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https://www.readbyqxmd.com/read/27916652/exploring-pericyte-and-cardiac-stem-cell-secretome-unveils-new-tactics-for-drug-discovery
#1
REVIEW
Georgina M Ellison-Hughes, Paolo Madeddu
Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair...
December 1, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27914146/pregnancy-and-delivery-in-a-generalized-dystonia-patient-treated-with-internal-globus-pallidal-deep-brain-stimulation-a-case-report
#2
Hye Ran Park, Jae Meen Lee, Hyeyoung Park, Chae Won Shin, Han Joon Kim, Hee Pyoung Park, Dong Gyu Kim, Beom Seok Jeon, Sun Ha Paek
Internal globus pallidus (GPi) deep brain stimulation (DBS) has been widely accepted as an effective treatment modality of medically refractory dystonia. However, there have been few studies regarding the safety issue of pregnancy and childbirth related with DBS. This report describes a female patient who was pregnant and delivered a baby after GPi DBS surgery. A 33-year-old female patient with acquired generalized dystonia underwent bilateral GPi DBS implantation. She obtained considerable improvement in both movement and disability after DBS implantation...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27910000/a-review-of-experimental-and-off-label-therapies-for-clostridium-difficile-infection
#3
REVIEW
Csaba Fehér, Alex Soriano, Josep Mensa
In spite of increased awareness and the efforts taken to optimize Clostridium difficile infection (CDI) management, with the limited number of currently available antibiotics for C. difficile the halt of this increasing epidemic remains out of reach. There are, however, close to 80 alternative treatment methods with controversial anti-clostridial efficacy or in experimental phase today. Indeed, some of these therapies are expected to become acknowledged members of the recommended anti-CDI arsenal within the next few years...
December 1, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27908434/an-observational-study-of-handwashing-compliance-in-a-child-care-facility
#4
Jeffrey Clark, Jennifer K Henk, Philip G Crandall, Mardel A Crandall, Corliss A O'Bryan
BACKGROUND: Handwashing (HW) compliance, although an effective means of limiting childhood illness, remains low among personnel in early childhood centers (ECCs). Our study determined HW compliance and efficacy of ECC personnel. METHODS: Surveillance cameras were used to determine HW opportunities, compliance, occurrences, and effectiveness based on child-care oriented criteria. RESULTS: We observed 349 HW triggering events, with 14 events per hour; a median of 2 personnel (caregivers, paraprofessional aides, or parents) were present at any given time period...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27897125/a-comparison-of-thresholds-of-auditory-steady-state-response-and-auditory-brainstem-response-in-healthy-term-babies
#5
Onur Çelik, Görkem Eskiizmir, Uzdan Uz
OBJECTIVE: The goal of this study was to assess the effectiveness of auditory steady-state response (ASSR), determine the cut-off values for each frequency, and detect the best correlated frequencies when compared with the auditory brainstem response (ABR) thresholds in term babies under the age of 12 months. MATERIALS AND METHODS: In total, 88 term babies with a mean age of 2.98 (1-11) months (174 ears) underwent ASSR and ABR tests. The ASSR thresholds for the frequencies of 500, 1000, 2000, and 4000 Hz were compared with the hearing level of the ABR thresholds...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27894578/pre-expanded-and-prefabricated-abdominal-superthin-skin-perforator-flap-for-total-hand-resurfacing
#6
REVIEW
Chunmei Wang, Junyi Zhang, Sifen Yang, Ping Song, Lun Yang, Lee L Q Pu
Reconstruction of the postburn hand remains a challenge for surgeons. For cosmetic and functional requirements, the desired flap should be thin enough to ensure the flexibility of the hand. Conventional perforator flaps serve as a viable option when reconstructing the postburn hand to regain functionality. However, limitations include the discrepancy in tissue thickness and the difficulty with donor site closure. Thus, a preexpanded superthin skin perforator flap is an ideal choice for postburn hand reconstruction, with the trade-off being a longer treatment course (3-4 months), but with results that satisfy both patients and their surgeons...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27894249/brief-compression-only-cardiopulmonary-resuscitation-training-video-and-simulation-with-homemade-mannequin-improves-cpr-skills
#7
Gregory K Wanner, Arayel Osborne, Charlotte H Greene
BACKGROUND: Cardiopulmonary resuscitation (CPR) training has traditionally involved classroom-based courses or, more recently, home-based video self-instruction. These methods typically require preparation and purchase fee; which can dissuade many potential bystanders from receiving training. This study aimed to evaluate the effectiveness of teaching compression-only CPR to previously untrained individuals using our 6-min online CPR training video and skills practice on a homemade mannequin, reproduced by viewers with commonly available items (towel, toilet paper roll, t-shirt)...
