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https://www.readbyqxmd.com/read/28809375/clinical-parameters-of-implants-placed-in-healed-sites-using-flapped-and-flapless-techniques-a-systematic-review
#1
O Llamas-Monteagudo, P Girbés-Ballester, J Viña-Almunia, D Peñarrocha-Oltra, M Peñarrocha-Diago
BACKGROUND: Dental implant placement using flapless surgery is a minimally invasive technique that improves blood supply compared with flapped surgery. However, the flapless technique does not provide access to allow bone regeneration. OBJECTIVE: The aim of this systematic review was to evaluate the clinical parameters following implant surgery in healed sites, using two procedures: flapped vs. flapless surgery. MATERIALS AND METHODS: A detailed electronic search was carried out in the PubMed/Medline, Embase and Cochrane Library databases...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28806750/characterization-of-novel-bangle-lectin-from-photorhabdus-asymbiotica-with-dual-sugar-binding-specificity-and-its-effect-on-host-immunity
#2
Gita Jančaříková, Josef Houser, Pavel Dobeš, Gabriel Demo, Pavel Hyršl, Michaela Wimmerová
Photorhabdus asymbiotica is one of the three recognized species of the Photorhabdus genus, which consists of gram-negative bioluminescent bacteria belonging to the family Morganellaceae. These bacteria live in a symbiotic relationship with nematodes from the genus Heterorhabditis, together forming a complex that is highly pathogenic for insects. Unlike other Photorhabdus species, which are strictly entomopathogenic, P. asymbiotica is unique in its ability to act as an emerging human pathogen. Analysis of the P...
August 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28806472/effects-of-clarithromycin-on-the-pharmacokinetics-of-evogliptin-in-healthy-volunteers
#3
E S Oh, C Choi, C O Kim, K H Kim, Y N Kim, S J Kim, M S Park
WHAT IS KNOWN AND OBJECTIVE: Evogliptin (DA-1229), a novel dipeptidyl peptidase (DPP)-4 inhibitor with high potency and selectivity, was approved in Korea for the treatment of type 2 diabetes. Preclinical studies suggest that it is metabolized by cytochrome (CYP) P450 isozymes. Based on these findings, a clinical study was designed to investigate the pharmacokinetic (PK) interaction of evogliptin with a CYP inhibitor, clarithromycin. METHODS: An open-label, two-phase, crossover study was conducted with 12 healthy subjects...
August 14, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28805560/glycation-of-matrix-proteins-in-the-artery-inhibits-migration-of-smooth-muscle-cells-from-the-media-to-the-intima
#4
A Kuzan, O Michel, A Gamian
Formation and growth of atherosclerotic plaques have serious clinical consequences. One mechanism that occurs during atherogenesis is migration of smooth muscle cells from the middle layer of the artery to the intima, where they proliferate and are transformed into foam cells. This degenerative process is accompanied by glycation, by which proteins are modified and change the biomechanical and biochemical properties. The aim of the study was to determine whether glycation of collagen and elastin building the walls of blood vessels alters the adhesion and rate of myocyte migration...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28804817/the-interface-between-immunotransfusion-and-hemostasis-and-thrombosis-testing
#5
Massimo Franchini
Increasing evidence supports the existence of a close relationship between immunotransfusion, hemostasis, and thrombosis. The best example of such linkage is given by the influence of the ABO blood group antigens on von Willebrand factor (VWF) plasma levels and activity. It is well known, for instance, that individuals with non-O blood type (i.e., A, B, and AB) have higher VWF and factor VIII plasma levels than O blood type subjects and are consequently exposed to an increased thrombotic risk. There is also a close relationship between immunotransfusion, hemostasis, and thrombosis testing...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28802226/taraxerol-a-pentacyclic-triterpenoid-from-abroma-augusta-leaf-attenuates-diabetic-nephropathy-in-type-2-diabetic-rats
#6
