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https://www.readbyqxmd.com/read/28527859/tackling-influenza-with-broadly-neutralizing-antibodies
#1
REVIEW
Davide Corti, Elisabetta Cameroni, Barbara Guarino, Nicole L Kallewaard, Qing Zhu, Antonio Lanzavecchia
Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses...
May 18, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28469033/a-highly-potent-extended-half-life-antibody-as-a-potential-rsv-vaccine-surrogate-for-all-infants
#2
Qing Zhu, Jason S McLellan, Nicole L Kallewaard, Nancy D Ulbrandt, Susan Palaszynski, Jing Zhang, Brian Moldt, Anis Khan, Catherine Svabek, Josephine M McAuliffe, Daniel Wrapp, Nita K Patel, Kimberly E Cook, Bettina W M Richter, Patricia C Ryan, Andy Q Yuan, JoAnn A Suzich
Prevention of respiratory syncytial virus (RSV) illness in all infants is a major public health priority. However, no vaccine is currently available to protect this vulnerable population. Palivizumab, the only approved agent for RSV prophylaxis, is limited to high-risk infants, and the cost associated with the requirement for dosing throughout the RSV season makes its use impractical for all infants. We describe the development of a monoclonal antibody as potential RSV prophylaxis for all infants with a single intramuscular dose...
May 3, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28379575/no-transfer-of-pressure-to-adjacent-discs-during-human-low-pressure-controlled-discography-a-prospective-clinical-study
#3
Jan Willem Kallewaard, José W Geurts, Michel Terheggen, Chris Terwiel, Alfons Kessels, Maarten van Kleef, Paul C Willems
Background. : A substantial part of low back pain (LBP) originates from degeneration of the intervertebral disc. To confirm the diagnosis of discogenic pain, provocation discography seems the best available tool. However, provocation discography is also considered to be a controversial and subjective test because the patient's personal pain response is the most crucial for the result of the test. Recently, an in vivo porcine study and a study in nine human subjects showed passing of pressure to the adjacent discs during discography...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27723170/systematic-review-of-patient-history-and-physical-examination-to-diagnose-chronic-low-back-pain-originating-from-the-facet-joints
#4
REVIEW
E T Maas, J N S Juch, R W J G Ostelo, J G Groeneweg, J W Kallewaard, B W Koes, A P Verhagen, F J P M Huygen, M W van Tulder
Patient history and physical examination are frequently used procedures to diagnose chronic low back pain (CLBP) originating from the facet joints, although the diagnostic accuracy is controversial. The aim of this systematic review is to determine the diagnostic accuracy of patient history and/or physical examination to identify CLBP originating from the facet joints using diagnostic blocks as reference standard. We searched MEDLINE, EMBASE, CINAHL, Web of Science and the Cochrane Collaboration database from inception until June 2016...
March 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27471961/broadening-horizons-new-antibodies-against-influenza
#5
COMMENT
Katherine J L Jackson, Scott D Boyd
Seasonal influenza vaccine formulation efforts struggle to keep up with viral antigenic variation. Two studies now report engineered or naturally occurring human antibodies targeting the influenza hemagglutinin (HA) stem, with exceptional neutralizing breadth (Joyce et al., 2016; Kallewaard et al., 2016). Antibodies with similar structural features are elicited in multiple subjects, suggesting that modified vaccine regimens could provide broad protection.
July 28, 2016: Cell
https://www.readbyqxmd.com/read/27453466/structure-and-function-analysis-of-an-antibody-recognizing-all-influenza-a-subtypes
#6
Nicole L Kallewaard, Davide Corti, Patrick J Collins, Ursula Neu, Josephine M McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances J Palmer-Hill, Andy Q Yuan, Philip A Walker, Matthias K Vorlaender, Siro Bianchi, Barbara Guarino, Anna De Marco, Fabrizia Vanzetta, Gloria Agatic, Mathilde Foglierini, Debora Pinna, Blanca Fernandez-Rodriguez, Alexander Fruehwirth, Chiara Silacci, Roksana W Ogrodowicz, Stephen R Martin, Federica Sallusto, JoAnn A Suzich, Antonio Lanzavecchia, Qing Zhu, Steven J Gamblin, John J Skehel
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when compared to other anti-stem antibodies. MEDI8852 is effective in mice and ferrets with a therapeutic window superior to that of oseltamivir...
