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https://www.readbyqxmd.com/read/28633455/fetal-metabolic-stress-disrupts-immune-homeostasis-and-induces-pro-inflammatory-responses-in-hiv-1-and-cart-exposed-infants
#1
Johannes C Schoeman, Gontse P Moutloatse, Amy C Harms, Rob J Vreeken, Henriette J Scherpbier, Liesbeth Van Leeuwen, Taco W Kuijpers, Carools J Reinecke, Ruud Berger, Thomas Hankemeier, Madeleine J Bunders
Increased morbidity and fetal growth restriction are reported in uninfected children born to HIV-1-infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress skewing the cell's immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART)-exposure on the infants' immune-metabolome. Peroxidized lipids, generated by reactive oxygen species, were increased in cART/HIV-1-exposed infants, indicating altered mitochondrial functioning...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28626833/the-lung-is-a-host-defense-niche-for-immediate-neutrophil-mediated-vascular-protection
#2
Bryan G Yipp, Jung Hwan Kim, Ronald Lima, Lori D Zbytnuik, Björn Petri, Nick Swanlund, May Ho, Vivian G Szeto, Tamar Tak, Leo Koenderman, Peter Pickkers, Anton T J Tool, Taco W Kuijpers, Timo K van den Berg, Mark R Looney, Matthew F Krummel, Paul Kubes
Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid treatment. However, upregulation of host defense proteins through toll-like receptors and NFκB requires hours after endotoxin detection. Using confocal pulmonary intravital microscopy, we identified that the lung provides a TLR4-Myd88-and abl tyrosine kinase-dependent niche for immediate CD11b-dependent neutrophil responses to endotoxin and Gram-negative bloodstream pathogens. In an in vivo model of bacteremia, neutrophils crawled to and rapidly phagocytosed Escherichia coli sequestered to the lung endothelium...
April 28, 2017: Science Immunology
https://www.readbyqxmd.com/read/28608162/diffusion-weighted-imaging-for-assessment-of-synovial-inflammation-in-juvenile-idiopathic-arthritis-a-promising-imaging-biomarker-as-an-alternative-to-gadolinium-based-contrast-agents
#3
Anouk M Barendregt, E Charlotte van Gulik, Cristina Lavini, Charlotte M Nusman, J Merlijn van den Berg, Dieneke Schonenberg-Meinema, Koert M Dolman, Taco W Kuijpers, Robert Hemke, Mario Maas
OBJECTIVES: To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA). METHODS: Regions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs...
June 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28585318/hermansky-pudlak-syndrome-type-2-aberrant-pre-mrna-splicing-and-mislocalization-of-granule-proteins-in-neutrophils
#4
Martin de Boer, Karin van Leeuwen, Judy Geissler, Floris van Alphen, Esther de Vries, Martijn van der Kuip, Suzanne W J Terheggen, Hans Janssen, Timo K van den Berg, Alexander B Meijer, Dirk Roos, Taco W Kuijpers
Hermansky-Pudlak syndrome type 2 (HPS2) is a syndrome caused by mutations in the beta-3A subunit of the adaptor protein (AP)-3 complex (AP3B1 gene). We describe five unreported cases with four novel mutations, one of which caused aberrant pre-mRNA splicing. A point mutation c.2702C>G in exon 23 of the AP3B1 gene caused deletion of 112 bp in the mRNA in two siblings. This mutation activates a cryptic donor splice site that overrules the wild-type donor splice site of this exon. Three other novel mutations in AP3B1 were identified, that is, a nonsense mutation c...
