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https://www.readbyqxmd.com/read/29756333/safe-use-of-epidural-corticosteroid-injections-recommendations-of-the-wip-benelux-workgroup
#1
REVIEW
Koen Van Boxem, Mienke Rijsdijk, Guy Hans, Jasper de Jong, Jan Willem Kallewaard, Kris Vissers, Maarten van Kleef, James P Rathmell, Jan Van Zundert
BACKGROUND: Epidural corticosteroid injections are used frequently worldwide in the treatment of radicular pain. Concerns have risen involving rare major neurologic injuries after this treatment. Recommendations to prevent these complications have been published, but local implementation is not always feasible due to local circumstances and necessitating local recommendations based on literature review. METHODS: A workgroup of 4 stakeholder pain societies in Belgium, The Netherlands and Luxembourg (Benelux) has reviewed the literature involving neurological complications after epidural corticosteroid injections and possible safety measures to prevent these major neurologic injuries...
May 14, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29707093/pulsed-radiofrequency-as-a-minimally-invasive-treatment-option-in-anterior-cutaneous-nerve-entrapment-syndrome-a-retrospective-analysis-of-26-patients
#2
Robbert C Maatman, Monique A H Steegers, Jan-Willem Kallewaard, Marc R M Scheltinga, Rudi M H Roumen
Background: Chronic abdominal pain is occasionally due to entrapped intercostal nerve endings (ACNES, abdominal cutaneous nerve entrapment syndrome). If abdominal wall infiltration using an anesthetic agent is unsuccessful, a neurectomy may be considered. Pulsed radiofrequency (PRF) is a relatively new treatment option for various chronic pain syndromes. Evidence regarding a beneficial effect of this minimally invasive technique in ACNES is lacking. The aim was to assess the effectiveness of PRF treatment in ACNES patients...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29617879/prevalence-and-significance-of-substitutions-in-the-fusion-protein-of-respiratory-syncytial-virus-resulting-in-neutralization-escape-from-antibody-medi8897
#3
Qing Zhu, Bin Lu, Patrick McTamney, Susan Palaszynski, Seme Diallo, Kuishu Ren, Nancy D Ulbrandt, Nicole Kallewaard, Weijia Wang, Fiona Fernandes, Steve Wong, Catherine Svabek, Brian Moldt, Mark T Esser, Hong Jing, JoAnn A Suzich
Background: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine is approved for the broad population of healthy infants. MEDI8897, a potent anti-RSV fusion antibody with extended serum half-life is currently under clinical investigation as a potential passive RSV vaccine for all infants. As an RNA virus, RSV is prone to mutation, the possibility of viral escape from MEDI8897 neutralization is a potential concern...
March 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29608807/long-term-effect-of-peripheral-nerve-field-stimulation-as-add-on-therapy-to-spinal-cord-stimulation-to-treat-low-back-pain-in-failed-back-surgery-syndrome-patients-a-12-month-follow-up-of-a-randomized-controlled-study
#4
Eric-Jan J A A van Gorp, Onno Teernstra, Hans J Aukes, Tanja Hamm-Faber, Katja Bürger, Jan Willem Kallewaard, Geert Spincemaille, Johannes W L C Schapendonk, Leon Vonhögen, Ewald Bronkhorst, Kris C P Vissers
OBJECTIVE: Different approaches in neuromodulation have been used to treat chronic low back pain in failed back surgery syndrome (FBSS) patients. We previously randomized 52 FBSS patients to be treated with spinal cord stimulation (SCS) and additional peripheral nerve field stimulation (PNFS) or SCS alone. At three months, we found a significant reduction of back pain in the PNFS-SCS group compared to the SCS group. In the subsequent open phase part of the study, all patients received optimal SCS and PNFS simultaneously...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28672319/effect-of-radiofrequency-denervation-on-pain-intensity-among-patients-with-chronic-low-back-pain-the-mint-randomized-clinical-trials
#5
RANDOMIZED CONTROLLED TRIAL
Johan N S Juch, Esther T Maas, Raymond W J G Ostelo, J George Groeneweg, Jan-Willem Kallewaard, Bart W Koes, Arianne P Verhagen, Johanna M van Dongen, Frank J P M Huygen, Maurits W van Tulder
Importance: Radiofrequency denervation is a commonly used treatment for chronic low back pain, but high-quality evidence for its effectiveness is lacking. Objective: To evaluate the effectiveness of radiofrequency denervation added to a standardized exercise program for patients with chronic low back pain. Design, Setting, and Participants: Three pragmatic multicenter, nonblinded randomized clinical trials on the effectiveness of minimal interventional treatments for participants with chronic low back pain (Mint study) were conducted in 16 multidisciplinary pain clinics in the Netherlands...
