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https://www.readbyqxmd.com/read/29785371/case-report-clitoromegaly-as-a-consequence-of-congenital-adrenal-hyperplasia-an-accurate-medical-and-surgical-approach
#1
Augusto Rafael Fernandez-Aristi, Andre Alonso Taco-Masias, Luis Montesinos-Baca
We present a case of a woman with a history of Congenital Adrenal Hyperplasia (CAH) diagnosed at the age of 12, who was referred to our unit for surgical treatment. Despite the initial diagnosis was an indirect inguinal hernia, it was a misdiagnosis. Once in our service, this was corrected into clitoromegaly secondary to CAH. Physical examination and imaging test discarded other abnormalities, such as secondary effects androgenization. Regarding surgical treatment, the techniques used were Spencer and Allen combined with Kumar, which are the most used for clitoroplasty but also less used in Peru...
May 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29783151/formation-and-characterization-of-chitosan-protein-particles-with-fractal-whey-protein-aggregates
#2
Khouloud Fekih Ahmed, Adel Aschi, Taco Nicolai
Hybrid protein-polysaccharide particles were formed by complexation of fractal whey protein aggregates and the cationic polysaccharide chitosan. The fractal aggregates were preformed by heating native whey protein isolate at pH 7 and subsequently mixed with chitosan at pH 3 where these proteins and polysaccharides don't interact with each other. Stable dispersions of protein-polysaccharide particles were formed spontaneously when the pH was gradually increased between 4.1 and 6.8, whereas in the absence of chitosan the fractal aggregates precipitated between pH 4...
May 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29779373/water-in-water-emulsion-gels-stabilized-by-cellulose-nanocrystals
#3
Emna Ben Ayed, Remy Cochereau, Cyrille Dechance, Isabelle Capron, Taco Nicolai, Lazhar Benyahia
Particle stabilized water-in-water emulsions were prepared by mixing dextran and poly(ethylene oxide) (PEO) in water and adding cellulose nanocrystals (CNC). The CNC formed a layer at the surface of the dispersed droplets formed by the PEO rich phase. Excess CNC partitioned to the continuous dextran phase. Aggregation of CNC at different rates was induced by adding NaCl between 10 mM and 100 mM. In the presence of more than 2 g/L CNC, fast aggregation led to the formation of an emulsion gel showing no signs of creaming...
May 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29765377/neutrophils-inhibit-synthesis-of-mineralized-extracellular-matrix-by-human-bone-marrow-derived-stromal-cells-in-vitro
#4
Okan W Bastian, Michiel Croes, Jacqueline Alblas, Leo Koenderman, Luke P H Leenen, Taco J Blokhuis
Although controlled local inflammation is essential for adequate bone regeneration, several studies have shown that hyper-inflammatory conditions after major trauma are associated with impaired fracture healing. These hyper-inflammatory conditions include the trauma-induced systemic inflammatory response to major injury, open fractures, and significant injury to the surrounding soft tissues. The current literature suggests that increased or prolonged influx of neutrophils into the fracture hematoma may mediate impairment of bone regeneration after hyper-inflammatory conditions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29762588/controlling-the-degree-of-polarization-of-partially-coherent-electromagnetic-beams-with-lenses
#5
Xinying Zhao, Taco D Visser, Govind P Agrawal
We show theoretically that the degree of polarization of a partially coherent electromagnetic beam changes dramatically as the beam is being focused. A low numerical aperture lens can considerably enhance the degree of polarization at its geometrical focus. When two identical lenses are employed in a 4f configuration, the degree of polarization of a beam can be tailored by using amplitude masks in the Fourier plane located in the middle of the two lenses. Our findings open up the possibility to control this fundamental property of random beams in a simple manner...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29751281/efficient-production-of-erythroid-megakaryocytic-and-myeloid-cells-using-single-cell-derived-ipsc-colony-differentiation
#6
Marten Hansen, Eszter Varga, Cathelijn Aarts, Tatjana Wust, Taco Kuijpers, Marieke von Lindern, Emile van den Akker
Hematopoietic differentiation of human induced pluripotent stem cells (iPSCs) provide opportunities not only for fundamental research and disease modelling/drug testing but also for large-scale production of blood effector cells for future clinical application. Although there are multiple ways to differentiate human iPSCs towards hematopoietic lineages, there is a need to develop reproducible and robust protocols. Here we introduce an efficient way to produce three major blood cell types using a standardized differentiation protocol that starts with a single hematopoietic initiation step...
