Read by QxMD icon Read


Y Lin, R Cohen, C Armali, J Callum, C Cserti-Gazdewich, L Lieberman, J Pendergrast
BACKGROUND AND OBJECTIVES: Approaches to preventing transfusion-associated circulatory overload (TACO) include the use of diuretics. The purpose of this study was to determine how commonly diuretics are prescribed in patients receiving a red-blood-cell (RBC) transfusion. MATERIALS AND METHODS: This was a retrospective study of 200 adult inpatient RBC transfusion orders, 50 consecutive at each of four academic institutions. Only the first transfusion order for each patient was included...
March 8, 2018: Vox Sanguinis
Okan W Bastian, Mikolaj H Mrozek, Marco Raaben, Luke P H Leenen, Leo Koenderman, Taco J Blokhuis
A controlled local inflammatory response is essential for adequate fracture healing. However, the current literature suggests that local and systemic hyper-inflammatory conditions after major trauma induce increased influx of neutrophils into the fracture hematoma (FH) and impair bone regeneration. Inhibiting neutrophil chemotaxis towards the FH without compromising the hosts' defense may therefore be a target of future therapies that prevent impairment of fracture healing after major trauma. We investigated whether chemotaxis of neutrophils towards the FH could be studied in vitro...
March 6, 2018: Inflammation
Grace Limandjaja, Lenie J van den Broek, Melanie Breetveld, Taco Waaijman, Stan Monstrey, Edith de Boer, Rik Scheper, Frank Niessen, Susan Gibbs
To understand scar pathology, develop new drugs, and provide a platform for personalized medicine, physiologically relevant human scar models are required which are characteristic of different scar pathologies. Hypertrophic scars and keloids are two types of abnormal scar resulting from unknown abnormalities in the wound healing process. While they display different clinical behavior, differentiation between the two can be difficult - which in turn means that it is difficult to develop optimal therapeutic strategies...
February 28, 2018: Tissue Engineering. Part C, Methods
Martine J M Breteler, Erik Huizinga, Kim van Loon, Luke P H Leenen, Daan A J Dohmen, Cor J Kalkman, Taco J Blokhuis
BACKGROUND AND OBJECTIVES: Intermittent vital signs measurements are the current standard on hospital wards, typically recorded once every 8 hours. Early signs of deterioration may therefore be missed. Recent innovations have resulted in 'wearable' sensors, which may capture patient deterioration at an earlier stage. The objective of this study was to determine whether a wireless 'patch' sensor is able to reliably measure respiratory and heart rate continuously in high-risk surgical patients...
February 27, 2018: BMJ Open
Dylan Lawless, Christoph B Geier, Jocelyn R Farmer, Hana Allen Lango, Daniel Thwaites, Faranaz Atschekzei, Matthew Brown, David Buchbinder, Siobhan O Burns, Manish J Butte, Krisztian Csomos, Sri V V Deevi, William Egner, Stephan Ehl, Martha M Eibl, Olajumoke Fadugba, Zsofia Foldvari, Deanna M Green, Sarah E Henrickson, Steven M Holland, Tami John, Christian Klemann, Taco W Kuijpers, Fernando Moreira, Alexander Piller, Paula Rayner-Matthews, Neil D Romberg, Ravishankar Sargur, Reinhold E Schmidt, Claudia Schröder, Catharina Schuetz, Svetlana O Sharapova, Ken G C Smith, Georgios Sogkas, Carsten Speckmann, Kathleen Stirrups, Adrian J Thrasher, Hermann M Wolf, Luigi D Notarangelo, Rashida Anwar, Joan Boyes, Boglarka Ujhazi, James Thaventhiran, Jolan E Walter, Sinisa Savic
No abstract text is available yet for this article.
February 22, 2018: Journal of Allergy and Clinical Immunology
Paul Tuijnenburg, Hana Lango Allen, Siobhan O Burns, Daniel Greene, Machiel H Jansen, Emily Staples, Jonathan Stephens, Keren J Carss, Daniele Biasci, Helen Baxendale, Moira Thomas, Anita Chandra, Sorena Kiani-Alikhan, Hilary J Longhurst, Suranjith L Seneviratne, Eric Oksenhendler, Ilenia Simeoni, Godelieve J de Bree, Anton T J Tool, Ester M M van Leeuwen, Eduard H T M Ebberink, Alexander B Meijer, Salih Tuna, Deborah Whitehorn, Matthew Brown, Ernest Turro, Adrian J Thrasher, Kenneth G C Smith, James E Thaventhiran, Taco W Kuijpers
BACKGROUND: The genetic etiology of primary immunodeficiency disease (PID) carries prognostic information. OBJECTIVE: We conducted a whole-genome sequencing study assessing a large proportion of the NIHR-BioResource - Rare Disease cohort. METHODS: In the predominantly European study population of principally sporadic unrelated PID cases (n=846), a novel Bayesian method identified NFKB1 as one most strongly associated with PID, and the association was explained by 16 novel heterozygous truncating, missense and gene deletion variants...
