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Cardiometabolic

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https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#1
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938440/sex-differences-in-the-hormonal-and-metabolic-response-to-dietary-protein-dilution
#2
Karlton R Larson, Kimberly A Russo, Yanbin Fang, Niloufar Mohajerani, Michael L Goodson, Karen K Ryan
Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein 'dilution' has been explained by resource-mediated trade-offs between reproduction and survival, such that fecundity is optimized at a greater relative intake of proteins:carbohydrates. The magnitude of this trade-off is thought to be sex-dependent. Here, we tested the hypothesis that metabolic responses to dietary protein dilution are likewise dependent on sex...
August 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938406/ct-derived-body-fat-distribution-and-incident-cardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#3
Morgana L Mongraw-Chaffin, Matthew A Allison, Gregory L Burke, Michael H Criqui, Kunihiro Matsushita, Pamela Ouyang, Ravi V Shah, Christina M Shay, Cheryl A M Anderson
Background: Visceral fat has been shown to be associated with increased cardiometabolic risk, but the role of subcutaneous fat remains unclear, and evidence from diverse populations is lacking. We hypothesized that visceral, but not subcutaneous fat, would be independently associated with incident cardiovascular disease and all-cause mortality. Methods: Among 1,910 participants from the Multi-Ethnic Study of Atherosclerosis with abdominal fat measurements from computed tomography (CT) scans and followed for an average of 9...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937860/association-of-adamts4-and-adamts9-levels-with-cardiovascular-risk-in-patients-with-primary-hyperparathyroidism
#4
Melia Karakose, Mustafa Caliskan, Muyesser Sayki Arslan, Taner Demirci, Suleyman Karakose, Esra Tutal, Erman Cakal
PURPOSE: Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a critical role in atherosclerosis. This study aimed to investigate the levels of ADAMTS4 and ADAMTS9 and relationship between these proteoglycanases and cardiometabolic abnormalities in PHPT...
September 22, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28936414/the-health-benefits-and-constraints-of-exercise-therapy-for-wheelchair-users-a-clinical-commentary
#5
Terry J Ellapen, Henriëtte V Hammill, Mariette Swanepoel, Gert L Strydom
BACKGROUND: There are approximately 1 billion people living with chronic lower limb disability, many of whom are wheelchair users. OBJECTIVES: Review cardiometabolic and neuromuscular risk profiles of wheelchair users, benefits of regular exercise and the causes of neuromuscular upper limb and hip injuries that hinder regular adherence. METHOD: Literature published between 2013 and 2017 was adopted according to the standard practices for systematic reviews (PRISMA) through Crossref Metadata and Google Scholar searches...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28935142/association-between-neck-and-wrist-circumferences-and-cardiometabolic-risk-in-children-and-adolescents-the-caspian-v-study
#6
Roya Kelishadi, Motahar Heidari-Beni, Mostafa Qorbani, Nazgol Motamed-Gorji, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Ramin Heshmat
OBJECTIVE: The predictive potentials of neck and wrist circumferences for cardiometabolic risks in children and adolescents remain to be determined. The aim of this study was to evaluate the association of neck and wrist circumferences with some cardiometabolic risk factors in children and adolescents. METHODS: This multicenter study was conducted during the 2014 to 2015 school year with 4200 children and adolescents ages 7 to 18 y. The children were selected by multistage cluster sampling from 30 provinces of Iran...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28934720/prenatal-exposure-to-perfluoroalkyl-substances-and-cardiometabolic-risk-in-children-from-the-spanish-inma-birth-cohort-study
#7
Cyntia B Manzano-Salgado, Maribel Casas, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, David Martinez, Dora Romaguera, Silvia Fernández-Barrés, Loreto Santa-Marina, Mikel Basterretxea, Thomas Schettgen, Damaskini Valvi, Jesus Vioque, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester)...