April 28, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29740447/high-complement-factor-h-related-fhr-3-levels-are-associated-with-the-atypical-hemolytic-uremic-syndrome-risk-allele-cfhr3-b
#7
Richard B Pouw, Irene Gómez Delgado, Alberto López Lera, Santiago Rodríguez de Córdoba, Diana Wouters, Taco W Kuijpers, Pilar Sánchez-Corral
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor prognosis. FH activity has been suggested to be downregulated by homologous FH-related (FHR) proteins, including FHR-3 and FHR-1. Hence, their relative levels in plasma could be disease-relevant. The genes coding for FH, FHR-3, and FHR-1 ( CFH, CFHR3 , and CFHR1 , respectively) are polymorphic and located adjacent to each other on human chromosome 1q31...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29734965/evaluation-of-mobile-applications-related-to-nutrition
#8
Vitória Negri Braz, Maria Helena Baena de Moraes Lopes
OBJECTIVE: To verify the reliability of information, the sources of information used and the user opinions of the free mobile applications (apps) with nutritional information available in Brazil. DESIGN: Descriptive, cross-sectional study. SETTING: We evaluated the content about nutrition of free apps available on the App Store of iPhone 5S with software iOS 8.4.1 and on the Play Store of the Android platform, version 2.3.6. For this, we compared the nutrition information provided by the app with (i) the Brazilian Food Composition Table (TACO), of 2011; (ii) food composition table: support for nutritional decision, of 2002; and (iii) the National Study of Family Expenditure: food composition tables, of 1999...
May 8, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29719534/complement-factor-h-related-protein-4a-is-the-dominant-circulating-splice-variant-of-cfhr4
#9
Richard B Pouw, Mieke C Brouwer, Anna E van Beek, Mihály Józsi, Diana Wouters, Taco W Kuijpers
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human surfaces. For the CFHR4 splice variants FHR-4A and FHR-4B, the individual circulating levels are unknown, with only total levels being described. Specific reagents for FHR-4A or FHR-4B are lacking due to the fact that the unique domains in FHR-4A show high sequence similarity with FHR-4B, making it challenging to distinguish them...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29692344/red-pulp-macrophages-in-the-human-spleen-are-a-distinct-cell-population-with-a-unique-expression-of-fc-%C3%AE-receptors
#10
Sietse Q Nagelkerke, Christine W Bruggeman, Joke M M den Haan, Erik P J Mul, Timo K van den Berg, Robin van Bruggen, Taco W Kuijpers
Tissue-resident macrophages in the spleen play a major role in the clearance of immunoglobulin G (IgG)-opsonized blood cells, as occurs in immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Blood cells are phagocytosed via the Fc-γ receptors (FcγRs), but little is known about the FcγR expression on splenic red pulp macrophages in humans, with only a few previous studies that showed conflicting results. We developed a novel method to specifically isolate red pulp macrophages from 82 human spleens...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29685542/normal-mri-findings-of-the-knee-in-patients-with-clinically-active-juvenile-idiopathic-arthritis
#11
E Charlotte van Gulik, Robert Hemke, Mendy M Welsink-Karssies, Dieneke Schonenberg-Meinema, Koert M Dolman, Anouk M Barendregt, Charlotte M Nusman, Mario Maas, Taco W Kuijpers, J Merlijn van den Berg
OBJECTIVE: In a number of patients with clinically active juvenile idiopathic arthritis (JIA), contrast-enhanced MRI shows no signs of synovitis. The objective of this study was to assess the frequency and the patient characteristics in clinically active JIA patients in which MRI showed no signs of synovitis. METHODS: From our cohort of 313 patients in which contrast-enhanced MRI of the knee had been performed, we selected 72 JIA patients with clinically active disease involving the target joint...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29669282/an-unusual-prohibitin-regulates-malaria-parasite-mitochondrial-membrane-potential
#12
Joachim Michael Matz, Christian Goosmann, Kai Matuschewski, Taco Wilhelmus Antonius Kooij
Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles. Here, we investigate the SPFH proteins of the murine malaria model parasite Plasmodium berghei, the conserved prohibitin 1, prohibitin 2, and stomatin-like protein and an unusual prohibitin-like protein (PHBL). The SPFH proteins localize to the parasite mitochondrion. While the conserved family members could not be deleted from the Plasmodium genome, PHBL was successfully ablated, resulting in impaired parasite fitness and attenuated virulence in the mammalian host...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29664740/ce-a-review-of-current-practice-in-transfusion-therapy
#13
Margaret Carman, Jennifer Schieferle Uhlenbrock, Sara Marie McClintock
: In the United States, roughly 4.5 million patients per year receive transfusions of various blood products. Despite the lifesaving benefits of transfusion therapy, it is an independent risk factor for infection, morbidity, and death in critically ill patients. It's important for nurses to understand the potential complications patients face when blood products are administered and to recognize that patients who have received blood products in the past remain at risk for delayed reactions, including immune compromise and infection...
