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https://www.readbyqxmd.com/read/28814043/design-of-a-wearable-interface-for-lightweight-robotic-arm-for-people-with-mobility-impairments
#1
Tommaso Lisini Baldi, Giovanni Spagnoletti, Mihai Dragusanu, Domenico Prattichizzo
Many common activities of daily living like open a door or fill a glass of water, which most of us take for granted, could be an insuperable problem for people who have limited mobility or impairments. For years the unique alternative to overcame this limitation was asking for human help. Nowadays thanks to recent studies and technology developments, having an assistive devices to compensate the loss of mobility is becoming a real opportunity. Off-the-shelf assistive robotic manipulators have the capability to improve the life of people with motor impairments...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813803/application-of-support-vector-machines-in-detecting-hand-grasp-gestures-using-a-commercially-off-the-shelf-wireless-myoelectric-armband
#2
Farshid Amirabdollahian, Michael L Walters
The propose of this study was to assess the feasibility of using support vector machines in analysing myoelectric signals acquired using an off the shelf device, the Myo armband from Thalmic Lab, when performing hand grasp gestures. Participants (n = 26) took part in the study wearing the armband and producing a series of required gestures. Support vector machines were used to train a model using participant training values, and to classify gestures produced by the same participants. Different Kernel functions and electrode combinations were studied...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28810960/talk-to-the-hand-u-s-army-biophysical-testing
#3
William R Santee, Adam W Potter, Karl E Friedl
BACKGROUND: Many people are unaware of the science underlying the biophysical properties of Soldier clothing and personal protective equipment, yet there is a well-refined biomedical methodology initiated by Army physiologists in World War II. This involves a methodical progression of systematic material testing technologies, computer modeling, and human testing that enables more efficient development and rapid evaluation of new concepts for Soldier health and performance. Sophisticated manikins that sweat and move are a central part of this testing continuum...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808577/transition-from-intravenous-to-enteral-ketamine-for-treatment-of-nonconvulsive-status-epilepticus
#4
Michael A Pizzi, Prasuna Kamireddi, William O Tatum, Jerry J Shih, Daniel A Jackson, William D Freeman
BACKGROUND: Nonconvulsive status epilepticus (NCSE) is a diagnosis that is often challenging and one that may progress to refractory NCSE. Ketamine is a noncompetitive N-methyl-d-aspartate antagonist that increasingly has been used to treat refractory status epilepticus. Current Neurocritical Care Society guidelines recommend intravenous (IV) ketamine infusion as an alternative treatment for refractory status epilepticus in adults. On the other hand, enteral ketamine use in NCSE has been reported in only 6 cases (1 adult and 5 pediatric) in the literature to date...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28807986/a-turbine-driven-ventilator-improves-adherence-to-advanced-cardiac-life-support-guidelines-during-a-cardiopulmonary-resuscitation-simulation
#5
Scott G Allen, Lara Brewer, Erik S Gillis, Nathan L Pace, Derek J Sakata, Joseph A Orr
BACKGROUND: Research has shown that increased breathing frequency during cardiopulmonary resuscitation is inversely correlated with systolic blood pressure. Rescuers often hyperventilate during cardiopulmonary resuscitation (CPR). Current American Heart Association advanced cardiac life support recommends a ventilation rate of 8 -10 breaths/min. We hypothesized that a small, turbine-driven ventilator would allow rescuers to adhere more closely to advanced cardiac life support (ACLS) guidelines...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28806632/clinical-utility-of-serum-lactate-levels-for-differential-diagnosis-of-generalized-tonic-clonic-seizures-from-psychogenic-nonepileptic-seizures-and-syncope
#6
Ebru Apaydın Doğan, Ali Ünal, Aslıhan Ünal, Çağla Erdoğan
BACKGROUND: The differential diagnosis of generalized tonic-clonic seizures (GTCS), psychogenic nonepileptic seizures (PNES), and syncope constitutes a major challenge. Misdiagnosis rates up to 20 to 30% are reported in the literature. PURPOSE: To assess the clinical utility of serum lactate levels for differentiation of GTCS, PNES, and syncope based on gender differences. METHODS: Data from 270 patients were evaluated retrospectively. Only patients ≥18 years old with the final diagnosis of GTCS, PNES, or syncope in their chart were recruited...
August 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28796170/slippage-detection-with-piezoresistive-tactile-sensors
#7
Rocco A Romeo, Calogero M Oddo, Maria Chiara Carrozza, Eugenio Guglielmelli, Loredana Zollo
One of the crucial actions to be performed during a grasping task is to avoid slippage. The human hand can rapidly correct applied forces and prevent a grasped object from falling, thanks to its advanced tactile sensing. The same capability is hard to reproduce in artificial systems, such as robotic or prosthetic hands, where sensory motor coordination for force and slippage control is very limited. In this paper, a novel algorithm for slippage detection is presented. Based on fast, easy-to-perform processing, the proposed algorithm generates an ON/OFF signal relating to the presence/absence of slippage...
