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Oral lichen planus

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https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#1
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328529/hinokitiol-ablates-myofibroblast-activation-in-precancerous-oral-submucous-fibrosis-by-targeting-snail
#2
Hui-Wen Yang, Ming-Yi Lu, Yu-Wei Chiu, Yi-Wen Liao, Yu-Feng Huang, Pin Ju Chueh, Pei-Ling Hsieh, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors...
January 12, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29314294/participation-of-the-th17-response-in-the-pathogenesis-of-oral-lichen-planus
#3
R A Melo, L A B Silva, A N Fernades-Costa, B V B Monteiro, E J D Silveira, M C C Miguel
Lichen planus is a chronic noninfectious inflammatory mucocutaneous disease that affects the skin, nails and mucosae, including the oral mucosa.1 Although the etiology of oral liquen planus (OLP) remains not fully elucidated, it is recognized that its pathogenesis arises from an immune-mediated response and many authors suggest the disease to be an autoimmune process.2-5 Despite the high prevalence and well-defined cytotoxic activity of CD8+ T lymphocytes against keratinocytes of the basal layer of the epithelium in OLP, helper CD4+ T lymphocytes also play an important role in the pathogenesis of this disease...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29301093/biomolecules-in-the-treatment-of-lichen-planus-refractory-to-corticosteroid-therapy-clinical-and-histopathological-assessment
#4
Laura Piñas, Mohammad Hamdan Alkhraisat, Ricardo Suárez Fernández, Eduardo Anitua
BACKGROUND: Local deficit of several biomolecules have been described in oral lichen planus (OLP). Such a deficit impairs cellular functions and cell-matrix communication. PURPOSE: Assess the efficacy of the local application of autologous biomolecules in the treatment of erosive OLP. MATERIALS AND METHODS: In this study, the use of plasma rich in growth factors (PRGF) as a source of blood-derived and autologous growth factors and proteins were tested in erosive oral lichen planus refractory to corticosteroids...
January 1, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29297958/randomized-placebo-controlled-double-blind-trial-of-clobetasol-propionate-0-05-in-the-treatment-of-oral-lichen-planus
#5
P G Arduino, M G Campolongo, V Sciannameo, D Conrotto, A Gambino, M Cabras, F Ricceri, S Carossa, R Broccoletti, M Carbone
OBJECTIVE: To perform a randomized, placebo-controlled, double-blind study, with a follow-up period of 6 months, for the use of topical clobetasol in cases of symptomatic oral lichen planus (OLP). SUBJECTS AND METHODS: Thirty-two participants were analyzed, with the aims of: (I) to compare the usefulness of topically applied clobetasol propionate 0.05% (mixed with 4% hydroxyethyl cellulose gel) and 4% hydroxyethyl cellulose gel alone (considered as placebo) in the management of OLP; (II) to describe which of them is quicker in decreasing signs and reported symptoms, and (III) which is able to give the proper longer remission in the follow-up...
January 3, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29288692/intraepithelial-cd8-lymphocytes-as-a-predictive-diagnostic-biomarker-for-the-remission-of-oral-lichen-planus
#6
Ai Enomoto, Eiichi Sato, Takashi Yasuda, Tatsuya Isomura, Toshitaka Nagao, Daichi Chikazu
Oral lichen planus (OLP) is an autoimmune inflammatory disease of the oral mucosa whose etiology remains unknown. Moreover, the possibility of OLP being a premalignant change is under debate. Various types of immune cells infiltrate the OLP lesion and affect its clinicopathological features. However, the diversity of infiltrating immune cells has not been fully clarified in relation to OLP diagnosis. In this study, we quantitatively examined CD8 (+) lymphocyte infiltration by immunohistochemistry, which is the principal effector of cytotoxic immune reaction in 123 cases of OLP specimens...
