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Oral lichen planus

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https://www.readbyqxmd.com/read/28345335/vegfr-3-expression-in-oral-lichen-planus
#1
Zahra Zolfaghari Saravi, Maryam Seyedmajidi, Majid Sharbatdaran, Ali Bijani, Fatemeh Mozaffari, Pouyan Aminishakib
Background and objective: Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. Material and Methods: This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28322362/immunopathogenic-oral-diseases-%C3%A2-an-overview-focusing-on-pemphigus-vulgaris-and-mucous-membrane-pemphigoid
#2
Liviu Feller, Raoul Ballyram, Razia Ag Khammissa, Mario Altini, Johan Lemmer
Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Treatment aims to eliminate exogenous risk factors, suppress the pathogenic immuno-inflammatory reactions, promote healing and prevent infection...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28317358/-epidemiological-investigation-of-chewing-fresh-or-dried-betel-nut-and-oral-mucosal-disease
#3
Du Yongxiu, Sun Dongye, Jian Xinchun, Mao Qiuhua, Cheng Yanan, Xu Pu
OBJECTIVE: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province. METHODS: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP)...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316915/pan-masala-habits-and-risk-of-oral-precancer-a-cross-sectional-survey-in-0-45-million-people-of-north-india
#4
Divya Mehrotra, Sumit Kumar, Shambhavi Mishra, Sandeep Kumar, Prashant Mathur, C M Pandey, Arvind Pandey, Kishore Chaudhry
OBJECTIVES: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India. METHODS: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. A two page survey tool was used to collect the data...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28304209/subgingival-microbiota-in-caucasian-patients-with-desquamative-gingivitis-a-cross-sectional-study
#5
Paolo G Arduino, Federica Romano, Danilo Sasia, Roberto Broccoletti, Fulvio Ricceri, Anna Maria Barbui, Silvia Brossa, Raffaella Cipriani, Luca Cricenti, Marco Cabras, Mario Aimetti
BACKGROUND: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI)...
March 17, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28296743/association-between-polymorphisms-in-interleukins-and-oral-lichen-planus-a-meta-analysis
#6
Quan Shi, Tong Zhang, Na Huo, Yang Huang, Juan Xu, Hongchen Liu
BACKGROUND: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. METHODS: PubMed, Embase, and the Cochrane Library were searched for eligible studies to evaluate the association between IL polymorphisms and the OLP...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295632/immunohistochemical-detection-of-mycoplasma-salivarium-in-oral-lichen-planus-tissue
#7
Harumi Mizuki, Ryosuke Abe, Shintaro Kogi, Toshinari Mikami
BACKGROUND: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Herein, we investigated the presence of M. salivarium in OLP tissue by immunohistochemistry to determine the causative factor of OLP. METHODS: Forty-one formalin-fixed, paraffin-embedded samples obtained from 31 patients with OLP were examined...
March 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28293492/a-rare-case-of-malignant-transformation-of-oral-lichen-planus-of-the-mandible
#8
Joanne Soo, George Kokosis, Michael Ogilvie, Xiaoyin Sara Jiang, David B Powers, Daniel J Rocke, Detlev Erdmann
Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28285919/free-palatal-mucosal-graft-for-treatment-of-erosive-oral-lichen-planus
#9
Ji-Jong Yan, Mark Yen-Ping Kuo, Chun-Pin Chiang
No abstract text is available yet for this article.
March 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28278185/myeloid-dendritic-cells-stimulated-by-thymic-stromal-lymphopoietin-promote-th2-immune-responses-and-the-pathogenesis-of-oral-lichen-planus
#10
Masaki Yamauchi, Masafumi Moriyama, Jun-Nosuke Hayashida, Takashi Maehara, Noriko Ishiguro, Keigo Kubota, Sachiko Furukawa, Miho Ohta, Mizuki Sakamoto, Akihiko Tanaka, Seiji Nakamura
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Here, we investigated the expression of TSLP and related molecules in OLP. Buccal mucosa specimens from patients with OLP, hyperkeratosis, and ulcer were analyzed by immunohistochemistry for expression of TSLP, its receptor (TSLPR), and inflammatory cells...
2017: PloS One
https://www.readbyqxmd.com/read/28275859/gene-expression-of-mirna-138-and-cyclin-d1-in-oral-lichen-planus
#11
Noha A Ghallab, Rehab Fawzy Kasem, Safa Fathy Abd El-Ghani, Olfat G Shaker
OBJECTIVES: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis. METHODS: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression...
