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Oral lichen planus

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https://www.readbyqxmd.com/read/28640079/a-genome-wide-association-scan-of-biological-processes-involved-in-oral-lichen-planus-and-oral-squamous-cell-carcinoma
#1
Qiaozhen Yang, Beiyun Xu, Hongying Sun, Xiaxia Wang, Jie Zhang, Xuedi Yu, Xiaojuan Ma
BACKGROUND: In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined. METHODS: High-throughput sequencing of long noncoding RNAs (lncRNAs) and mRNAs of normal subjects and patients with OLP and OSCC was conducted. RNA-seq reads were mapped, lncRNA and mRNA transcripts were assembled, and expression levels were estimated. The targets of lncRNAs were predicted. Finally, Gene Ontology (GO) and pathway enrichment analyses of differentially expressed genes (DEGs) and lncRNA targets were performed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639683/traitement-m%C3%A3-dicamenteux-du-lichen-plan-buccal
#2
Jan S Schenkel, Heinz-Theo Lübbers, Claudio Rostetter, Philipp Metzler
Oral lichen planus is a relatively common T-cell mediated inflammatory disease with potential malignant transformation. It may present itself with pain and oral lesions such as ulcers and Wickham’s striae. Treatment includes topical corticosteroids, preferably Clobetasol, immunosuppressive drugs and retinoids. Hyaluronic acid and aloe vera have been proven to be successful. If topical treatment fails, systemic therapy with corticosteroids may be needed. Because of the potential malignant transformation periodic follow-up is mandatory...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28634600/oral-mucous-membrane-pemphigoid-associated-with-hypothyroidism-a-retrospective-study-and-a-case-report
#3
Ann Siassipour, Joseph Katz
OBJECTIVE: The purpose of the study was to evaluate the relationship between mucous membrane pemphigoid and a state of hypothyroidism. The study included analysis of the dental charts of 40 subjects with clinically and histologically confirmed diagnosis of mucous membrane pemphigoid and 35 age- and gender-matched subjects, from the same clinic, with no diagnosis of vesiculo-ulcerative lesions. RESULTS: Thirteen subjects from the pemphigoid group (32%) had a hypothyroid condition, compared to four subjects (11%) from the control group (P = ...
2017: Quintessence International
https://www.readbyqxmd.com/read/28627728/can-atrophic-erosive-oral-lichen-planus-promote-cardiovascular-diseases-a-population-based-study
#4
Davide Conrotto, Roberta Barattero, Mario Carbone, Alessio Gambino, Veronica Sciannameo, Fulvio Ricceri, Federico Conrotto, Roberto Broccoletti, Paolo G Arduino
OBJECTIVES: Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. SUBJECTS AND METHODS: Patients were analysed through a complete collection of all the risk factors for CVDs...
June 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28624699/toll-like-receptor-2-rs4696480-polymorphism-and-risk-of-oral-cancer-and-oral-potentially-malignant-disorder
#5
Camila de Barros Gallo, Xabier Marichalar-Mendia, Amaia Setien-Olarra, Amelia Acha-Sagredo, Naiara Garcia Bediaga, Maria Luisa Gainza-Cirauqui, Norberto Nobuo Sugaya, Jose Manuel Aguirre-Urizar
OBJECTIVES: The aim of this study was to identify the possible association between TLR polymorphisms and an increased risk of developing head and neck cancer, including oral (OSCC) and laryngeal squamous cell carcinoma (LSCC), and oral potentially malignant disorders, such as oral lichenoid disease (OLD), including oral lichen planus (OLP) and oral lichenoid lesions (OLL). DESIGN: This case-control study included 40 OSCC, 35 LSCC, 175 OLD (129 OLP and 46 OLL) patients and 89 healthy controls, all of them from the Basque Country, Spain...
June 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28622422/patient-reported-outcome-measures-in-oral-lichen-planus-a-comprehensive-review-of-the-literature-with-focus-on-psychometric-properties-and-interpretability
#6
REVIEW
P Wiriyakijja, S Fedele, S Porter, V Mercadante, R Ni Riordain
OBJECTIVE: To review the range of patient reported outcome measures (PROMs) used in clinical studies of patients with oral lichen planus (OLP) and to assess their psychometric properties and interpretability. METHODS: Literature searches were performed on MEDLINE, Embase and Web of Science databases (1990 - September 2016) to retrieve relevant studies related to the development, psychometric testing and/or use of PROMs assessing oral symptoms, psychosocial status, and quality of life in individuals with OLP...