July 28, 2016: Cell
https://www.readbyqxmd.com/read/27049174/a-novel-antibody-discovery-platform-identifies-anti-influenza-a-broadly-neutralizing-antibodies-from-human-memory-b-cells
#7
Xiaodong Xiao, Yan Chen, Reena Varkey, Nicole Kallewaard, Adem C Koksal, Qing Zhu, Herren Wu, Partha S Chowdhury, William F Dall'Acqua
Monoclonal antibody isolation directly from circulating human B cells is a powerful tool to delineate humoral responses to pathological conditions and discover antibody therapeutics. We have developed a platform aimed at improving the efficiencies of B cell selection and V gene recovery. Here, memory B cells are activated and amplified using Epstein-Barr virus infection, co-cultured with CHO-muCD40L cells, and then assessed by functional screenings. An in vitro transcription and translation (IVTT) approach was used to analyze variable (V) genes recovered from each B cell sample and identify the relevant heavy/light chain pair(s)...
July 2016: MAbs
https://www.readbyqxmd.com/read/26890014/subcutaneous-stimulation-as-add-on-therapy-to-spinal-cord-stimulation-is-effective-in-treating-low-back-pain-in-patients-with-failed-back-surgery-syndrome-a-multicenter-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Eric-Jan J A A van Gorp, Onno P M Teernstra, Ismail Gültuna, Tanja Hamm-Faber, Katja Bürger, Ronald Schapendonk, Jan Willem Kallewaard, Geert Spincemaille, Leon H Vonhögen, Jan C M Hendriks, Kris C P Vissers
OBJECTIVE: Suppression of back pain with traditional spinal cord stimulation (SCS) in failed back surgery syndrome patients is often insufficient. The objective of this study was to investigate the efficacy of subcutaneous stimulation (SubQ) as ADD-ON therapy to SCS in treating back pain in failed back surgery syndrome patients. MATERIALS AND METHODS: Patients with a minimal pain score of 50 on a 100 mm visual analog scale for both leg and back pain were eligible...
February 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/26590962/efficacy-and-cost-effectiveness-of-intradiscal-methylene-blue-injection-for-chronic-discogenic-low-back-pain-study-protocol-for-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
José W Geurts, Jan-Willem Kallewaard, Alfons Kessels, Paul C Willems, Henk van Santbrink, Carmen Dirksen, Maarten van Kleef
BACKGROUND: Low back pain (LBP) is a common health problem and a substantial part of LBP is presumed to be attributable to degeneration of the intervertebral disc. For patients suffering from intractable discogenic LBP, there are few evidence-based effective interventional treatment options available. In 2010, the results of a randomized controlled trial (RCT) were published concerning "intradiscal methylene blue injection" (IMBI), in which this intervention appeared to be very successful in relieving discogenic pain...
2015: Trials
https://www.readbyqxmd.com/read/26092165/measuring-the-effect-of-choosing-wisely-an-integrated-framework-to-assess-campaign-impact-on-low-value-care
#10
REVIEW
R Sacha Bhatia, Wendy Levinson, Samuel Shortt, Ciara Pendrith, Elana Fric-Shamji, Marjon Kallewaard, Wilco Peul, Jeremy Veillard, Adam Elshaug, Ian Forde, Eve A Kerr
The Choosing Wisely campaign began in the USA in 2012 to encourage physicians and patients to discuss inappropriate and potentially harmful tests, treatments and procedures. Since its inception, the campaign has grown substantially and has been adopted by 12 countries around the world. Of great interest to countries implementing the campaign, is the effectiveness of Choosing Wisely to reduce overutilisation. This article presents an integrated measurement framework that may be used to assess the impact of a Choosing Wisely campaign on physician and provider awareness and attitudes on low-value care, provider practice behaviour and overuse of low-value services...
