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Oral lichen planus

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https://www.readbyqxmd.com/read/28794568/severely-crusted-cheilitis-as-an-initial-presentation-of-systemic-lupus-erythematosus
#1
Wai Man Mandy Chan, Shiu Ming Pang, See Ket Ng
Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. We will discuss the clinical and histological features of lupus cheilitis...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28766765/impact-of-oral-potentially-malignant-disorders-on-quality-of-life
#2
Jyothi Tadakamadla, Santhosh Kumar, Ratilal Lalloo, Gandhi Babu, Newell W Johnson
BACKGROUND: Oral Potentially Malignant Disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the Quality of Life (QoL) of affected patients. METHODS: Oral Leukoplakia (OL), Oral Lichen Planus (OLP) and Oral Submucous Fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population...
August 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28766756/efficacy-of-low-level-laser-therapy-compared-to-steroid-therapy-in-the-treatment-of-oral-lichen-planus-a-systematic-review
#3
REVIEW
Zohaib Akram, Tariq Abduljabbar, Fahim Vohra, Fawad Javed
BACKGROUND: Low level laser therapy (LLLT) has been proposed as a potential treatment strategy for the treatment of oral lichen planus (OLP). The aim of this systematic review was to assess the efficacy of LLLT, in comparison with corticosteroid therapy, in the treatment of OLP. MATERIALS AND METHODS: This systematic review aimed to address the following focused question: "Does LLLT yield better clinical outcomes than corticosteroid therapy in the treatment of OLP?" Indexed databases were searched up to and including April 2017...
August 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28760660/semaphorin4d-drives-cd8-t-cell-lesional-trafficking-in-oral-lichen-planus-via-cxcl9-cxcl10-upregulations-in-oral-keratinocytes
#4
Yao Ke, Erle Dang, Shengxian Shen, Tongmei Zhang, Hongjiang Qiao, Yuqian Chang, Qing Liu, Gang Wang
Chemokine mediated CD8(+) T cell recruitment is an essential but not well-established event for the persistence of oral lichen planus (OLP). Semaphorin 4D (Sema4D)/CD100 is implicated in immune dysfunction, chemokine modulation and cell migration, which are critical aspects for OLP progression, but its implication in OLP pathogenesis has not been determined. In this study, we sought to explicate the effect of Sema4D on human oral keratinocytes and its capacity to drive CD8(+) T cell lesional trafficking via chemokine modulation...
July 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28756997/treatment-of-oral-lichen-planus-systematic-review-and-therapeutic-guide
#5
REVIEW
María José García-Pola, Laura González-Álvarez, José M Garcia-Martin
In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. different active principle, drug vs. phytotherapy and drug vs. treatment with phototherapy. Based on the results, an algorithm is proposed to guide the treatment of OLP in its atrophic and erosive clinical forms...
July 27, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28749626/salivary-mmp-1-mmp-2-mmp-3-and-mmp-13-levels-in-patients-with-oral-lichen-planus-and-squamous-cell-carcinoma
#6
Tahereh Nosratzehi, Ebrahim Alijani, Marziyeh Moodi
The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28745229/delivering-resveratrol-on-the-buccal-mucosa-using-mucoadhesive-tablets-a-potential-treatment-strategy-for-inflammatory-oral-lesions
#7
Isadora Conde Ferreira Martins, Nádia Rezende Barbosa Raposo, Hanny Reis Mockdeci, Hudson Caetano Polonini, Anderson de Oliveira Ferreira, Gisele Maria Campos Fabri, Maria das Graças Afonso Miranda Chaves
Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. We observed that the tablet with a lower percentage of viscosity agents delivered more resveratrol, although a large amount of the drug was found retained within the stratum corneum...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28743667/integrative-analysis-of-mrna-and-mirna-expression-profiles-in-oral-lichen-planus-preliminary-results
#8
Junjun Chen, Guanhuan Du, Yufeng Wang, Linjun Shi, Jun Mi, Guoyao Tang
OBJECTIVE: Oral lichen planus (OLP), a chronic inflammatory disease of unknown etiology, is considered a potentially malignant oral disorder. The aim of the present study was to analyze candidate microRNAs (miRNAs) and genes from patients with OLP and healthy controls (HCs). STUDY DESIGN: Biopsy specimens of the oral mucosa were collected from patients with OLP (n = 9) and from HCs (n = 4). Differentially expressed miRNAs and differentially expressed genes were screened by using next-generation sequencing with DESeq and edgeR software algorithms...
June 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28743666/biological-significance-of-5-hydroxymethylcytosine-in-oral-epithelial-dysplasia-and-oral-squamous-cell-carcinoma
#9
Maria Carolina Cuevas-Nunez, Camilla Borges F Gomes, Sook-Bin Woo, Matthew R Ramsey, Xiaoxin L Chen, Shuyun Xu, Ting Xu, Qian Zhan, George F Murphy, Christine G Lian
OBJECTIVES: The aim of this study was to determine the levels of 5-hydroxylmethylcytosine (5-hmC) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) compared with those in benign, reactive inflammatory lesions and to explore whether DNA hydroxymethylation may serve as a novel biomarker for early diagnosis and prognosis of OSCC. STUDY DESIGN: The study included normal mucosa from uninvolved margins of 9 fibromas, 10 oral lichen planus, 15 OED, and 23 OSCC...