June 6, 2017: Human Mutation
https://www.readbyqxmd.com/read/28566370/enhanced-effector-functions-due-to-antibody-defucosylation-depend-on-the-effector-cell-fc%C3%AE-receptor-profile
#5
Christine W Bruggeman, Gillian Dekkers, Arthur E H Bentlage, Louise W Treffers, Sietse Q Nagelkerke, Suzanne Lissenberg-Thunnissen, Carolien A M Koeleman, Manfred Wuhrer, Timo K van den Berg, Theo Rispens, Gestur Vidarsson, Taco W Kuijpers
Abs of the IgG isotype are glycosylated in their Fc domain at a conserved asparagine at position 297. Removal of the core fucose of this glycan greatly increases the affinity for FcγRIII, resulting in enhanced FcγRIII-mediated effector functions. Normal plasma IgG contains ∼94% fucosylated Abs, but alloantibodies against, for example, Rhesus D (RhD) and platelet Ags frequently have reduced fucosylation that enhances their pathogenicity. The increased FcγRIII-mediated effector functions have been put to use in various afucosylated therapeutic Abs in anticancer treatment...
May 31, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28533096/transfusion-associated-circulatory-overload-in-a-pediatric-patient-with-neuroblastoma
#6
Ryu Yanagisawa, Ikuko Fujihara, Kazutoshi Komori, Seiki Abe, Takako Ono, Kazuo Sakashita, Tomohiko Nakamura
There have been few reports on pediatric transfusion-associated circulatory overload (TACO). A 5-year-old boy with neuroblastoma underwent resection of the residual tumor. Because anemia progressed at the end of the operation, transfusion of red cell component was initiated. Ten minutes later, he suddenly developed hypoxemia, tachypnea, and tachycardia. Although elevated blood pressure and bilateral infiltrative shadows on chest X-rays were not observed, TACO was diagnosed based on positive balance during operation and N-terminal pro-brain natriuretic peptide elevation...
April 26, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28520689/the-course-prediction-and-treatment-of-acute-and-posttraumatic-stress-in-trauma-patients-a-systematic-review
#7
Eva Visser, Taco Gosens, Brenda Leontine Den Oudsten, Jolanda De Vries
BACKGROUND: Trauma patients suffer from acute stress disorder (ASD) and posttraumatic stress disorder (PTSD), but it is unknown how these disorders develop over time and when treatment is effective. Our aim was to systematically review (1) the course and predictors of ASD and PTSD after trauma and (2) which and when psychological treatments are effective. METHODS: Embase, Medline, Web of Science, Scopus, PsycInfo, Cinahl, Cochrane, PubMed, and Google Scholar were searched up to September 14, 2015...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28511539/exploiting-salt-induced-micro-phase-separation-to-form-soy-protein-microcapsules-or-microgels-in-aqueous-solution
#8
Nannan Chen, Mouming Zhao, Taco Nicolai, Christophe Chassenieux
Self-assembly of native glycinin at room temperature was investigated as a function of the pH and the NaCl concentration. Microphase separation leading to the formation of dense protein microdomains was observed by confocal laser scanning microscopy. Depending on the conditions, the microdomains coalesced into a continuous protein rich phase or associated into large clusters. Addition of β-conglycinin inhibited phase separation and reduced the pH range in which it occurred. Microdomains of glycinin that were formed in the presence of 0...
May 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28470756/differentiating-pulmonary-transfusion-reactions-using-recipient-and-transfusion-factors
#9
Nareg H Roubinian, Mark R Looney, Sheila Keating, Daryl J Kor, Clifford A Lowell, Ognjen Gajic, Rolf Hubmayr, Michael Gropper, Monique Koenigsberg, Gregory A Wilson, Michael A Matthay, Pearl Toy, Edward L Murphy
BACKGROUND: It is increasingly recognized that recipient risk factors play a prominent role in possible transfusion-related acute lung injury (pTRALI) and transfusion-associated circulatory overload (TACO). We hypothesized that both transfusion and recipient factors including natriuretic peptides could be used to distinguish TRALI from TACO and pTRALI. STUDY DESIGN AND METHODS: We performed a post hoc analysis of a case-control study of pulmonary transfusion reactions conducted at the University of California at San Francisco and Mayo Clinic, Rochester...
