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Oral lichen planus

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https://www.readbyqxmd.com/read/29146053/usefulness-of-a-direct-immunofluorescence-in-the-diagnosis-of-plaque-type-oral-lichen-planus
#1
Patricia Alejandra Masquijo-Bisio, Mariana Silvia Gandolfo, Alicia Keszler, Maria Elina Itoiz, María Luisa Paparella
No abstract text is available yet for this article.
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29139359/oral-lichen-planus-a-cross-sectional-descriptive-study-of-33-patients
#2
Virendra N Sehgal, Nazim Hussain Syed, Ashok Aggarwal, Shruti Sehgal
Oral lichen planus (OLP), a well-known entity, is often neglected; however, its assessment is considered essential for evolving future strategies for treatment. Thirty-three patients with OLP from 200 consecutive patients with oral mucosal lesions were studied according to demography. Tobacco chewing, smoking, and alcohol intake were recorded. Examination of the oral cavity, using a head light and tongue depressor, was undertaken to define the morphology of the lesion(s). Colored photographs were an essential part of the process...
2017: Skinmed
https://www.readbyqxmd.com/read/29139037/prevalence-of-oral-lichen-planus-in-iranian-children-and-adolescents-a-12-year-retrospective-study
#3
S Bakhtiari, J B Taheri, P Toossi, S Azimi, Sh Kawosi Nezhad
AIM: To investigate the prevalence of oral lichen planus in patients younger than 18 years, referred to a dermatology centre in Iran during 2002-2014. Lichen planus is a chronic inflammatory, immune-mediated disease that could affect the oral mucosa and is a pre-cancerous condition. The disease usually develops in middle age with female predominance and is rare in children. METHODS: In this retrospective study, cases with definitive histopathologic diagnosis of lichen planus, over a 12-year period from 2002 to 2014 from a dermatologic hospital archive were evaluated...
November 14, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29138813/reduced-mirna%C3%A2-214-expression-in-oral-mucosa-contributes-to-the-pathogenesis-of-oral-lichen-planus-by-targeting-cd44
#4
Haiyan Zheng, Shaohui Li
The present study aimed to investigate the role of miRNAs during the pathogenesis of oral lichen planus (OLP). OLP is a chronic inflammatory disorder, which involves T‑cell mediated autoimmunity and affects the skin, scalp, nails and mucosa. Abundant T lymphocytes have been demonstrated to infiltrate the oral mucosa, in which the activated T cells trigger apoptosis of oral epithelial cells. Overexpression of osteopontin (OPN) and CD44 has been observed in the mucosa of patients with OLP, and it has been confirmed that OPN suppresses the apoptosis of activated CD8+ T cells via CD44...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29135114/expression-and-role-of-p53-in-oral-lichen-planus-patients
#5
Milos Hadzi-Mihailovic, Renata Petrovic, Helene Raybaud, Dragan Stanimirovic, Meltem Ozar Koray
PURPOSE: Oral lichen planus (OLP) is an autoimmune skin and mucosal disorder. The range of malignant transformation in OLP varies between 0.1-3%. p53 is a tumor suppressor protein. Defective p53 could allow abnormal cells to proliferate, resulting in cancer. p53 plays an important role in cell cycle control and apoptosis and loss of p53 function has been demonstrated in about half of all human cancers. The purpose of the study was to investigate the malignant potential of OLP on the basis of p53 expression and to correlate p53 expression with clinical and histopathological features of OLP...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29130773/alteration-of-salivary-glycopatterns-in-oral-lichen-planus
#6
Liang Fang, Qing Liu, Pengfei He, Xinwen Wang, Ying Wang, Minghui Wei, Lihua Chen
BACKGROUND: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Structural changes in the glycans of saliva proteins might be reliable indicators of OLP. However, little is known about the alteration of salivary glycopatterns during OLP. OBJECTIVE: We aimed to investigate the alterations of salivary protein glycosylation related to OLP...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29124831/a-prospective-observational-study-to-compare-efficacy-of-topical-triamcinolone-acetonide-0-1-oral-paste-oral-methotrexate-and-a-combination-of-topical-triamcinolone-acetonide-0-1-and-oral-methotrexate-in-moderate-to-severe-oral-lichen-planus
#7
P Chauhan, D De, S Handa, T Narang, U N Saikia
Topical corticosteroids are considered to be the most effective treatment for oral lichen planus (OLP). Methotrexate has been found to be effective in extensive cutaneous lichen planus. The objectives of the study were to evaluate the clinical efficacy and safety of topical triamcinolone 0.1% oral paste, oral methotrexate and a combination of these in symptomatic moderate-to- severe OLP. Forty-five patients were recruited and were allocated to three treatment arms with 15 patients in each treatment arm. They were treated for a period of 16 weeks or until complete clinical remission, whichever was earlier...