November 29, 2016: BMC Emergency Medicine
https://www.readbyqxmd.com/read/27891221/brood-size-moderates-associations-between-relative-size-telomere-length-and-immune-development-in-european-starling-nestlings
#8
Daniel Nettle, Clare Andrews, Sophie Reichert, Tom Bedford, Annie Gott, Craig Parker, Claire Kolenda, Carmen Martin-Ruiz, Pat Monaghan, Melissa Bateson
For young birds in a nest, body size may have implications for other aspects of development such as telomere length and immune function. However, it is possible to predict associations in either direction. On the one hand, there may be trade-offs between growth and telomere maintenance, and growth and investment in immune function, suggesting there will be negative correlations. On the other hand, relatively larger individuals might be advantaged in competition with their nest-mates, allowing them to garner more resources overall, leading to positive correlations...
November 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27888176/nailfold-capillary-morphological-characteristics-of-hand-arm-vibration-syndrome-a-cross-sectional-study
#9
QingSong Chen, GuiPing Chen, Bin Xiao, HanSheng Lin, HongYing Qu, DanYing Zhang, MaoGong Shi, Li Lang, Bei Yang, MaoSheng Yan
OBJECTIVE: The purpose of this study was to investigate the characteristics of nailfold capillaroscopy associated with hand-arm vibration syndrome (HAVS). METHODS: In total, 113 male gold miners were recruited: 35 workers who were chronically exposed to vibration and developed vibration-induced white finger were defined as the HAVS group, 39 workers who were exposed to vibration but did not have HAVS were classified as the vibration-exposed controls (VEC) group, and 39 workers without vibration exposure were categorised as the non-VEC (NVEC) group...
November 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27887756/needlestick-injuries-among-healthcare-professionals-in-training-using-the-surgical-time-out-and-hand-off-protocols-to-deter-high-risk-needlesticks
#10
EDITORIAL
G A Katsevman, J A Braca, C L Sedney, L Hatchett
No abstract text is available yet for this article.
November 3, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27880057/ankle-plantarflexor-spasticity-is-not-differentially-disabling-for-those-who-are-weak-following-traumatic-brain-injury
#11
Gavin Williams, Megan Banky, Dean McKenzie, John Olver
PRIMARY OBJECTIVES: The main aim of this study was to determine whether the presence of distal lower-limb spasticity had a greater impact on mobility for those who had greater levels of muscle paresis following traumatic brain injury (TBI). RESEARCH DESIGN: This was a cross-sectional cohort study of convenience. Seventy-five people attending physiotherapy for mobility limitations following TBI participated in this study. All participants had sustained a moderate-severe TBI and were grouped according to the presence or absence of ankle plantarflexor spasticity for comparison...
November 23, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27872991/shoulder-manual-muscle-resistance-test-cannot-fully-detect-muscle-weakness
#12
Takayuki Nagatomi, Tatsuo Mae, Teruyoshi Nagafuchi, Shin-Ichi Yamada, Koutatsu Nagai, Minoru Yoneda
PURPOSE: The shoulder manual resistance test is one of the common clinical assessments for patients with muscle weakness. However, there have been no studies investigating the threshold for muscle weakness. The purpose of this study was to clarify the threshold for muscle weakness in the shoulder manual muscle resistance test. METHODS: Fifty-three patients (37.9 ± 20.6 years old) with either rotator cuff tear (21 patients), superior labrum anterior-to-posterior (SLAP) lesion (7 patients), or Bankart lesion (25 patients) of one shoulder were administered three manual muscle resistance tests (abduction strength, external rotation, and belly press tests)...
November 21, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27870256/factors-related-to-a-decline-in-upper-extremity-function-among-patients-with-a-wrist-fracture-due-to-a-fall
#13
Nerea González, Ane Antón-Ladislao, Miren Orive, Jon Zabala, Susana García-Gutiérrez, Carlota Las Hayas, Jose Maria Quintana
AIMS: The aim of this study was to identify factors related to a decline in function following a wrist fracture. METHODS: Observational, prospective cohort study done in five public hospitals of the Basque Health Service. We recruited adults aged 65 or older with a wrist fracture due to a fall who attended the emergency department (ED) of one of these hospitals. Sociodemographic and clinical data were collected, along with information about health-related quality of life (HRQoL) and functionality...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27865927/structural-perturbations-induced-by-asn131-and-asn171-glycosylation-converge-within-the-efsam-core-and-enhance-stromal-interaction-molecule-1-mediated-store-operated-calcium-entry
#14
Yoo Jung Choi, Yue Zhao, Moshmi Bhattacharya, Peter B Stathopulos
A major intracellular calcium (Ca(2+)) uptake pathway in both excitable and non-excitable eukaryotic cells is store-operated Ca(2+) entry (SOCE). SOCE is the process by which endoplasmic reticulum (ER)-stored Ca(2+) depletion leads to activation of plasma membrane Ca(2+) channels to provide a sustained increase in cytosolic Ca(2+) levels that mediate a plethora of physiological processes ranging from the immune response to platelet aggregation. Stromal interaction molecule-1 (STIM1) is the principal regulator of SOCE and responds to changes in ER stored Ca(2+) through luminal sensing machinery composed of EF-hand and SAM domains (EFSAM)...