December 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/29284468/evaluation-of-the-content-quality-of-websites-for-recurrent-aphthous-ulcers-and-oral-lichen-planus
#7
Xiaosheng Hu, Hui Pan, Wenxiu He, Hong Hua, Zhimin Yan
BACKGROUND: The Internet is one of the most popular resources for people to obtain medical information; however, only a limited number of studies have reported the quality of the available health information related to oral mucosal diseases. The present study aimed to evaluate the quality of information on websites for recurrent aphthous ulcers (RAU) and oral lichen planus (OLP), in both Chinese and English. METHODS: Common search engines, BaiDu, Google, and Yahoo in Chinese; and Bing, Google, and Yahoo in English were used to identify websites providing content related to the oral mucosal diseases...
December 29, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29279685/psychological-factors-in-oral-mucosal-and-orofacial-pain-conditions
#8
REVIEW
Mohammad S Alrashdan, Mustafa Alkhader
The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29279568/rapid-detection-of-candida-albicans-in-oral-exfoliative-cytology-samples-by-loop-mediated-isothermal-amplification
#9
Hiroyasu Noguchi, Takashi Iwase, Daisuke Omagari, Masatake Asano, Ryota Nakamura, Kosuke Ueki, Keiji Shinozuka, Tadayoshi Kaneko, Morio Tonogi, Hiderou Ohki
Loop-mediated isothermal amplification (LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. These patients had been clinically diagnosed with leukoplakia, squamous cell carcinoma, oral lichen planus (OLP), stomatitis, oral candidiasis, and other malignancies...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29276184/evaluation-of-the-mirna-146a-and-mirna-155-expression-levels-in-patients-with-oral-lichen-planus
#10
Fatemeh Ahmadi-Motamayel, Zeynab Bayat, Mehrdad Hajilooi, Soroosh Shahryar-Hesami, Ali Mahdavinezhad, Lida Samie, Ghasem Solgi
BACKGROUND: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. OBJECTIVE: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. METHODS: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Oral lichen planus was diagnosed clinically and pathologically...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29247855/-omics-in-oral-cancer-new-approaches-for-biomarker-discovery
#11
REVIEW
Vertika Rai, Rashmi Mukherjee, Ananta K Ghosh, Aurobinda Routray, Chandan Chakraborty
OBJECTIVES: In this review paper, we explored the application of "omics" approaches in the study of oral cancer (OC). It will provide a better understanding of how "omics" approaches may lead to novel biomarker molecules or molecular signatures with potential value in clinical practice. A future direction of "omics"-driven research in OC is also discussed. METHODS: Studies on "omics"-based approaches [genomics/proteomics/transcriptomics/metabolomics] were investigated for differentiating oral squamous cell carcinoma,oral sub-mucous fibrosis, oral leukoplakia, oral lichen planus, oral erythroplakia from normal cases...
December 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29247492/new-evidence-of-connections-between-increased-o-glcnacylation-and-inflammasome-in-the-oral-mucosa-of-patients-with-oral-lichen-planus
#12
Thao Thi Do, Chatchai Phoomak, Voraratt Champattanachai, Atit Silsirivanit, Ponlatham Chaiyarit
Oral lichen planus (OLP) is considered a chronic inflammatory immune-mediated disease of the oral mucosa. Immunopathogenesis of OLP is thought to be associated with cell-mediated immune dysregulation. O-GlcNAcylation is a form of reversible glycosylation. It has been demonstrated that O-GlcNAcylation promoted NF-κB signaling. Activation of NF-кB can induce expression of NLRP3 inflammasome which is a large intracellular multiprotein complex involving an immune response. Dysregulated expression of the NLRP3 inflammasome was reported to be associated with autoinflammatory diseases...
December 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29243374/molecular-classification-of-autofluorescence-excision-margins-in-oral-potentially-malignant-disorders
#13
Camile S Farah, Farzaneh Kordbacheh, Keziah John, Nigel Bennett, Simon A Fox
OBJECTIVE: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles. MATERIALS AND METHODS: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other...