November 10, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29123636/management-of-oral-lichen-planus-by-980-nm-diode-laser
#8
Nahid Derikvand, Seyedeh Sara Ghasemi, Mohammad Moharami, Ehsan Shafiei, Nasim Chiniforush
Introduction: Oral lichen planus (OLP) is a mucocutaneous disease with uncertain etiology. As the etiology is unknown standard treatment modalities are not available. The traditional and common treatment relies on corticosteroids whether topical or systemic. In recent years, development of lasers made a proper path to use this instrument for treatment of the diseases which are refractory to conventional treatments. Previous studies in this field used CO2, ND:YAG, Excimer and some wavelength of diode lasers for the treatment of different types of lichen planus...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29121431/outcomes-of-oral-lichen-planus-and-oral-lichenoid-lesions-treated-with-topical-corticosteroid
#9
M A Gonzalez-Moles, J A Gil-Montoya, L Gonzalez-Ruiz, P Ramos, M Bravo
OBJECTIVE: To determine corticosteroid treatment effectiveness in patients with Oral Lichen Planus/Oral Lichenoid Lesions (OLP/OLL). MATERIAL AND METHODS: Twenty-one OLP and eighty-one OLL patients received 0.05% clobetasol propionate (CP) or 0.05% triamcinolone acetonide (TA) in aqueous solution (AS) or orabase (OB), evaluating responses to treatment and follow-up compliance. RESULTS: Lesions were atrophic (72/102; 70.6%), extensive (58/100; 58%), producing eating difficulties (62/102; 60...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29118700/looking-beyond-the-cyclosporine-swish-and-spit-technique-in-a-recalcitrant-case-of-erosive-lichen-planus-involving-the-tongue
#10
Aastha Gupta, Kabir Sardana, Ram Kishan Gautam
Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the "swish and spit" technique, is a valid therapeutic intervention. In our case, though, this therapeutic option had to be replaced by the systemic use of cyclosporine with gratifying results.
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29104603/oral-lichen-planus-in-a-pediatric-patient-a-novel-therapeutic-approach
#11
Gaurav Sharma, Divesh Sardana, Puneeta Vohra, Shweta Rehani, Archna Nagpal
Lichen planus is a mucocutaneous disease, predominantly affecting the middle-aged individuals and may be associated with a plethora of signs and symptoms related to the skin, scalp, nails and mucous membranes. The definitive etiology of lichen planus is not yet known and no therapeutic modality has yet been universally accepted. Lichen planus in pediatric patients is a rare phenomenon and its presence in the oral mucosa is even rarer. The aim of this article is to present a rare case of a symptomatic oral lichen planus (OLP) occurring in a 12-year old child that was managed successfully with a novel sequential modality of topical retinoids followed by aloe vera gel application...
March 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29101247/evidence-of-earlier-thyroid-dysfunction-in-newly-diagnosed-oral-lichen-planus-patients-a-hint-for-endocrinologists
#12
Paolo G Arduino, Dora Karimi, Federico Tirone, Veronica Sciannameo, Fulvio Ricceri, Marco Cabras, Alessio Gambino, Davide Conrotto, Stefano Salzano, Mario Carbone, Roberto Broccoletti
The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29057516/porphyromonas-gingivalis-lipopolysaccharide-induces-over-production-of-cc-chemokine-ligand-2-via-toll-like-receptor-4-in-oral-lichen-planus
#13
Qi Zeng, Xi Yang, Xiaobing Chen, Juan Xia, Bin Cheng, Xiaoan Tao
BACKGROUND: We recently reported that the CC chemokine ligand 2 (CCL2)-CC receptor 2 (CCR2) axis was involved in the pathogenesis of oral lichen planus (OLP). However, the exact mechanism for the high expression of CCL2 in OLP specimens is not clear. Therefore, this study was designed to investigate the potential role of the toll-like receptor 4 (TLR-4) pathway in overproduction of CCL2 in OLP lesions. METHODS: Immunohistochemical staining and real-time RT-PCR were used to detect TLR-4, CCL2, and CCR2 expression in OLP lesions...
