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https://www.readbyqxmd.com/read/28643174/natural-language-processing-for-ehr-based-pharmacovigilance-a-structured-review
#1
REVIEW
Yuan Luo, William K Thompson, Timothy M Herr, Zexian Zeng, Mark A Berendsen, Siddhartha R Jonnalagadda, Matthew B Carson, Justin Starren
The goal of pharmacovigilance is to detect, monitor, characterize and prevent adverse drug events (ADEs) with pharmaceutical products. This article is a comprehensive structured review of recent advances in applying natural language processing (NLP) to electronic health record (EHR) narratives for pharmacovigilance. We review methods of varying complexity and problem focus, summarize the current state-of-the-art in methodology advancement, discuss limitations and point out several promising future directions...
June 22, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28643155/mind-wandering-how-do-i-measure-thee-with-probes-let-me-count-the-ways
#2
Yana Weinstein
In the past decade, a new field has formed to investigate the concept of mind-wandering, or task-unrelated thought. The state of mind-wandering is typically contrasted with being on-task, or paying attention to the task at hand, and is related to decrements in performance on cognitive tasks. The most widely used method for collecting mind-wandering data-the probe-caught method-involves stopping participants during a task and asking them where their attention is directed. In this review, 145 studies from 105 articles published between 2005 and 2015 were classified according to the framing and wording of the thought probe and response options...
June 22, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28639597/evaluation-of-75-g-glucose-load-in-non-fasting-state-diabetes-in-pregnancy-study-group-of-india-dipsi-criteria-as-a-diagnostic-test-for-gestational-diabetes-mellitus
#3
Reva Tripathi, Divya Verma, Vinod Kumar Gupta, Shakun Tyagi, M Kalaivani, Siddarth Ramji, Y M Mala
BACKGROUND & OBJECTIVES: There is no consensus regarding optimal standard for diagnosis of gestational diabetes mellitus (GDM). In this study, use of 75 g glucose load in non-fasting state [Diabetes in Pregnancy Study Group of India (DIPSI) criteria] as a diagnostic test for GDM in pregnant women was compared with different oral glucose tolerance tests (OGTTs). METHODS: This prospective study included 936 pregnant women, who underwent plasma glucose evaluation two hours after the challenge of 75 g glucose load irrespective of the timing of last meal (DIPSI criteria for GDM)...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28637477/determinants-of-intra-household-food-allocation-between-adults-in-south-asia-a-systematic-review
#4
REVIEW
Helen Harris-Fry, Niva Shrestha, Anthony Costello, Naomi M Saville
BACKGROUND: Nutrition interventions, often delivered at the household level, could increase their efficiency by channelling resources towards pregnant or lactating women, instead of leaving resources to be disproportionately allocated to traditionally favoured men. However, understanding of how to design targeted nutrition programs is limited by a lack of understanding of the factors affecting the intra-household allocation of food. METHODS: We systematically reviewed literature on the factors affecting the allocation of food to adults in South Asian households (in Afghanistan, Bangladesh, Bhutan, India, Islamic Republic of Iran, Maldives, Nepal, Pakistan, Sri Lanka) and developed a framework of food allocation determinants...
June 21, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28636458/contamination-of-firefighter-personal-protective-equipment-and-skin-and-the-effectiveness-of-decontamination-procedures
#5
Kenneth W Fent, Barbara Alexander, Jennifer Roberts, Shirley Robertson, Christine Toennis, Deborah Sammons, Stephen Bertke, Steve Kerber, Denise Smith, Gavin Horn
Firefighters' skin may be exposed to chemicals via permeation/penetration of combustion byproducts through or around personal protective equipment (PPE) or from the cross-transfer of contaminants on PPE to the skin. Additionally, volatile contaminants can evaporate from PPE following a response and be inhaled by firefighters. Using polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) as respective markers for non-volatile and volatile substances, we investigated the contamination of firefighters' turnout gear and skin following controlled residential fire responses...
June 21, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28628686/off-face-usage-of-poly-l-lactic-acid-for-body-rejuvenation
#6
Ahmad Jabbar, Suleima Arruda, Neil Sadick
<p>Injectable soft-tissue augmentation agents have become popular alternatives to surgical procedures for the aging face and body. In contrast to temporary, space-occupying replacement fillers such as collagen-based and hyaluronic acid products, poly-l-lactic acid (PLLA) has been demonstrated to gradually promotes deposition of collagen via a biostimulatory response, with therapeutic effects lasting approximately two years. In 2004, the FDA approved its use for rejuvenation of facial contours secondary to lipoatrophy associated with antiretroviral therapy for HIV infection...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28628379/visuomotor-behaviors-and-performance-in-a-dual-task-paradigm-with-and-without-vibrotactile-feedback-when-using-a-myoelectric-controlled-hand
#7
Eitan Raveh, Jason Friedman, Sigal Portnoy
Prosthesis users allocate visual attention to their prosthetic hand while performing activities of daily living (ADLs), due to absence of sensory feedback. Dual-task assignments present competition for visual attention and may affect the performance of ADLs. Vibrotactile feedback (VTF) is a frequently-used method to provide prosthesis users with tactile feedback. However, the effect of adding VTF on visual attention and performance in a motor dual-task paradigm has not been investigated. Our aim was to compare visual attention and performance during ADLs in a motor dual-task paradigm when using binary VTF and without using VTF...
