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https://www.readbyqxmd.com/read/29031180/design-of-silk-proteins-with-increased-heme-binding-capacity-and-fabrication-of-silk-heme-materials
#1
Trevor D Rapson, Jian-Wei Liu, Alagacone Sriskantha, Mustafa Musameh, Christopher J Dunn, Jeffrey S Church, Andrea Woodhead, Andrew C Warden, Mark J Riley, Jeffrey R Harmer, Christopher J Noble, Tara D Sutherland
In our previous studies, heme was bound into honeybee silk to generate materials that could function as nitric oxide sensors or as recoverable heterogeneous biocatalysts. In this study, we sought to increase the heme-binding capacity of the silk protein by firstly redesigning the heme binding site to contain histidine as the coordinating residue and secondly, by adding multiple histidine residues within the core of the coiled coil core region of the modified silk protein. We used detergent and a protein denaturant to confirm the importance of the helical structure of the silk for heme coordination...
September 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29028153/tailored-intraoperative-localization-of-non-palpable-pulmonary-lesions-for-thoracoscopic-wedge-resection-using-hybrid-room-technology
#2
Alessia Stanzi, Federico Mazza, Francesco Lucio, Donatella Ghirardo, Maurizio Grosso, Alessandro Locatelli, Giulio Melloni
INTRODUCTION: VATS wedge resection can require conversion to thoracotomy when pulmonary lesions cannot be identified. Hybrid operating rooms (HOR) provide real-time image acquisition capabilities allowing the intraoperative placement of markers, to facilitate the removal of non-palpable nodules during VATS. OBJECTIVES: To present our workflow based on the alternative use of two different markers according to the location of the lung lesion, and report our initial results...
October 13, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29027950/control-design-and-digital-implementation-of-a-fast-2-degree-of-freedom-translational-optical-image-stabilizer-for-image-sensors-in-mobile-camera-phones
#3
Jeremy H-S Wang, Kang-Fu Qiu, Paul C-P Chao
This study presents design, digital implementation and performance validation of a lead-lag controller for a 2-degree-of-freedom (DOF) translational optical image stabilizer (OIS) installed with a digital image sensor in mobile camera phones. Nowadays, OIS is an important feature of modern commercial mobile camera phones, which aims to mechanically reduce the image blur caused by hand shaking while shooting photos. The OIS developed in this study is able to move the imaging lens by actuating its voice coil motors (VCMs) at the required speed to the position that significantly compensates for imaging blurs by hand shaking...
October 13, 2017: Sensors
https://www.readbyqxmd.com/read/29027870/flow-diversion-of-a-recurrent-iatrogenic-basilar-tip-aneurysm-in-a-pediatric-patient-case-report
#4
Rahul A Sastry, Matthew J Koch, Benjamin L Grannan, Christopher J Stapleton, William E Butler, Aman B Patel
Endoscopic third ventriculostomy (ETV) is a common treatment for noncommunicating hydrocephalus. Although rare, vascular injury and traumatic pseudoaneurysm development during ETV have been reported. The authors present the case of a 13-year-old boy who underwent repeat ETV (rETV) for shunt and ETV failure, and who suffered an intraoperative subarachnoid hemorrhage due to iatrogenic injury to the basilar tip, with subsequent development of a pseudoaneurysm. Despite initial primary coil embolization, the aneurysm recurred and was definitively treated with flow diversion...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29027862/effect-of-body-mass-index-on-outcome-after-aneurysmal-subarachnoid-hemorrhage-treated-with-clipping-versus-coiling
#5
Lorenzo Rinaldo, Joshua D Hughes, Alejandro A Rabinstein, Giuseppe Lanzino
OBJECTIVE It has been suggested that increased body mass index (BMI) may confer a protective effect on patients who suffer from aneurysmal subarachnoid hemorrhage (aSAH). Whether the modality of aneurysm occlusion influences the effect of BMI on patient outcomes is not well understood. The authors aimed to compare the effect of BMI on outcomes for patients with aSAH treated with surgical clipping versus endovascular coiling. METHODS The authors retrospectively reviewed the outcomes for patients admitted to their institution for the management of aSAH treated with either clipping or coiling...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027724/adsorbed-eutectic-gain-structures-on-a-neoprene-foam-for-stretchable-mri-coils
#6
Matija Varga, Andreas Mehmann, Josip Marjanovic, Jonas Reber, Christian Vogt, Klaas Paul Pruessmann, Gerhard Tröster
Stretchable conductors based on eutectic gallium-indium (eGaIn) alloy are patterned on a polychloroprene substrate (neoprene foam) using stencil printing. By tuning the amount of eGaIn on the neoprene substrate, different strain-sensitivity of electrical resistance is achieved. Conductors with a layer of eGaIn, which adsorbs to the walls of 60-100 µm wide neoprene cells, change their electrical resistance for 5% at 100% strain. When the amount of eGaIn is increased, the cells are filled with eGaIn and the strain-sensitivity of the electrical resistance rises to 300% at 100% strain...
