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https://www.readbyqxmd.com/read/28231167/antibacterial-activity-of-fructus-forsythia-essential-oil-and-the-application-of-eo-loaded-nanoparticles-to-food-borne-pathogens
#1
Na Guo, Qing-Yan Gai, Jiao Jiao, Wei Wang, Yuan-Gang Zu, Yu-Jie Fu
Fructus forsythia essential oil (FEO) with excellent antibacterial activity was rarely reported. The objective of the present study was to investigate the antibacterial activity and the antibacterial mechanism of FEO against two food-borne pathogenic bacteria, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro. When treated FEO, the zones of inhibition (ZOI) of E. coli (20.5 ± 0.25 mm) and S. aureus (24.3 ± 0.21 mm) were much larger than control (p < 0.05). The minimum inhibitory concentrations (MICs) of FEO were 3...
October 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230992/novel-design-of-heptad-amphiphiles-to-enhance-cell-selectivity-salt-resistance-anti-biofilm-properties-and-their-membrane-disruptive-mechanism
#2
Xiujing Dou, Xin Zhu, Jiajun Wang, Na Dong, Anshan Shan
Coiled-coil, a basic folding pattern of native proteins, was previously demonstrated to be associated with the specific spatial recognition, association, and dissociation of proteins and can be used to perfect engineering peptide model. Thus, in this study, a series of amphiphiles composed of heptads repeats with coiled-coil structures was constructed, and the designed peptides exhibited a broad spectrum of antimicrobial activities. Circular dichroism and biological assays showed that the heptad repeats and length of the linker between the heptads largely influenced the amphiphile's helical propensity and cell selectivity...
February 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230348/nmr-structures-of-gcn4p-are-largely-conserved-when-ion-pairs-are-disrupted-at-acidic-ph-but-show-a-relaxation-of-the-coiled-coil-superhelix
#3
Anne R Kaplan, Megan R Brady, Mark W Maciejewski, Richard A Kammerer, Andrei T Alexandrescu
To understand the roles ion pairs play in stabilizing coiled coils we determined NMR structures of GCN4p at three pH values. At pH 6.6 all acidic residues are fully charged, at pH 4.4 they are half-charged, and at pH 1.5 they are protonated and uncharged. The α-helix monomer and coiled coil structures of GCN4p are largely conserved, except for a loosening of the coiled coil quaternary structure with decreasing pH. Differences going from neutral to acidic pH include (i) an unwinding of the coiled coil superhelix due to the loss of inter-chain ion pair contacts, (ii) a small increase in the separation of the monomers in the dimer, (iii) a loosening of knobs-into-holes packing motifs, and (iv) an increased separation between oppositely charged residues that participate in ion pairs at neutral pH...
February 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28230230/bronchoscopic-lung-volume-reduction-procedures-for-chronic-obstructive-pulmonary-disease
#4
REVIEW
Joseph Em van Agteren, Khin Hnin, Dion Grosser, Kristin V Carson, Brian J Smith
BACKGROUND: In the recent years, a variety of bronchoscopic lung volume reduction (BLVR) procedures have emerged that may provide a treatment option to participants suffering from moderate to severe chronic obstructive pulmonary disease (COPD). OBJECTIVES: To assess the effects of BLVR on the short- and long-term health outcomes in participants with moderate to severe COPD and determine the effectiveness and cost-effectiveness of each individual technique. SEARCH METHODS: Studies were identified from the Cochrane Airways Group Specialised Register (CAGR) and by handsearching of respiratory journals and meeting abstracts...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28230071/probing-the-molecular-mechanism-of-human-soluble-guanylate-cyclase-activation-by-no-in-vitro-and-in-vivo
#5
Jie Pan, Hong Yuan, Xiaoxue Zhang, Huijuan Zhang, Qiming Xu, Yajun Zhou, Li Tan, Shingo Nagawa, Zhong-Xian Huang, Xiangshi Tan
Soluble guanylate cyclase (sGC) is a heme-containing metalloprotein in NO-sGC-cGMP signaling. NO binds to the heme of sGC to catalyze the synthesis of the second messenger cGMP, which plays a critical role in several physiological processes. However, the molecular mechanism for sGC to mediate the NO signaling remains unclear. Here fluorophore FlAsH-EDT2 and fluorescent proteins were employed to study the NO-induced sGC activation. FlAsH-EDT2 labeling study revealed that NO binding to the H-NOX domain of sGC increased the distance between H-NOX and PAS domain and the separation between H-NOX and coiled-coil domain...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229334/specific-amyloid-binding-of-polybasic-peptides-in-vivo-is-retained-by-%C3%AE-sheet-conformers-but-lost-in-the-disrupted-coil-and-all-d-amino-acid-variants
#6
Jonathan S Wall, Angela Williams, Tina Richey, Alan Stuckey, Craig Wooliver, J Christopher Scott, Robert Donnell, Emily B Martin, Stephen J Kennel
PURPOSE: The heparin-reactive, helical peptide p5 is an effective amyloid imaging agent in mice with systemic amyloidosis. Analogs of p5 with modified secondary structure characteristics exhibited altered binding to heparin, synthetic amyloid fibrils, and amyloid extracts in vitro. Herein, we further study the effects of peptide helicity and chirality on specific amyloid binding using a mouse model of systemic inflammation-associated (AA) amyloidosis. PROCEDURES: Peptides with disrupted helical structure [p5(coil) and p5(Pro3)], with an extended sheet conformation [p5(sheet)] or an all-D enantiomer [p5(D)], were chemically synthesized, radioiodinated, and their biodistribution studied in WT mice as well as transgenic animals with severe systemic AA amyloidosis...
