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https://www.readbyqxmd.com/read/28922169/app-based-bradykinesia-tasks-for-clinic-and-home-assessment-in-parkinson-s-disease-reliability-and-responsiveness
#1
Dustin A Heldman, Enrique Urrea-Mendoza, Lilia C Lovera, David A Schmerler, Xiomara Garcia, Mohammad E Mohammad, Maria Catalina U McFarlane, Joseph P Giuffrida, Alberto J Espay, Hubert H Fernandez
BACKGROUND: Clinical rating of bradykinesia in Parkinson disease (PD) is challenging as it must combine several movement features into a single score. Additionally, in-clinic assessment cannot capture fluctuations throughout the day. OBJECTIVE: To evaluate the reliability and responsiveness of a motion sensor-based tablet app for objective bradykinesia assessment in clinic and at home as compared to clinical ratings. METHODS: Thirty-two PD patients treated with subthalamic deep brain stimulation (DBS) were outfitted with a motion sensor on the index finger of the more affected hand to perform two repetitions of finger-tapping, hand opening-closing, and arm pronation-supination tasks with DBS on and 10, 20, and 30 minutes after turning DBS off...
September 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28917388/improvised-hand-injury-treatment-using-traditional-veterinary-medicine-in-ethiopia
#2
Raf Aerts, Eva J J November, Maissa Rayyan
In remote wilderness environments, local people with traditional knowledge of medicinal plants are potentially important first-line health care providers. We present a case of a 31-year-old man who fell off a horse while trekking through a remote mountain landscape in Ethiopia and sustained blunt force trauma to the hand. A local mountain hut keeper examined the patient's hand and used heated leaves of the succulent plant Kalanchoe petitiana to treat a suspected metacarpal fracture. As first responder in a low-resource setting, the hut keeper relied on his traditional knowledge of ethnoveterinary medicine to improvise a treatment for a human injury in a remote mountain environment...
September 13, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28915580/molecular-and-functional-characterization-of-a-new-3-end-kit-juxtamembrane-deletion-in-a-duodenal-gist-treated-with-neoadjuvant-imatinib
#3
Vittorio Perfetti, Erik Laurini, Suzana Aulić, Maurizio Fermeglia, Roberta Riboni, Marco Lucioni, Elena Dallera, Sara Delfanti, Luigi Pugliese, Francesco Saverio Latteri, Andrea Pietrabissa, Sabrina Pricl
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express the receptor tyrosine kinase KIT, and the majority of GISTs present KIT gain-of-function mutations that cluster in the 5' end of the receptor juxtamembrane domain. On the other hand, little information is known about GISTs carrying mutations in the 3' end of the KIT juxtamembrane domain. Here we report and discuss a clinical case of localized duodenal GIST whose molecular characterization revealed the presence of a new 21 nucleotide/7 amino acid deletion in the 3' end of KIT juxtamembrane domain (Δ574-580)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914519/inadequate-hand-off-communication
#4
(no author information available yet)
No abstract text is available yet for this article.
September 12, 2017: Sentinel Event Alert
https://www.readbyqxmd.com/read/28912216/a-cargo-sorting-dna-robot
#5
Anupama J Thubagere, Wei Li, Robert F Johnson, Zibo Chen, Shayan Doroudi, Yae Lim Lee, Gregory Izatt, Sarah Wittman, Niranjan Srinivas, Damien Woods, Erik Winfree, Lulu Qian
Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles...
September 15, 2017: Science
https://www.readbyqxmd.com/read/28910795/multidimensional-classification-of-dialysis-membranes
#6
Claudio Ronco, Mauro Neri, Anna Lorenzin, Francesco Garzotto, William R Clark
Hemodialysis is a process of mass separation by a semipermeable membrane, utilized to cleanse blood from waste products retained in case of kidney failure. Traditionally, dialysis membranes have been classified based on composition and hydraulic conductance, creating the net differentiation between cellulosic versus non-cellulosic on one hand and low-flux versus high-flux on the other. With the evolution of biomaterials and improved spinning technology, new membranes have been introduced in the market with specific characteristics and refined individual properties...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28902098/repair-of-the-thumb-ulnar-collateral-ligament-with-suture-tape-augmentation
#7
Anthony F De Giacomo, Steven S Shin
One of the most commonly injured structures of the thumb metacarpophalangeal (MCP) joint is the ulnar collateral ligament (UCL). An acute injury of this ligament is often amenable to primary repair. Despite the favorable outcomes of primary repair, the thumb is often restricted during initial healing of the ligament with immobilization and delayed rehabilitation. We present a novel technique to augment the repair of the UCL with suture tape to provide immediate biomechanical support and strength during the critical time of ligament healing...