February 22, 2018: Journal of Allergy and Clinical Immunology
Syaiful Redzwan Mohd Shah, Jacob Velander, Parul Mathur, Mauricio D Perez, Noor Badariah Asan, Dhanesh G Kurup, Taco J Blokhuis, Robin Augustine
In recent research, microwave sensors have been used to follow up the recovery of lower extremity trauma patients. This is done mainly by monitoring the changes of dielectric properties of lower limb tissues such as skin, fat, muscle, and bone. As part of the characterization of the microwave sensor, it is crucial to assess the signal penetration in in vivo tissues. This work presents a new approach for investigating the penetration depth of planar microwave sensors based on the Split-Ring Resonator in the in vivo context of the femoral area...
February 21, 2018: Sensors
Marco Raaben, H Charles Vogely, Taco J Blokhuis
BACKGROUND: Previous studies have shown limited therapy compliance in weight-bearing in patients following total hip arthroplasty. RESEARCH QUESTION: The purpose of this pilot RCT is to determine the immediate and late effect of real-time, visual biofeedback on weight-bearing during rehabilitation after THA in elderly. METHODS: 24 participants who underwent THA were randomized to either the control or the intervention group. The intervention group received real-time, visual biofeedback on weight-bearing during training with the physical therapist during hospitalization and at twelve weeks follow up...
January 31, 2018: Gait & Posture
Yuri Souwerm, Tom Groot Kormelink, Esther W Taanman-Kueter, Femke J Muller, Toni M M van Capel, Domonkos V Varga, Yotam E Bar-Ephraim, Marcel B M Teunissen, S Marieke van Ham, Taco W Kuijpers, Diana Wouters, Linde Meyaard, Esther C de Jong
No abstract text is available yet for this article.
January 29, 2018: Journal of Allergy and Clinical Immunology
Pishtiwan H S Kalmet, Guido Meys, Yvette Y V Horn, Silvia M A A Evers, Henk A M Seelen, Paul Hustinx, Heinrich Janzing, Alexander Vd Veen, Coen Jaspars, Jan Bernard Sintenie, Taco J Blokhuis, Martijn Poeze, Peter R G Brink
BACKGROUND: The standard aftercare treatment in surgically treated trauma patients with fractures around or in a joint, known as (peri)- or intra-articular fractures of the lower extremities, is either non-weight bearing or partial weight bearing. We have developed an early permissive weight bearing post-surgery rehabilitation protocol in surgically treated patients with fractures of the lower extremities. In this proposal we want to compare our early permissive weight bearing protocol to the existing current non-weight bearing guidelines in a prospective comparative cohort study...
February 2, 2018: BMC Surgery
Lise De Cloedt, Guillaume Emeriaud, Émilie Lefebvre, Niina Kleiber, Nancy Robitaille, Christine Jarlot, Jacques Lacroix, France Gauvin
BACKGROUND: The incidence of transfusion-associated circulatory overload (TACO) is not well known in children, especially in pediatric intensive care unit (PICU) patients. STUDY DESIGN AND METHODS: All consecutive patients admitted over 1 year to the PICU of CHU Sainte-Justine were included after they received their first red blood cell transfusion. TACO was diagnosed using the criteria of the International Society of Blood Transfusion, with two different ways of defining abnormal values: 1) using normal pediatric values published in the Nelson Textbook of Pediatrics and 2) by using the patient as its own control and comparing pre- and posttransfusion values with either 10 or 20% difference threshold...
February 1, 2018: Transfusion
Martin De Boer, Ronit Gavrieli, Karin van Leeuwen, Haike Reznik Wolf, Maya Dushnitzki, Yifaat Bar-Yosef, Anat Bar-Ziv, Doron Behar, Shlomo Lipitz, Tal Elkan Miller, Anton T J Tool, Taco W Kuijpers, Timo K van den Berg, Baruch Wolach, Dirk Roos, Elon Pras
BACKGROUND: Mutations in the NCF1 gene that encodes p47phox, a subunit of the NADPH oxidase complex, cause chronic granulomatous disease (CGD). In Kavkazi Jews, a c.579G>A (p.Trp193Ter) mutation in NCF1 is frequently found, leading to CGD. The same mutation is found in about 1% of Ashkenazi Jews, although Ashkenazi CGD patients with this mutation have never been described. METHODS: We used Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), gene scan analysis and Ion Torrent Next Generation Sequencing for genetic analysis, and measured NADPH oxidase activity and p47phox expression...
January 13, 2018: Journal of Medical Genetics
Lisette Meerstein-Kessel, Robin van der Lee, Will Stone, Kjerstin Lanke, David A Baker, Pietro Alano, Francesco Silvestrini, Chris J Janse, Shahid M Khan, Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Siebelink-Stoter, Taco W A Kooij, Matthias Marti, Chris Drakeley, Joseph J Campo, Teunis J P van Dam, Robert Sauerwein, Teun Bousema, Martijn A Huynen
Plasmodium gametocytes are the sexual forms of the malaria parasite essential for transmission to mosquitoes. To better understand how gametocytes differ from asexual blood-stage parasites, we performed a systematic analysis of available 'omics data for P. falciparum and other Plasmodium species. 18 transcriptomic and proteomic data sets were evaluated for the presence of curated "gold standards" of 41 gametocyte-specific versus 46 non-gametocyte genes and integrated using Bayesian probabilities, resulting in gametocyte-specificity scores for all P...