June 16, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28742296/mucocutaneous-diseases-oral-lichen-planus-mucous-membrane-pemphigoid-and-pemphigus-vulgaris
#10
Seena Patel, Satish Kumar, Joel M Laudenbach, Antonia Teruel
Mucocutaneous diseases affect the oral cavity and can present a diagnostic challenge. They can have systemic involvement, necessitating multidisciplinary management. Frequently, patients will see their general dentists initially for evaluation. A better understanding of mucocutaneous diseases can prevent delay in appropriate diagnosis and treatment. Oral lichen planus, mucous membrane pemphigoid and pemphigus vulgaris are three mucocutaneous diseases that affect the oral mucosa. This review describes the clinical features, epidemiology, etiology, pathogenesis and management for each condition...
September 2016: Journal—California Dental Association
https://www.readbyqxmd.com/read/28741807/il-17a-polymorphism-and-elevated-il-17a-serum-levels-are-associated-with-oral-lichen-planus
#11
Luiz Alcino Gueiros, Telma Arão, Thayse Souza, Camila Lins Vieira, Ricardo Santiago Gomez, Oslei Paes de Almeida, Giovani Lodi, Jair Carneiro Leão
OBJECTIVE: The aim of this study was to evaluate the association of IL-17A G197A polymorphism and serum levels with oral lichen planus susceptibility and clinical presentation. SUBJECTS AND METHODS: Eighty three individuals diagnosed with oral lichen planus (OLP) and ninety nine healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL-17A (G197A) genotyping. Blood samples of 42 OLP individuals and 23 healthy controls were collected for evaluation of IL-17A serum levels...
July 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28732699/triggers-of-oral-lichen-planus-flares-and-the-potential-role-of-trigger-avoidance-in-disease-management
#12
Hannah X Chen, Rachel Blasiak, Edwin Kim, Ricardo Padilla, Donna A Culton
OBJECTIVE: Many patients with oral lichen planus (OLP) report triggers of flares, some of which overlap with triggers of other oral diseases, including oral allergy syndrome and oral contact dermatitis. The purpose of this study was to evaluate the prevalence of commonly reported triggers of OLP flares, their overlap with triggers of other oral diseases, and the potential role of trigger avoidance as a management strategy. STUDY DESIGN: Questionnaire-based survey of 51 patients with biopsy-proven lichen planus with oral involvement seen in an academic dermatology specialty clinic and/or oral pathology clinic between June 2014 and June 2015...
May 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28712412/the-relationship-between-levels-of-salivary-and-serum-interleukin-6-and-oral-lichen-planus-a-systematic-review-and-meta-analysis
#13
REVIEW
Jinglong Liu, Quan Shi, Shuo Yang, Qianxin Wang, Juan Xu, Bin Guo
BACKGROUND: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants. METHODS: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. The authors used meta-analysis to compare the standardized mean differences (SMD) of the levels of salivary and serum IL-6 between people who had OLP and people who did not have OLP and between patients with erosive OLP and patients with nonerosive OLP...
July 13, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28706407/incidence-of-oral-lichen-planus-in-perimenopausal-women-a-cross-sectional-study-in-western-uttar-pradesh-population
#14
Ravi Prakash Sasankoti Mohan, Akanksha Gupta, Nagaraju Kamarthi, Sangeeta Malik, Sumit Goel, Swati Gupta
BACKGROUND: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28705287/generalized-discoid-lupus-erythematosus-as-the-presenting-sign-of-small-cell-lung-carcinoma
#15
Tania M Gonzalez Santiago, David A Wetter, Garrett C Lowe, Gabriel F Sciallis
A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs...
2017: Skinmed
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#16
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702063/salivary-levels-of-interleukin-8-in-oral-lichen-planus-and-diabetic-patients-a-biochemical-study
#17
Atefeh Tavangar, Parichehr Ghalayani, Mahsa Abbasi Boroujeni, Fereshteh Sadat Ghoreishian
BACKGROUND: This study aimed to assess the salivary levels of interleukin-8 (IL-8) in oral lichen planus (OLP) and diabetes mellitus (DM) patients, and OLP + DM patients in comparison with healthy individuals. MATERIALS AND METHODS: This descriptive cross-sectional study was conducted on 75 patients (30 with OLP, 5 with both OLP and DM, 20 with DM and 20 healthy controls). The salivary levels of IL-8 and fasting blood sugar and 2-h postprandial blood glucose levels were measured in all the subjects...
May 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28701998/thyroid-autoimmunity-and-lichen
#18
REVIEW
Fabrizio Guarneri, Roberta Giuffrida, Flavia Di Bari, Serafinella Patrizia Cannavò, Salvatore Benvenga
Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1.27-2.0% for oral LP, and 0.1-3.3% for LS. While etiology of lichen is still unknown, clinical and histological evidence show an (auto)immune pathogenesis. Association of lichen with autoimmune thyroid disease (AITD) has been investigated in few studies. This association appears better defined in the case of LS, while is more controversial for LP...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28695565/dental-patch-testing-in-patients-with-undifferentiated-oral-lichen-planus
#19
Shevya M Tiwari, Kurt Gebauer, Agnieszka M Frydrych, Sally Burrows
BACKGROUND/OBJECTIVES: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP...
July 11, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28691457/human-%C3%AE-2-defensin-in-oral-lichen-planus-expresses-the-degree-of-inflammation
#20
L Azzi, P Moretto, R Vinci, F Croveri, A Boggio, J Silvestre-Rangil, L Tettamanti, A Tagliabue, A Passi
Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease, were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. There was no statistically significant difference between the groups (p=0.523; p=0.897). However, patients affected by OLP showed a dycotomic distribution of values: while 10 of them showed similar values to those found out in the other two groups, 7 patients expressed high levels of HBD-2 and 3500 pg/ml was the threshold to distinguish the subgroups...
April 2017: Journal of Biological Regulators and Homeostatic Agents
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