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Oral lichen planus

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https://www.readbyqxmd.com/read/27904285/benefits-of-screening-for-oral-lichen-planus
#1
Gian Paolo Bombeccari, Francesco Spadari, Aldo Bruno Giannì
No abstract text is available yet for this article.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27889928/elucidating-the-role-of-cyclooxygenase-2-in-the-pathogenesis-of-oral-lichen-planus-an-immunohistochemical-study-with-supportive-histochemical-analysis
#2
Pratyush Singh, Jasleen Grover, Aditi Amit Byatnal, Vasudeva Guddattu, Raghu Radhakrishnan, Monica Charlotte Solomon
OBJECTIVE: Oral lichen planus (OLP) is a chronic, inflammatory disorder that affects the oral mucous membrane. During an inflammatory response, several chemokines and cytokines are released by the cells of the immune system. Activation of MMPs, along with mast cell-derived chymase and tryptase, degrades the basement membrane structural proteins, resulting in basement membrane breaks. AIM: To investigate the association between the COX-2 expressions, presence of intact or degranulating mast cells within the connective tissue and the extent of basement membrane discontinuity in OLP cases...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27866178/low-level-laser-therapy-a-review-of-its-applications-in-the-management-of-oral-mucosal-disorders
#3
Juliana Cassol Spanemberg, Maria Antonia Zancanaro Figueiredo, Karen Cherubini, Fernanda Gonçalves Salum
Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27862315/evaluation-of-salivary-nitric-oxide-levels-and-c-reactive-protein-in-patients-with-oral-lichen-planus-and-burning-mouth-syndrome
#4
Tvarijonaviciute Asta, Aznar Cayuela Cristina, Peres Rubio Camila, Ceron José Joaquin, Pia López-Jornet
OBJECTIVES: The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS). METHODS: This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the Xerostomia Inventory...
November 8, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27858075/-clinical-effect-of-nd-yag-laser-combined-with-total-glucosides-of-paeony-for-the-treatment-of-erosive-oral-lichen-planus
#5
Ai-Ping Hu, Zong-Xiang Liu
PURPOSE: To investigate the clinical effect of Nd:YAG laser combined with total glucosides of paeony (TGP) taken orally for the treatment of erosive oral lichen planus (OLP). METHODS: Sixty patients who were diagnosed as erosive OLP with clinical symptoms were divided into experimental group (n=28) and control group (n=32) using a random number table. All patients received TGP while the patients in the experimental group were given Nd:YAG laser irradiation. The clinical effects were evaluated 3 months after treatment...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27858067/-the-expression-and-clinical-significance-of-il-35-in-periodontitis-and-oral-lichen-planus
#6
Yu Wang, Ying Jin, Yi-Yue Wang, Dan-Ni Xu, Xiao-Ping Lin
PURPOSE: To investigate the influence of IL-35 in the pathogenesis of periodontitis and oral lichen planus, and the correlation between periodontitis and oral lichen planus patients. METHODS: The gingival crevicular fluid(GCF) and serum were collected from patients with oral lichen planus (n=20), periodontitis (n=20), periodontitis and oral lichen planus (n=20) and healthy controls (n=12). The patients' basic information, probing depth, clinical attachment loss, gingival index, sulcus bleeding index were measured and collected...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27858066/-correlation-of-treg-and-il-15-expression-in-the-peripheral-blood-of-patients-with-oral-lichen-planus
#7
Cui-Jie Wang, Yan-Jun Li, Jiang-Nan Xue, Hao-Su Ci, Li-Ping Li, Ling Li
PURPOSE: To investigate the expression of Treg and IL-15 in the peripheral blood of patients with oral lichen planus (OLP). METHODS: The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package. RESULTS: In the peripheral blood of OLP patients, the proportion of CD4(+)CD25(+)Foxp3(+) Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27857766/serum-level-of-interleukin-8-in-subjects-with-diabetes-diabetes-plus-oral-lichen-planus-and-oral-lichen-planus-a-biochemical-study
#8
Atefeh Tavangar, Faezeh Khozeimeh, Fereshtehossadat Ghoreishian, Mahsa Abbasi Boroujeni
BACKGROUND: Correlation between diabetes mellitus (DM) and oral lichen planus (OLP) seems probable. Since Interleukin-8 (IL-8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of IL-8 in DM, OLP, and DM + OLP patients in comparison with healthy individuals. MATERIALS AND METHODS: This cross sectional study was conducted on 75 patients (30 OLP, 5 OLP and type II DM, 20 type II DM, and 20 healthy controls)...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27829754/a-randomized-triple-blind-clinical-trial-to-compare-the-effectiveness-of-topical-triamcinolone-acetonate-0-1-clobetasol-propionate-0-05-and-tacrolimus-orabase-0-03-in-the-management-of-oral-lichen-planus
#9
Shivakumar Sivaraman, Krishnamoorthy Santham, Aruldoss Nelson, Bijaykumar Laliytha, Pandian Azhalvel, John Hearty Deepak
BACKGROUND: Oral lichen planus (OLP) is believed to result from an abnormal T-cell mediated immune response. The most useful agent in the treatment is corticosteroids. The present study will be aimed at evaluation of therapeutic efficiency of two corticosteroids triamcinolone acetonate (0.1%) and clobetasol propionate with tacrolimus orabase (0.03%), an immunomodulator in the management of OLP. AIM: To compare the effectiveness of topical triamcinolone acetonate (0...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27826983/medical-treatments-for-pregnant-patients-with-oral-lichen-planus
#10
Jiao Wei, Danhua Ma, Min Qiu, Hongxia Dan, Xin Zeng, Lu Jiang, Yu Zhou, Jiayi Wang, Qianming Chen
Oral lichen planus (OLP) is a common chronic inflammatory disorder that manifests as papular, reticular, or erosive lesions. OLP seriously affects a patient's quality of life, as it is associated with symptoms such as pain and a burning sensation. It is also accompanied by a risk of carcinogenic tendency. During pregnancy, the treatment will be more complicated because of the effect of medical treatment on both the mother and foetus. Thus, appropriate drugs for those pregnant patients will be more essential...
