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https://www.readbyqxmd.com/read/28098585/the-missing-record-of-mental-status-in-written-sign-outs
#1
Michael Croix, Donna Miller, Jeff Whittle, Siddhartha Singh, Marilyn M Schapira, Jennifer Carnahan, Jessica Kuester, Christa Kallio, Susan Framberg, Kathlyn E Fletcher
OBJECTIVE: The aim of the study was to determine how frequently mental status and mental status changes are documented in the written patient summary ("sign-out") provided to covering physicians. PATIENTS AND METHODS: This was a retrospective cohort study of general medical patients hospitalized between March 16, 2009, and March 15, 2010, conducted at 2 teaching hospitals. Participants included patients with mental status change adverse events (MSAEs) and their providers...
January 16, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28097044/study-on-the-single-dose-toxicity-of-shineumhur-pharmacopuncture-injected-into-the-muscles-of-rats
#2
Hohyun Jeong, Eunhye Cha, Jongcheol Lee, Seongjin Lee, Manyong Park, Dongwoung Kim, Bongkeun Song, Jongdeok Lee, Sungchul Kim
OBJECTIVES: This study was carried out to analyze the single dose toxicity of ShinEumHur (SEH) pharmacopuncture injected into the muscles of Sprague-Dawley rats. METHODS: The SEH pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (K-GMP). After the mixing process with sterile distilled water had been completed, the pH was controlled to between 7.0 and 7.5. All experiments were conducted at Biotoxtech, an institution authorized to perform non-clinical studies under the Good Laboratory Practice (GLP) regulations...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28096607/diagnosis-and-management-of-bovine-babesiosis-outbreaks-in-cattle-in-punjab-state
#3
Mandeep Singh Bal, Vishal Mahajan, Gursimran Filia, Paramjit Kaur, Amarjit Singh
AIM: The aim of the present study was to diagnose severe outbreaks of bovine babesiosis in Punjab state, in the year 2015 and to suggest control and preventive measures to animal owners. MATERIALS AND METHODS: Mortality of animals was recorded in two cattle herd comprising a total of 465 cattle in Sangrur (n=125) and Faridkot (n=340) districts. There was a history of purchase of animals at one farm. 23 blood samples were collected from diseased (n=15) and healthy animals (n=8) for hematological analysis, parasitological, and polymerase chain reaction (PCR)-based diagnosis...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28096254/factors-predicting-antibiotic-prescription-and-referral-to-hospital-for-children-with-respiratory-symptoms-secondary-analysis-of-a-randomised-controlled-study-at-out-of-hours-services-in-primary-care
#4
Ingrid Keilegavlen Rebnord, Hogne Sandvik, Anders Batman Mjelle, Steinar Hunskaar
OBJECTIVES: Acute respiratory infections and fever among children are highly prevalent in primary care. It is challenging to distinguish between viral and bacterial infections. Norway has a relatively low prescription rate of antibiotics, but it is still regarded as too high as the antimicrobial resistance is increasing. The aim of the study was to identify predictors for prescribing antibiotics or referral to hospital among children. DESIGN: Secondary analysis of a randomised controlled study...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28095408/patient-safety-incidents-involving-sick-children-in-primary-care-in-england-and-wales-a-mixed-methods-analysis
#5
Philippa Rees, Adrian Edwards, Colin Powell, Peter Hibbert, Huw Williams, Meredith Makeham, Ben Carter, Donna Luff, Gareth Parry, Anthony Avery, Aziz Sheikh, Liam Donaldson, Andrew Carson-Stevens
BACKGROUND: The UK performs poorly relative to other economically developed countries on numerous indicators of care quality for children. The contribution of iatrogenic harm to these outcomes is unclear. As primary care is the first point of healthcare contact for most children, we sought to investigate the safety of care provided to children in this setting. METHODS AND FINDINGS: We undertook a mixed methods investigation of reports of primary care patient safety incidents involving sick children from England and Wales' National Reporting and Learning System between 1 January 2005 and 1 December 2013...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28094535/comparing-the-coral-and-random-forest-approaches-for-modelling-the-in-vitro-cytotoxicity-of-silica-nanomaterials
#6
Antonio Cassano, Richard L Marchese Robinson, Anna Palczewska, Tomasz Puzyn, Agnieszka Gajewicz, Lang Tran, Serena Manganelli, Mark T D Cronin
Nanotechnology is one of the most important technological developments of the 21st century. In silico methods to predict toxicity, such as quantitative structure-activity relationships (QSARs), promote the safe-by-design approach for the development of new materials, including nanomaterials. In this study, a set of cytotoxicity experimental data corresponding to 19 data points for silica nanomaterials were investigated, to compare the widely employed CORAL and Random Forest approaches in terms of their usefulness for developing so-called 'nano-QSAR' models...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28093564/postoperative-conversion-disorder-presenting-as-inspiratory-stridor-and-hemiparesis-in-a-pediatric-patient
#7
Erik J Nelson, Jennifer Y Wu
BACKGROUND Postoperative conversion disorder is rare and has been reported. The diagnosis is usually made after all major organic causes have been ruled out. CASE REPORT We describe a case of a 13-year-old female who presented in the post-anesthesia care unit with acute-onset inspiratory stridor and unresponsiveness to verbal or painful stimuli after receiving a general anesthetic for upper endoscopy. Later in the post-anesthesia care unit, she presented with acute-onset right hemiplegia and sensory loss. She was first evaluated for causes of her stridor and unresponsiveness...