October 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29027094/multimodal-functional-neuroimaging-by-simultaneous-bold-fmri-and-fiber-optic-calcium-recordings-and-optogenetic-control
#7
REVIEW
Franziska Albers, Lydia Wachsmuth, Timo Mauritz van Alst, Cornelius Faber
Recent developments of optogenetic tools and fluorescence-based calcium recording techniques enable the manipulation and monitoring of neural circuits on a cellular level. Non-invasive imaging of brain networks, however, requires the application of methods such as blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), which is commonly used for functional neuroimaging. While BOLD fMRI provides brain-wide non-invasive reading of the hemodynamic response, it is only an indirect measure of neural activity...
October 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29026365/incidental-finding-of-bronchopulmonary-sequestration-in-a-64-year-old-female
#8
Pichapong Tunsupon, Ayesha Arshad, Sumit Patel, M Jeffery Mador
BACKGROUND: Bronchopulmonary sequestration is a congenital abnormality of the primitive foregut. In adults, the typical age at presentation is 20-25 years. CASE REPORT: A 64-year-old female was referred for evaluation of an 8 × 6-cm right lower lobe cystic lesion. Her medical history was significant for recurrent right lower lobe pneumonia requiring multiple hospitalizations. Her physical examination was significant for crackles at the right lung base. Computed tomography (CT) of the chest with contrast showed cystic changes with thickened septation of the medial segment of the right lower lobe lacking distinct visceral pleura and with arterial supply from the anomalous branch of the thoracic aorta arising near the celiac trunk...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025918/contemporary-endovascular-and-open-aneurysm-treatment-in-the-era-of-flow-diversion
#9
REVIEW
Marcus D Mazur, Philipp Taussky, Min S Park, William T Couldwell
Clinical outcomes have improved considerably over the last decade for patients with ruptured and unruptured aneurysms. Modern endovascular techniques, such as flow diversion, are associated with high aneurysm occlusion rates and have become a popular treatment modality for many types of aneurysms. However, the safety and effectiveness of flow diversion has not yet been established in trials comparing it with traditional aneurysm treatments. Moreover, there are some types of aneurysms that may not be appropriate for endovascular coiling, such as wide-necked aneurysms located at branch points of major vessels, large saccular aneurysms with multiple efferent arteries, dolichoectatic aneurysms, large aneurysms with mass effect, when there are technical complications with endovascular treatment, when patients cannot tolerate or have contraindications to antiplatelet therapy or in the setting of a subarachnoid haemorrhage...