September 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934524/associations-of-sleep-duration-and-disturbances-with-hypertension-in-metropolitan-cities-of-delhi-chennai-and-karachi-in-south-asia-cross-sectional-analysis-of-the-carrs-study
#8
Roopa Shivashankar, Dimple Kondal, Mohammed K Ali, Ruby Gupta, Rajendra Pradeepa, Viswanathan Mohan, Muhammad Masood Kadir, K M Venkat Narayan, Nikhil Tandon, Dorairaj Prabhakaran, Anne Peasey
Objectives: Sleep duration and disturbances may be risk factors for hypertension. Despite the high burden of hypertension in South Asia, little is known about this relationship in this region. Methods: We analyzed population-level cross-sectional data from the Centre for Cardiometabolic Risk Reduction in South Asia (CARRS) study that recruited representative samples of adults ≥ 20 years from three cities-Delhi, Chennai (India), and Karachi (Pakistan) during 2010-2011...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28933565/sleep-duration-nightshift-work-and-the-timing-of-meals-and-urinary-levels-of-8-isoprostane-and-6-sulfatoxymelatonin-in-japanese-women
#9
Chisato Nagata, Takashi Tamura, Keiko Wada, Kie Konishi, Yuko Goto, Yasuko Nagao, Kazuhiro Ishihara, Satoru Yamamoto
It has been hypothesized that disruption of circadian rhythms affects human health. Shift work and sleep deprivation are thought to disrupt the normal light-dark cycle, although the disruption due to shiftwork may be dependent on sleep deprivation. Both conditions have been suggested to be associated with an increased risk of cardiometabolic disorders. Non-photic environmental factors, such as the timing of eating, are also thought to regulate circadian rhythm and thus, may have effects on health, but the evidence from human studies is scarce...
September 21, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28932598/the-effects-of-socioeconomic-determinants-on-hypertension-in-a-cardiometabolic-at-risk-european-country
#10
Sarah Cuschieri, Josanne Vassallo, Neville Calleja, Nikolai Pace, Julian Mamo
BACKGROUND: A relationship has been established between socioeconomic status and hypertension. The aim of this study was to determine the prevalence of hypertension and to explore the links between hypertension and socioeconomic factors in the adult population of Malta. METHODS: A national representative cross-sectional health examination study was performed between 2014 and 2016. Sociodemographic and medical history data was gathered by validated questionnaires while blood pressure was measured...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/28931588/a-25-hydroxycholecalciferol-fortified-dairy-drink-is-more-effective-at-raising-a-marker-of-postprandial-vitamin-d-status-than-cholecalciferol-in-men-with-suboptimal-vitamin-d-status
#11
Jing Guo, Kim G Jackson, Che Suhaili Binti Che Taha, Yue Li, David I Givens, Julie A Lovegrove
Background: One strategy for improving population vitamin D status is consumption of fortified foods. However, the effects of dairy products fortified with different vitamin D isoforms on postprandial vitamin D status and metabolic outcomes have not been addressed.Objective: We investigated whether consumption of dairy drinks fortified with either 25-hydroxycholecalciferol [25(OH)D3] or cholecalciferol (vitamin D3) had differential effects on 24-h circulating plasma 25(OH)D3 concentration (a marker of vitamin D status) and cardiometabolic risk markers...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28931409/clinical-review-of-24-35%C3%A2-year-olds-conceived-with-and-without-in-vitro-fertilization-study-protocol
#12
Sharon Lewis, Joanne Kennedy, David Burgner, Robert McLachlan, Sarath Ranganathan, Karin Hammarberg, Richard Saffery, David J Amor, Michael M H Cheung, Lex W Doyle, Markus Juonala, Susan Donath, John McBain, Jane Halliday
BACKGROUND: Children conceived by assisted reproductive technologies (ART) currently comprise 4% of Australian births. The manipulation of biological parameters related to fertilization and implantation are integral to successful ART but potentially pose a risk to the longer-term health of the offspring. There is consensus that many common adult health problems (particularly cardiovascular, metabolic and respiratory conditions) have their origins in early life, possibly before birth, and that risk trajectories track through childhood until clinical disease manifests in adulthood...
September 20, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28931017/trends-in-medication-use-by-body-mass-index-and-age-between-1988-and-2012-in-the-united-states
#13
Arshdeep K Randhawa, Jash S Parikh, Jennifer L Kuk
OBJECTIVE: Whether the increase in prescription medication use over time differs by age and obesity status is unclear. METHOD: National Health and Nutrition Examination Survey (NHANES) between 1988 and 2012 was analyzed (n = 57,543). FINDINGS: Increased medication use over time was seen in older individuals of all body mass index (BMI) classes, with the most prominent increase in those with obesity (p<0.001). For example, older men (≥65y) with obesity took 3...