August 2015: BMJ Quality & Safety
https://www.readbyqxmd.com/read/25753429/efficacy-safety-and-predictors-of-intradiscal-methylene-blue-injection-for-discogenic-low-back-pain-results-of-a-multicenter-prospective-clinical-series
#11
MULTICENTER STUDY
Jan Willem Kallewaard, José W Geurts, Alphons Kessels, Paul Willems, Henk van Santbrink, Maarten van Kleef
STUDY DESIGN: Prospective clinical study of intradiscal methylene blue injection for the treatment of lumbar discogenic pain. OBJECTIVE: The objective of this study was to collect information about efficacy, safety, and acceptability of the intervention, gain and burden of outcome measures, and sample size assumptions for a potential following randomized controlled trial (RCT). If the pilot study demonstrates that this treatment is potentially effective and safe, and the methods and procedures used in this study are feasible, a RCT follows...
April 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/25552584/-choosing-wisely-a-growing-international-campaign
#12
REVIEW
Wendy Levinson, Marjon Kallewaard, R Sacha Bhatia, Daniel Wolfson, Sam Shortt, Eve A Kerr
Much attention has been paid to the inappropriate underuse of tests and treatments but until recently little attention has focused on the overuse that does not add value for patients and may even cause harm. Choosing Wisely is a campaign to engage physicians and patients in conversations about unnecessary tests, treatments and procedures. The campaign began in the United States in 2012, in Canada in 2014 and now many countries around the world are adapting the campaign and implementing it. This article describes the present status of Choosing Wisely programs in 12 countries...
February 2015: BMJ Quality & Safety
https://www.readbyqxmd.com/read/25296253/rapid-development-of-broadly-influenza-neutralizing-antibodies-through-redundant-mutations
#13
Leontios Pappas, Mathilde Foglierini, Luca Piccoli, Nicole L Kallewaard, Filippo Turrini, Chiara Silacci, Blanca Fernandez-Rodriguez, Gloria Agatic, Isabella Giacchetto-Sasselli, Gabriele Pellicciotta, Federica Sallusto, Qing Zhu, Elisa Vicenzi, Davide Corti, Antonio Lanzavecchia
The neutralizing antibody response to influenza virus is dominated by antibodies that bind to the globular head of haemagglutinin, which undergoes a continuous antigenic drift, necessitating the re-formulation of influenza vaccines on an annual basis. Recently, several laboratories have described a new class of rare influenza-neutralizing antibodies that target a conserved site in the haemagglutinin stem. Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues...
December 18, 2014: Nature
https://www.readbyqxmd.com/read/24696468/a-broadly-neutralizing-human-monoclonal-antibody-directed-against-a-novel-conserved-epitope-on-the-influenza-virus-h3-hemagglutinin-globular-head
#14
Ebony Benjamin, Weijia Wang, Josephine M McAuliffe, Frances J Palmer-Hill, Nicole L Kallewaard, Zhongying Chen, JoAnn A Suzich, Wade S Blair, Hong Jin, Qing Zhu
UNLABELLED: Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunodominant, variable epitopes on the globular head region of hemagglutinin (HA), which leads to narrow strain protection. In this report, we describe the properties of a unique anti-HA monoclonal antibody (MAb), D1-8, that was derived from human B cells and exhibits potent, broad neutralizing activity across antigenically diverse influenza H3 subtype viruses. Based on selection of escape variants, we show that D1-8 targets a novel epitope on the globular head region of the influenza virus HA protein...
June 2014: Journal of Virology
https://www.readbyqxmd.com/read/23941663/epiduroscopy-for-patients-with-lumbosacral-radicular-pain
#15
REVIEW
Jan Willem Kallewaard, Pascal Vanelderen, Jonathan Richardson, Jan Van Zundert, James Heavner, Gerbrand Jan Groen
Lumbosacral radicular pain is a pain in the distribution area of one of the nerves of the lumbosacral plexus, with or without sensory and/or motor impairment. A major source of lumbosacral radicular pain is failed back surgery, which is defined as persistent or recurrent pain, mainly in the region of the lower back and legs even after technically, anatomically successful spine surgeries. If lumbosacral radicular neuropathic pain fails to respond to conservative or interventional treatments, epiduroscopy can be performed as part of a multidisciplinary approach...