March 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28259920/identification-of-the-key-genes-implicated-in-the-transformation-of-olp-to-oscc-using-rna-sequencing
#12
Qiaozhen Yang, Bin Guo, Hongying Sun, Jie Zhang, Shangfeng Liu, Saiyin Hexige, Xuedi Yu, Xiaxia Wang
Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the differently expressed genes (DEGs) in OLP vs. normal and OSCC vs. normal groups, respectively, were identified by limma package in R language, and then clustering analysis were conducted by Pheatmap package in R language...
March 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28258757/-frontal-fibrosing-alopecia-a-prospective-study-of-20%C3%A2-cases
#13
S Elloudi, S Gallouj, M Meziane, F-Z Mernissi, M Rimani
BACKGROUND: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment. PATIENTS AND METHODS: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. RESULTS: Mean patient age was 46 years...
February 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28256018/oral-lichen-planus-in-childhood-a-case-series
#14
Marco Cascone, Antonio Celentano, Daniela Adamo, Stefania Leuci, Elvira Ruoppo, Michele D Mignogna
BACKGROUND: Although the exact incidence of pediatric oral lichen planus (OLP) is unknown, the oral mucosa seems to be less commonly involved, and the clinical presentation is often atypical. The aim of the study is to present a case series of OLP in childhood. METHODS: From our database, we retrospectively selected and analyzed the clinical data of OLP patients under the age of 18 where the diagnosis had been confirmed by histopathological analysis. RESULTS: The case series from our database shows eight patients, four males and four females...
March 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28253295/tissue-specific-regulation-of-cxcl9-10-11-chemokines-in-keratinocytes-implications-for-oral-inflammatory-disease
#15
Alison Marshall, Antonio Celentano, Nicola Cirillo, Michael McCullough, Stephen Porter
The IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 play a key role in many inflammatory conditions, particularly those mediated by T cells. Therefore, the production of these chemokines in peripheral tissues could be instrumental in the pathophysiology of tissue-specific immunological diseases such as oral lichen planus (OLP). In the present study, we assessed the production of keratinocyte-derived CXCL9/10/11 under basal and inflammatory conditions and investigated whether these chemokines were involved in the pathogenesis of OLP...
2017: PloS One
https://www.readbyqxmd.com/read/28252812/hepatitis-c-virus-and-its-cutaneous-manifestations-treatment-in-the-direct-acting-antiviral-era
#16
REVIEW
L E Wiznia, M E Laird, A G Franks
New all-oral direct acting antivirals (DAA) have changed the hepatitis C virus (HCV) treatment landscape. Given that dermatologists frequently encounter HCV-infected patients, knowledge of the current treatment options and their utility in treating HCV-associated dermatologic disorders is important. In addition to highlighting the new treatment options, we review four classically HCV-associated dermatologic disorders - mixed cryoglobulinemia (MC), lichen planus (LP), porphyria cutanea tarda (PCT), and necrolytic acral erythema (NAE) - and examine the role for all-oral direct acting antiviral (DAA) regimens in their treatment...
March 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28237528/identification-of-potential-therapeutic-target-genes-key-mirnas-and-mechanisms-in-oral-lichen-planus-by-bioinformatics-analysis
#17
Cuihua Gong, Shangtong Sun, Bing Liu, Jing Wang, Xiaodong Chen
The study aimed to identify the potential target genes and key miRNAs as well as to explore the underlying mechanisms in the pathogenesis of oral lichen planus (OLP) by bioinformatics analysis. The microarray data of GSE38617 were downloaded from Gene Expression Omnibus (GEO) database. A total of 7 OLP and 7 normal samples were used to identify the differentially expressed genes (DEGs) and miRNAs. The DEGs were then performed functional enrichment analyses. Furthermore, DEG-miRNA network and miRNA-function network were constructed by Cytoscape software...
February 12, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28231625/experimental-study-on-1-25-oh-2-d3-amelioration-of-oral-lichen-planus-through-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#18
Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang
OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it. METHODS: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28215546/analysis-of-human-serum-metabolome-for-potential-biomarkers-identification-of-erosive-oral-lichen-planus
#19
Xu-Yan Yang, Shuai-Nan Zhang, Xu-Zhao Li, Yu Wang, Xiao-Dong Yin
BACKGROUND: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. METHODS: Ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) combined with pattern recognition approaches were integrated to acquire differentially expressed metabolites for the pathways analysis and elucidate mechanisms of disease...
February 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28210449/oral-mucosal-lesions-in-a-chilean-elderly-population-a-retrospective-study-with-a-systematic-review-from-thirteen-countries
#20
César Rivera, Daniel Droguett, María-Jesús Arenas-Márquez
BACKGROUND: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. MATERIAL AND METHODS: It was conducted a retrospective study (Talca, Chile)...
February 2017: Journal of Clinical and Experimental Dentistry
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