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Simon D Carr, John A Rutka
INTRODUCTION: Bilateral posterior semicircular canal (PSCC) occlusion is a successful treatment of bilateral benign positional vertigo (BPV) refractory to particle repositioning manoeuvers. Little about the effects on the vestibular ocular reflex (VOR) postoperatively, which is the intent of this study. METHODS: All patients who underwent bilateral posterior canal occlusion for BPV at the University Health Network by the senior author (J.A.R.) between 2001 and 2017 with pre- and postoperative vestibular testing were included in the study...
June 15, 2018: Otology & Neurotology
Jian Chen, Qian Wang, Wei Zhou, Zheng Zhou, Peng-Yu Tang, Tao Xu, Wei Liu, Lin-Wei Li, Lin Cheng, Zhi-Min Zhou, Jin Fan, Guo-Yong Yin
GPCR kinase 2-interacting protein-1 (GIT1) is a scaffold protein that plays an important role in cell adaptation, proliferation, migration, and differentiation; however, the role of GIT1 in the regulation of neuronal death after spinal cord injury remains obscure. Here, we demonstrate that GIT1 deficiency remarkably increased neuronal apoptosis and enhanced JNK/p38 signaling, which resulted in stronger motor deficits by ischemia-reperfusion in vivo, consistent with the finding of oxygen-glucose deprivation/reoxygenation-induced neuronal injury in vitro...
June 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Emmanuel Amlabu, Henrietta Mensah-Brown, Prince B Nyarko, Ojo-Ajogu Akuh, Grace Opoku, Philip Ilani, Richard Oyagbenro, Kwame Asiedu, Yaw Aniweh, Gordon A Awandare
Plasmodium falciparum erythrocyte invasion is a multi-step process that involves a spectrum of interactions that are not well characterized. We have characterized a 113 kDa immunogenic protein PF3D7_1431400 (PF14_0293) that possesses coiled-coil structures. The protein is localized on the surfaces of both merozoites and gametocytes, hence the name PlasmodiumfalciparumSurface Related Antigen (PfSRA). The processed 32 kDa fragment of PfSRA binds normal human erythrocytes with different sensitivities to enzyme treatments...
April 18, 2018: Journal of Infectious Diseases
Eric A Woodcock, Muzamil Arshad, Dalal Khatib, Jeffrey A Stanley
Background: Single-voxel proton magnetic resonance spectroscopy (1 H MRS) is a powerful technique for studying in vivo neurochemistry, but has an often-overlooked source of error variance: inconsistent voxel placement between scans. We developed and evaluated an Automated Voxel Placement (AVP) procedure for accurate and reliable 1 H MRS voxel prescription. AVP is a suite of Linux-based programs that facilitate automated template-driven single-voxel coregistration. Methods: Three studies were conducted to evaluate AVP for prescription of one voxel: left dorsolateral prefrontal cortex...
2018: Journal of Neuroimaging in Psychiatry & Neurology
E Perdikakis, I Fezoulidis, V Tzortzis, C Rountas
PURPOSE: To present anatomical variations of left internal spermatic vein and a comparison between treatments with hydrogel-coated and non-coated platinum coils in patients with varicocele. MATERIALS AND METHODS: A total of 153 men (mean age, 27.5±6.7 [SD] years; range: 18-45 years) with left sided varicocele underwent coil embolization. Anatomic variants of gonadal vein were categorized into five subtypes (I-V). Additional venous collaterals were also recorded...
June 14, 2018: Diagnostic and Interventional Imaging
E Jambon, A Hocquelet, F Petitpierre, Y Le Bras, C Marcelin, V Dubuisson, N Grenier, F Cornelis
PURPOSE: To compare intervention duration and fluoroscopy time for proximal embolization of splenic arteries in acute trauma using the Penumbra occlusion device (POD® ), coils or Amplatzer™ vascular plug (AVP). MATERIAL AND METHODS: A total of 29 patients with splenic injury without vascular injury who were treated by proximal splenic artery embolization using POD® (n=12), coils (n=9) or AVP (n=8) were retrospectively included. There were 25 men and 4 women with a median age of 34 years (range: 10-69 years)...
June 14, 2018: Diagnostic and Interventional Imaging
Hasan Hodaj, Jean-François Payen, Jean-Pascal Lefaucheur
OBJECTIVE: To show that repetitive transcranial magnetic stimulation (rTMS) delivered at high frequency over the motor cortex can improve patients with chronic pain syndrome even if this procedure does not provide an analgesic response. CASE REPORT: A 77-year-old woman presented with drug-resistant chronic neuropathic pain affecting both lower limbs due to segmental spine compression at T9-T10 level. She underwent an rTMS protocol with an induction phase of 12 rTMS sessions during three weeks and a maintenance phase of 3 additional rTMS sessions for 5 weeks...