June 19, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28624736/fluorescence-of-tautomeric-forms-of-curcumin-in-different-ph-and-biosurfactant-rhamnolipids-systems-application-towards-on-off-ratiometric-fluorescence-temperature-sensing
#8
Zeinab Moussa, Mazhar Chebl, Digambara Patra
Medicinal properties of curcumin are widely getting realized. For its applicability as a hydrophobic drug molecule and food spice interaction of curcumin with rhamnolipids, a biosurfactant, bears importance. Here we have explored interaction of curcumin with rhamnolipids biosurfactant and its aggregation behavior. The impact of pH on critical micelle concentration (cmc) of rhamnolipids has been studied using fluorescence of curcumin and found that cmc of rhamnolipids increases with increase in pH of the medium...
June 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28616682/evidence-responsiveness-and-the-ongoing-autonomy-of-treatment-preferences
#9
Steven Weimer
To be an autonomous agent is to determine one's own path in life. However, this cannot plausibly be seen as a one-off affair. An autonomous agent does not merely set herself on a particular course and then lock the steering wheel in place, so to speak, but must maintain some form of ongoing control over her direction in life-must keep her eyes on the road and her hands on the wheel. Circumstances often change in important and unexpected ways, after all, and it is reasonable to think that a crucial part of autonomy consists of the ability and disposition to recognize and properly respond to such changes...
June 14, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28615291/high-affinity-cooperative-ca-2-binding-by-micu1-micu2-serves-as-an-on-off-switch-for-the%C3%A2-uniporter
#10
Kimberli J Kamer, Zenon Grabarek, Vamsi K Mootha
The mitochondrial calcium uniporter is a Ca(2+)-activated Ca(2+) channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca(2+) signals. It is regulated by two paralogous EF-hand proteins-MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate that both MICU1 and MICU2 are stabilized by Ca(2+) We reconstitute the MICU1-MICU2 heterodimer and demonstrate that it binds Ca(2+) cooperatively with high affinity. We discover that both MICU1 and MICU2 exhibit affinity for the mitochondria-specific lipid cardiolipin...
June 14, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28614671/gestalt-breastfeeding-helping-mothers-and-infants-optimize-positional-stability-and-intraoral-breast-tissue-volume-for-effective-pain-free-milk-transfer
#11
Pamela Douglas, Renee Keogh
In the past decade, biological nurturing and activation of maternal and infant instincts after birth have constituted a major advance in clinical breastfeeding support. Yet, physiologic breastfeeding initiation is not enough to ensure ongoing pain-free and effective breastfeeding for many pairs. Current interventions, including "hands-off" mammalian approaches, do not improve breastfeeding outcomes, including in randomized controlled trials. Back-arching, difficulty latching or staying on the breast, and fussing at the breast are common signs of infant positional instability during breastfeeding...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28611398/derivation-and-validation-of-a-mortality-risk-score-for-severe-hand-foot-and-mouth-disease-in-china
#12
Jun Qiu, Xiulan Lu, Xiao Liu, Ping Zang, Wenjiao Zhao, Pingping Liu, Zhenghui Xiao
Outbreaks of hand, foot and mouth disease (HFMD) have increased recently, as has the case fatality rate in severe cases. No scoring system currently exists to predict mortality risk for severe HFMD in previous study. We retrospectively collected laboratory parameters for 546 patients with severe HFMD (a derivation and a validation cohort) at Hunan Children's Hospitals between January 2012 and December 2014. We developed a mortality risk score comprising four laboratory parameters: blood glucose (GLU), white blood cells (WBC), lactate (LAC), and N-terminal-probrain natriuretic peptide (NT-proBNP)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28608597/perineal-techniques-during-the-second-stage-of-labour-for-reducing-perineal-trauma
#13
REVIEW
Vigdis Aasheim, Anne Britt Vika Nilsen, Liv Merete Reinar, Mirjam Lukasse
BACKGROUND: Most vaginal births are associated with trauma to the genital tract. The morbidity associated with perineal trauma can be significant, especially when it comes to third- and fourth-degree tears. Different interventions including perineal massage, warm or cold compresses, and perineal management techniques have been used to prevent trauma. This is an update of a Cochrane review that was first published in 2011. OBJECTIVES: To assess the effect of perineal techniques during the second stage of labour on the incidence and morbidity associated with perineal trauma...
June 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28596445/development-of-a-new-care-model-for-hospitalized-children-with-medical-complexity
#14
Christine M White, Joanna E Thomson, Angela M Statile, Katherine A Auger, Ndidi Unaka, Matthew Carroll, Karen Tucker, Derek Fletcher, David E Hall, Jeffrey M Simmons, Patrick W Brady
Children with medical complexity are a rapidly growing inpatient population with frequent, lengthy, and costly hospitalizations. During hospitalization, these patients require care coordination among multiple subspecialties and their outpatient medical homes. At a large freestanding children's hospital, a new inpatient model of care was developed in an effort to consistently provide coordinated, family-centered, and efficient care. In addition to expanding the multidisciplinary team to include a pharmacist, dietician, and social worker, the team redesign included: (1) medication reconciliation rounds, (2) care coordination rounds, and (3) multidisciplinary weekly handoff with outpatient providers...