October 12, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29025534/-endovascular-treatment-of-a-gastroduodenal-artery-pseudoaneurysm-rupture-after-a-car-accident
#10
Sofia Dutra, Filipe Veloso Gomes, Tiago Bilhim, Élia Coimbra
The authors present a case of a 39-year-old man with alcoholic chronic pancreatitis that was admitted in the emergency department after a car accident, complaining of abdominal pain and looking pale. The patient was hemodinamically unstable, requiring blood transfusions. He underwent computed tomography angiogram of the abdomen and pelvis, showing a pseudoaneurysm of the gastroduodenal artery and a hemoperitoneum. He was referred to our interventional radiology unit and submitted to endovascular treatment, consisting of 'backdoor' and 'frontdoor' embolization of the gastroduodenal artery and pseudoaneurysm neck with coils, with total exclusion in control angiography...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29023249/priming-with-1-hz-rtms-over-contralesional-leg-motor-cortex-does-not-increase-the-rate-of-regaining-ambulation-within-3-months-of-stroke-a-randomized-controlled-trial
#11
Ying-Zu Huang, Li-Fong Lin, Kwang-Hwa Chang, Chaur-Jong Hu, Tsan-Hon Liou, Yen-Nung Lin
BACKGROUND: The potential benefits of repetitive transcranial magnetic stimulation (rTMS), applied either alone or as a combination treatment, on recovery of lower extremities after stroke have been insufficiently studied. OBJECTIVE: To evaluate the effect of priming with 1-Hz rTMS over contralesional leg motor area with a double cone coil prior physical therapy (PT) on regaining ambulation. METHODS: Thirty-eight subacute stroke patients with significant leg disabilities were randomly assigned into the experimental (E) group or control (C) group to receive a 15-min real or sham 1-Hz rTMS, respectively, over the contralesional motor cortex representing the quadriceps muscle followed by 45-min PT for 15 sessions over 3 weeks...
October 10, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29021865/minimally-invasive-pericardial-implantable-cardioverter-defibrillator-placement-in-a-young-child
#12
Wakana Maki, Hiroko Asakai, Kazuhiro Shiraga, Takahiro Shindo, Yoichiro Hirata, Ryo Inuzuka, Yasutaka Hirata, Akira Oka
We report the successful minimally invasive placement of a pericardial implantable cardioverter-defibrillator (ICD) in a 16-kg child. A transvenous ICD dual coil was advanced through a small subxiphoid incision and screwed into the oblique sinus pericardium under fluoroscopic guidance. An additional sense-pace lead was sutured onto the right ventricular apex, and the generator was placed in the upper abdominal wall through the same incision. Threshold testing demonstrated successful defibrillation at 15 J...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29021533/an-integrated-microfluidic-system-using-a-micro-fluxgate-and-micro-spiral-coil-for-magnetic-microbeads-trapping-and-detecting
#13
Xuecheng Sun, Zhu Feng, Shaotao Zhi, Chong Lei, Di Zhang, Yong Zhou
We report an innovative integrated microfluidic platform based on micro-fluxgate and micro-coils for trapping and detecting magnetic beads. A micro-spiral coil fabricated by microfabrication technology is used to trap the magnetic beads, and the micro-fluxgate is employed to detect the weak magnetic field induced by the trapped magnetic beads. The fabrication process of the magnetic bead trapping system using a micro-coil is highly compatible with that of the micro-fluxgate sensor, making fabrication of this integrated microfluidic system convenient and efficient...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021142/knotted-urethral-catheter-an-unusual-complication-in-adults
#14
Samer Jallad, Anupa Shah, Jeetesh Bhardwa
Knotting of feeding tubes or urinary catheters has been reported as a rare complication in paediatrics when draining the bladder. This is caused by inserting thin flexible tubes too far in, allowing it to coil. We present a case of a 70-year-old woman who was catheterised during a routine spinal surgery, and the catheter coiled and balloon failed to deflate requiring a cystostopic approach to puncture the balloon and remove it. Awareness of this complication in female catheterisation and education on length of catheter insertion is important to avoid this...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29020104/the-n-terminal-domains-of-flash-and-lsm11-form-a-2-1-heterotrimer-for-histone-pre-mrna-3-end-processing
#15
Wei Shen Aik, Min-Han Lin, Dazhi Tan, Ashutosh Tripathy, William F Marzluff, Zbigniew Dominski, Chi-Yuan Chou, Liang Tong
Unlike canonical pre-mRNAs, animal replication-dependent histone pre-mRNAs lack introns and are processed at the 3'-end by a mechanism distinct from cleavage and polyadenylation. They have a 3' stem loop and histone downstream element (HDE) that are recognized by stem-loop binding protein (SLBP) and U7 snRNP, respectively. The N-terminal domain (NTD) of Lsm11, a component of U7 snRNP, interacts with FLASH NTD and these two proteins recruit the histone cleavage complex containing the CPSF-73 endonuclease for the cleavage reaction...
