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https://www.readbyqxmd.com/read/28899854/non-classical-fcgr2c-haplotype-is-associated-with-protection-from-red-blood-cell-allo-immunization-in-sickle-cell-disease
#1
Sanne M Meinderts, Joep W R Sins, Karin Fijnvandraat, Sietse Q Nagelkerke, Judy Geissler, Michael W Tanck, Christine Bruggeman, Bart J Biemond, Anita W Rijneveld, Jean-Louis H Kerkhoffs, Sadaf Pakdaman, Anoosha Habibi, Robin van Bruggen, Taco W Kuijpers, France Pirenne, Timo K van den Berg
Red blood cell (RBC) transfusions are of vital importance in patients with sickle cell disease (SCD). However, a major complication of transfusion therapy is allo-immunization. The low-affinity Fc gamma receptors (FcγRs), expressed on immune cells, are important regulators of antibody responses. Genetic variation in FCGR genes has been associated with various auto- and allo-immune diseases. The aim of this study was to evaluate the association between genetic variation of FCGR and RBC allo-immunization in SCD...
September 12, 2017: Blood
https://www.readbyqxmd.com/read/28889989/the-tnf-receptor-superfamily-nf-%C3%AE%C2%BAb-axis-is-critical-to-maintain-effector-regulatory-t-cells-in-lymphoid-and-non-lymphoid-tissues
#2
Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, Axel Kallies
After exiting the thymus, Foxp3(+) regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription factor IRF4. Here, we show that tumor necrosis factor receptor superfamily (TNFRSF) signaling plays a crucial role in the development and maintenance of eTreg cells. TNFRSF signaling activated the NF-κB transcription factor RelA, which was required to maintain eTreg cells in lymphoid and non-lymphoid tissues, including RORγt(+) Treg cells in the small intestine...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28886419/mutation-in-an-exonic-splicing-enhancer-site-causing-chronic-granulomatous-disease
#3
Martin de Boer, Karin van Leeuwen, Judy Geissler, Bernd H Belohradsky, Taco W Kuijpers, Dirk Roos
In a male patient suffering from X-linked chronic granulomatous disease (CGD) we found a c.389G>T mutation in exon 5 of the CYBB gene. We have analyzed why 95% of the transcripts of this gene lacked exon 5, leading to a frameshift and premature termination codon. The mutation was located in a region comprising three putative exonic splicing enhancer binding sites, for SRSF1, SRFS2 and SRFS6, according to the ESEfinder Tool (http://rulai.cshl.edu/cgi-bin/tools/ESE3/esefinder.cgi). With the Analyser Splice Tool we calculated the probability of skipping of exon 5 in CYBB mRNA, and by means of Sroogle the number of putative binding motifs for splicing enhancer and splicing silencer proteins (http://astlab...
July 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28868147/intra-body-microwave-communication-through-adipose-tissue
#4
Noor Badariah Asan, Daniel Noreland, Emadeldeen Hassan, Syaiful Redzwan Mohd Shah, Anders Rydberg, Taco J Blokhuis, Per-Ola Carlsson, Thiemo Voigt, Robin Augustine
The human body can act as a medium for the transmission of electromagnetic waves in the wireless body sensor networks context. However, there are transmission losses in biological tissues due to the presence of water and salts. This Letter focuses on lateral intra-body microwave communication through different biological tissue layers and demonstrates the effect of the tissue thicknesses by comparing signal coupling in the channel. For this work, the authors utilise the R-band frequencies since it overlaps the industrial, scientific and medical radio (ISM) band...
August 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28866585/taco-visualizing-changes-in-tables-over-time
#5
Christina Niederer, Holger Stitz, Reem Hourieh, Florian Grassinger, Wolfgang Aigner, Marc Streit
Multivariate, tabular data is one of the most common data structures used in many different domains. Over time, tables can undergo changes in both structure and content, which results in multiple versions of the same table. A challenging task when working with such derived tables is to understand what exactly has changed between versions in terms of additions/deletions, reorder, merge/split, and content changes. For textual data, a variety of commonplace "diff" tools exist that support the task of investigating changes between revisions of a text...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28864286/abnormalities-of-t-cell-receptor-repertoire-in-cd4-regulatory-and-conventional-t-cells-in-patients-with-rag-mutations-implications-for-autoimmunity
#6
Jared H Rowe, Brian D Stadinski, Lauren A Henderson, Lisa Ott de Bruin, Ottavia Delmonte, Yu Nee Lee, M Teresa de la Morena, Rakesh K Goyal, Anthony Hayward, Huang Chiung-Hui, Maria Kanariou, Alejandra King, Taco W Kuijpers, Jian Yi Soh, Benedicte Neven, Jolan E Walter, Eric S Huseby, Luigi D Notarangelo
No abstract text is available yet for this article.