February 22, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28229215/sequence-analysis-and-expression-of-a-blue-light-photoreceptor-gene-slwc-1-from-the-cauliflower-mushroom-sparassis-latifolia
#7
Chi Yang, Lu Ma, Zhenghe Ying, Xiaoling Jiang, Yanquan Lin
Light is a necessary environmental factor for fruit body formation and development of the cauliflower mushroom Sparassis latifolia, a well-known edible and medicinal fungus. In this study, we firstly characterized the SP-C strain, which belonged to S. latifolia. And then we cloned and sequenced a photoreceptor gene (Slwc-1) from S. latifolia. The product of Slwc-1, SlWC-1 (872 aa residues) contained a coiled-coil region, a LOV domain, and two PAS domains. Phylogenetic tree result showed that SLWC-1 was most close to GfWC-1 from Grifola frondosa in edible and medicinal fungus...
February 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28229036/direct-surgery-of-previously-coiled-large-internal-carotid-ophthalmic-aneurysm-for-the-purpose-of-optic-nerve-decompression
#8
Shuhei Kawabata, Shingo Toyota, Tetsuya Kumagai, Tetsu Goto, Kanji Mori, Takuyu Taki
Background Progressive visual loss after coil embolization of a large internal carotid ophthalmic aneurysm has been widely reported. It is generally accepted that the primary strategy for this complication should be conservative, including steroid therapy; however, it is not well known as to what approach to take when the conservative therapy is not effective. Case Presentation We report a case of a 55-year-old female presenting with progressive visual loss after the coiling of a ruptured large internal carotid ophthalmic aneurysm...
January 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28228899/stent-assisted-modified-coil-protection-technique-for-bilobulated-aneurysm-technical-note
#9
Yunsuk Her, Jin Pyeong Jeon, Hyuk Jai Choi, Yong Jun Cho
Endovascular treatment of deeply located bilobulated aneurysms in elderly patients is still challenging because of the acute angulation of the carotid siphon and poor microcatheter support. In particular, generating a frame coil to cover each lobe is difficult in bilobulated aneurysms with narrow isthmus in the fused portion. Here, we report a successfully treated bilobulated aneurysm using a modified coil protection technique with stent assistance.
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28227978/modulation-of-motor-cortex-excitability-by-peripheral-magnetic-stimulation-of-different-stimulus-sites-and-frequencies
#10
A Sato, X Liu, T Torii, M Iwahashi, K Iramina, A Sato, X Liu, T Torii, M Iwahashi, K Iramina, M Iwahashi, X Liu, A Sato, K Iramina, T Torii
Peripheral stimulation is known to influence the state of cortical excitability. The purpose of this study is to investigate whether peripheral magnetic stimulation has similar effects on cortical excitability to transcranial magnetic stimulation (TMS). A magnetic stimulator with a flat figure-of-eight coil was used for both TMS, and peripheral magnetic stimulation applied to the bilateral forearms. TMS was performed on the left primary motor cortex to evaluate influence of the peripheral magnetic stimulation, and motor evoked potential (MEP) was measured from the right first dorsal interosseous...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227956/a-wirelessly-powered-homecage-with-animal-behavior-analysis-and-closed-loop-power-control
#11
Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Donald Rainnie, Chia-Chun Hsu, Teresa E Madsen, Morgan Tinkler, Daniel Canales, Zheyuan Wang, S Abdollah Mirbozorgi, Maysam Ghovanloo, Yaoyao Jia
This paper presents a new EnerCage-homecage system, EnerCage-HC2, for longitudinal electrophysiology data acquisition experiments on small freely moving animal subjects, such as rodents. EnerCage-HC2 is equipped with multi-coil wireless power transmission (WPT), closed-loop power control, bidirectional data communication via Bluetooth Low Energy (BLE), and Microsoft Kinect® based animal behavior tracking and analysis. The EnerCage-HC2 achieves a homogeneous power transfer efficiency (PTE) of 14% on average, with ~42 mW power delivered to the load (PDL) at a nominal height of 7 cm by the closed-loop power control mechanism...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227941/a-three-element-1-h-31-p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#12
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Jeremy Sia, Romina Del Bosque, Kurt Parizek, Mary P McDougall, Matthew D Wilcox, Edwin D Eigenbrodt
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for (31)P-(1)H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the (1)H and (31)P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227940/magnetic-resonance-imaging-receiver-coil-decoupling-using-circumferential-shielding-structures
#13
Jhy-Neng Tasso Yeh, Fa-Hsuan Lin, Jhy-Neng Tasso Yeh, Fa-Hsuan Lin, Jhy-Neng Tasso Yeh, Fa-Hsuan Lin