2017: PloS One
https://www.readbyqxmd.com/read/29018013/stroke-resulting-from-an-isolated-pulmonary-arteriovenous-malformation
#16
Jakob Saidman, Hossam Abdou, Sridhar Sampath Kumar
Isolated pulmonary arteriovenous malformations (PAVM) are rare, but can be responsible for paradoxical embolic events. It is important to recognise these situations early and intervene quickly to attain the best outcome. We describe the case of a 45-year-old woman with a long-standing history of migraines with aura who presented to the emergency department with left-sided weakness and slurred speech. Work-up was unclear and she was diagnosed with cryptogenic stroke. Follow-up transoesophageal echocardiogram was suggestive of an atrial septal defect, though no clear defect was evident...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29017949/tumor-necrosis-factor-receptor-associated-factor-3-from-anodonta-woodiana-is-an-important-factor-in-bivalve-immune-response-to-pathogen-infection
#17
Fufa Qu, Zhiming Xiang, Yingli Zhou, Yanping Qin, Ziniu Yu
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a multifunctional adaptor protein in innate and acquired immune system that plays a key role in the regulation of the RIG-I-like receptor (RLR) and Toll-like receptor (TLR) signaling pathway in mammals. However, the immune function of TRAF3 homologs in freshwater mollusks is not well understood. In this study, we identified a bivalve TRAF3 gene (AwTRAF3) from Anodonta woodiana and investigated its potential roles during immune challenges. The present AwTRAF3 encoded a polypeptide of 562 amino acids with predicted molecular mass of 64...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29017883/effect-of-salt-on-the-coil-helix-transition-of-gelatin-at-early-stages-optical-rotation-rheology-and-dsc-studies
#18
Congde Qiao, Jianlong Zhang, Xianguang Ma, Weiliang Liu, Qinze Liu
The influence of the concentration and type of salt on the physical gelation of gelatin at early stages was explored by polarimeter, rheometer and differential scanning calorimetry (DSC). With the increase of salt concentration, both the triple helix content and the storage modulus of gelatin increased slightly and then decreased in CaCl2 solutions, whereas they decreased monotonically in NaCl and CrCl3 solutions. The addition of CaCl2 at low concentrations facilitated the coil-helix transition of gelatin, which could be significantly inhibited by high salt concentrations...
October 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29016986/retained-pacemaker-and-implantable-cardioverter-defibrillator-components-after-heart-transplantation-are-common-and-may-lead-to-adverse-events
#19
Stephen J Pettit, Mateusz Orzalkiewicz, Muhammad A Nawaz, Clive Lewis, Jayan Parameshwar, Steven Tsui
Aims: Many patients have a cardiac implantable electronic device (CIED) extracted at the time of heart transplantation. CIED components may be retained after heart transplantation, but their frequency, nature, and clinical significance is uncertain. Methods and results: Consecutive patients that underwent heart transplantation over 10 years from 1 January 2007 until 1 January 2017 were identified from the unit database. Pre- and post-operative chest radiographs were reviewed by two independent observers for the presence of CIED components...
July 19, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016223/impending-carotid-blowout-from-a-large-neck-mass-treated-sequentially-with-endovascular-coil-embolization-followed-by-induction-chemotherapy
#20
Rohit Venkatesan, Natasha Hirani, Maurice Willis, Bagi Jana, Zulfiqar Cheema
No abstract text is available yet for this article.
October 10, 2017: Journal of Oncology Practice
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