June 16, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28618186/therapeutic-efficacy-of-fresh-allogeneic-mesenchymal-stem-cells-for-severe-refractory-feline-chronic-gingivostomatitis
#7
Boaz Arzi, Kaitlin C Clark, Ayswarya Sundaram, Mathieu Spriet, Frank J M Verstraete, Naomi J Walker, Megan R Loscar, Nasim Fazel, William J Murphy, Natalia Vapniarsky, Dori L Borjesson
Mesenchymal stem cells (MSCs) have potent immunomodulatory functions and are a promising therapy for immune-mediated inflammatory disorders. We previously demonstrated the efficacy of fresh, autologous, adipose-derived MSCs (ASCs) to treat feline chronic gingivostomatitis (FCGS), a chronic oral mucosal inflammatory disease similar to human oral lichen planus. Here, we investigate the use of fresh allogeneic ASCs for treatment of FCGS in seven cats. Radiolabeled ASCs were also tracked systemically. Each cat received two intravenous injections of 20 million ASCs, 1 month apart...
June 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28613065/-the-research-progress-of-co-2-laser-in-the-treatment-of-oral-lichen-planus
#8
Y J Shi, J K Wang, Q M Chen, X Zeng
Oral lichen planus (OLP) is a common oral mucosal disease. The etiology of OLP is not clear. The treatment of OLP is difficult as some of the OLP patients have little effects to the conventional mucosal treatments. In recent years, laser therapy has been adopted to treat patients with OLP. The CO(2) laser therapy has drawn much attention of doctors and scholars because of its advantages in treating the OLP. This review article mainly discusses the principle, effects and some state-of-the-art progresses in OLP treatment using CO(2) laser...
June 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28601424/a-diagnostic-approach-to-recurrent-orofacial-swelling-a-retrospective-study-of-104-patients
#9
Rachel Y Miest, Alison J Bruce, Nneka I Comfere, Elena Hadjicharalambous, Dawnielle Endly, Christine M Lohse, Roy S Rogers
OBJECTIVE: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach. PATIENTS AND METHODS: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011. RESULTS: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial...
June 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28592251/distinct-expression-profile-of-hcmv-encoded-mirnas-in-plasma-from-oral-lichen-planus-patients
#10
Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang, Chunni Zhang
BACKGROUND: Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of various diseases, but the clinical relevance of HCMV in OLP has not been thoroughly investigated. METHODS: In the present study, we firstly examined twenty-three HCMV-encoded microRNA (miRNA) expression profiles in plasma from training set that including 21 OLP patients and 18 healthy controls using RT-qPCR technology...
June 7, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28584781/clinicopathological-profile-and-malignant-transformation-in-oral-lichen-planus-a-retrospective-study
#11
Alokenath Bandyopadhyay, Shyam Sundar Behura, Roquaiya Nishat, Kailash Chandra Dash, Lipsa Bhuyan, Sujatha Ramachandra
OBJECTIVES: The aim of this study was to analyze the histopathologically diagnosed cases of oral lichen planus (OLP) in terms of age, gender, clinical variant, site, hyperpigmentation, systemic illness, grade of dysplasia, and associated malignant transformation. This study also intended to do a review of reported cases of OLP with malignant transformation. MATERIALS AND METHODS: One hundred and forty-three cases of histopathologically diagnosed OLP between 2010 and 2016 were retrospectively reviewed...
May 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28584533/salivary-oxidative-stress-in-oral-lichen-planus-treated-with-triamcinolone-mouthrinse
#12
Arash Mansourian, Farzaneh Agha-Hosseini, Hamed Hossein Kazemi, Nazanin Mortazavi, Mahdieh-Sadat Moosavi, Jalil Beytollahi, Iraj Mirzaii-Dizgah
BACKGROUND: Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation. MATERIALS AND METHODS: Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences...
March 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28571271/evaluation-of-efficacy-of-1-curcuminoids-as-local-application-in-management-of-oral-lichen-planus-interventional-study
#13
Anju Elizabeth Thomas, Beena Varma, Seema Kurup, Renju Jose, Marina Lazar Chandy, Sreeja P Kumar, M S Aravind, Athira Aruna Ramadas
INTRODUCTION: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Currently, the effective treatment of choice remains the use of corticosteroids. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Turmeric and its active ingredient, "curcumin", have been found to have anti-inflammatory, antioxidant and anticancer properties...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569171/oral-mucosal-lesions-in-teenagers-a-cross-sectional-study
#14
Francesca Amadori, Elena Bardellini, Giulio Conti, Alessandra Majorana
BACKGROUND: Adolescence is a period of transition to adulthood. Little is known about oral mucosal lesions (OMLs) in teenagers, in which the emergence of new habits, unfamiliar to children, could affect the type of lesions. The aim of this study was to evaluate the distribution of oral mucosal lesions (OMLs) in a wide sample of adolescents. METHODS: A retrospective cross-sectional study was carried out examining all medical records of adolescents (aged 13-18 years) treated at the Dental Clinic of the University of Brescia (Italy) in the period from 2008 to 2014...