June 14, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Haihong Li, Liyun Chen, Mingjun Zhang, Sitian Xie, Liuhanghang Cheng
Previously studies showed that Forkhead transcription factor A1 (FoxA1) was associated with sweat secretion. To investigate the expression and localization of FoxA1 in the three-dimensional (3D) reconstructed eccrine sweat glands, eccrine sweat gland cells were transplanted subcutaneously into nude mice with Matrigel, and at 2, 3, 4, 5, 6, 8, 10 and 12 weeks post-transplantation, the reconstructed eccrine sweat glands were removed and immunostained for FoxA1 and co-immunostained for FoxA1 and eccrine sweat markers, K7, carbonic anhydrase II (CA Ⅱ), gross cystic disease fluid protein-15 (GCDFP-15) and α-smooth muscle actin (α-SMA), and FoxA1 and sweat secretion-related proteins, Na+ -K+ -ATPase α and Na+ -K+ -2Cl- cotransporter 1 (NKCC1)...
June 14, 2018: Acta Histochemica
Mian Wu, Wen-Ping Wu, Cheng-Chen Liu, Ying-Na Liu, Xiao-Yi Wu, Fang-Fang Ma, An-Qi Zhu, Jia-Yin Yang, Bin Wang, Jian-Qun Chen
In the soybean cultivar Suweon 97, BCMV-resistance gene was fine-mapped to a 58.1-kb region co-localizing with the Soybean mosaic virus (SMV)-resistance gene, Rsv1-h raising a possibility that the same gene is utilized against both viral pathogens. Certain soybean cultivars exhibit resistance against soybean mosaic virus (SMV) or bean common mosaic virus (BCMV). Although several SMV-resistance loci have been reported, the understanding of the mechanism underlying BCMV resistance in soybean is limited. Here, by crossing a resistant cultivar Suweon 97 with a susceptible cultivar Williams 82 and inoculating 220 F2 individuals with a BCMV strain (HZZB011), we observed a 3:1 (resistant/susceptible) segregation ratio, suggesting that Suweon 97 possesses a single dominant resistance gene against BCMV...
June 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Orlando M Diaz, Maria M Toledo, John O F Roehm, Richard P Klucznik, Ponraj Chinnadurai, Gloria Viviana Lopez, Gavin W Britz
PURPOSE: To report percutaneous transcranial puncture, embolisation and occlusion of a very symptomatic hypoglossal canal/anterior condylar vein dural arteriovenous fistula (DAVF) using syngo iGuide navigational software in a patient in whom transarterial and transvenous embolisation and surgery had failed. METHODS: After unsuccessful arterial and venous embolisation and surgical treatment of a symptomatic hypoglossal canal DAVF, a 47-year-old man was transferred for further management...
June 16, 2018: Journal of Neurointerventional Surgery
Shuhei Kawabata, Hirotoshi Imamura, Keita Suzuki, Shoichi Tani, Hidemitsu Adachi, Nobuyuki Sakai
A middle-aged patient with an internal carotid-posterior communicating artery aneurysm and basilar artery tip aneurysm was treated by stent-assisted coiling. One ischemic infarction and two transient ischemic attacks occurred with the same symptoms (inability to walk unassisted and tendency to fall to the left) during the first 2 years post-treatment. The ischemic infarction was found in the right side of the pons, consistent with the vascular territory of the stent-containing vessel. The cause of the delayed ischemic stroke was investigated on DSA and cone beam CT, which revealed that the proximal end of the stent, one marker band, was just covering a small perforating artery of the basilar artery trunk...
June 16, 2018: Journal of Neurointerventional Surgery
Yong Cheol Lim, Yong Sam Shin, Joonho Chung
A new Low-profile Visualized Intraluminal Support device (LVIS Blue) is a braided stent that provides a higher degree of metal coverage. This stent may be beneficial for complete obliteration of an aneurysm due not only to its support of a higher occlusion rate using coils inside of the aneurysm but also to its flow diverting effect. We introduce and describe a new flow diversion technique using an LVIS Blue-within-an-Enterprise for patients with vertebral artery (VA) dissecting aneurysms. A 6-Fr guiding catheter was positioned in the ipsilateral VA...
June 14, 2018: World Neurosurgery
Ruihua Zhang, Xiaoyang Pang, Jing Lu, Lu Liu, Shuwen Zhang, Jiaping Lv
This work investigated the impact of high intensity ultrasound (HIUS) pretreatment on the functional properties and structural characteristics of micellar casein concentrate (MCC). Microfiltered casein protein retentates were treated with HIUS for 0.5, 1, 2, and 5 min prior to spray drying. The results showed that conductivity, solubility, emulsifying, gelling increased significantly as the ultrasonic time prolonged, but the change of pH value were insignificant. In addition, the structural characteristics of MCC for all samples were studied...
