a-patient-with-multiple-myeloma-and-a-review-of-literature
#5
Amirreza Veisi, Kimia Daneshvar, Sadid Hooshmandi, Maryam Najafi, Peyman Mohammadi Torbati, Kiana Hassanpour
INTRODUCTION: Multiple myeloma (MM), a plasma cell malignancy, is a systemic disease affecting various body organs. Plasmacytoma of bone and extramedullary disease (EMD) are presentations of MM. EMD is usually the sign of a more aggressive form of the disease. Herein, we report a patient with refractory MM presenting with extramedullary plasmacytoma in the superior oblique (SO) muscle. CASE PRESENTATION: A 51-year-old female presented complaining of gradual protrusion of the left eye and ocular pain from 20 days prior...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38525127/live-imaging-basement-membrane-assembly-under-the-pupal-notum-epithelium
#6
JOURNAL ARTICLE
Thomas M Mehaffey, Chloe A Hecht, James S White, M Shane Hutson, Andrea Page-McCaw
Basement membranes are sheet-like extracellular matrices containing Collagen IV, and they are conserved across the animal kingdom. Basement membranes usually line the basal surfaces of epithelia, where they contribute to structure, maintenance, and signaling. Although adult epithelia contact basement membranes, in early embryos the epithelia contact basement membranes only after basement membranes are assembled in embryogenesis. In Drosophila , the pupal notum epithelium is a useful model for live imaging epithelial cell behaviors, yet it is unclear when the basement membrane assembles in the pupa, as pupae are undergoing metamorphosis, similar to embryogenesis...
2024: microPublication. Biology
https://read.qxmd.com/read/38520933/a-cu-ag-double-layer-coating-strategy-for-stable-and-reversible-zn-metal-anodes
#7
JOURNAL ARTICLE
Junnan Liu, Qiuyang Luo, Shu Xia, Xingfu Yang, Jie Lei, Qi Sun, Xiaohu Chen, Jiaojing Shao, Xiaoning Tang, Guangmin Zhou
Structuring a stable artificial coating to mitigate dendrite growth and side reactions is an effective strategy for protecting the Zn metal anode. Herein, a Cu-Ag double-layer metal coating is constructed on the Zn anode (Zn@Cu-Ag) by simple and in-situ displacement reactions. The Cu layer enhances the bond between the Ag layer and Zn substrate by acting as an intermediary, preventing the Ag coating from detachment. Concurrently, the Ag layer serves to improve the corrosion resistance of Cu metal. During plating, the initial Cu sheets and Ag particles on the surface of Zn@Cu-Ag electrode gradually transform into a flat and smooth layer, resulting in the formation of AgZn, AgZn3 , and (Ag, Cu)Zn4 alloys...
March 20, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38518180/linker-free-functionalization-of-phosphorene-nanosheets-by-sialic-acid-biomolecules
#8
JOURNAL ARTICLE
Nasrin Khazamipour, Asma Souri, Omid Babaee, Behzad Dadashnia, Pouya Soltan-Khamsi, Sadegh Mousavi, Shams Mohajerzadeh
The importance of sialic acid on cell functions has been recently unveiled, and consequently, great attention has been paid to its interaction with tumor cells. In this line of research, we have realized phosphorene nanosheets functionalized with sialic acid molecules for biological applications with no need for another linker molecule. The formation of phosphorene sheets is feasible by using hydrogen plasma treatment and conversion of amorphous phosphorus on silicon substrates into highly crystalline nanosheets...
March 22, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38515628/research-progress-in-cell-therapy-for-oral-diseases-focus-on-cell-sources-and-strategies-to-optimize-cell-function
#9
REVIEW
Jing Wang, Zeqing Zhao, Kai Yang, Yuxing Bai
In recent years, cell therapy has come to play an important therapeutic role in oral diseases. This paper reviews the active role of mesenchymal stem cells, immune cell sources, and other cells in oral disorders, and presents data supporting the role of cell therapy in oral disorders, including bone and tooth regeneration, oral mucosal disorders, oral soft tissue defects, salivary gland dysfunction, and orthodontic tooth movement. The paper will first review the progress of cell optimization strategies for oral diseases, including the use of hormones in combination with stem cells, gene-modified regulatory cells, epigenetic regulation of cells, drug regulation of cells, cell sheets/aggregates, cell-binding scaffold materials and hydrogels, nanotechnology, and 3D bioprinting of cells...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38512568/systematic-inspection-on-the-interplay-between-mona-induced-sodium-and-the-formation-of-mose-2-intermediate-layer-in-cigse-mo-heterostructures
#10
JOURNAL ARTICLE
Fazliyana 'Izzati Za'abar, Camellia Doroody, Manzoore Elahi Mohammad Soudagar, Puvaneswaran Chelvanathan, Wan Syakirah Wan Abdullah, Ahmad Wafi Mahmood Zuhd, Erdem Cuce, Shaik Saboor
The critical impact of sodium-doped molybdenum (MoNa) in shaping the MoSe2 interfacial layer, influencing the electrical properties of CIGSe/Mo heterostructures, and achieving optimal MoSe2 formation conditions, leading to improved hetero-contact quality. Notably, samples with a 600-nm-thick MoNa layer demonstrate the highest resistivity (73 μΩcm) and sheet resistance (0.45 Ω/square), highlighting the substantial impact of MoNa layer thickness on electrical conductivity. Controlled sodium diffusion through MoNa layers is essential for achieving desirable electrical characteristics, influencing Na diffusion rates, grain sizes, and overall morphology, as elucidated by EDX and FESEM analyses...