May 31, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28567139/xerostomia-and-salivary-gland-hypofunction-in-patients-with-oral-lichen-planus-before-and-after-treatment-with-topical-corticosteroids
#15
Hala Al-Janaby, Haytham El-Sakka, Manal Masood, Walimuni Ashani W Mendis, Linda M Slack-Smith, Richard Parsons, Agnieszka M Frydrych
BACKGROUND: Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness. OBJECTIVE: The purpose of this observational before and after comparison study was to examine the effect of treatment of oral lichen planus with topical corticosteroids on mouth dryness...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28564620/survivin-in-autoimmune-diseases
#16
REVIEW
G Gravina, C Wasén, M J Garcia-Bonete, M Turkkila, M C Erlandsson, S Töyrä Silfverswärd, M Brisslert, R Pullerits, K M Andersson, G Katona, M I Bokarewa
Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is required for the innate and adaptive immune responses, controlling differentiation and maintenance of CD4(+) and CD8(+) memory T-cells, and in B cell maturation. Recently, survivin has emerged as an important player in the pathogenesis of autoimmune diseases...
May 28, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28562162/high-percentage-of-oral-lichen-planus-and-lichenoid-lesion-in-oral-squamous-cell-carcinomas
#17
Hellevi M A Ruokonen, Aino Juurikivi, Timo Kauppila, Anna Maria Heikkinen, Riitta Seppänen-Kaijansinkko
OBJECTIVE: Oral lichen planus (OLP) and lichenoid lesions (OLL) are regarded as precursor lesions of oral squamous cell carcinoma (OSCC) with potential for malignant transformation. This potential is not clear due to difficulties in diagnosis of OLP and OLL. Our aim was therefore to evaluate previously identified OLP and OLL as precursor lesions in OSCC and to identify cancer related etiological factors such as smoking and alcohol consumption. MATERIAL AND METHODS: We retrospectively reviewed all cases (total 323, comprising 164 females and 159 males) with OSCC treated at the Department of Oral and Maxillofacial Diseases and Surgery, Helsinki University Hospital during 2015...
May 31, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28559811/isolated-actinic-lichen-planus-of-the-lower-lip
#18
Ellie Choi, Kong Bing Tan, Nisha Suyien Chandran
Oral lichen planus (LP) is a common manifestation in patients with LP; however, isolated lip LP is rare and may mimic other conditions such as lichenoid drug eruptions, actinic cheilitis, and early carcinoma in situ in the absence of typical skin lesions. Actinic lichen planus (ALP) is a variant of LP occurring on light-exposed areas in patients with dark skin. We report the case of a Chinese female with isolated ALP of the lower lip, mimicking herpes simplex infection at presentation. The presence of prognathism, involvement of the lower lip, and flares associated with sunlight reinforces the role of sun exposure in the development of this condition...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28556960/the-cellular-character-of-liquefaction-degeneration-in-oral-lichen-planus-and-the-role-of-interferon-gamma
#19
Yuan Liu, Guicai Liu, Qing Liu, Jun Tan, Xin Hu, Jinjin Wang, Qintao Wang, Xinwen Wang
BACKGROUND: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, liquefaction degeneration in the basal keratinocytes is one of the specific histological changes. However, the understanding of liquefaction degeneration is still very limited, and how does it affect the prognosis of LP is largely unknown. Therefore, the objective of this study is to clarify the intrinsic change behind the liquefaction degeneration in lichen planus, and evaluate the effect of the OLP typical cytokines IFN-γon these changes...
May 29, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28554768/caveolin-1-expression-in-oral-lichen-planus-dysplastic-lesions-and-squamous-cell-carcinoma
#20
Zohreh Jaafari-Ashkavandi, Ehsan Aslani
Caveolin-1(Cav-1), the main part of caveolae structure, is supposed to play a role in pathogenesis of many human tumors. Since oral lichen planus (OLP) is considered as a potential premalignant disease, this study evaluated Cav-1 expression in OLP in comparison with benign hyperkeratosis, dysplastic epithelium and oral squamous cell carcinoma (OSCC), to investigate its possible role in pathogenesis and malignant transformation of OLP. In this cross-sectional retrospective study, immunohistochemical expression of Cav-1 in the epithelial component and stroma was evaluated in 81 samples, including 12 cases of hyperkeratosis, 24 OLP, 22 epithelial dysplasia, and 23 OSCC samples...
March 9, 2017: Pathology, Research and Practice
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