June 8, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28591657/agc-kinases-mechanisms-of-regulation-%C3%A2-and-innovative-drug-development
#15
REVIEW
Alejandro E Leroux, Jörg Schulze, Ricardo M Biondi
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, and YANK, while two other families, Aurora and PLK, are the most closely related to the group. Eight of these families are physiologically activated downstream of growth factor signaling, while other AGC kinases are downstream effectors of a wide range of signals. The different AGC kinase families share aspects of their mechanisms of inhibition and activation...
June 4, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28587803/effects-of-moisture-content-of-food-waste-on-residue-separation-larval-growth-and-larval-survival-in-black-soldier-fly-bioconversion
#16
Jack Y K Cheng, Sam L H Chiu, Irene M C Lo
In order to foster sustainable management of food waste, innovations in food waste valorization technologies are crucial. Black soldier fly (BSF) bioconversion is an emerging technology that can turn food waste into high-protein fish feed through the use of BSF larvae. The conventional method of BSF bioconversion is to feed BSF larvae with food waste directly without any moisture adjustment. However, it was reported that difficulty has been experienced in the separation of the residue (larval excreta and undigested material) from the insect biomass due to excessive moisture...
June 3, 2017: Waste Management
https://www.readbyqxmd.com/read/28582693/analysis-of-the-pen-pressure-and-grip-force-signal-during-basic-drawing-tasks-the-timing-and-speed-changes-impact-drawing-characteristics
#17
Arthur Gatouillat, Antoine Dumortier, Subashan Perera, Youakim Badr, Claudine Gehin, Ervin Sejdić
Writing is a complex fine and trained motor skill, involving complex biomechanical and cognitive processes. In this paper, we propose the study of writing kinetics using three angles: the pen-tip normal force, the total grip force signal and eventually writing quality assessment. In order to collect writing kinetics data, we designed a sensor collecting these characteristics simultaneously. Ten healthy right-handed adults were recruited and were asked to perform four tasks: first, they were instructed to draw circles at a speed they considered comfortable; they then were instructed to draw circles at a speed they regarded as fast; afterwards, they repeated the comfortable task compelled to follow the rhythm of a metronome; and eventually they performed the fast task under the same timing constraints...
May 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28578220/development-of-disposable-membrane-hydrophones-for-a-frequency-range-from-1mhz-to-10mhz
#18
Jae-Wan Lee, Won-Suk Ohm, Yong-Tae Kim
A method for fabricating disposable membrane hydrophones is presented. The disposable hydrophones are intended for onetime use in such damaging environments as chemically contaminating fluids and high-amplitude (peak amplitude ∼100MPa) shock wave fields, where the use of commercial membrane hydrophones is not recommended. Fabrication of a hydrophone is done using only off-the-shelf components and hand tools, which translates into ease of fabrication and orders-of-magnitude reduction in unit cost. In particular, poling and sputtering, the two processes that are chiefly responsible for the cost and difficulty associated with the conventional fabrication method, are replaced with the use of pre-poled polyvinylidene fluoride (PVDF) films and polyethylene terephthalate (PET)-coated aluminum foils, respectively...
May 25, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28578190/correlation-between-dynamic-light-scattering-and-size-exclusion-high-performance-liquid-chromatography-for-monitoring-the-effect-of-ph-on-stability-of-biopharmaceuticals
#19
Medhat A Al-Ghobashy, Moushira M Mostafa, Heba S Abed, Faten A Fathalla, Maissa Y Salem
Aggregate formation is a major problem affecting both safety and efficacy of biopharmaceuticals and is associated with protein immunogenicity. Size exclusion high performance liquid chromatography (SE-HPLC) has always been the gold standard technique for detection and determination of protein aggregates. However, large protein aggregates may be filtered off and build up on top of the column leading to deterioration in column performance. Moreover, low-affinity protein aggregates may dissociate during analysis and thus not detected...
May 26, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28576543/pycnodysostosis-at-otorhinolaryngology
#20
Tekin Baglam, Adem Binnetoglu, Muhammet Fatih Topuz, Nilay Baş Ikizoglu, Refika Ersu, Serap Turan, Murat Sarı
AIM: Pycnodysostosis is a rare autosomal, recessive, skeletal dysplasia caused by a mutation in the cathepsin k gene. Pycnodysostosis is characterized by short stature, characteristic facial appearance (delayed closure of fontanelles and cranial sutures, mandibular hypoplasia and angle disorder, blue sclera), and acroosteolysis of the distal phalanges. Our aim was to describe the otorhinolaryngologic findings, differential diagnoses, various treatment options, and followup in eight cases of pycnodysostosis...
April 2017: International Journal of Pediatric Otorhinolaryngology
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