August 10, 2017: Sensors
https://www.readbyqxmd.com/read/28794667/mbarara-university-research-training-initiative-a-spin-off-of-the-medical-education-partnership-initiative-in-uganda
#8
Edith Wakida, Samuel Maling, Celestino Obua
Scientific productivity in Africa is insignificant compared to that in the rest of the world. This has been attributed to the fact that, in spite of academic qualifications, junior faculty, who form the majority of academics in low- and middle-income countries lack experience in research. This calls for a need to put in place programs that provide hands-on training in research so that junior faculty can conduct relevant research. The Mbarara University Research Training Initiative, a Fogarty International Center-funded program, is one such program that was developed to provide research capacity training for junior faculty at the Mbarara University of Science and Technology...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28790016/tau-imaging-in-neurodegeneration
#9
REVIEW
Gérard N Bischof, Heike Endepols, Thilo van Eimeren, Alexander Drzezga
Pathological cerebral aggregations of proteins are suggested to play a crucial role in the development of neurodegenerative disorders. For example, aggregation of the protein ß-amyloid in form of extracellular amyloid-plaques as well as intraneuronal depositions of the protein tau in form of neurofibrillary tangles represent hallmarks of Alzheimer's disease (AD). Recently, novel tracers for in vivo molecular imaging of tau-aggregates in the brain have been introduced, complementing existing tracers for imaging amyloid-plaques...
August 5, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28777300/a-visual-based-approach-for-indoor-radio-map-construction-using-smartphones
#10
Tao Liu, Xing Zhang, Qingquan Li, Zhixiang Fang
Localization of users in indoor spaces is a common issue in many applications. Among various technologies, a Wi-Fi fingerprinting based localization solution has attracted much attention, since it can be easily deployed using the existing off-the-shelf mobile devices and wireless networks. However, the collection of the Wi-Fi radio map is quite labor-intensive, which limits its potential for large-scale application. In this paper, a visual-based approach is proposed for the construction of a radio map in anonymous indoor environments...
August 4, 2017: Sensors
https://www.readbyqxmd.com/read/28776654/the-latency-complex-the-dead-hand-of-anti-development
#11
Barry D Proner
It is common knowledge that the same phenomena can be viewed in a variety of ways. This paper considers the implications of a constellation observed in some adult patients who have increasingly reminded the author of some of the children of latency age with whom he has also worked. In the literature these patients may also have been thought about in terms of 'defences of the self' (Fordham), patients who are 'difficult to reach' (Joseph), 'psychic retreats' (Steiner), and those who make 'attacks on linking' (Bion)...
September 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28774178/quantized-transport-strain-induced-perfectly-conducting-modes-and-valley-filtering-on-shape-optimized-graphene-corbino-devices
#12
Gareth W Jones, Dario Andres Bahamon, Antonio H Castro Neto, Vitor M Pereira
The extreme mechanical resilience of graphene and the peculiar coupling it hosts between lattice and electronic degrees of freedom have spawned a strong impetus toward strain-engineered graphene where, on the one hand, strain augments the richness of its phenomenology and makes possible new concepts for electronic devices, and on the other hand, new and extreme physics might take place. Here, we demonstrate that the shape of substrates supporting graphene sheets can be optimized for approachable experiments where strain-induced pseudomagnetic fields (PMF) can be tailored by pressure for directionally selective electronic transmission and pinching-off of current flow down to the quantum channel limit...
August 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/28766068/pediatric-soft-tissue-sarcoma-of-the-limbs-clinical-outcome-of-97-patients
#13
Andrea Sambri, Giuseppe Bianchi, Ilaria Cucurnia, Marco Gambarotti, Davide Maria Donati
PURPOSE: Soft tissue sarcomas (STS) of the extremities in children are a heterogeneous group of tumors with a very different prognosis for which optimal treatment remains controversial. PATIENTS AND METHODS: We retrospectively evaluated 97 patients younger than 15 years old affected by limb soft tissue sarcomas. All cases were histologically revised, and tumor grade was assessed according to the FNLCC system. Thirty-two were rhabdomyosarcoma (RMS) and 65 non-rhabdomyosarcoma (NRMSTS); among these, 40 (61...
August 1, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28762380/rasch-measurement-properties-of-the-pain-medication-questionnaire-in-persons-with-spinal-cord-injury
#14
B N Hand, C A Velozo, J S Krause
STUDY DESIGN: Secondary analysis of cross-sectional population-based self-report data. OBJECTIVE: To determine how well the Pain Medication Questionnaire (PMQ) measures risk of pain medication misuse and its precision in separating individuals with spinal cord injury (SCI) into meaningful classification categories. SETTING: Academic medical center in Southeastern United States. METHODS: Data were collected from a population-based registry of SCI (n=971)...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28750681/drug-induced-amino-acid-deprivation-as-strategy-for-cancer-therapy
#15
REVIEW
Marcus Kwong Lam Fung, Godfrey Chi-Fung Chan
Cancer is caused by uncontrollable growth of neoplastic cells, leading to invasion of adjacent and distant tissues resulting in death. Cancer cells have specific nutrient(s) auxotrophy and have a much higher nutrient demand compared to normal tissues. Therefore, different metabolic inhibitors or nutrient-depleting enzymes have been tested for their anti-cancer activities. We review recent available laboratory and clinical data on using various specific amino acid metabolic pathways inhibitors in treating cancers...