January 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28093335/intracoerulear-microinjection-of-orexin-a-induces-morphine-withdrawal-like-signs-in-rats
#8
Masoumeh Ghaemi-Jandabi, Hossein Azizi, S Mohammad Ahmadi-Soleimani, Saeed Semnanian
Orexin (hypocretin) neuropeptides play a pivotal role in expression of opioid withdrawal signs. Hypothalamic orexinergic neurons provide dense afferents for the nucleus locus coeruleus (LC). Somatic signs of opioid withdrawal are associated with the enhanced activity of LC neurons. In addition, intra-LC administration of orexin-A leads to the hyperactivity of LC neurons. The present study was an attempt to investigate whether intra-LC microinjection of orexin-A induces morphine withdrawal-like signs in both morphine dependent and control rats...
January 13, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28093098/tlr-induced-immunomodulatory-cytokine-expression-by-human-gingival-stem-progenitor-cells
#9
Mohamed K Mekhemar, Sabine Adam-Klages, Dietrich Kabelitz, Christof E Dörfer, Karim M Fawzy El-Sayed
During therapeutic application, mesenchymal stem cells (MSCs) may interact with their environment via their expressed toll-like-receptors (TLRs) leading to pro- or anti-inflammatory immune responses. The present study aimed to describe the gingival margin-derived stem/progenitor cells' (G-MSCs) TLR-induced immune regulatory response to specific TLR agonists. Gingival cells were obtained, immunomagnetically sorted via anti-STRO-1 antibodies and seeded out to achieve colony forming units (CFUs). G-MSCs were investigated for stem cell characteristics and TLR expression...
January 10, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28092984/vipera-ammodytes-bites-treated-with-antivenom-viperatab-a-case-series-with-pharmacokinetic-evaluation
#10
Miran Brvar, Tihana Kurtović, Damjan Grenc, Maja Lang Balija, Igor Križaj, Beata Halassy
CONTEXT: In clinical practice it is difficult to differentiate between V. berus and V. ammodytes venomous bites. In the past this was not a concern, but due to the current shortage in Viperfav™ and European viper venom antiserum availability, V. a. ammodytes venomous bites have recently been treated with ViperaTAb(®), which is a pharmaceutical formulation containing a monospecific ovine Fab fragments against the venom of V. berus. OBJECTIVE: To evaluate ViperaTAb(®) in V...
January 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28086988/computed-tomographic-findings-and-treatment-of-a-bull-with-pituitary-gland-abscess
#11
Ueli Braun, Alexandra Malbon, Manon Kochan, Barbara Riond, Fredi Janett, Cornelia Iten, Matthias Dennler
BACKGROUND: In cattle, the prognosis of brain abscess is unfavourable and treatment is therefore not recommended. To the knowledge of the authors, there has been no report of successful treatment of a brain abscess in cattle.This report describes the clinical, computed tomographic and postmortem findings in a Holstein-Friesian bull with a hypophyseal abscess. CASE REPORT: The main clinical findings were generalised ataxia, ptyalism, prolapse of the tongue, dropped jaw, dysphagia, head tilt and unilateral ptosis...
January 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28086977/people-living-with-hiv-on-art-have-accurate-perception-of-lipodystrophy-signs-a-cross-sectional-study
#12
Paulo R Alencastro, Nemora T Barcellos, Fernando H Wolff, Maria Letícia R Ikeda, Fabiana Schuelter-Trevisol, Ajácio B M Brandão, Sandra C Fuchs
BACKGROUND: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution changes. Although several methods have been developed, there is no gold standard for characterization of LA and LH, or mixed forms. This study aimed to compare self-reported signs of lipodystrophy with objective measures by skinfolds and circumferences, and to evaluate the prevalence of lipoatrophy (LA) and lipohypertrophy (LH) among subjects living with HIV/AIDS on ART...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28086754/making-the-most-of-mealtimes-m3-protocol-of-a-multi-centre-cross-sectional-study-of-food-intake-and-its-determinants-in-older-adults-living-in-long-term-care-homes
#13
Heather H Keller, Natalie Carrier, Susan Slaughter, Christina Lengyel, Catriona M Steele, Lisa Duizer, K Steve Brown, Habib Chaudhury, Minn N Yoon, Alison M Duncan, Veronique M Boscart, George Heckman, Lita Villalon
BACKGROUND: Older adults living in long term care (LTC) homes are nutritionally vulnerable, often consuming insufficient energy, macro- and micronutrients to sustain their health and function. Multiple factors are proposed to influence food intake, yet our understanding of these diverse factors and their interactions are limited. The purpose of this paper is to fully describe the protocol used to examine determinants of food and fluid intake among older adults participating in the Making the Most of Mealtimes (M3) study...