March 21, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38511123/pentamidine-loaded-gelatin-decreases-adhesion-formation-of-flexor-tendon
#11
JOURNAL ARTICLE
Guidong Shi, Nakagawa Koichi, Rou Wan, Yicun Wang, Ramona Reisdorf, Abigayle Wilson, Tony C T Huang, Peter C Amadio, Alexander Meves, Chunfeng Zhao, Steven L Moran
BACKGROUND: Prevention of adhesion formation following flexor tendon repair is essential for restoration of normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application is limited due to the complexity of application and delivery in clinical translation. METHODS: In this study, optimal dosages of gelatin and pentamidine were validated by gelatin concentration test. Following cell viability, cell migration, live and dead cell, and cell adhesion assay of the Turkey tenocytes, a model of Turkey tendon repair was established to evaluate the effectiveness of the Pentamidine-Gelatin sheet...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38509326/open-top-multisample-dual-view-light-sheet-microscope-for-live-imaging-of-large-multicellular-systems
#12
JOURNAL ARTICLE
Franziska Moos, Simon Suppinger, Gustavo de Medeiros, Koen Cornelius Oost, Andrea Boni, Camille Rémy, Sera Lotte Weevers, Charisios Tsiairis, Petr Strnad, Prisca Liberali
Multicellular systems grow over the course of weeks from single cells to tissues or even full organisms, making live imaging challenging. To bridge spatiotemporal scales, we present an open-top dual-view and dual-illumination light-sheet microscope dedicated to live imaging of large specimens at single-cell resolution. The configuration of objectives together with a customizable multiwell mounting system combines dual view with high-throughput multiposition imaging. We use this microscope to image a wide variety of samples and highlight its capabilities to gain quantitative single-cell information in large specimens such as mature intestinal organoids and gastruloids...
March 20, 2024: Nature Methods
https://read.qxmd.com/read/38508521/expanding-the-spectrum-of-nr4a3-fusion-positive-gynecologic-leiomyosarcomas
#13
JOURNAL ARTICLE
Amir Momeni-Boroujeni, Kerry Mullaney, Sara E DiNapoli, Mario M Leitao, Martee L Hensley, Nora Katabi, Douglas H R Allison, Kay J Park, Cristina R Antonescu, Sarah Chiang
Recurrent gene fusions have been observed in epithelioid and myxoid variants of uterine leiomyosarcoma. PGR::NR4A3 fusion was recently described in a subset of epithelioid leiomyosarcomas exhibiting rhabdoid morphology. In this study, we sought to expand the clinical, morphologic, immunohistochemical, and genetic features of gynecologic leiomyosarcomas harboring NR4A3 rearrangement with PGR and novel fusion partners. We identified 9 gynecologic leiomyosarcomas harboring PGR::NR4A3, CARMN::NR4A3, ACTB::NR4A3, and possible SLCO5A1::NR4A3 fusions by targeted RNA sequencing...
March 18, 2024: Modern Pathology
https://read.qxmd.com/read/38508465/enhanced-performance-of-acridine-degradation-and-power-generation-by-microbial-fuel-cell-with-g-c-3-n-4-pani-da-cf-anode
#14
JOURNAL ARTICLE
Minjie Jian, Ping Xue, Xingjun Zhang, Yaqin Xing, Lan Ma, Xiaodong Lv, Keren Shi
Microbial fuel cell (MFC) has attracted much attention in treating organic wastewater due to its double functions of degrading organics and generating electricity with microorganisms as biocatalysts. Unfortunately, some organics with biological toxicity such as acridine could inhibit the growth and activity of the microorganisms on the anode so that the double functions of MFC would recede. Enhancing microbial activity by using new biocompatible materials as anodes is prospective to solve problem. A novel anode was achieved by electrodepositing g-C3 N4 sheets to the carbon felt (CF) modified with polyaniline-dopamine composite film, and used to treat wastewater containing acridine for the first time...
March 18, 2024: Chemosphere
https://read.qxmd.com/read/38507809/fabrication-of-a-tailor-made-conductive-polyaniline-ascorbic-acid-coated-nanofibrous-mat-as-a-conductive-and-antioxidant-cell-free-cardiac-patch
#15
JOURNAL ARTICLE
Farzad Moradikhah, Iman Shabani, Mohammad Tafazzoli-Shadpour
Polyaniline (PANI) was in-situ polymerized on nanofibrous polycaprolactone mats as cell-free antioxidant cardiac patches (CPs), providing electrical conductivity and antioxidant properties. The fabricated CPs took advantage of intrinsic and additive antioxidant properties in the presence of PANI backbone and ascorbic acid as a biocompatible dopant of PANI. The antioxidant nature of CPs may reduce the serious repercussions of oxidative stress, produced during the ischemia-reperfusion (I/R) process following myocardial infarction...