Ritu Khanra, Niloy Bhattacharjee, Tarun K Dua, Ashis Nandy, Achintya Saha, Jatin Kalita, Prasenjit Manna, Saikat Dewanjee
Persistent hyperglycaemia coupled with inflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). Present study examined the therapeutic potential of taraxerol isolated from the methanol extract of Abroma augusta leaf against DN using rodent model of type 2 diabetes (T2D). T2D was experimentally induced by high fat diet and a single low-single dose of streptozotocin (35mg/kg, i.p.). Accumulation of serum creatinine, urea, and uric acid, activation of lactate dehydrogenase and creatinin kinase, and release of urinary albumin represented the glomerular damage and the progression of nephropathy in T2D rats...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28796818/hypercholesterolemia-induced-cerebral-small-vessel-disease
#7
Peter Kraft, Michael K Schuhmann, Cornelia Garz, Solveig Jandke, Daniela Urlaub, Stine Mencl, Alma Zernecke, Hans-Jochen Heinze, Roxana O Carare, Christoph Kleinschnitz, Stefanie Schreiber
BACKGROUND: While hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed relationship between hypercholesterolemia and CSVD using the well described Ldlr-/- mouse model. METHODS: We used Ldlr-/- mice (n = 16) and wild-type (WT) mice (n = 15) at the age of 6 and 12 months. Ldlr-/- mice develop high plasma cholesterol levels following a high fat diet...
2017: PloS One
https://www.readbyqxmd.com/read/28790167/chemoprotective-effects-of-butanol-fraction-of-buchholzia-coriacea-capparidaceae-against-type-2-diabetes-and-oxidative-stress-in-male-wistar-rats
#8
Amanda Chikaosolu Okolie, Oluwafemi Ezekiel Kale, Odutola Osilesi
Recent studies have shown that Type 2 diabetes (T2D) in rats can result through a synergy that link obesity to insulin resistance and β-cell dysfunction. This present study achieved T2D via high fructose (20%(w/v), p.o.), streptozotocin single dose (40 mg/kg, i.p.) (HFSTZ) in rats. Also, chemoprotective potential of butanol fraction of buchholzia coriacea (BFBC) was demonstrated. Control normal and diabetic untreated (HFSTZ-induced T2D) rats received carboxymethyl cellulose (1 mg/kg, p.o.). Diabetic rats received intragastric BFBC (20, 200, 400 mg/kg), glibenclamide (0...
August 8, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28782191/tadalafil-a-phosphodiesterase-type-5-inhibitor-improves-bladder-blood-supply-and-restores-the-initial-phase-of-lower-urinary-tract-dysfunction-in-diabetic-rats
#9
Daisuke Gotoh, Kazumasa Torimoto, Yoshihiro Tatsumi, Shunta Hori, Atsushi Yamada, Makito Miyake, Yosuke Morizawa, Katsuya Aoki, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto
AIMS: To investigate the effect of tadalafil on bladder blood flow and lower urinary tract function in a rat model of diabetes. MATERIALS AND METHODS: We studied female Sprague-Dawley rats and induced diabetes in some using a single intraperitoneal injection of streptozotocin. We divided the rats into nondiabetes (ND), diabetes (D), and diabetes with tadalafil (DT) groups. The rats were raised for an additional 7 weeks after diabetes induction. The DT group received oral tadalafil (2 mg/kg/day) for 7 days before the experiments...
August 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28770459/effect-of-liraglutide-on-myocardial-glucose-uptake-and-blood-flow-in-stable-chronic-heart-failure-patients-a-double-blind-randomized-placebo-controlled-live-sub-study
#10
Roni Nielsen, Anders Jorsal, Peter Iversen, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jens Sørensen, Hendrik Johannes Harms, Allan Flyvbjerg, Lise Tarnow, Caroline Kistorp, Ida Gustafsson, Hans Erik Bøtker, Henrik Wiggers
BACKGROUND: The glucagon-like peptide-1 analog liraglutide increases heart rate and may be associated with more cardiac events in chronic heart failure (CHF) patients. We studied whether this could be ascribed to effects on myocardial glucose uptake (MGU), myocardial blood flow (MBF) and MBF reserve (MFR). METHODS AND RESULTS: CHF patients with left ventricular ejection fraction ≤45% and without type 2 diabetes were randomized to liraglutide (N = 18) 1.8 mg once daily or placebo (N = 18) for 24 weeks in a double-blinded design...