August 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28857162/utilizing-mushrooms-to-reduce-overall-sodium-in-taco-filling-using-physical-and-sensory-evaluation
#7
Kristin M Wong, Eric A Decker, Wesley R Autio, Ken Toong, Garett DiStefano, Amanda J Kinchla
This project investigated the use of integrating mushrooms into beef taco filling as a means to reduce overall sodium for food service applications. Initial product development used physical characterization analysis (moisture, yield, color, and texture) to determine initial threshold of mushroom inclusion with minimal differences against an all-meat control. Increasing mushroom inclusion increased moisture and yield before draining but decreased yield after draining, lightness, redness, and texture. Results showed that inclusion under 50% by weight minimized physical attribute deviation from an all-meat control...
August 30, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28856391/dissociable-effects-of-cocaine-and-yohimbine-on-impulsive-action-and-relapse-to-cocaine-seeking
#8
Nienke Broos, Yvar van Mourik, Dustin Schetters, Taco J De Vries, Tommy Pattij
RATIONALE: A strong association has been demonstrated between various forms of impulsivity and addiction-like behavior in both humans and rats. OBJECTIVES: In this study, we investigated how impulsive action, as measured in the 5-choice serial reaction time task (5-CSRTT), is affected during various stages of cocaine taking and seeking and by relapse-provoking stimuli in animals that were trained both in an intravenous cocaine self-administration paradigm and in the 5-CSRTT...
August 30, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28835875/hip-fractures-in-elderly-people-surgery-or-no-surgery-a-systematic-review-and-meta-analysis
#9
REVIEW
Cornelis L P van de Ree, Mariska A C De Jongh, Charles M M Peeters, Leonie de Munter, Jan A Roukema, Taco Gosens
INTRODUCTION: Increasing numbers of patients with hip fractures also have advanced comorbidities. A majority are treated surgically. However, a significantly increasing percentage of medically unfit patients with unacceptably high risk of perioperative death are treated nonoperatively. Important questions about patients' prefracture quality of life (QOL) and future perspectives should be asked before considering different treatment options to assess what kind of treatment is advisable in frail elderly high-risk patients with a hip fracture...
September 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28821525/point-of-care-washing-of-allogeneic-red-blood-cells-for-the-prevention-of-transfusion-related-respiratory-complications-war-prc-a-protocol-for-a-multicenter-randomised-clinical-trial-in-patients-undergoing-cardiac-surgery
#10
Matthew A Warner, Ian J Welsby, Phillip J Norris, Christopher C Silliman, Sarah Armour, Erica D Wittwer, Paula J Santrach, Laurie A Meade, Lavonne M Liedl, Chelsea M Nieuwenkamp, Brian Douthit, Camille M van Buskirk, Phillip J Schulte, Rickey E Carter, Daryl J Kor
INTRODUCTION: The transfusion-related respiratory complications, transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), are leading causes of transfusion-related morbidity and mortality. At present, there are no effective preventive strategies with red blood cell (RBC) transfusion. Although mechanisms remain incompletely defined, soluble biological response modifiers (BRMs) within the RBC storage solution may play an important role. Point-of-care (POC) washing of allogeneic RBCs may remove these BRMs, thereby mitigating their impact on post-transfusion respiratory complications...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821099/xyloglucan-gelation-induced-by-enzymatic-degalactosylation-kinetics-and-the-effect-of-the-molar-mass
#11
Caroline Novak Sakakibara, Maria Rita Sierakowski, Christophe Chassenieux, Taco Nicolai, Rilton Alves de Freitas