September 8, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28900068/-efficacy-of-topical-agents-for-symptomatic-treatment-of-rotigotine-patch-induced-skin-disorders
#8
Yuki Yasutaka, Shinsuke Fujioka, Hirotomo Shibaguchi, Fumiaki Kiyomi, Koyomi Hara, Kentaro Ogata, Yoshio Tsuboi, Hidetoshi Kamimura
Since the effect of a percutaneous absorption-type dopamine agonist (DA) preparation, rotigotine patch, stably persists by once-a-day application, this dosage form is appropriate for Parkinson's disease patients showing levodopa induced wearing off phenomenon. On the other hand, skin disorders, mainly application site reaction, are characteristic problems associated with use of the patch. In this study, to clarify the influence of a topical agent used to prevent or treat rotigotine patch-induced skin disorder on continuation of the patch application, patients who started rotigotine patch application at our hospital were retrospectively surveyed...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28898602/parallel-patterns-of-host-specific-morphology-and-genetic-admixture-in-sister-lineages-of-a-commensal-barnacle
#9
Christine Ewers-Saucedo, Benny K K Chan, John D Zardus, John P Wares
Symbiotic relationships are often species specific, allowing symbionts to adapt to their host environments. Host generalists, on the other hand, have to cope with diverse environments. One coping strategy is phenotypic plasticity, defined by the presence of host-specific phenotypes in the absence of genetic differentiation. Recent work indicates that such host-specific phenotypic plasticity is present in the West Pacific lineage of the commensal barnacle Chelonibia testudinaria (Linnaeus, 1758). We investigated genetic and morphological host-specific structure in the genetically distinct Atlantic sister lineage of C...
June 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28894990/feeding-preference-and-daily-ration-of-12-dominant-copepods-on-mono-and-mixed-diets-of-phytoplankton-rotifers-and-detritus-in-a-tropical-coastal-water
#10
L Jagadeesan, R Jyothibabu, N Arunpandi, A Anjusha, S Parthasarathi, R S Pandiyarajan
Results of the experimental studies on the feeding habit and daily ration (DR) of 12 dominant copepods from a tropical coastal water (off Kochi, Southwest coast of India) on different food items (phytoplankton, rotifers, and detritus) are presented. Even though, all species of copepods consumed all types of food items in the experiments, they showed noticeable feeding preferences, having important ecological implications. Calanoid Paracalanus parvus and Acrocalanus gracilis consumed phytoplankton and rotifers equally in mono diets (74-89% of DR) and mixed diets (53-82% of DR), which indicated their ability to shift their diet in natural environment based on the availability of food items...
September 11, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28894913/european-otorhinolaryngology-training-programs-results-of-a-european-survey-about-training-satisfaction-work-environment-and-conditions-in-six-countries
#11
N Oker, Naif H Alotaibi, A C Reichelt, P Herman, M Bernal-Sprekelsen, Andreas E Albers
ORL-students and residents have an ongoing debate about the "best" programme in Europe. Aim of this study was to comparatively assess differences among programmes in training, satisfaction, quality of life (QoL) of residents and recent otorhinolaryngologist (ORL) specialists in France, Germany, Spain, Italy, Austria, and Belgium. A self-administered anonymous questionnaire, structured in ten sections including general information, provided guidance, working environment, training structure, teaching of medical students, publication work, QoL, and satisfaction with training, were emailed to residents and recent ORL specialists...
September 11, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28892637/functional-circuitry-on-commercial-fabric-via-textile-compatible-nanoscale-film-coating-process-for-fibertronics
#12
Hagyoul Bae, Byung Chul Jang, Hongkeun Park, Soo-Ho Jung, Hye Moon Lee, Jun-Young Park, Seung-Bae Jeon, Gyeongho Son, Il-Woong Tcho, Kyoungsik Yu, Sung Gap Im, Sung-Yool Choi, Yang-Kyu Choi
Fabric-based electronic textiles (e-textiles) are the fundamental components of wearable electronic systems, which can provide convenient hand-free access to computer and electronics applications. However, e-textile technologies presently face significant technical challenges. These challenges include difficulties of fabrication due to the delicate nature of the materials, and limited operating time, a consequence of the conventional normally on computing architecture, with volatile power-hungry electronic components, and modest battery storage...
September 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28890457/healing-animals-in-an-antibiotic-age-veterinary-drugs-and-the-professionalism-crisis-1945-1970
#13
Kendra Smith-Howard
Between 1945 and 1970, the introduction of antibiotics in agriculture forced veterinarians to articulate the boundaries of their professional identity. While veterinarians welcomed the new aid to arrest infectious diseases of livestock, they worried as farmers took animal healing into their own hands without veterinary supervision, and resented the competition from retail outlets that sold the drugs. Veterinary antibiotics also set off heated debates within the field about whether the profession should position itself as preventers or healers of disease, debates that were akin to the kinds of professional discourses among physicians and pharmacists in the same period...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28886450/driving-performance-at-lateral-system-limits-during-partially-automated-driving
#14
Frederik Naujoks, Christian Purucker, Katharina Wiedemann, Alexandra Neukum, Stefan Wolter, Reid Steiger
This study investigated driver performance during system limits of partially automated driving. Using a motion-based driving simulator, drivers encountered different situations in which a partially automated vehicle could no longer safely keep the lateral guidance. Drivers were distracted by a non-driving related task on a touch display or driving without an additional secondary task. While driving in partially automated mode drivers could either take their hands off the steering wheel for only a short period of time (10s, so-called 'Hands-on' variant) or for an extended period of time (120s, so-called 'Hands-off' variant)...