July 27, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28750493/concomitant-semi-quantitative-and-visual-analysis-improves-the-predictive-value-on-treatment-outcome-of-interim-18f-fluorodeoxyglucose-positron-emission-tomography-in-advanced-hodgkin-lymphoma
#16
Alberto Biggi, Fabrizio Bergesio, Stephane Chauvie, Andrea Bianchi, Massimo Menga, Federico Fallanca, Martin Hutchings, Michele Gregianin, Michel Meignan, Andrea Gallamini
BACKGROUND: Qualitative assessment using the Deauville five-point scale (DS) is the gold standard for interim and end-of treatment PET interpretation in lymphoma. In the present study we assessed the reliability and the prognostic value of different semi- quantitative (SQ) parameters in comparison with DS for interim PET (iPET) interpretation in Hodgkin lymphoma (HL). METHODS: A cohort of 82 out of 260 patients with advanced stage HL enrolled in the International Validation Study (IVS), scored as 3 to 5 by the expert panel was included in the present report...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28746915/molecular-and-functional-characterization-of-a-new-3-end-kit-juxtamembrane-deletion-in-a-duodenal-gist-treated-with-neoadjuvant-imatinib
#17
Vittorio Perfetti, Erik Laurini, Suzana Aulić, Maurizio Fermeglia, Roberta Riboni, Marco Lucioni, Elena Dallera, Sara Delfanti, Luigi Pugliese, Francesco Saverio Latteri, Andrea Pietrabissa, Sabrina Pricl
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express the receptor tyrosine kinase KIT, and the majority of GISTs present KIT gain-of-function mutations that cluster in the 5' end of the receptor juxtamembrane domain. On the other hand, little information is known about GISTs carrying mutations in the 3' end of the KIT juxtamembrane domain. Here we report and discuss a clinical case of localized duodenal GIST whose molecular characterization revealed the presence of a new 21 nucleotide/7 amino acid deletion in the 3' end of KIT juxtamembrane domain (Δ574-580)...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743570/chemical-structure-and-anti-inflammatory-effect-of-polysaccharides-obtained-from-infusion-of-sedum-dendroideum-leaves
#18
Ana Flávia de Oliveira, Geórgia Erdmann do Nascimento, Marcello Iacomini, Lucimara Mach Côrtes Cordeiro, Thales Ricardo Cipriani
Sedum dendroideum is popularly known as balsam and used for treatment of inflammatory disorders. Two polysaccharides (RSBAL-H2O and RSBAL-0.5) were isolated from infusion of its dried leaves, using dialysis at 100kDa cut-off membrane and anion exchange chromatography. Methylation and NMR analyses showed that RSBAL-H2O is a highly methyl-esterified homogalacturonan, constituted by (1→4)-α-D-GalA residues, whereas RSBAL-0.5 is a highly methyl-esterified homogalacturonan branched at O-3, probably by type II arabinogalactans and arabinans...
July 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28743247/a-randomized-phase-ii-study-of-paclitaxel-alone-versus-paclitaxel-plus-sorafenib-in-second-and-third-line-treatment-of-patients-with-her2-negative-metastatic-breast-cancer-paso
#19
Thomas Decker, Friedrich Overkamp, Siegfried Rösel, Arnd Nusch, Thomas Göhler, Martin Indorf, Jörg Sahlmann, Tanja Trarbach
BACKGROUND: We conducted an open-label, randomized, two-arm multi-center study to assess the efficacy and safety of paclitaxel versus paclitaxel + sorafenib in patients with locally advanced or metastatic HER2-negative breast cancer. METHODS: Patients were randomly assigned to receive either paclitaxel monotherapy (80 mg/m(2)) weekly (3 weeks on, 1 week off) plus sorafenib 400 mg orally, twice a day taken continuously throughout 28 day cycles. Sorafenib dose was gradually escalated from a starting dose of 200 mg twice a day...
July 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28742346/molecular-dynamics-of-double-stranded-xylo-nucleic-acid-xylona
#20
Amutha Ramaswamy, Daryna Smyrnova, Mattheus Froeyen, Mohitosh Maiti, Piet Herdewijn, Arnout Ceulemans
Xylo-nucleic acid (XyloNA) is a synthetic analogue of ribo-nucleic acid (RNA), where the ribose sugar has been replaced by xylose. We present a Molecular Dynamics study of the conformational evolution of XyloNA double strand oligomers derived from A-RNA through the substitution of beta-ᴅ-ribofuranose by beta-ᴅ-xylofuranose and having lengths of 8, 16 and 29 base pairs, using a set of independent all-atom simulations performed at various time scales ranging from 55 to 100 ns, , with one long 500 ns simulation of the 29-mer...
July 25, 2017: Journal of Chemical Theory and Computation
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