January 11, 2018: Scientific Reports
E Charlotte van Gulik, Mendy M Welsink-Karssies, J Merlijn van den Berg, Dieneke Schonenberg-Meinema, Koert M Dolman, Anouk M Barendregt, Charlotte M Nusman, Mario Maas, Taco W Kuijpers, Robert Hemke
BACKGROUND: Synovial thickening detected on magnetic resonance imaging (MRI) is present in a significant number of children with clinically inactive juvenile idiopathic arthritis (JIA). OBJECTIVE: To evaluate patient characteristics and disease activity parameters in a cohort of children with clinically inactive JIA, both with and without synovial thickening, in order to clarify the observed discrepancy between clinical and MRI assessments. MATERIALS AND METHODS: We prospectively enrolled 52 clinically inactive JIA patients (median age 13...
January 6, 2018: Pediatric Radiology
Louis de Jong, Taco M A L Klem, Tjallingius M Kuijper, Gert R Roukema
PURPOSE: The minimally invasive (MI) anterolateral approach is a relatively new approach for the treatment of femoral neck fractures with a hemiarthroplasty (HA). There is limited research available presenting clinical outcomes after an HA using the MI approach. Therefore the aim of the present study was to compare clinical outcomes of the MI and traditional anterolateral approaches in patients after HA. METHODS: Data were extracted from a prospective hip fracture database and completed by retrospective review of the electronic medical records...
January 6, 2018: International Orthopaedics
Donald R Branch, Åsa Hellberg, Christine W Bruggeman, Jill R Storry, Darinka Sakac, Megan Blacquiere, Tik Nga Tong, Emeralda Burke-Murphy, Beth Binnington, Nagina Parmar, Lorna Sampson Riden, Kezia Willie, Chantal Armali, Jiwajee Aziz, Lani Lieberman, Vincent Laroche, Jeannie Callum, Yulia Lin, Nadine Shehata, Katerina Pavenski, Wendy Lau, Barbara Hannach, Taco W Kuijpers, Martin L Olsson, Christine Cserti-Gazdewich, Jacob Pendergrast
No abstract text is available yet for this article.
February 15, 2018: Blood
Gireeshkumar Balakrishnan, Juliana V C Silva, Taco Nicolai, Christophe Chassenieux, Claudine Bovay, Johann Buczkowski, Christophe Schmitt
Aqueous suspensions of micellar casein (MC) gel when heated above a critical temperature that depends on the pH. The effect of adding CaCl2 and EDTA on thermal gelation was studied in order to assess the effect of increasing or decreasing the amount of bound Ca2+ on the process. The effect of adding NaCl was investigated in order to distinguish the effect of Ca2+ binding from the effect of screening of electrostatic interactions. Shear moduli were measured as a function of the temperature during heating ramps up to 90 °C...
December 16, 2017: Colloids and Surfaces. B, Biointerfaces
Salman Daniel, Kimmo Saastamoinen, Toni Saastamoinen, Ismo Vartiainen, Ari T Friberg, Taco D Visser
Surface plasmon polaritons (SPPs) are electromagnetic surface waves that travel along the boundary of a metal and a dielectric medium. They can be generated when freely propagating light is scattered by structural metallic features such as gratings or slits. In plasmonics, SPPs are manipulated, amplified, or routed before being converted back into light by a second scattering event. In this process, the light acquires a dynamic phase and perhaps an additional geometric phase associated with polarization changes...
December 22, 2017: Physical Review Letters
Sanne M Meinderts, Per-Arne Oldenborg, Boukje M Beuger, Thomas R L Klei, Johanna Johansson, Taco W Kuijpers, Takashi Matozaki, Elise J Huisman, Masja de Haas, Timo K van den Berg, Robin van Bruggen
Red blood cell (RBC) clearance is known to occur primarily in the spleen, and is presumed to be executed by red pulp macrophages. Erythrophagocytosis in the spleen takes place as part of the homeostatic turnover of RBCs to remove old RBCs. It can be strongly promoted by immunoglobulin G (IgG) opsonization of RBCs, a condition that can occur as a consequence of autoantibody or alloantibody formation. The purpose of our study was to investigate which phagocytes are involved in IgG-mediated RBC clearance in the human spleen...
June 13, 2017: Blood Advances
Joachim J Bosboom, Robert B Klanderman, Maarten Zijp, Markus W Hollmann, Denise P Veelo, Jan M Binnekade, Bart F Geerts, Alexander P J Vlaar
BACKGROUND: The objective of this study was to determine the incidence, risk factors, and outcome of transfusion-associated circulatory overload (TACO) in a cohort of mixed intensive care unit patients and to compare risk factors with those for cardiac overload in the absence of transfusion. STUDY DESIGN AND METHODS: In a retrospective cohort study, patients who developed TACO were compared using multivariate analysis of two control groups: patients without pulmonary deterioration who received transfusion and patients who developed circulatory overload in the absence of transfusion...
December 13, 2017: Transfusion
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"