April 2014: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/23017097/stellate-ganglion-block-as-a-treatment-for-severe-postmenopausal-flushing
#16
P van Gastel, J-W Kallewaard, M van der Zanden, H de Boer
OBJECTIVE: Hormone replacement therapy is the most effective treatment for postmenopausal flushing. Unfortunately, its use is often contraindicated. A limited amount of uncontrolled data suggests that stellate-ganglion block (SGB) may be useful for the treatment of hot flushes. In the present study, we examined whether previously reported results could be reproduced in women with severe postmenopausal flushing. METHODS: Twenty postmenopausal women with a baseline hot flush score ≥ 15  were treated with SGB in an open, uncontrolled setting...
February 2013: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/22145706/wash-free-electrochemical-platform-for-the-quantitative-multiplexed-detection-of-specific-antibodies
#17
Ryan J White, Hannah M Kallewaard, Wen Hsieh, Adriana S Patterson, Jesse B Kasehagen, Kevin J Cash, Takanori Uzawa, H Tom Soh, Kevin W Plaxco
The diagnosis, prevention, and treatment of many illnesses, including infectious and autoimmune diseases, would benefit from the ability to measure specific antibodies directly at the point of care. Thus motivated, we designed a wash-free, electrochemical method for the rapid, quantitative detection of specific antibodies directly in undiluted, unprocessed blood serum. Our approach employs short, contiguous polypeptide epitopes coupled to the distal end of an electrode-bound nucleic acid "scaffold" modified with a reporting methylene blue...
January 17, 2012: Analytical Chemistry
https://www.readbyqxmd.com/read/20825564/15-discogenic-low-back-pain
#18
REVIEW
Jan Willem Kallewaard, Michel A M B Terheggen, Gerbrand J Groen, Menno E Sluijter, Richard Derby, Leonardo Kapural, Nagy Mekhail, Maarten van Kleef
An estimated 40% of chronic lumbosacral spinal pain is attributed to the discus intervertebralis. Degenerative changes following loss of hydration of the nucleus pulposus lead to circumferential or radial tears within the annulus fibrosus. Annular tears within the outer annulus stimulate the ingrowth of blood vessels and accompanying nociceptors into the outer and occasionally inner annulus. Sensitization of these nociceptors by various inflammatory repair mechanisms may lead to chronic discogenic pain. The current criterion standard for diagnosing discogenic pain is pressure-controlled provocative discography using strict criteria and at least one negative control level...
November 2010: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/19616768/tissue-specific-deletion-of-the-coxsackievirus-and-adenovirus-receptor-protects-mice-from-virus-induced-pancreatitis-and-myocarditis
#19
Nicole L Kallewaard, Lili Zhang, Jin-Wen Chen, Marta Guttenberg, Melissa D Sanchez, Jeffrey M Bergelson
In cultured cells, infection by group B coxsackievirus (CVB) is mediated by the coxsackievirus and adenovirus receptor (CAR), but the importance of this molecule in CVB-induced disease has not been determined. We generated mice with tissue-specific ablation of CAR within each of two major CVB target organs, the pancreas and heart. In the pancreas, deletion of CAR resulted in a significant reduction in both virus titers and virus-induced tissue damage. Similarly, cardiomyocyte-specific CAR deletion resulted in a marked reduction in virus titer, infection-associated cytokine production, and histopathology within the heart...
July 23, 2009: Cell Host & Microbe
https://www.readbyqxmd.com/read/18322207/functional-maturation-of-the-human-antibody-response-to-rotavirus
#20
Nicole L Kallewaard, Brett A McKinney, Yingqi Gu, Annie Chen, B V Venkataram Prasad, James E Crowe
Infant Abs induced by viruses exhibit poor functional activity compared with those of adults. The human B cell response to rotavirus is dominated by use of the V(H)1-46 gene segment in both adults and infants, but only adult sequences are highly mutated. We investigated in detail the kinetic, structural, and functional advantage conferred by individual naturally occurring somatic mutations in rotavirus-specific human Abs encoded by the immunodominant V(H)1-46 gene segment. Adult Abs achieved enhanced binding through naturally occurring somatic mutations in the H chain CDR2 region that conferred a markedly prolonged off-rate and a desirable increase in antiviral potency...
March 15, 2008: Journal of Immunology: Official Journal of the American Association of Immunologists
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