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28633457/the-hemagglutinin-a-stem-antibody-medi8852-prevents-and-controls-disease-and-limits-transmission-of-pandemic-influenza-viruses
#6
Catharine I Paules, Seema Lakdawala, Josephine M McAuliffe, Myeisha Paskel, Leatrice Vogel, Nicole L Kallewaard, Qing Zhu, Kanta Subbarao
Background: MEDI8852 is a novel monoclonal antibody (mAb) that neutralizes both group I and group II influenza A viruses (IAVs) in vitro. We evaluated whether MEDI8852 was effective for prophylaxis and therapy against representative group I (H5N1) and group II (H7N9) pandemic IAVs in mice and ferrets and could be used to block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control mAb R347 and oseltamivir. Methods: MEDI8852 was administered to mice and ferrets by intraperitoneal injection at varying doses, 24 hours prior to intranasal infection with H5N1 and H7N9 viruses for prophylaxis, and 24, 48, and 72 hours post-infection for treatment...
August 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28527859/tackling-influenza-with-broadly-neutralizing-antibodies
#7
REVIEW
Davide Corti, Elisabetta Cameroni, Barbara Guarino, Nicole L Kallewaard, Qing Zhu, Antonio Lanzavecchia
Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses...
June 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28469033/a-highly-potent-extended-half-life-antibody-as-a-potential-rsv-vaccine-surrogate-for-all-infants
#8
Qing Zhu, Jason S McLellan, Nicole L Kallewaard, Nancy D Ulbrandt, Susan Palaszynski, Jing Zhang, Brian Moldt, Anis Khan, Catherine Svabek, Josephine M McAuliffe, Daniel Wrapp, Nita K Patel, Kimberly E Cook, Bettina W M Richter, Patricia C Ryan, Andy Q Yuan, JoAnn A Suzich
Prevention of respiratory syncytial virus (RSV) illness in all infants is a major public health priority. However, no vaccine is currently available to protect this vulnerable population. Palivizumab, the only approved agent for RSV prophylaxis, is limited to high-risk infants, and the cost associated with the requirement for dosing throughout the RSV season makes its use impractical for all infants. We describe the development of a monoclonal antibody as potential RSV prophylaxis for all infants with a single intramuscular dose...
May 3, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28379575/no-transfer-of-pressure-to-adjacent-discs-during-human-low-pressure-controlled-discography-a-prospective-clinical-study
#9
Jan Willem Kallewaard, José W Geurts, Michel Terheggen, Chris Terwiel, Alfons Kessels, Maarten van Kleef, Paul C Willems
Background. : A substantial part of low back pain (LBP) originates from degeneration of the intervertebral disc. To confirm the diagnosis of discogenic pain, provocation discography seems the best available tool. However, provocation discography is also considered to be a controversial and subjective test because the patient's personal pain response is the most crucial for the result of the test. Recently, an in vivo porcine study and a study in nine human subjects showed passing of pressure to the adjacent discs during discography...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27723170/systematic-review-of-patient-history-and-physical-examination-to-diagnose-chronic-low-back-pain-originating-from-the-facet-joints
#10
REVIEW
E T Maas, J N S Juch, R W J G Ostelo, J G Groeneweg, J W Kallewaard, B W Koes, A P Verhagen, F J P M Huygen, M W van Tulder
Patient history and physical examination are frequently used procedures to diagnose chronic low back pain (CLBP) originating from the facet joints, although the diagnostic accuracy is controversial. The aim of this systematic review is to determine the diagnostic accuracy of patient history and/or physical examination to identify CLBP originating from the facet joints using diagnostic blocks as reference standard. We searched MEDLINE, EMBASE, CINAHL, Web of Science and the Cochrane Collaboration database from inception until June 2016...