May 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29650034/complex-fracture-orthopedic-rehabilitation-comfort-real-time-visual-biofeedback-on-weight-bearing-versus-standard-training-methods-in-the-treatment-of-proximal-femur-fractures-in-the-elderly-study-protocol-for-a-multicenter-randomized-controlled-trial
#14
Marco Raaben, Syaiful Redzwan, Robin Augustine, Taco Johan Blokhuis
BACKGROUND: Proximal femur fractures are a common injury after low energy trauma in the elderly. Most rehabilitation programs are based on restoring mobility and early resumption of weight-bearing. However, therapy compliance is low in patients following lower extremity fractures. Moreover, little is known about the relevance of gait parameters and how to steer the rehabilitation after proximal femur fractures in the elderly. Therefore, the aim of this prospective, randomized controlled trial is to gain insight in gait parameters and evaluate if real-time visual biofeedback can improve therapy compliance after proximal femur fractures in the elderly...
April 12, 2018: Trials
https://www.readbyqxmd.com/read/29603946/comparison-of-different-theories-for-focusing-through-a-plane-interface-reply
#15
S H Wiersma, P Török, Taco D Visser, P Varga
The correction pointed out by Kim et al. [J. Opt. Soc. Am. A35, 591 (2018)JOAOD60740-323210.1364/JOSAA.35.000591] to our paper [J. Opt. Soc. Am. A14, 1482 (1997)JOAOD60740-323210.1364/JOSAA.14.001482] is welcome. A few additional remarks are included in this reply.
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29599104/physical-trauma-patients-with-symptoms-of-an-acute-and-posttraumatic-stress-disorder-protocol-for-an-observational-prospective-cohort-study
#16
Eva Visser, Taco Gosens, Brenda Den Oudsten, Jolanda De Vries
BACKGROUND: Injury, medical treatment, and rehabilitation can have major impacts on patients' wellbeing. About 25-33% of the patients experience an acute stress disorder (ASD) or a posttraumatic stress disorder (PTSD) after injury. ASD is a relatively new diagnosis. Therefore, knowledge about patients' experiences, the course of ASD and PTSD, and who is at risk for developing ASD or PTSD is lacking. OBJECTIVE: The aims of this multi-method study are to explore patients' experiences with injury (and their care) using a focus group study...
March 29, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29580301/changes-in-the-nutritional-quality-of-fast-food-items-marketed-at-restaurants-2010-v-2013
#17
Jackie Soo, Jennifer L Harris, Kirsten K Davison, David R Williams, Christina A Roberto
OBJECTIVE: To examine the nutritional quality of menu items promoted in four (US) fast-food restaurant chains (McDonald's, Burger King, Wendy's, Taco Bell) in 2010 and 2013. DESIGN: Menu items pictured on signs and menu boards were recorded at 400 fast-food restaurants across the USA. The Nutrient Profile Index (NPI) was used to calculate overall nutrition scores for items (higher scores indicate greater nutritional quality) and was dichotomized to denote healthier v...
March 27, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29516511/transfusion-associated-circulatory-overload-prevention-a-retrospective-observational-study-of-diuretic-use
#18
Y Lin, R Cohen, C Armali, J Callum, C Cserti-Gazdewich, L Lieberman, J Pendergrast
BACKGROUND AND OBJECTIVES: Approaches to preventing transfusion-associated circulatory overload (TACO) include the use of diuretics. The purpose of this study was to determine how commonly diuretics are prescribed in patients receiving a red-blood-cell (RBC) transfusion. MATERIALS AND METHODS: This was a retrospective study of 200 adult inpatient RBC transfusion orders, 50 consecutive at each of four academic institutions. Only the first transfusion order for each patient was included...
March 8, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29511935/serum-from-the-human-fracture-hematoma-contains-a-potent-inducer-of-neutrophil-chemotaxis
#19
Okan W Bastian, Mikolaj H Mrozek, Marco Raaben, Luke P H Leenen, Leo Koenderman, Taco J Blokhuis
A controlled local inflammatory response is essential for adequate fracture healing. However, the current literature suggests that local and systemic hyper-inflammatory conditions after major trauma induce increased influx of neutrophils into the fracture hematoma (FH) and impair bone regeneration. Inhibiting neutrophil chemotaxis towards the FH without compromising the hosts' defense may therefore be a target of future therapies that prevent impairment of fracture healing after major trauma. We investigated whether chemotaxis of neutrophils towards the FH could be studied in vitro...
March 6, 2018: Inflammation
https://www.readbyqxmd.com/read/29490604/characterization-of-in-vitro-reconstructed-human-normotrophic-hypertrophic-and-keloid-scar-models
#20
Grace C Limandjaja, Lenie J van den Broek, Melanie Breetveld, Taco Waaijman, Stan Monstrey, Edith M de Boer, Rik J Scheper, Frank B Niessen, Susan Gibbs
To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required, which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two types of abnormal scar resulting from unknown abnormalities in the wound healing process. While they display different clinical behavior, differentiation between the two can be difficult-which in turn means that it is difficult to develop optimal therapeutic strategies...
April 2018: Tissue Engineering. Part C, Methods
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