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Oral lichen planus

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https://www.readbyqxmd.com/read/28425240/oral-lichen-planus-a-4-year-clinical-follow-up-study
#1
Arūnas Rimkevičius, Jolanta Aleksejūnienė, Alina Pūrienė, Dmitrij Šeinin, Rūta Rastenienė
BACKGROUND/AIM: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. MATERIALS AND METHODS: All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28422565/ascorbic-acid-deficiency-in-patients-with-lichen-planus
#2
Ilinca Nicolae, Cristina Iulia Mitran, Madalina Irina Mitran, Corina Daniela Ene, Mircea Tampa, Simona Roxana Georgescu
OBJECTIVES: Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin. MATERIAL AND METHOD: We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP) - 49 cases, oral LP (OLP) - 28 cases) and 50 control subjects...
April 19, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28412610/overexpression-and-varied-clinical-significance-of-th9-versus-th17-cells-in-distinct-subtypes-of-oral-lichen-planus
#3
Hui Wang, Jingping Bai, Zhenhua Luo, Jie Fu, Hongjian Wang, Zheng Sun
OBJECTIVE: Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. MATERIALS AND METHODS: Peripheral blood samples were collected from 41 OLP patients and 18 healthy controls (HCs)...
April 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28410381/qualitative-analysis-of-the-impact-of-oral-potentially-malignant-disorders-on-daily-life-activities
#4
Jyothi Tadakamadla, Santhosh Kumar, Ratilal Lalloo, Newell W Johnson
OBJECTIVE: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities. MATERIALS AND METHODS: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Voice recordings were transcribed and translated from Telugu to English...
2017: PloS One
https://www.readbyqxmd.com/read/28400896/treatment-of-recalcitrant-erosive-oral-lichen-planus-and-desquamative-gingivitis-with-oral-apremilast
#5
Mohn'd AbuHilal, Scott Walsh, Neil Shear
BACKGROUND: Erosive oral lichen planus and desquamative gingivitis are uncommon but severe debilitating variants of oral lichen planus. Treatment of these presentations is difficult and challenging. MAIN OBSERVATION: A 44-year-old woman was referred to the dermatology clinic with chronic painful lichen planus-related gingivitis and buccal erosions. She has failed multiple treatments including topical clobetasol and tacrolimus, intralesional corticosteroids and several systemic and immunosuppressive agents...
November 30, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28400582/detection-of-ama-m2-in-human-saliva-potentials-in-diagnosis-and-monitoring-of-primary-biliary-cholangitis
#6
Chong Lu, Xianliang Hou, Minwei Li, Lin Wang, Ping Zeng, Hongyu Jia, Jianing Chen, Yingfeng Wei, Hong He, Xiangdong Liu, Hongyan Diao
Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as a pivotal biomarker for the diagnosis of primary biliary cholangitis (PBC). However, serological tests have many limitations, including inconvenience, invasiveness, and infection risks. Thus, a less invasive approach to detect AMA-M2 titer is desirable. We examined salivary AMA-M2 of potential PBC patients and found that AMA-M2 could be detected only in saliva of serum AMA-M2-positive PBC patients, but not in saliva of serum AMA-M2-negative PBC patients, oral lichen planus patients (OLP) patients, or healthy controls...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390130/oral-diseases-a-14-year-experience-of-a-chilean-institution-with-a-systematic-review-from-eight-countries
#7
C Rivera, C Jones-Herrera, P Vargas, B Venegas, D Droguett
BACKGROUND: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce. MATERIAL AND METHODS: This study investigated the frequency of OD in a Chilean population. For this, we included all patients treated at the University of Talca (UTALCA, Chile) between 2001 and 2014...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28390063/psychological-profiles-in-patients-with-symptomatic-reticular-forms-of-oral-lichen-planus-a-prospective-cohort-study
#8
Daniela Adamo, Marco Cascone, Antonio Celentano, E Ruoppo, Stefania Leuci, Massimo Aria, Michele D Mignogna
OBJECTIVES: To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP). MATERIALS AND METHODS: Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI) and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered...
April 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28381149/two-unusual-cases-of-oral-lichen-planus-arising-after-oral-squamous-cell-carcinoma
#9
Davide Bartolomeo Gissi, Sofia Asioli, Andrea Gabusi
Autoimmune diseases occur when the immune system fails to recognize self-antigens expressed on the body's own cells and attacks them. Oral lichen planus (OLP) is a chronic autoimmune mucocutaneous disease of the oral cavity characterized by white/red lesions. Considered a potentially malignant disorder, OLP evolution into oral squamous cell carcinoma (OSCC) is still a matter of debate. While chronic autoimmune inflammation is considered a potential risk factor for malignant transformation in many solid tumors, the opposite idea that cancer may trigger autoimmune responses remains controversial...