May 3, 2017: Transfusion
https://www.readbyqxmd.com/read/28460084/protein-array-autoantibody-profiles-to-determine-diagnostic-markers-for-neuropsychiatric-systemic-lupus-erythematosus
#10
Pomme M van der Meulen, Anouk M Barendregt, Eloy Cuadrado, César Magro-Checa, Gerda M Steup-Beekman, Dieneke Schonenberg-Meinema, J Merlijn Van den Berg, Quan-Zhen Li, Paul A Baars, Diana Wouters, Alexandre E Voskuyl, Ineke R J M Ten Berge, Tom W J Huizinga, Taco W Kuijpers
Objective.: The aim was to investigate the association between autoantibodies (autoAbs) and neuropsychiatric (NP) involvement in patients with SLE and to evaluate whether any autoAb or a combination of these autoAbs could indicate the underlying pathogenic process. Methods.: Using a multiplexed protein array for 94 antigens, we compared the serum autoAb profiles of 69 NPSLE patients, 203 SLE patients without NP involvement (non-NPSLE) and 51 healthy controls. Furthermore, we compared the profiles of NPSLE patients with clinical inflammatory (n = 38) and ischaemic (n = 31) NP involvement...
April 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28453292/discovery-of-mixed-pharmacology-melanocortin-3-agonists-and-melanocortin-4-receptor-tetrapeptide-antagonist-compounds-tacos-based-on-the-sequence-ac-xaa-1-arg-pi-dphe-xaa-4-nh2
#11
Skye R Doering, Katie T Freeman, Sathya M Schnell, Erica M Haslach, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh G Santos, Marc A Giulianotti, Clemencia Pinilla, Jon R Appel, Robert C Speth, Richard A Houghten, Carrie Haskell-Luevano
The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa(1)-Arg-(pI)DPhe-Xaa(4)-NH2] is reported. The scaffold was derived from results obtained from a MC3R mixture-based positional scanning campaign. From these results, a set of 48 tetrapeptides were designed and pharmacologically characterized at the mouse melanocortin-1, -3, -4, and -5 receptors...
May 25, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28449860/timing-of-definitive-fixation-of-major-long-bone-fractures-can-fat-embolism-syndrome-be-prevented
#12
Taco J Blokhuis, Hans-Christoph Pape, Jan-Paul Frölke
Fat embolism is common in patients with major fractures, but leads to devastating consequences, named fat embolism syndrome (FES) in some. Despite advances in treatment strategies regarding the timing of definitive fixation of major fractures, FES still occurs in patients. In this overview, current literature is reviewed and optimal treatment strategies for patients with multiple traumatic injuries, including major fractures, are discussed. Considering the multifactorial etiology of FES, including mechanical and biochemical pathways, FES cannot be prevented in all patients...
April 24, 2017: Injury
https://www.readbyqxmd.com/read/28449857/management-of-traumatic-bone-defects-metaphyseal-versus-diaphyseal-defects
#13
Taco J Blokhuis
Although bone defects after trauma appear in different locations and forms, many clinicians have adopted a single strategy to deal with any defect. In this overview, a distinction is made between metaphyseal, or cancellous defects, and diaphyseal, or cortical defects. The treatment goals and background of these two types of defects are discussed in order to describe the difference in strategy and hence the difference in treatment method.
April 24, 2017: Injury
https://www.readbyqxmd.com/read/28401296/associations-of-specific-psychiatric-disorders-with-isolated-focal-dystonia-and-monogenic-and-idiopathic-parkinson-s-disease
#14
Susanne Steinlechner, Johann Hagenah, Hans-Jürgen Rumpf, Christian Meyer, Ulrich John, Tobias Bäumer, Norbert Brüggemann, Meike Kasten, Alexander Münchau, Christine Klein, Rebekka Lencer
Comorbidity of psychiatric disorders in patients with movement disorders is common. Often, psychiatric symptoms manifest before the onset of the movement disorder, thus not representing a mere reaction to its burden. How the disease mechanisms of psychiatric and movement disorders are related is still poorly understood. The aim of the present study was to compare prevalence rates of specific psychiatric disorders between different movement disorders including isolated focal dystonia (IFD, N = 91), monogenic Parkinson's disease (PD, N = 41), idiopathic PD (N = 45), and a sample from a Northern Germany general population (TACOS Study; N = 4075)...