November 9, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27802920/anemia-and-hematinic-deficiencies-in-gastric-parietal-cell-antibody-positive-and-antibody-negative-erosive-oral-lichen-planus-patients-with-thyroid-antibody-positivity
#11
Julia Y-F Chang, I-Chang Chen, Yi-Ping Wang, Yu-Hsueh Wu, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA(+)/TGA/TMA/EOLP patients) or negativity (GPCA(-)/TGA/TMA/EOLP patients). METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA(+)/TGA/TMA/EOLP patients, 80 GPCA(-)/TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs(-)/EOLP patients), and 218 healthy control individuals...
October 29, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27801978/high-resolution-dna-content-analysis-of-microbiopsy-samples-in-oral-lichen-planus
#12
M Pentenero, M Monticone, R Marino, C Aiello, G Marchitto, D Malacarne, W Giaretti, S Gandolfo, P Castagnola
OBJECTIVES: DNA aneuploidy has been reported to be a predictor of poor prognosis in both premalignant and malignant lesions. In oral lichen planus (OLP) this hypothesis remains to be proved. This study aims to determine the rate of occurrence of DNA aneuploidy in OLP patients by high-resolution DNA flow cytometry. METHODS: OLP patients were consecutively enrolled. Tissue samples were subdivided for formalin fixation and routine histological assessment and for immediate storage at -20°C for later DNA ploidy analysis, which was performed by DAPI staining of the extracted nuclei and excitation with a UV lamp...
November 1, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27782368/issues-related-to-diagnosing-oral-lichen-planus-among-oral-pathologists-in-south-india-a-pilot-survey
#13
D Sharathkumar Sanketh, Samuel Raj Srinivasan, Shankargouda Patil, Kannan Ranganathan
AIM: In the present study, we simulated clinical scenarios by explicitly describing the history and clinical and histological features of hypothetical patients presenting with oral lichen planus (OLP), oral lichenoid lesion, and epithelial dysplasia in a self-designed questionnaire. By doing so, we aimed to elicit a diagnosis from oral pathologists and trainees, analyze their responses, appraise issues, and propose solutions regarding the diagnosis of OLP. METHODS: The questionnaire was distributed to 100 oral pathologists and trainees in South India...
October 26, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27781495/prevalence-of-oral-cancer-oral-potentially-malignant-disorders-and-other-oral-mucosal-lesions-in-cambodia
#14
Tepirou Chher, Sithan Hak, Thomas George Kallarakkal, Callum Durward, Anand Ramanathan, Wan Maria Nabillah Ghani, Ishak Abdul Razak, Masitah Hayati Harun, Nor Atika Md Ashar, Rama Krsna Rajandram, Pisethraingsey Prak, Haizal Mohd Hussaini, Rosnah Binti Zain
OBJECTIVES: To obtain data on the prevalence of oral mucosal lesions (OMLs) among Cambodians, and to assess the relationship between known risk habits of oral diseases with prevalence of oral potentially malignant disorders (OPMDs). DESIGN: This was a population-based, cross-sectional study whereby subjects were adults aged 18 years old and above. A workshop on the identification of OML was held to train and calibrate dental officers prior to data collection in the field...
October 26, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27771589/urine-metabolic-profiling-for-the-pathogenesis-research-of-erosive-oral-lichen-planus
#15
Xu-Zhao Li, Xu-Yan Yang, Yu Wang, Shuai-Nan Zhang, Wei Zou, Yan Wang, Xiao-Nan Li, Ling-Shu Wang, Zhi-Gang Zhang, Liang-Zhen Xie
OBJECTIVE: Oral lichen planus (OLP) is a relatively common chronic immune-pathological and inflammatory disease and potentially oral precancerous lesion. Erosive OLP patients show the higher rate of malignant transformation than patients with non-erosive OLP. Identifying the potential biomarkers related to erosive OLP may help to understand the pathogenesis of the diseases. METHODS: Metabolic profiles were compared in control and patient subjects with erosive OLP by using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) coupled with pattern recognition methods An integrative analysis was used to identify the perturbed metabolic pathways and pathological processes that may be associated with the disease...