September 5, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28883640/a-somatotopic-bidirectional-hand-prosthesis-with-transcutaneous-electrical-nerve-stimulation-based-sensory-feedback
#15
Edoardo D'Anna, Francesco M Petrini, Fiorenzo Artoni, Igor Popovic, Igor Simanić, Stanisa Raspopovic, Silvestro Micera
According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, and their long-term usability still needs to be fully investigated. Here, we developed a non-invasive alternative which maintains some of the advantages of invasive approaches, such as a somatotopic sensory restitution scheme. We used transcutaneous electrical nerve stimulation (TENS) to induce referred sensations to the phantom hand of amputees...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878042/interactions-of-the-bacillus-subtilis-dnae-polymerase-with-replisomal-proteins-modulate-its-activity-and-fidelity
#16
Vasileios Paschalis, Emmanuelle Le Chatelier, Matthew Green, François Képès, Panos Soultanas, Laurent Janniere
During Bacillus subtilis replication two replicative polymerases function at the replisome to collectively carry out genome replication. In a reconstituted in vitro replication assay, PolC is the main polymerase while the lagging strand DnaE polymerase briefly extends RNA primers synthesized by the primase DnaG prior to handing-off DNA synthesis to PolC. Here, we show in vivo that (i) the polymerase activity of DnaE is essential for both the initiation and elongation stages of DNA replication, (ii) its error rate varies inversely with PolC concentration, and (iii) its misincorporations are corrected by the mismatch repair system post-replication...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28874896/phase-i-ii-trial-of-dose-reduced-capecitabine-in-elderly-patients-with-advanced-colorectal-cancer
#17
M D Vincent, D Breadner, M C Cripps, D J Jonker, P Klimo, J J Biagi, W Lam, A O'Connell, F Whiston, L Stitt, S A Welch
BACKGROUND: Combination chemotherapy is associated with improved outcomes in trials of selected fit patients with advanced colorectal cancer (acrc). For older or less-fit patients, combination chemotherapy is associated with greater toxicity and less benefit. Capecitabine monotherapy is a reasonable option for those patients, but the optimal dose remains controversial. METHODS: A multicentre phase i/ii trial of reduced-dose capecitabine (2000 mg/m(2), days 1-14 every 21 days) was conducted in 221 patients representing one or more of the following subsets: age greater than 65 years (n = 167), Eastern Cooperative Oncology Group (ecog) performance status of 1 or greater (n = 139), elevated lactate dehydrogenase (ldh) (n = 105), or prior pelvic radiation (n = 54)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28870921/significance-of-circulating-galectin-3-in-patients-with-pancreatobiliary-cancer
#18
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Yasuhide Kofunato, Ryo Okada, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Koji Kono, Shigeru Marubashi
BACKGROUND/AIM: Pancreatobiliary cancer is a disease associated with a dismal prognosis and limited treatment options. The aim of the present study was to clarify the usefulness of circulating galectin-3 in pancreatobiliary cancer. PATIENTS AND METHODS: We examined serum galectin-3 concentrations in 45 patients with pancreatobiliary cancer. Receiver operating characteristic curves were utilized to evaluate the accuracy of circulating galectin-3 to discriminate pancreatobiliary cancer patients from controls and predict the prognostic outcomes...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870129/intra-articular-distal-radius-fractures-in-elderly-a-randomized-prospective-study-of-casting-versus-volar-plating
#19
Daniel Martinez-Mendez, Alejandro Lizaur-Utrilla, Joaquin de-Juan-Herrero
We compared outcomes in elderly patients with intra-articular distal radius fractures treated by closed reduction and plaster immobilization or open reduction and internal fixation with a volar plate. Ninety-seven patients older than 60 years were randomly allocated to conservative (47 patients) or surgical (50 patients) treatment. Over a 2-year period, we assessed patient-rated wrist evaluation score, DASH (disability arm, shoulder and hand) questionnaire, pain, wrist range of motion, grip strength, and radiological parameters...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28870077/interplay-of-nanoscale-hybrid-p3ht-zto-interface-on-optoelectronics-and-photovoltaic-cells
#20
Jian-Jhong Lai, Yu-Hsun Li, Bo-Rui Feng, Shiow-Jing Tang, Wen-Bin Jian, Chuan-Min Fu, Jiun-Tai Chen, Xu Wang, Pooi-See Lee
Photovoltaic effects in poly(3-hexylthiophene-2,5-diyl) (P3HT) attract much attention recently. Here natively p-type doped P3HT nanofibers and n-type doped zinc tin oxide (ZTO) nanowires are used for making not only field-effect transistors but also p-n nanoscale diodes. The hybrid P3HT/ZTO p-n heterojunction shows applications in many directions and it also facilitates the investigation of photoelectrons and photovoltaic effects at the nanoscale. As for applications, the heterojunction device shows simultaneously high on/off ratio of n- and p-type field-effect transistors, gatable p-n junction diodes, tri-state buffer device, gatable photodetectors, and gatable solar cells...
September 5, 2017: ACS Applied Materials & Interfaces
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