March 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28367894/roles-of-serum-uric-acid-prolactin-levels-and-psychosocial-factors-in-oral-lichen-planus
#10
Akanksha Gupta, Ravi Prakash S Mohan, Swati Gupta, Sangeeta S Malik, Sumit Goel, Nagaraju Kamarthi
Free radicals play important roles in the mechanisms underlying lichen planus (LP). Uric acid (UA) is an important anti-oxidant in plasma. Prolactin (PRL) is an immunomodulatory hormone that may promote LP, as has been documented in other autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. PRL has multiple immune-stimulatory effects and promotes the development of such autoimmune disorders. Prolactin and uric acid may serve as biomarkers of disease activity in lichen planus...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28358035/oral-health-status-in-sichuan-province-findings-from-the-oral-health-survey-of-sichuan-2015-2016
#11
Wei Yin, Ying-Ming Yang, Hong Chen, Xue Li, Zhuo Wang, Li Cheng, Qiu-Dan Yin, Hong-Zhi Fang, Wei Fei, Fang-Lin Mi, Min-Hai Nie, Tao Hu, Xue-Dong Zhou
To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3-5 years, adolescents aged 12 years, and people aged 65-74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28353022/topical-application-of-morphine-for-wound-healing-and-analgesia-in-patients-with-oral-lichen-planus-a-randomized-double-blind-placebo-controlled-study
#12
Ruth Zaslansky, Cynthia Schramm, Christoph Stein, Claas Güthoff, Andrea Maria Schmidt-Westhausen
OBJECTIVE: The objective of this study was to investigate the effect of topical morphine on erosive/ulcerative lesions in patients with oral lichen planus (OLP). Previous studies reported on an enhanced remission of skin wounds when morphine was applied topically. MATERIALS AND METHODS: This was single-center, prospective, double-blind, placebo-controlled, randomized, multi-arm (3), phase II study (RCT). Patients diagnosed with erosive and/or ulcerative OLP applied 0...
March 28, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28351570/topical-agents-for-oral-cancer-chemoprevention-a-systematic-review-of-the-literature
#13
REVIEW
Lucy Chau, Justin T Jabara, Wanda Lai, Peter F Svider, Blake M Warner, Ho-Sheng Lin, S Naweed Raza, Andrew M Fribley
OBJECTIVES/HYPOTHESIS: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28345335/vegfr-3-expression-in-oral-lichen-planus
#14
Zahra Zolfaghari Saravi, Maryam Seyedmajidi, Majid Sharbatdaran, Ali Bijani, Fatemeh Mozaffari, Pouyan Aminishakib
Background and objective: Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. Material and Methods: This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28322362/immunopathogenic-oral-diseases-%C3%A2-an-overview-focusing-on-pemphigus-vulgaris-and-mucous-membrane-pemphigoid
#15
Liviu Feller, Raoul Ballyram, Razia Ag Khammissa, Mario Altini, Johan Lemmer
Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Treatment aims to eliminate exogenous risk factors, suppress the pathogenic immuno-inflammatory reactions, promote healing and prevent infection...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28317358/-epidemiological-investigation-of-chewing-fresh-or-dried-betel-nut-and-oral-mucosal-disease
#16
Du Yongxiu, Sun Dongye, Jian Xinchun, Mao Qiuhua, Cheng Yanan, Xu Pu
OBJECTIVE: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province. METHODS: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP)...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316915/pan-masala-habits-and-risk-of-oral-precancer-a-cross-sectional-survey-in-0-45-million-people-of-north-india
#17
Divya Mehrotra, Sumit Kumar, Shambhavi Mishra, Sandeep Kumar, Prashant Mathur, C M Pandey, Arvind Pandey, Kishore Chaudhry
OBJECTIVES: This cross-sectional community based study was conducted to estimate the prevalence of consumption habits for non tobacco pan masala (ASU) and the risk of developing oral precancer in North India. METHODS: This study was conducted in the old town of Lucknow city in the state of Uttar Pradesh in India. Subjects residing for more than 6 months and aged 15 years or above, were enrolled in the study after their informed consent. A two page survey tool was used to collect the data...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28304209/subgingival-microbiota-in-caucasian-patients-with-desquamative-gingivitis-a-cross-sectional-study
#18
Paolo G Arduino, Federica Romano, Danilo Sasia, Roberto Broccoletti, Fulvio Ricceri, Anna Maria Barbui, Silvia Brossa, Raffaella Cipriani, Luca Cricenti, Marco Cabras, Mario Aimetti
BACKGROUND: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI)...
March 17, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28296743/association-between-polymorphisms-in-interleukins-and-oral-lichen-planus-a-meta-analysis
#19
Quan Shi, Tong Zhang, Na Huo, Yang Huang, Juan Xu, Hongchen Liu
BACKGROUND: More and more studies have suggested that single-nucleotide polymorphisms (SNPs) in interleukin (IL) genes are correlated with an increased risk of developing oral lichen planus (OLP). However, these results were inconsistent. Therefore, the aim of this meta-analysis is to retrieve and comprehensively analyze all related clinical studies to investigate the association of ILs gene polymorphisms with the OLP risk. METHODS: PubMed, Embase, and the Cochrane Library were searched for eligible studies to evaluate the association between IL polymorphisms and the OLP...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295632/immunohistochemical-detection-of-mycoplasma-salivarium-in%C3%A2-oral-lichen-planus-tissue
#20
Harumi Mizuki, Ryosuke Abe, Shintaro Kogi, Toshinari Mikami
BACKGROUND: Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Herein, we investigated the presence of M. salivarium in OLP tissue by immunohistochemistry to determine the causative factor of OLP. METHODS: Forty-one formalin-fixed, paraffin-embedded samples obtained from 31 patients with OLP were examined...
March 10, 2017: Journal of Oral Pathology & Medicine
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