August 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28769806/a-red-blood-cell-membrane-camouflaged-nanoparticle-counteracts-streptolysin-o-mediated-virulence-phenotypes-of-invasive-group-a-streptococcus
#11
Tamara Escajadillo, Joshua Olson, Brian T Luk, Liangfang Zhang, Victor Nizet
Group A Streptococcus (GAS), an important human-specific Gram-positive bacterial pathogen, is associated with a broad spectrum of disease, ranging from mild superficial infections such as pharyngitis and impetigo, to serious invasive infections including necrotizing fasciitis and streptococcal toxic shock syndrome. The GAS pore-forming streptolysin O (SLO) is a well characterized virulence factor produced by nearly all GAS clinical isolates. High level expression of SLO is epidemiologically linked to intercontinental dissemination of hypervirulent clonotypes and poor clinical outcomes...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28767771/parapneumonic-pleural-effusion-early-versus-late-thoracoscopy
#12
Rodrigo Romualdo Pereira, Cristina Gonçalves Alvim, Cláudia Ribeiro de Andrade, Cássio da Cunha Ibiapina
Objective: To evaluate the best time to perform thoracoscopy for the treatment of complicated parapneumonic pleural effusion in the fibrinopurulent phase in patients ≤ 14 years of age, regarding the postoperative evolution and occurrence of complications. Methods: This was a retrospective comparative study involving patients with parapneumonic pleural effusion presenting with septations or loculations on chest ultrasound who underwent thoracoscopy between January of 2000 and January of 2013...
July 31, 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28756771/prognostic-role-of-abo-blood-type-in-patients-with-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-triple-center-study
#13
Ya-Jun Li, Ping-Yong Yi, Ji-Wei Li, Xian-Ling Liu, Tian Tang, Pei-Ying Zhang, Wen-Qi Jiang
BACKGROUND: The prognostic significance of ABO blood type for lymphoma is largely unknown. We evaluated the prognostic role of ABO blood type in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). METHODS: We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer centers. The prognostic value of ABO blood type was evaluated using Kaplan-Meier curves and Cox proportional hazard models. The prognostic values of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were also evaluated...
July 31, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28755841/gene-expression-profiles-in-whole-blood-and-associations-with-metabolic-dysregulation-in-obesity
#14
Amanda J Cox, Ping Zhang, Tiffany J Evans, Rodney J Scott, Allan W Cripps, Nicholas P West
BACKGROUND: Gene expression data provides one tool to gain further insight into the complex biological interactions linking obesity and metabolic disease. This study examined associations between blood gene expression profiles and metabolic disease in obesity. METHODS: Whole blood gene expression profiles, performed using the Illumina HT-12v4 Human Expression Beadchip, were compared between (i) individuals with obesity (O) or lean (L) individuals (n=21 each), (ii) individuals with (M) or without (H) Metabolic Syndrome (n=11 each) matched on age and gender...