March 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27471961/broadening-horizons-new-antibodies-against-influenza
#11
COMMENT
Katherine J L Jackson, Scott D Boyd
Seasonal influenza vaccine formulation efforts struggle to keep up with viral antigenic variation. Two studies now report engineered or naturally occurring human antibodies targeting the influenza hemagglutinin (HA) stem, with exceptional neutralizing breadth (Joyce et al., 2016; Kallewaard et al., 2016). Antibodies with similar structural features are elicited in multiple subjects, suggesting that modified vaccine regimens could provide broad protection.
July 28, 2016: Cell
https://www.readbyqxmd.com/read/27453466/structure-and-function-analysis-of-an-antibody-recognizing-all-influenza-a-subtypes
#12
Nicole L Kallewaard, Davide Corti, Patrick J Collins, Ursula Neu, Josephine M McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances J Palmer-Hill, Andy Q Yuan, Philip A Walker, Matthias K Vorlaender, Siro Bianchi, Barbara Guarino, Anna De Marco, Fabrizia Vanzetta, Gloria Agatic, Mathilde Foglierini, Debora Pinna, Blanca Fernandez-Rodriguez, Alexander Fruehwirth, Chiara Silacci, Roksana W Ogrodowicz, Stephen R Martin, Federica Sallusto, JoAnn A Suzich, Antonio Lanzavecchia, Qing Zhu, Steven J Gamblin, John J Skehel
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when compared to other anti-stem antibodies. MEDI8852 is effective in mice and ferrets with a therapeutic window superior to that of oseltamivir...
July 28, 2016: Cell
https://www.readbyqxmd.com/read/27049174/a-novel-antibody-discovery-platform-identifies-anti-influenza-a-broadly-neutralizing-antibodies-from-human-memory-b-cells
#13
Xiaodong Xiao, Yan Chen, Reena Varkey, Nicole Kallewaard, Adem C Koksal, Qing Zhu, Herren Wu, Partha S Chowdhury, William F Dall'Acqua
Monoclonal antibody isolation directly from circulating human B cells is a powerful tool to delineate humoral responses to pathological conditions and discover antibody therapeutics. We have developed a platform aimed at improving the efficiencies of B cell selection and V gene recovery. Here, memory B cells are activated and amplified using Epstein-Barr virus infection, co-cultured with CHO-muCD40L cells, and then assessed by functional screenings. An in vitro transcription and translation (IVTT) approach was used to analyze variable (V) genes recovered from each B cell sample and identify the relevant heavy/light chain pair(s)...
July 2016: MAbs
https://www.readbyqxmd.com/read/26890014/subcutaneous-stimulation-as-add-on-therapy-to-spinal-cord-stimulation-is-effective-in-treating-low-back-pain-in-patients-with-failed-back-surgery-syndrome-a-multicenter-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Eric-Jan J A A van Gorp, Onno P M Teernstra, Ismail Gültuna, Tanja Hamm-Faber, Katja Bürger, Ronald Schapendonk, Jan Willem Kallewaard, Geert Spincemaille, Leon H Vonhögen, Jan C M Hendriks, Kris C P Vissers
OBJECTIVE: Suppression of back pain with traditional spinal cord stimulation (SCS) in failed back surgery syndrome patients is often insufficient. The objective of this study was to investigate the efficacy of subcutaneous stimulation (SubQ) as ADD-ON therapy to SCS in treating back pain in failed back surgery syndrome patients. MATERIALS AND METHODS: Patients with a minimal pain score of 50 on a 100 mm visual analog scale for both leg and back pain were eligible...
February 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/26590962/efficacy-and-cost-effectiveness-of-intradiscal-methylene-blue-injection-for-chronic-discogenic-low-back-pain-study-protocol-for-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
José W Geurts, Jan-Willem Kallewaard, Alfons Kessels, Paul C Willems, Henk van Santbrink, Carmen Dirksen, Maarten van Kleef
BACKGROUND: Low back pain (LBP) is a common health problem and a substantial part of LBP is presumed to be attributable to degeneration of the intervertebral disc. For patients suffering from intractable discogenic LBP, there are few evidence-based effective interventional treatment options available. In 2010, the results of a randomized controlled trial (RCT) were published concerning "intradiscal methylene blue injection" (IMBI), in which this intervention appeared to be very successful in relieving discogenic pain...