June 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28396495/clonal-selection-and-asymmetric-distribution-of-human-leukemia-in-murine-xenografts-revealed-by-cellular-barcoding
#15
Mirjam E Belderbos, Taco Koster, Bertien Ausema, Sabrina Jacobs, Sharlaine Sowdagar, Erik Zwart, Eveline de Bont, Gerald de Haan, Leonid V Bystrykh
Genetic and phenotypic heterogeneity of human leukemia is thought to drive leukemia progression through a Darwinian process of selection and evolution of increasingly malignant clones. However, the lack of markers to uniquely identify individual leukemia clones precludes high resolution tracing of their clonal dynamics. Here, we employ cellular barcoding to analyze the clonal behavior of patient-derived leukemia-propagating cells (LPCs) in murine xenografts. Using a leukemic cell line and diagnostic bone marrow cells from six patients with B-progenitor cell acute lymphoblastic leukemia (B-ALL), we demonstrate that patient-derived xenografts were highly polyclonal, consisting of tens to hundreds of LPC clones...
April 10, 2017: Blood
https://www.readbyqxmd.com/read/28388010/comparison-of-atmp-gingiva-and-skin-substitutes-and-their-in-vitro-wound-healing-potentials
#16
Mireille A Boink, Sanne Roffel, Melanie Breetveld, Maria Thon, Michiel S P Haasjes, Taco Waaijman, Rik J Scheper, Chantal S Blok, Susan Gibbs
Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal products. We present in vitro mode of action methods to i) determine viability: epithelial expansion, proliferation (Ki-67), metabolic activity (MTT-assay); ii) characterize skin and gingiva substitutes: histology and immunohistochemistry; and iii) determine potency: soluble wound healing mediator release (ELISA)...
April 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28386221/deep-brain-stimulation-of-the-nucleus-accumbens-core-affects-trait-impulsivity-in-a-baseline-dependent-manner
#17
Maria C Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I Mesman, Damiaan Denys, Taco J De Vries, Tommy Pattij
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28370719/brain-structure-and-organization-five-decades-after-childhood-onset-epilepsy
#18
Camille Garcia-Ramos, Sam Bobholz, Kevin Dabbs, Bruce Hermann, Juho Joutsa, Juha O Rinne, Mira Karrasch, Vivek Prabhakaran, Shlomo Shinnar, Matti Sillanpää
The purpose of this project was to characterize brain structure and organization in persons with active and remitted childhood onset epilepsy 50 years after diagnosis compared with healthy controls. Participants from a population-based investigation of uncomplicated childhood onset epilepsy were followed up 5 decades later. Forty-one participants had a history of childhood onset epilepsy (mean age of onset = 5.2 years, current chronological age = 56.0 years) and were compared with 48 population-based controls (mean age = 55...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28357319/phylogenetic-profiles-of-all-membrane-transport-proteins
#19
January Weiner, Taco W A Kooij
In order to combat the on-going malaria epidemic, discovery of new drug targets remains vital. Proteins that are essential to survival and specific to malaria parasites are key candidates. To survive within host cells, the parasites need to acquire nutrients and dispose of waste products across multiple membranes. Additionally, like all eukaryotes, they must redistribute ions and organic molecules between their various internal membrane bound compartments. Membrane transport proteins mediate all of these processes and are considered important mediators of drug resistance as well as drug targets in their own right...
August 30, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28342909/the-cellular-immune-system-comes-of-age
#20
EDITORIAL
René A W van Lier, Taco W Kuijpers
No abstract text is available yet for this article.
June 2017: Journal of Allergy and Clinical Immunology
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