July 26, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28754313/the-5-ht4-receptor-mediated-inhibition-of-visceral-nociceptive-neurons-in-the-rat-caudal-ventrolateral-medulla
#15
O A Lyubashina, I B Sivachenko
Activation of the serotonin type 4 (5-HT4) receptors has been reported to improve abdominal pain in patients with functional gastrointestinal disorders and reduce visceral nociception in animal models. Earlier studies have proposed that 5-HT4 agonist can produce visceral analgesia by acting at the supraspinal level, but the underlying neuronal mechanisms remain unclear. The caudal ventrolateral medulla (CVLM) is the first site for processing of visceral nociceptive signals ascending via spinal pathways and an important component of the endogenous pain modulatory system...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28745674/-gene-mutations-in-patients-with-hereditary-cavernous-malformations
#16
O B Belousova, E S Bulygina, D N Okishev, E B Prohorchuk, S V Tsygankova, I N Pronin, L V Shishkina, M V Ryzhova, K G Skryabin, A N Konovalov
AIM: To identify mutations in cerebral cavernous malformation (CCM) genes in patients with hereditary and sporadic CCMs in the Russian population. MATERIAL AND METHODS: Blood samples from 73 randomly selected patients, including 29 MRI-confirmed familial cases, 8 clinically confirmed familial cases and 38 so-called sporadic cases, were examined. A search for large deletions/duplications was performed using multiplex ligation-dependent probe amplification (MPLA)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28740328/assessment-of-equivalence-of-adipose-tissue-treatment-with-a-noncontact-field-rf-system-delivering-200-w-for-30-min-and-300-w-for-20-min-an-in-vivo-porcine-study
#17
Tae-Rin Kwon, Jong Hwan Kim, Seok Joon, Seok Kyun Mun, Chan Woong Kim, Beom Joon Kim
BACKGROUND AND AIMS: Abdominal circumferential reduction with noncontact high frequency apoptosis-inducing field RF (AiRF) is becoming very popular. The present study compared the treatment results from two different sets of parameters giving the same dose from the same system in an in vivo porcine model. MATERIALS AND METHODS: Two 10 cm × 10 cm areas were symmetrically marked on both sides of the midline (total of 4 areas) over the rectus abdominis muscle of two anesthetized female micropigs...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28738267/gram-scale-synthesis-of-a-type-2-and-b-type-2-blood-group-tetrasaccharides-through-1-6-anhydro-n-acetyl-%C3%AE-d-glucosamine
#18
Tatiana V Tyrtysh, Elena Yu Korchagina, Ivan M Ryzhov, Nicolai V Bovin
Gram scale synthesis of A (type 2) and B (type 2) tetrasaccharides in the form of 3-aminopropyl glycosides is proposed starting from 3-O-benzoyl-1,6-anhydro-N-acetylglucosamine. Its galactosylation followed by re-protection gave lactosamine derivative with single free 2'-OH group in total yield 75%. Standard fucosylation and next run of re-protection in total yield 88% gave a trisaccharide Fuc-Gal-anhydroGlcNAc with single free 3'-OH group. Its standard α-galactosylation gave protected B (type 2) tetrasaccharide...
June 27, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28737223/a-network-meta-analysis-of-the-clinical-properties-of-various-types-of-supraglottic-airway-device-in-children
#19
REVIEW
T Mihara, A Asakura, G Owada, A Yokoi, K Ka, T Goto
We conducted both conventional pairwise and Bayesian network meta-analyses to compare the clinical properties of supraglottic airway devices in children. We searched six databases for randomised clinical trials. Our primary end-points were oropharyngeal leak pressure, risk of insertion failure at first attempt, and blood staining risk. The risk of device failure, defined as the abandonment of the supraglottic airway device and replacement with a tracheal tube or another device, was also analysed. Sixty-five randomised clinical trials with 5823 participants were identified, involving 16 types of supraglottic airway device...
July 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28736804/study-of-the-association-between-histo-blood-group-antigens-and-norovirus-infection-in-chinese-children
#20
Zhu-Lun Zhuang, Yu Jin, Kun-Long Yan, Wei-Xia Cheng
Human caliciviruses (HuCVs) have been recognized as a major cause of sporadic viral diarrhea in children, among which norovirus genotype GII.4 is the most prevalent genotype. Stool and saliva samples were collected from 295 children with acute diarrhea and 150 asymptomatic children at a hospital in China. The HuCV detection rate was 10.85% (32/295) among the children with acute diarrhea, and all of these 32 children were either HBGA secretors (12/32) or partial secretors (20/32). HuCV was detected in two (1...
July 24, 2017: Archives of Virology
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