November 21, 2015: Trials
https://www.readbyqxmd.com/read/26092165/measuring-the-effect-of-choosing-wisely-an-integrated-framework-to-assess-campaign-impact-on-low-value-care
#16
REVIEW
R Sacha Bhatia, Wendy Levinson, Samuel Shortt, Ciara Pendrith, Elana Fric-Shamji, Marjon Kallewaard, Wilco Peul, Jeremy Veillard, Adam Elshaug, Ian Forde, Eve A Kerr
The Choosing Wisely campaign began in the USA in 2012 to encourage physicians and patients to discuss inappropriate and potentially harmful tests, treatments and procedures. Since its inception, the campaign has grown substantially and has been adopted by 12 countries around the world. Of great interest to countries implementing the campaign, is the effectiveness of Choosing Wisely to reduce overutilisation. This article presents an integrated measurement framework that may be used to assess the impact of a Choosing Wisely campaign on physician and provider awareness and attitudes on low-value care, provider practice behaviour and overuse of low-value services...
August 2015: BMJ Quality & Safety
https://www.readbyqxmd.com/read/25753429/efficacy-safety-and-predictors-of-intradiscal-methylene-blue-injection-for-discogenic-low-back-pain-results-of-a-multicenter-prospective-clinical-series
#17
MULTICENTER STUDY
Jan Willem Kallewaard, José W Geurts, Alphons Kessels, Paul Willems, Henk van Santbrink, Maarten van Kleef
STUDY DESIGN: Prospective clinical study of intradiscal methylene blue injection for the treatment of lumbar discogenic pain. OBJECTIVE: The objective of this study was to collect information about efficacy, safety, and acceptability of the intervention, gain and burden of outcome measures, and sample size assumptions for a potential following randomized controlled trial (RCT). If the pilot study demonstrates that this treatment is potentially effective and safe, and the methods and procedures used in this study are feasible, a RCT follows...
April 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/25552584/-choosing-wisely-a-growing-international-campaign
#18
REVIEW
Wendy Levinson, Marjon Kallewaard, R Sacha Bhatia, Daniel Wolfson, Sam Shortt, Eve A Kerr
Much attention has been paid to the inappropriate underuse of tests and treatments but until recently little attention has focused on the overuse that does not add value for patients and may even cause harm. Choosing Wisely is a campaign to engage physicians and patients in conversations about unnecessary tests, treatments and procedures. The campaign began in the United States in 2012, in Canada in 2014 and now many countries around the world are adapting the campaign and implementing it. This article describes the present status of Choosing Wisely programs in 12 countries...
February 2015: BMJ Quality & Safety
https://www.readbyqxmd.com/read/25296253/rapid-development-of-broadly-influenza-neutralizing-antibodies-through-redundant-mutations
#19
Leontios Pappas, Mathilde Foglierini, Luca Piccoli, Nicole L Kallewaard, Filippo Turrini, Chiara Silacci, Blanca Fernandez-Rodriguez, Gloria Agatic, Isabella Giacchetto-Sasselli, Gabriele Pellicciotta, Federica Sallusto, Qing Zhu, Elisa Vicenzi, Davide Corti, Antonio Lanzavecchia
The neutralizing antibody response to influenza virus is dominated by antibodies that bind to the globular head of haemagglutinin, which undergoes a continuous antigenic drift, necessitating the re-formulation of influenza vaccines on an annual basis. Recently, several laboratories have described a new class of rare influenza-neutralizing antibodies that target a conserved site in the haemagglutinin stem. Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues...
December 18, 2014: Nature
https://www.readbyqxmd.com/read/24696468/a-broadly-neutralizing-human-monoclonal-antibody-directed-against-a-novel-conserved-epitope-on-the-influenza-virus-h3-hemagglutinin-globular-head
#20
Ebony Benjamin, Weijia Wang, Josephine M McAuliffe, Frances J Palmer-Hill, Nicole L Kallewaard, Zhongying Chen, JoAnn A Suzich, Wade S Blair, Hong Jin, Qing Zhu
UNLABELLED: Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunodominant, variable epitopes on the globular head region of hemagglutinin (HA), which leads to narrow strain protection. In this report, we describe the properties of a unique anti-HA monoclonal antibody (MAb), D1-8, that was derived from human B cells and exhibits potent, broad neutralizing activity across antigenically diverse influenza H3 subtype viruses. Based on selection of escape variants, we show that D1-8 targets a novel epitope on the globular head region of the influenza virus HA protein...
June 2014: Journal of Virology
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