Pedro Leonidas Oseliero Filho, Barbara Bianca Gerbelli, Franccesca Fornasier, Adriano B Chaves Filho, Marcos Yukio Yoshinaga, Sayuri Miyamoto, Laura Mortara, Caroline Dutra Lacerda, Iolanda Midea Cuccovia, André Silva Pimentel, Cristiano Luis Pinto Oliveira
Two commercial exogenous pulmonary surfactants, Curosurf and Survanta, are investigated. Their thermotropic behavior and associated structural changes for the samples in bulk are characterized and described. For Survanta, the obtained results of differential scanning calorimetry showed a thermogram with three peaks on heating and only a single peak on cooling. Curosurf on the other hand, presents calorimetric thermograms with only one peak in both the heating and cooling scans. This distinct thermotropic behavior between the two pulmonary surfactants, a consequence of their particular compositions, is associated with structural changes that were evaluated by simultaneous small- and wide-angle X-ray scattering experiments with in situ temperature variation...
November 19, 2020: Langmuir: the ACS Journal of Surfaces and Colloids