November 17, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27865371/assessing-head-and-neck-cancer-patient-preferences-and-expectations-a-systematic-review
#15
REVIEW
Pierre Blanchard, Robert J Volk, Jolie Ringash, Susan K Peterson, Katherine A Hutcheson, Steven J Frank
INTRODUCTION: To enhance the value of care, interventions should aim at improving endpoints that matter to patients. The preferences of head and neck cancer patients regarding treatment outcomes are therefore a major topic for patient-centered research. METHODS: A systematic review (PROSPERO number CRD42016035692) was conducted by searching electronic databases (Medline, Embase, Cochrane, CINAHL) for articles evaluating patient or surrogate preferences in head and neck cancer...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27864445/comparison-of-fiber-optic-and-conduit-attenuated-total-reflection-atr-fourier-transform-infrared-ft-ir-setup-for-in-line-fermentation-monitoring
#16
Cosima Koch, Andreas E Posch, Christoph Herwig, Bernhard Lendl
The performance of a fiber optic and an optical conduit in-line attenuated total reflection mid-infrared (IR) probe during in situ monitoring of Penicillium chrysogenum fermentation were compared. The fiber optic probe was connected to a sealed, portable, Fourier transform infrared (FT-IR) process spectrometer via a plug-and-play interface. The optical conduit, on the other hand, was connected to a FT-IR process spectrometer via a knuckled probe with mirrors that had to be adjusted prior to each fermentation, which were purged with dry air...
November 18, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27862238/validation-of-distal-limb-mounted-inertial-measurement-unit-sensors-for-stride-detection-in-warmblood-horses-at-walk-and-trot
#17
F M Bragança, S Bosch, J P Voskamp, M Marin-Perianu, B J Van der Zwaag, J C M Vernooij, P R van Weeren, W Back
BACKGROUND: Inertial-measurement-unit (IMU)-sensor-based techniques are becoming more popular in horses as a tool for objective locomotor assessment. OBJECTIVES: To describe, evaluate and validate a method of stride detection and quantification at walk and trot using distal limb mounted IMU-sensors. STUDY DESIGN: Prospective validation study comparing IMU-sensors and motion capture with force plate data. METHODS: Seven Warmblood horses equipped with metacarpal/metatarsal IMU-sensors and reflective markers for motion capture were hand walked and trotted over a force plate...
November 12, 2016: Equine Veterinary Journal
https://www.readbyqxmd.com/read/27856021/interdisciplinary-development-of-an-improved-emergency-department-procedural-work-surface-through-iterative-design-and-use-testing-in-simulated-and-clinical-environments
#18
Xiao C Zhang, Ana M Bermudez, Pranav M Reddy, Ravi R Sarpatwari, Darin B Chheng, Taylor J Mezoian, Victoria R Schwartz, Quinneil J Simmons, Gregory D Jay, Leo Kobayashi
STUDY OBJECTIVE: A stable and readily accessible work surface for bedside medical procedures represents a valuable tool for acute care providers. In emergency department (ED) settings, the design and implementation of traditional Mayo stands and related surface devices often limit their availability, portability, and usability, which can lead to suboptimal clinical practice conditions that may affect the safe and effective performance of medical procedures and delivery of patient care...
November 14, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27850010/370-descriptive-analysis-of-hands-off-activity-in-cpr-events-using-real-time-video-data
#19
Mahsheed Taeb, Jamie Schwartz, Michael Spaeder, Amanda Levin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847116/nutritional-assessment-using-stable-isotope-ratios-of-carbon-and-nitrogen-in-the-scalp-hair-of-geriatric-patients-who-received-enteral-and-parenteral-nutrition-formulas
#20
M Hayasaka, H Ogasawara, Y Hotta, K Tsukagoshi, O Kimura, T Kura, T Tarumi, H Muramatsu, T Endo
BACKGROUND & AIMS: The δ(13)C and δ(15)N values in the scalp hair of geriatric patients in Japan who received the enteral or parenteral nutrition formula were measured to assess nutritional status. METHODS: The relations among δ(13)C, δ(15)N, calorie intake, BMI, albumin concentration, total cholesterol (T-CHO) and geriatric nutritional risk index (GNRI) in the patients were investigated. Furthermore, the enrichment of δ(13)C and δ(15)N from the nutrients to the hair was investigated...
October 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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