Gelation kinetics of aqueous solutions of xyloglucan (XG) extracted from H. courbaril seeds were investigated, in-situ, during enzymatic removal of galactose units by oscillatory shear rheological measurements, at different XG and enzyme (β-galactosidase) concentrations. Increasing the enzyme concentration (Cenz) led to an increase of the gelation rate. Master curves of the evolution of the storage shear modulus at different Cenz could be formed by time-Cenz superposition showing that Cenz influenced the kinetics, but not the gelation process and the final gel stiffness...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28769999/non-operative-management-for-penetrating-splenic-trauma-how-far-can-we-go-to-save-splenic-function
#12
Roy Spijkerman, Michel Paul Johan Teuben, Fatima Hoosain, Liezel Phyllis Taylor, Timothy Craig Hardcastle, Taco Johan Blokhuis, Brian Leigh Warren, Luke Petrus Hendrikus Leenen
BACKGROUND: Selective non-operative management (NOM) for the treatment of blunt splenic trauma is safe. Currently, the feasibility of selective NOM for penetrating splenic injury (PSI) is unclear. Unfortunately, little is known about the success rate of spleen-preserving surgical procedures. The aim of this study was to investigate the outcome of selective NOM for penetrating splenic injuries. METHODS: A dual-centre study is performed in two level-one trauma centres...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28769923/natural-killer-cells-from-patients-with-recombinase-activating-gene-and-non-homologous-end-joining-gene-defects-comprise-a-higher-frequency-of-cd56-bright-nkg2a-cells-and-yet-display-increased-degranulation-and-higher-perforin-content
#13
Kerry Dobbs, Giovanna Tabellini, Enrica Calzoni, Ornella Patrizi, Paula Martinez, Silvia Clara Giliani, Daniele Moratto, Waleed Al-Herz, Caterina Cancrini, Morton Cowan, Jacob Bleesing, Claire Booth, David Buchbinder, Siobhan O Burns, Talal A Chatila, Janet Chou, Vanessa Daza-Cajigal, Lisa M Ott de Bruin, MaiteTeresa de la Morena, Gigliola Di Matteo, Andrea Finocchi, Raif Geha, Rakesh K Goyal, Anthony Hayward, Steven Holland, Chiung-Hui Huang, Maria G Kanariou, Alejandra King, Blanka Kaplan, Anastasiya Kleva, Taco W Kuijpers, Bee Wah Lee, Vassilios Lougaris, Michel Massaad, Isabelle Meyts, Megan Morsheimer, Benedicte Neven, Sung-Yun Pai, Alessandro Plebani, Susan Prockop, Ismail Reisli, Jian Yi Soh, Raz Somech, Troy R Torgerson, Yae-Jaen Kim, Jolan E Walter, Andrew R Gennery, Sevgi Keles, John P Manis, Emanuela Marcenaro, Alessandro Moretta, Silvia Parolini, Luigi D Notarangelo
Mutations of the recombinase-activating genes 1 and 2 (RAG1 and RAG2) in humans are associated with a broad range of phenotypes. For patients with severe clinical presentation, hematopoietic stem cell transplantation (HSCT) represents the only curative treatment; however, high rates of graft failure and incomplete immune reconstitution have been observed, especially after unconditioned haploidentical transplantation. Studies in mice have shown that Rag(-/-) natural killer (NK) cells have a mature phenotype, reduced fitness, and increased cytotoxicity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28766723/comparing-transfusion-reaction-rates-for-various-plasma-types-a-systematic-review-and-meta-analysis-regression
#14
Nicholas H Saadah, Fabienne M A van Hout, Martin R Schipperus, Saskia le Cessie, Rutger A Middelburg, Johanna C Wiersum-Osselton, Johanna G van der Bom
BACKGROUND: We estimated rates for common plasma-associated transfusion reactions and compared reported rates for various plasma types. STUDY DESIGN AND METHODS: We performed a systematic review and meta-analysis of peer-reviewed articles that reported plasma transfusion reaction rates. Random-effects pooled rates were calculated and compared between plasma types. Meta-regression was used to compare various plasma types with regard to their reported plasma transfusion reaction rates...