October 17, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27770642/defb1-polymorphisms-and-salivary-hbd-1-concentration-in-oral-lichen-planus-patients-and-healthy-subjects
#16
Vania Polesello, Luisa Zupin, Roberto Di Lenarda, Matteo Biasotto, Gabriele Pozzato, Giulia Ottaviani, Margherita Gobbo, Sergio Crovella, Ludovica Segat
OBJECTIVES: The aetiology of Oral Lichen Planus (OLP), a chronic inflammatory disease of oral mucosa, is not yet well understood. Since innate immunity may be hypothesized as involved in the susceptibility to OLP, we studied human beta defensin 1 (hBD-1) an antimicrobial peptide constitutively expressed in the saliva, looking at functional genetic variants possibly able to diminish hBD-1 production an consequently conferring major susceptibility to OLP. DESIGN: We analysed three DEFB1 polymorphisms at 5' UTR, -52G>A (rs1799946), -44C>G (rs1800972), -20G>A (rs11362) and two DEFB1 polymorphisms at 3'UTR, c*5G>A (rs1047031), c*87A>G (rs1800971), with the aim of correlating these genetic variants and hBD-1 salivary level in a group of OLP patients and in healthy subjects...
October 12, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27765331/altered-expression-of-interleukin-17a-and-its-targeting-micrornas-in-oral-lichen-planus-a-pilot-study
#17
Zhengyu Shen, Chenping Zhang, Zengtong Zhou, Wei Liu, Linjun Shi, Xuemin Shen
OBJECTIVE: To investigate the potential role of interleukin (IL)-17A and its targeting microRNAs (miRNAs) in oral lichen planus (OLP). STUDY DESIGN: We compared the IL-17A expression levels in biopsies from patients with OLP (n = 50) against normal controls (n = 19) by using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot analyses, identified the targeting miRNAs of IL-17A, and examined the miRNA expression levels in OLP...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27763705/in-vitro-cell-culture-system-optimization-of-keratinocytes-from-oral-lichen-planus-olp-patients
#18
Tianyi Cao, Han Zhang, Leilei Zhou, Yufeng Wang, Guanhuan Du, Hui Yao, Yanni Wang, Qingqiong Luo, Fuxiang Chen, Wanchun Wang, Guoyao Tang
OBJECTIVES: The aim of this study was to optimize the culture system of keratinocytes obtained from oral lichen planus (OLP) patients and verify whether this model could simulate the local inflammatory environment of OLP. MATERIALS AND METHODS: Keratinocytes were isolated from 48 OLP patients and cultured in vitro. The ultrastructure of OLP keratinocytes was observed via electron microscopy. The expression of pancytokeratin and vimentin was determined by immunohistochemistry, and the proliferation of OLP keratinocytes was measured by CCK-8 assay...
October 20, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27762043/tlr4-induced-b7-h1-on-keratinocytes-negatively-regulates-cd4-t-cells-and-cd8-t-cells-responses-in-oral-lichen-planus
#19
Jing Zhang, Ya-Qin Tan, Ming-Hui Wei, Xiao-Jing Ye, Guan-Ying Chen, Rui Lu, Ge-Fei Du, Gang Zhou
Oral lichen planus (OLP) is a T-cell-mediated autoimmune mucocutaneous disease affected by the interactions among the keratinocytes, CD4(+) T cells and CD8(+) T cells. B7-H1 induced by Toll-like receptors (TLRs), can suppress T cell immune reaction, thereby resulting in immune tolerance. However, the role of TLRs-mediated B7-H1 on keratinocytes in the immune response of OLP is still unknown. The present study showed that TLR4 could induce time-coursed B7-H1 expression on oral keratinocytes, and blocking NF-κB or PI3K/mTOR pathway down-regulated B7-H1 transcriptional expression...
October 20, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27726411/esophageal-lichen-planus-clinical-and-radiographic-findings-in-eight-patients
#20
Andreas M Rauschecker, Marc S Levine, Matthew J Whitson, Rashmi Tondon, Stephen E Rubesin, Emma E Furth, David C Metz
OBJECTIVE: The purpose of this study is to present the clinical and radiographic findings of esophageal lichen planus. MATERIALS AND METHODS: A search of computerized medical records identified 15 patients with pathologic findings of esophageal lichen planus on endoscopic biopsy specimens. Three other patients had presumed esophageal lichen planus, although no biopsy specimens were obtained. Twelve of these 18 patients (67%) had double-contrast esophagography performed at our institution; for eight of the 12 patients (67%), the studies revealed abnormalities in the esophagus...
October 11, 2016: AJR. American Journal of Roentgenology
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