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Oral lichen planus

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https://www.readbyqxmd.com/read/28231625/experimental-study-on-1-25-oh-2-d3-amelioration-of-oral-lichen-planus-through-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang
OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it. METHODS: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28215546/analysis-of-human-serum-metabolome-for-potential-biomarkers-identification-of-erosive-oral-lichen-planus
#2
Xu-Yan Yang, Shuai-Nan Zhang, Xu-Zhao Li, Yu Wang, Xiao-Dong Yin
BACKGROUND: Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment. METHODS: Ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) combined with pattern recognition approaches were integrated to acquire differentially expressed metabolites for the pathways analysis and elucidate mechanisms of disease...
February 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28210449/oral-mucosal-lesions-in-a-chilean-elderly-population-a-retrospective-study-with-a-systematic-review-from-thirteen-countries
#3
César Rivera, Daniel Droguett, María-Jesús Arenas-Márquez
BACKGROUND: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. MATERIAL AND METHODS: It was conducted a retrospective study (Talca, Chile)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28203017/-analysis-of-type-c-behavior-in-patients-with-oral-lichen-planus
#4
Y S Guo, S Li, M Y Lyu, D Yang, H Hua
OBJECTIVE: To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention, treatment and psychological intervention of OLP. METHODS: Type C behavior scale was used on 85 OLP patients and 85 control patients, who were in accordance with the inclusion criteria, in order to investigate their type C behavior. The scale included 9 items: anxiety, depression, anger, anger toward inside (anger-in), anger toward outside (anger-out), reasoning, domination, optimism, and social support...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199766/dysbiosis-of-oral-buccal-mucosa-microbiota-in-patients-with-oral-lichen-planus
#5
Yuan He, Diping Gong, Cong Shi, Fangyang Shao, Jiahao Shi, Jian Fei
OBJECTIVE: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control. SUBJECTS AND METHODS: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. RESULTS: 94.26% of the total buccal bacteria were classified into 15 abundant genera...
February 15, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28199027/investigating-the-level-of-salivary-endothelin-1-in-premalignant-and-malignant-lesions
#6
Tahereh Nosratzehi, Sirous Risbaf Fakour, Ebrahim Alijani, Maryam Salehi
PURPOSE: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions. MATERIALS AND METHODS: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. The samples were collected between 9 and 12 a.m. They were sent to the lab shortly after being collected and salivary endothelin-1 was recorded for each sample according to the instruction of factory by using enzyme-linked immunosorbent assay and optical density at a wavelength of 450 nm...
February 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28195069/salivary-oxidative-status-in-patients-with-oral-lichen-planus
#7
D Darczuk, W Krzysciak, P Vyhouskaya, B Kesek, D Galecka-Wanatowicz, W Lipska, T Kaczmarzyk, M Gluch-Lutwin, B Mordyl, M Chomyszyn-Gajewska
Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28186659/is-chronic-ulcerative-stomatitis-a-variant-of-lichen-planus-or-a-distinct-disease
#8
REVIEW
Liviu Feller, Razia A G Khammissa, Johan Lemmer
Chronic ulcerative stomatitis is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers. Most cases are limited to the mouth. The histopathological features are non-specific or mimic those of oral lichen planus, and studies by immunoflorescent microscopy are essential for definitive diagnosis. The defining immunopathogenic mechanism is the binding of IgG to the nuclear protein deltaNp63alpha of keratinocytes in the basal and parabasal cell layers of the oral stratified epithelium...
February 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28174362/most-frequent-oral-lesions-in-patients-with-type-2-diabetes-mellitus
#9
Micheline S Trentin, Georgia Verardi, Michele De C Ferreira, João P de Carli, Soluete O da Silva, Igor Fp Lima, Luiz R Paranhos
AIM: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease. MATERIALS AND METHODS: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28168769/topical-tacrolimus-triamcinolone-acetonide-and-placebo-in-oral-lichen-planus-a-pilot-randomized-controlled-trial
#10
M Siponen, L Huuskonen, S Kallio-Pulkkinen, P Nieminen, T Salo
OBJECTIVE: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP. SUBJECTS AND METHODS: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0.1% TAC ointment (n=11), 0.1% TRI paste (n=7) or Orabase(®) paste as PLA (n=9) for 3 weeks. If the CS dropped ≥ 20% (interpreted as response), the patients continued the same medication for another 3 weeks...