September 2017: Transfusion
https://www.readbyqxmd.com/read/28749449/food-sources-of-sodium-intake-in-an-adult-mexican-population-a-sub-analysis-of-the-salmex-study
#15
Eloisa Colin-Ramirez, Ángeles Espinosa-Cuevas, Paola Vanessa Miranda-Alatriste, Verónica Ivette Tovar-Villegas, JoAnne Arcand, Ricardo Correa-Rotter
Excessive dietary sodium intake increases blood pressure and cardiovascular risk. In Western diets, the majority of dietary sodium comes from packaged and prepared foods (≈75%); however, in Mexico there is no available data on the main food sources of dietary sodium. The main objective of this study was to identify and characterize the major food sources of dietary sodium in a sample of the Mexican Salt and Mexico (SALMEX) cohort. Adult male and female participants of the SALMEX study who provided a complete and valid three-day food record during the baseline visit were included...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28651884/-transfusions-in-myelodysplastic-syndromes
#16
C Rose
PRBC transfusion remains the mainstay of treatment of anemia in MDS after failure of erythropoiesis stimulating agents. The most common transfusion trigger in transfusion-dependent MDS patients is 80g/L. This level is based only on expert consensus; a randomized controlled trial comparing restrictive against liberal policy is required to evaluate potential impact of transfusion policy on with QoL and survival. Prophylactic antigen matching for RhCE and K must be used in order to reduce the risk of red blood cell (RBC) alloimmunization...
September 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28642178/neurologic-outcome-after-decompressive-craniectomy-predictors-of-outcome-in-different-pathologic-conditions
#17
Taco Goedemans, Dagmar Verbaan, Bert A Coert, Bertjan J Kerklaan, René van den Berg, Jonathan M Coutinho, Tessa van Middelaar, Paul J Nederkoorn, William Peter Vandertop, Pepijn van den Munckhof
OBJECTIVE: Decompressive craniectomy (DC) has been proposed as a lifesaving treatment in patients with elevated intracranial pressure, but its effectiveness on reaching a favorable neurologic outcome remains unclear. We identified predictors of outcome in a large, single-center cohort of patients undergoing DC for different pathologic conditions. METHODS: This retrospective study included all patients undergoing DC from 2006 to 2014. The 1-year outcome, assessed using the Glasgow Outcome Scale (GOS), was dichotomized into favorable (GOS 4-5) and unfavorable (GOS 1-3) outcome...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28633455/fetal-metabolic-stress-disrupts-immune-homeostasis-and-induces-proinflammatory-responses-in-human-immunodeficiency-virus-type-1-and-combination-antiretroviral-therapy-exposed-infants
#18
Johannes C Schoeman, Gontse P Moutloatse, Amy C Harms, Rob J Vreeken, Henriette J Scherpbier, Liesbeth Van Leeuwen, Taco W Kuijpers, Carools J Reinecke, Ruud Berger, Thomas Hankemeier, Madeleine J Bunders
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)-infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell's immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART) exposure on the infants' immune metabolome...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28626833/the-lung-is-a-host-defense-niche-for-immediate-neutrophil-mediated-vascular-protection
#19
Bryan G Yipp, Jung Hwan Kim, Ronald Lima, Lori D Zbytnuik, Björn Petri, Nick Swanlund, May Ho, Vivian G Szeto, Tamar Tak, Leo Koenderman, Peter Pickkers, Anton T J Tool, Taco W Kuijpers, Timo K van den Berg, Mark R Looney, Matthew F Krummel, Paul Kubes
Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid treatment. However, upregulation of host defense proteins through toll-like receptors and NFκB requires hours after endotoxin detection. Using confocal pulmonary intravital microscopy, we identified that the lung provides a TLR4-Myd88-and abl tyrosine kinase-dependent niche for immediate CD11b-dependent neutrophil responses to endotoxin and Gram-negative bloodstream pathogens. In an in vivo model of bacteremia, neutrophils crawled to and rapidly phagocytosed Escherichia coli sequestered to the lung endothelium...
April 28, 2017: Science Immunology
https://www.readbyqxmd.com/read/28608162/diffusion-weighted-imaging-for-assessment-of-synovial-inflammation-in-juvenile-idiopathic-arthritis-a-promising-imaging-biomarker-as-an-alternative-to-gadolinium-based-contrast-agents
#20
Anouk M Barendregt, E Charlotte van Gulik, Cristina Lavini, Charlotte M Nusman, J Merlijn van den Berg, Dieneke Schonenberg-Meinema, Koert M Dolman, Taco W Kuijpers, Robert Hemke, Mario Maas
OBJECTIVES: To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA). METHODS: Regions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs...
June 12, 2017: European Radiology
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