December 14, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29234717/vulvar-lichen-planus-pemphigoides
#14
J Loyal, S Rashtak
Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. This clinical scenario can be confused with a number of similarly appearing entities such as erosive vulvar lichen planus, mucous membrane pemphigoid, and erosive lichen sclerosus et atrophicus...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29225365/a-review-of-the-effectiveness-and-side-effects-of-fluocinolone-acetonide-0-1-in-the-treatment-of-oral-mucosal-diseases
#15
REVIEW
Kobkan Thongprasom
Topical steroids have been widely used in the treatment of symptomatic oral lesions to reduce pain and inflammation. Potent topical steroids such as clobetasol propionate, fluocinolone acetonide (FA), and fluocinonide have been widely used in the treatment of severe oral mucosal lesions. Many reports have demonstrated that these steroids were effective in treating oral lesions with only minor side-effects. This review describes the effectiveness and side-effects of using FA 0.1% in the treatment of symptomatic oral lichen planus (OLP), oral lichenoid drug reaction (OLDR), oral pemphigus, and herpes associated erythema multiforme (HAEM)...
September 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/29223131/photodynamic-therapy-in-the-treatment-of-symptomatic-oral-lichen-planus-a-systematic-review
#16
REVIEW
Zohaib Akram, Fawad Javed, Mervyn Hosein, Mohammed Ayedh Al-Qahtani, Fayez Alshehri, Ahmed Ibrahim Alzahrani, Fahim Vohra
BACKGROUND: The aim of this systematic review was to assess the efficacy of photodynamic therapy (PDT) in the treatment of symptomatic oral lichen planus (OLP). METHODS: This systematic review aimed to address the following focused question: "Is PDT effective in the treatment of symptomatic OLP?" Indexed databases; MEDLINE, EMBASE and CENTRAL were searched up to and including August 2017. RESULTS: Six clinical studies were included. The risk of bias was considered high in five studies and moderate in one study...
December 9, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29211124/association-of-oral-lichen-planus-and-electrocardiographic-p-wave-dispersion-an-original-research
#17
R Aditi, S Sathasivasubramanian, M Emmanuel Bhaskar
Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29208790/oral-manifestation-in-patients-diagnosed-with-dermatological-diseases
#18
Sanjay G Thete, Meena Kulkarni, Atul P Nikam, Tejashree Mantri, Dhiraj Umbare, Sushant Satdive, Dinraj Kulkarni
AIM: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India. MATERIALS AND METHODS: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29207828/micronucleus-assay-an-early-diagnostic-tool-to-assess-genotoxic-changes-in-patients-with-tobacco-use-oral-leukoplakia-and-oral-submucous-fibrosis
#19
Moulshree Kohli, Puneet Ahuja, Monica Mehendiratta, Mohit Sharma, Jahnobi Dutta
Introduction: Micronuclei (MNi) are acentric chromatid or chromosome fragments produced via genetic damage through genotoxic agents contained in tobacco and betel nut. Evidently, the various Oral Potentially Malignant Disorders (OPMDs) like oral lichen Planus, oral leukoplakia and Oral Submucous Fibrosis (OSMF) demonstrate MNi, as a substantiation of genetic damage. As these changes can be easily appreciated in oral exfoliated cells, an exfoliated cell based MNi assay might be utilized as handy and non invasive biomonitoring tool for gauging the genetic damage and hence the propensity for malignant transformation in OPMDs...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202564/systematic-review-the-efficacy-of-topical-hyaluronic-acid-on-oral-ulcers
#20
M Casale, A Moffa, P Vella, V Rinaldi, M A Lopez, V Grimaldi, F Salvinelli
The management of oral ulcers is a challenge for clinicians. Whilst there is widespread use of topical corticosteroids, antibiotics and antimicrobial, there is only weak evidence for the effectiveness of any of the topical treatments. Hyaluronic Acid (HA) has been recently proposed for topical administration in the treatment of oral ulcers and other painful oral lesions. The aim of the study is to systematically review the published literature regarding all the therapeutic effects of HA on painful oral lesions such as oral ulcers and oral lichen planus...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
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