February 6, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28164620/comparison-of-b-cell-activating-factor-expression-in-neutrophils-in-patients-with-potentially-malignant-disorders-and-patients-with-cancer-in-the-same-site
#11
Ewa Jab O Ska, Bo Ena S Odczyk, Natalia Wawrusiewicz-Kurylonek, Dorota Dziemia Czyk-Pakie A, Marzena Garley, Wioletta Ratajczak-Wrona, Jan Borys, Adam Kr Towski
BACKGROUND: B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC), suggesting a tumor-promoting activity of those cells. Taking into consideration that numerous OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs), involving e...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160592/development-of-proliferative-verrucous-leukoplakia-pvl-in-oral-lichen-planus-is-it-not-a-clinical-spectrum-of-pvl
#12
D-T Fernandes, A-R Santos-Silva, P-A Vargas, M-A Lopes
In their recent publication, Garcia-Pola et al. (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred (1). They presented a retrospective analysis with a long-term follow-up, showing an interesting relationship between these lesions. It is important to emphasize that the clinical profile of patients with PVL is well recognized in the literature, mainly affecting non-smoking and non-drinking elderly women, older than 60 years (2-4)...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28160582/the-use-of-topical-corticosteroides-in-the-treatment-of-oral-lichen-planus-in-spain-a-national-survey
#13
L Piñas, A García-García, M Pérez-Sayáns, R Suárez-Fernández, M-H Alkhraisat, E Anitua
BACKGROUND: Explore the treatment of oral lichen planus with topical corticosteroids by the healthcare professionals in Spain. MATERIAL AND METHODS: A questionnaire targeted health professionals who treat OLP, in particular maxillofacial surgeons, dermatologist and dentist. The dissemination of the questionnaires was conducted through professional associations and dental and medical societies. The questionnaire was previously evaluated by means of a cognitive pre-test procedure to ensure that the questions were opportune and appropriate, understandable and accep-table among the professionals...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28134970/allergen-getriggerte-lichenoide-mundschleimhautl%C3%A3-sionen-diagnose-und-therapie-anhand-eines-fallbeispiels
#14
Constanze Olms, Torsten W Remmerbach
Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Therefore all patients with OLP should be included into a close control interval due to the the potential malignant transformation, whereas in the literature a higher risk of malignancy is attributed to OLL in comparison with OLP. Based on a clinical case, it is demonstrated that an interdisciplinary approach in allergy and mucous diagnosis is necessary to verify the correaltion between a contact allergy to amalgam and the lichenoid mucosal lesions...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28122164/increased-circulating-cxcr5-cd4-t-follicular-helper-like-cells-in-oral-lichen-planus
#15
Ya-Qin Tan, Qing Li, Jing Zhang, Ge-Fei Du, Rui Lu, Gang Zhou
BACKGROUND: CD4(+) T helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (OLP). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of CD4(+) T helper cells, has been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in OLP, the expression of circulating Tfh-like cells and its correlations with IL-21 and B cells were investigated...
January 25, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28119140/a-clinical-evaluation-of-the-efficacy-of-photodynamic-therapy-in-the-treatment-of-erosive-oral-lichen-planus-a-case-series
#16
Magdalena Sulewska, Ewa Duraj, Stefan Sobaniec, Alfreda Graczyk, Robert Milewski, Marta Wróblewska, Jan Pietruski, Małgorzata Pietruska
BACKGROUND: Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the study was to evaluate the efficacy of PDT in the treatment of EOLP. METHODS: Twelve female patients aged 63-80 with 22 OLP lesions (16 on the buccal mucosa, 6 on gingiva and tongue), underwent authors' own PDT scheme with the use of 5% solution of 5-aminolevulinic acid (ALA) as photosensitizer...
January 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28113036/clinical-and-histopathologic-characterization-of-canine-chronic-ulcerative-stomatitis
#17
J G Anderson, S Peralta, A Kol, P H Kass, B Murphy
Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28079787/oral-and-vulvo-vaginal-lichenoid-reactions-due-to-mitotane-lysodren-a-case-report
#18
Arthur Schmouchkovitch, Héloïse Herry, Philippe Thuillier, Véronique Kerlan, Camille Fleuret, Guy Le Toux, Sylvie Boisramé
BACKGROUND: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Mitotane (Lysodren) is used for treating adrenocortical carcinoma...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077900/prevalence-of-oral-lichen-planus-in-diabetes-mellitus-a-meta-analysis-study
#19
Hamid Reza Mozaffari, Roohollah Sharifi, Masoud Sadeghi
BACKGROUND: Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study. METHODS: In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28076499/association-between-the-clinical-severity-of-oral-lichen-planus-and-anti-tpo-level-in-thyroid-patients
#20
Milad Alikhani, Parichehr Ghalaiani, Elham Askariyan, Zahra Ahmadi Khunsaraki, Atefeh Tavangar, Aliasghar Naderi
This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. The study and control groups (92) were divided to two subgroups of erosive OLP (EOLP) and non-erosive OLP (NEOLP)...
January 5, 2017: Brazilian Oral Research
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