March 20, 2024: Biofabrication
https://read.qxmd.com/read/38507238/%C3%AE-catenin-middle-and-actin-binding-domain-unfolding-mutants-differentially-impact-epithelial-strength-and-sheet-migration
#16
JOURNAL ARTICLE
Jeanne M Quinn, Yuou Wang, Megan Wood, Annette S Flozak, Phuong M Le, Alex Yemelyanov, Patrick W Oakes, Cara J Gottardi
α-catenin (α-cat) displays force-dependent unfolding and binding to actin filaments through direct and indirect means, but features of adherens junction structure and function most vulnerable to loss of these allosteric mechanisms have not been directly compared. By reconstituting an α-cat F-actin-binding domain unfolding mutant known to exhibit enhanced binding to actin (α-cat-H0-FABD+ ) into α-cat knock-out Madin Darby Canine Kidney (MDCK) cells, we show that partial loss of the α-cat catch bond mechanism (via an altered H0 α-helix) leads to stronger epithelial sheet integrity with greater co-localization between the α-cat-H0-FABD+ mutant and actin...
March 20, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38504469/oligodendrocyte-progenitor-cells-fate-after-neonatal-asphyxia-puzzling-implications-for-the-development-of-hypoxic-ischemic-encephalopathy
#17
JOURNAL ARTICLE
Justyna Janowska, Justyna Gargas, Karolina Zajdel, Michal Wieteska, Kamil Lipinski, Malgorzata Ziemka-Nalecz, Malgorzata Frontczak-Baniewicz, Joanna Sypecka
Premature birth or complications during labor can cause temporary disruption of cerebral blood flow, often followed by long-term disturbances in brain development called hypoxic-ischemic (HI) encephalopathy. Diffuse damage to the white matter is the most frequently detected pathology in this condition. We hypothesized that oligodendrocyte progenitor cell (OPC) differentiation disturbed by mild neonatal asphyxia may affect the viability, maturation, and physiological functioning of oligodendrocytes. To address this issue, we studied the effect of temporal HI in the in vivo model in P7 rats with magnetic resonance imaging (MRI), microscopy techniques and biochemical analyses...
March 19, 2024: Brain Pathology
https://read.qxmd.com/read/38497459/the-celiac-disease-superantigen-oligomerizes-and-increases-permeability-in-an-enterocyte-cell-model
#18
JOURNAL ARTICLE
Maria Georgina Herrera, Maria Julia Amundarain, Philipp W Dörfler, Veronica I Dodero
Celiac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting approximately 1% of the global population. The 33-mer deamidated gliadin peptide (DGP) is a metabolically modified wheat-gluten superantigen for CeD. Here, we demonstrate that the 33-mer DGP spontaneously assembles into oligomers with a diameter of approximately 24 nm. The 33-mer DGP oligomers present two main secondary structural motifs-a major polyproline II helix and a minor β-sheet structure. Importantly, in the presence of 33-mer DGP oligomers, there is a statistically significant increase in the permeability in the gut epithelial cell model Caco-2, accompanied by the redistribution of zonula occludens-1, a master tight junction protein...
March 18, 2024: Angewandte Chemie
https://read.qxmd.com/read/38496764/case-report-primary-pulmonary-low-grade-fibromyxoid-sarcoma-progressing-to-dedifferentiation-probably-due-to-tp53-driver-mutation
#19
Jiawen Zhang, Haisheng Fang, Xiaomei Zhu, Chenchen Yao, Qinhe Fan, Qixing Gong
Low Grade Fibromyxoid Sarcoma (LGFMS), a rare entity characterized by bland histologic features, typically affects deep soft tissues of the trunk and lower extremities. Rare cases have been reported arising from the viscera and few demonstrating morphology of high-grade dedifferentiation. Here we report a 39-year-old Chinese woman presenting with primary lung LGFMS, which metastasized to the pancreas five years after diagnosis and then relapsed ten years later as a mediastinum mass. Microscopically, the lung and pancreatic lumps shared similar classical features of LGFMS, composed of bland spindle-shaped cells with low mitotic activity...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38496522/comprehensive-mapping-of-sensory-and-sympathetic-innervation-of-the-developing-kidney
#20
Pierre-Emmanuel Y N'Guetta, Sarah R McLarnon, Adrien Tassou, Matan Geron, Sepenta Shirvan, Rose Z Hill, Grégory Scherrer, Lori L O'Brien
The kidney functions as a finely tuned sensor to balance body fluid composition and filter out waste through complex coordinated mechanisms. This versatility requires tight neural control, with innervating efferent nerves playing a crucial role in regulating blood flow, glomerular filtration rate, water and sodium reabsorption, and renin release. In turn sensory afferents provide feedback to the central nervous system for the modulation of cardiovascular function. However, the cells targeted by sensory afferents and the physiological sensing mechanisms remain poorly characterized...
March 7, 2024: bioRxiv
keyword
keyword
55986
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.