2017: PloS One
https://www.readbyqxmd.com/read/28930524/hypertension-and-cardiometabolic-disease
#14
Ivan Tasic, Dragan Lovic
Hypertension has  a central role in cardiometabolic disease and is usually associated with  metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase cardiovascular (CV) risk through its promotion of hypertension, which is possibly a result of chronic enhancement of sympathetic nervous system activity, stimulation of the renin-angiotensin-aldosterone system leading to increased renal tubular sodium reabsorption, modulating cation transport, or inducing vascular smooth muscle cell hypertrophy...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28929633/symposium-vasopressin-novel-roles-for-an-old-hormone-emerging-therapies-in-cardiometabolic-and-renal-diseases
#15
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28929632/vasopressin-novel-roles-for-a-new-hormone-emerging-therapies-in-cardiometabolic-and-renal-diseases
#16
O Melander
No abstract text is available yet for this article.
October 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28928306/correlates-of-cardiometabolic-risk-factors-among-women-of-an-ethnic-tribal-community-of-tripura
#17
Purnajita Sen, Sandeep Das, Dipayan Choudhuri
Cardiometabolic health status of 356 women (age 25-65 years) from Tripuri tribal community of Tripura, a Northeastern state of India was evaluated. The height, weight, waist, hip circumference and blood pressure, blood sugar, total cholesterol, triglyceride; high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol were recorded. Cardiometabolic risk was assessed according to the recent definition for Asian Indians. The overall prevalence of cardiometabolic risk was found to be 27...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28928169/individual-serum-saturated-fatty-acids-and-markers-of-chronic-subclinical-inflammation-the-insulin-resistance-atherosclerosis-study-iras
#18
Ingrid D Santaren, Steven M Watkins, Angela D Liese, Lynne E Wagenknecht, Marian J Rewers, Steven M Haffner, Carlos Lorenzo, Andreas Festa, Richard P Bazinet, Anthony J Hanley
Recent evidence has documented distinct effects of individual saturated fatty acids (SFA) on cardiometabolic outcomes, with potential protective effects from odd- and very long-chain (VLSFA) SFA. Cross-sectional and prospective associations of individual serum SFA (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the Insulin Resistance Atherosclerosis Study (IRAS). Principal components (PC) analysis of proinflammatory markers yielded 3 clusters: PC 1: fibrinogen, white cell count, CRP; PC 2: PAI-1, TNF-α; IL-18; PC 3: IL-6, IL-8...
September 19, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28927573/sex-differences-in-early-life-programming-of-the-hypothalamic-pituitary-adrenal-axis-in-humans
#19
REVIEW
Robert M Gifford, Rebecca M Reynolds
Increasing evidence supports fetal glucocorticoid exposure with associated altered offspring hypothalamic-pituitary-adrenal (HPA) axis activity as a key mechanism linking early life events with later life disease. Alterations in HPA axis activity are linked to a range of cardiometabolic and psychiatric diseases. As many of these diseases manifest sex differences in presentation we review the evidence for programmed sex-differences in the HPA axis. Available literature suggests vulnerability of the female HPA axis to prenatal stressors with female offspring demonstrating increased HPA axis reactivity...
September 15, 2017: Early Human Development
https://www.readbyqxmd.com/read/28927181/relationship-of-depression-screening-in-cardiometabolic-disease-with-vascular-events-and-mortality-findings-from-a-large-primary-care-cohort-with-4-years-follow-up
#20
Bhautesh Dinesh Jani, Charles Boachie, Colin McCowan, Sarah J E Barry, Jonathan Cavanagh, Frances S Mair
Aims: Benefits of routine depression screening for cardiometabolic disease patients remain unclear. We examined the association between depression screening and all-cause mortality and vascular events in cardiometabolic disease patients. Methods and results: 125 143 patients with cardiometabolic diseases (coronary heart disease, diabetes or previous stroke) in the UK participated in primary care chronic disease management in 2008/09, which included depression screening using the Hospital Anxiety and Depression Score...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
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