October 23, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29053652/a-report-on-the-clinical-pathological-correlations-of-788-gingival-lesion
#14
A Gambino, M Carbone, R Broccoletti, P Carcieri, D Conrotto, M Carrozzo, P-G Arduino
BACKGROUND: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population. MATERIAL AND METHODS: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Statistical analysis was performed by calculating the odds ratio and 95% confidence interval (C...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29034442/correlation-between-tissue-expression-of-microrna-137-and-cd8-in-oral-lichen-planus
#15
Sana Maher Hasan Aghbari, Abdelrahman Ibrahim Abushouk, Olfat Gamil Shakir, Shaimaa Omar Zayed, Attia Attia
OBJECTIVES: Oral lichen planus (OLP) is a chronic, inflammatory condition, classified by the World Health Organization as a premalignant lesion. We performed this study to evaluate the correlation between microRNA-137 (miR-137) and CD8 oral tissue expression in OLP patients. MATERIALS AND METHODS: Twenty OLP patients [classified into three groups: (a) papular, reticular, or plaque; (b) atrophic; and (c) erosive] and 20 healthy controls were subjected to biopsy of the oral mucosa...
October 15, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29029370/elder-neglect-oral-diseases-and-injuries
#16
Stefano Petti
Elder Neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandatory in many countries. However, only few claims are substantiated, as EN could be confused with Self-Neglect, neglect could be unintentional or due to caregiver unawareness. Screening tools are inaccurate and their use is discouraged by public health organizations, because they lead to too many false positives, which engulf the already overwhelmed APSs...
October 13, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29021479/a-japanese-case-of-esophageal-lichen-planus-that-was-successfully-treated-with-systemic-corticosteroids
#17
Yuki Sato, Ryuta Takenaka, Akihiro Matsumi, Kensuke Takei, Shotaro Okanoue, Eriko Yasutomi, Daisuke Kawai, Koji Takemoto, Hirofumi Tsugeno, Takayoshi Miyake, Shigeatsu Fujiki
Esophageal lichen planus (ELP) is rare and only about 80 cases have been reported in the literature. An 85-year-old woman presented with dysphagia and odynophagia. Endoscopy revealed a severe stricture in the proximal esophagus. Oral examinations at two years after the first endoscopy revealed erosions around the gingiva, and an examination of biopsy specimens taken from the site of erosion led to a diagnosis of oral LP. Esophageal endoscopy was performed again, and biopsy specimens showed spongiosis and necrotic keratinocytes in the epithelium (civatte bodies)...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28983467/ultrastructural-changes-during-the-life-cycle-of-mycoplasma-salivarium-in-oral-biopsies-from-patients-with-oral-leukoplakia
#18
Harumi Mizuki, Ryosuke Abe, Toshinari Mikami
Bacteria in genus Mycoplasma spp. are the smallest and simplest form of freely replicating bacteria, with 16 species known to infect humans. In the mouth, M. salivarium is the most frequently identified species. Mycoplasma spp. are parasites with small genomes. Although most of the Mycoplasma spp. that infect humans remain attached to the host cell surface throughout their life cycle, we have previously reported the presence of Mycoplasma salivarium in the epithelial cells of oral leukoplakia and oral lichen planus...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28976032/dna-methylation-patterns-of-genes-related-to-immune-response-in-the-different-clinical-forms-of-oral-lichen-planus
#19
Aline Fernanda Cruz, Renata Gonçalves de Resende, Júlio César Tanos de Lacerda, Núbia Braga Pereira, Leonardo Augusto Melo, Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Ricardo Santiago Gomez
BACKGROUND: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus...
October 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28969269/role-of-cathepsin-b-as-a-marker-of-malignant-transformation-in-oral-lichen-planus-an-immunohistochemical-study
#20
Krishnanand Prakash Satelur, Shiny Bopaiah, Radhika Manoj Bavle, Prashant Ramachandra
INTRODUCTION: Malignant transformation of Oral Lichen Planus (OLP) remains a much discussed but very less understood realm. Various hypotheses and theories have been put forward to explain the same. Malignant transformation is a complex interplay of epithelial mesenchymal factors acting in tandem. This study tries to identify and asses the stromal changes that pave the way for epithelial migration using Cathepsin B (CB) a cysteine protease belonging to the Cathepsin family. Various studies have been done to study its role in human cancers which have proven that CB helps mark and identify tissue digestion...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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