January 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28078662/low-immunoglobulin-e-flags-two-distinct-types-of-immune-dysregulation
#14
M Elkuch, V Greiff, C T Berger, M Bouchenaki, T Daikeler, A Bircher, A A Navarini, I Heijnen, M Recher
During the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a single-centre out-patient immunodeficiency and allergy clinic...
January 11, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28078316/covert-narrative-capacity-mental-life-in-patients-thought-to-lack-consciousness
#15
Lorina Naci, Mackenzie Graham, Adrian M Owen, Charles Weijer
Despite the apparent absence of external signs of consciousness, a significant proportion of behaviorally nonresponsive patients can respond to commands by willfully modulating their brain activity. However, little is known about the mental life of these patients. We discuss a recent innovative approach, which sheds light on the preserved cognitive capacities of these patients, including executive function, theory of mind, and the experience of affective states. This research represents a fundamental shift in our understanding of these patients, and has important implications for both their continued treatment and care...
January 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28077620/mitogen-induced-distinct-epi-alleles-are-phosphorylated-at-either-h3s10-or-h3s28-depending-on-h3k27-acetylation
#16
Dilshad H Khan, Shannon Healy, Shihua He, Daniel Lichtensztejn, Ludger Klewes, Kiran L Sharma, Veronica Lau, Sabine Mai, Geneviève P Delcuve, James R Davie
Stimulation of the MAPK pathway results in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediate-early (IE) genes. In 10T1/2 mouse fibroblasts, phosphorylation of H3S10 and H3S28 occurs on different H3 molecules and in different nuclear regions. Likewise, we show that mitogen-induced H3S10 and H3S28 phosphorylation occurs in separate pools in human primary fibroblasts. High-resolution imaging studies on both cell types have revealed that H3S10 and H3S28 phosphorylation events can be induced in a single cell but on different alleles, giving rise to H3S10ph and H3S28ph epi-alleles...
January 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28077059/ignorance-is-not-bliss-the-effect-of-systematic-information-on-immigrants-knowledge-of-and-satisfaction-with-the-danish-healthcare-system
#17
Signe Smith Jervelund, Thomas Maltesen, Camilla Lawaetz Wimmelmann, Jørgen Holm Petersen, Allan Krasnik
AIMS: Suboptimal healthcare utilisation and lower satisfaction with the patient-doctor encounter among immigrants has been documented. Immigrants' lack of familiarity with the healthcare system has been proposed as an explanation for this. This study investigated whether a systematic delivery of information affected immigrants' knowledge of and satisfaction with the Danish healthcare system. METHODS: A prospective, randomised intervention study of 1158 adult immigrants attending two language schools in Copenhagen was conducted...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28076736/australian-institute-of-sport-and-australian-medical-association-position-statement-on-concussion-in-sport
#18
Lisa J Elkington, David C Hughes
Sport-related concussion is a growing health concern in Australia. Public concern is focused on the incidence and potential long term consequences of concussion. Children may be more prone to concussion and take longer to recover. The Australian Institute of Sport and the Australian Medical Association have collaborated to present the most contemporary evidence-based information in a format appropriate for all stakeholders. This position statement aims to ensure that participant safety and welfare is paramount when dealing with concussion in sport...
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28076596/prevalence-of-inter-hemispheric-asymetry-in-children-and-adolescents-with-interdisciplinary-diagnosis-of-non-verbal-learning-disorder
#19
Alessandra Bernardes Caturani Wajnsztejn, Bianca Bianco, Caio Parente Barbosa
Objective: To describe clinical and epidemiological features of children and adolescents with interdisciplinary diagnosis of non-verbal learning disorder and to investigate the prevalence of inter-hemispheric asymmetry in this population group. Methods: Cross-sectional study including children and adolescents referred for interdisciplinary assessment with learning difficulty complaints, who were given an interdisciplinary diagnosis of non-verbal learning disorder...
October 2016: Einstein
https://www.readbyqxmd.com/read/28075090/carpal-tunnel-syndrome-diagnosis-and-management
#20
Jennifer Wipperman, Kyle Goerl
Carpal tunnel syndrome, the most common entrapment neuropathy of the upper extremity, is caused by compression of the median nerve as it travels through the carpal tunnel. Classically, patients with the condition experience pain and paresthesias in the distribution of the median nerve, which includes the palmar aspect of the thumb, index and middle fingers, and radial half of the ring finger. Additional clues include positive physical examination findings, such as the flick sign, Phalen maneuver, and median nerve compression test...
December 15, 2016: American Family Physician
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