October 2018: Ultrasonics Sonochemistry
Anna Hurshkainen, Anton Nikulin, Elodie Georget, Benoit Larrat, Djamel Berrahou, Ana Luisa Neves, Pierre Sabouroux, Stefan Enoch, Irina Melchakova, Pavel Belov, Stanislav Glybovski, Redha Abdeddaim
In this paper, we propose, design and test a new dual-nuclei RF-coil inspired by wire metamaterial structures. The coil operates as a result of resonant excitation of hybridized eigenmodes in multimode flat periodic structures comprising several coupled thin metal strips. It was shown that the field distribution of the coil (i.e. penetration depth) can be controlled independently at two different Larmor frequencies by selecting a proper eigenmode in each of two mutually orthogonal periodic structures. The proposed coil requires no lumped capacitors to be tuned and matched...
June 15, 2018: Scientific Reports
N Shinoda, M Mori, S Tamura, K Korosue, S Kose, E Kohmura
Treatment of blood blister-like aneurysm (BBA) is a challenge due to its unfavourable morphology, small size and the friable neck of BBA. In the management of ruptured BBA, coil placement can be achieved by stent-assisted coil embolisation. We propose to incorporate a new technique using a steam-shaped microcatheter to improve safety. A 59-year-old woman was transferred to our hospital and diagnosed with subarachnoid haemorrhage (SAH) due to a ruptured BBA of the left internal carotid artery (ICA) at the C2 portion...
June 12, 2018: Neuro-Chirurgie
Wei Kang, Fan Jiang, Yun-Dong Wu
The coupling between neighboring backbone ϕ and ψ dihedral-angles (torsions) has been well appreciated in protein force field development, as in the correction-map (CMAP) potentials. However, although preferences of backbone torsions are significantly affected by side-chain conformation, there has been no easy way to optimize this coupling. Herein, we prove that the three-dimensional (3D) free energy hyper-surface of joint (ϕ, ψ, χ1) torsions can be decomposed into three separated 2D surfaces. Thus, each of the 2D torsional surfaces can be efficiently and automatically optimized using a CMAP potential...
June 15, 2018: Journal of Chemical Theory and Computation
Eyleen Sabine Heidrich, Thomas Brüser
PspA is a key component of the bacterial Psp membrane-stress response system. The biochemical and functional characterization of PspA is impeded by its oligomerization and aggregation properties. It was recently possible to solve the coiled coil structure of a completely soluble PspA fragment, PspA(1-144), that associates with the σ54 enhancer binding protein PspF at its W56-loop and thereby down-regulates the Psp response. We now found that the C-terminal part of PspA, PspA(145-222), also interacts with PspF and inhibits its activity in the absence of full-length PspA...
2018: PloS One
Elizabeth Lee, Jiaqi Luo, Biao Sun, Vincent Ramalingam, Ying Zhang, Qijie Wang, Fei Yu, Xia Yu
We demonstrate flexible single-mode transmission of a high average power 2 µm nanosecond pulse using antiresonant hollow-core fibers (AR-HCFs). 39.1 W average power is delivered using a coiled 1.7 m AR-HCF, which is designed for single-mode guidance and good higher-order mode suppression. The effect of bending on the fiber output power and beam profile is also investigated. The Gaussian-like output beam profile is maintained up to a 7.5 cm bending radius. This is the highest average power delivered by a flexible long HCF in this wavelength without the need for an enclosed controlled environment, to the best of our knowledge...
June 15, 2018: Optics Letters
Saswati S Lenka, Mahismita Paichha, Madhubanti Basu, Mrinal Samanta
The high-mobility group box 1 (HMGB1) protein is a highly conserved nonhistone chromosomal protein ubiquitously present in almost all cell types. In the nucleus, it facilitates DNA repair and replication, V(D)J recombination, stabilization of nucleosome, and in the cytoplasm, it regulates autophagy and apoptosis. In addition to these intracellular functions, HMGB1 also facilitates activation of innate immune responses and plays key roles in host defense. To investigate its role in fish, we cloned and characterized HMGB1 in Labeo rohita (LrHMGB1), the most important freshwater fish species in the Indian subcontinent...
June 15, 2018: DNA and Cell Biology
Malay Sharma, Saurabh Jindal, Piyush Somani, Bhupendra Kumar Basnet, Raghav Bansal
No abstract text is available yet for this article.
October 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
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