We propose a flexible phased-array design using circular coils with circumferential shielding structure to achieve robust decoupling between coil elements when the array is either bended or on a flat plane. Two types of circumferential shielding were tested through numerical simulation and imaging experiment. The results demonstrated that our arrays have good decoupling between coils when they are on a curved surface with S21 <; -16.72 dB. Both types perform higher SNR images than a commercially available 32-channel adult head coil array...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227939/effects-of-coplanar-shielding-for-high-field-mri
#14
Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall, Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall, Matthew D Wilcox, Steven M Wright, Samantha By, Mary P McDougall, Joseph V Rispoli
This work investigates the efficacy of "coplanar shielding," in which copper shields are oriented concentric and coplanar to the RF coils rather than implemented as a full ground plane behind them. Following FDTD simulations to determine optimal shielding parameters, two coil geometries were constructed: a circular loop surface coil and a half-volume five-element receive array. Each was evaluated using bench measurements with and without coplanar shielding. Imaging, including accelerated SENSE imaging, was performed with the shielded and unshielded receive arrays on a whole-body 7T scanner...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227938/integrated-rf-shim-coil-allowing-two-degrees-of-freedom-shim-current
#15
Jiazheng Zhou, Ying-Hua Chu, Yi-Cheng Hsu, Pu-Yeh Wu, Jason P Stockmann, Fa-Hsuan Lin, Jiazheng Zhou, Ying-Hua Chu, Yi-Cheng Hsu, Pu-Yeh Wu, Jason P Stockmann, Fa-Hsuan Lin, Pu-Yeh Wu, Jason P Stockmann, Fa-Hsuan Lin, Jiazheng Zhou, Ying-Hua Chu, Yi-Cheng Hsu
High-quality magnetic resonance imaging and spectroscopic measurements require a highly homogeneous magnetic field. Different from global shimming, localized off-resonance can be corrected by using multi-coil shimming. Previously, integrated RF and shimming coils have been used to implement multi-coil shimming. Such coils share the same conductor for RF signal reception and shim field generation. Here we propose a new design of the integrated RF-shim coil at 3-tesla, where two independent shim current paths are allowed in each coil...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227937/effects-of-tuning-conditions-on-near-field-of-mri-transmit-birdcage-coil-at-64-mhz
#16
Mikhail Kozlov, Elena Lucano, Leonardo M Angelone, Mikhail Kozlov, Elena Lucano, Leonardo M Angelone, Elena Lucano, Leonardo M Angelone, Mikhail Kozlov
This study investigates how the tuning conditions of a 64 MHz / 1.5 T radio frequency (RF) birdcage coil modeled with an RF circuit and 3D electromagnetic co-simulation affect the electric and magnetic near-field distribution. Four models were implemented with different tuning conditions and difference between numerical results and measurements was evaluated. The results show that the simulated near-field depends significantly on coil tuning conditions, especially in volumes close to the ASTM phantom walls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227661/parameter-optimization-of-pseudo-rigid-body-models-of-mri-actuated-catheters
#17
Tipakorn Greigarn, Taoming Liu, M Cenk Cavusoglu, Tipakorn Greigarn, Taoming Liu, M Cenk Cavusoglu, Taoming Liu, Tipakorn Greigarn, M Cenk Cavusoglu
Simulation and control of a system containing compliant mechanisms such as cardiac catheters often incur high computational costs. One way to reduce the costs is to approximate the mechanisms with Pseudo-Rigid-Body Models (PRBMs). A PRBM generally consists of rigid links connected by spring-loaded revolute joints. The lengths of the rigid links and the stiffnesses of the springs are usually chosen to minimize the tip deflection differences between the PRBM and the compliant mechanism. In most applications, only the relationship between end load and tip deflection is considered...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227587/optimal-frequency-for-powering-millimeter-sized-biomedical-implants-inside-an-inductively-powered-homecage
#18
Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani
This paper presents the optimal design and operation frequency (f) of an inductively-powered homecage for powering biomedical devices with millimeter (mm) dimensions, implanted inside the body of freely-behaving small animal subjects, for longitudinal behavioral neuroscience and electrophysiology experiments. In order to improve the power transmission efficiency (PTE) for powering mm-sized implants, the geometry of the multi-coil inductive links in the form of 3- and 4-coil links as well as fp need to be co-optimized...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227586/inductive-power-transmission-to-millimeter-sized-biomedical-implants-using-printed-spiral-coils
#19
Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani
The operation frequency (f) has been a key parameter in optimizing wireless power transmission links for biomedical implants with millimeter (mm) dimensions. This paper studies the feasibility of using printed spiral coils (PSCs) for powering mm-sized implants with high power transmission efficiency (PTE) at different fps. Compared to wire-wound coils (WWCs), using a PSC in the implant side allows batch fabrication on rigid or flexible substrates, which can also be used as a platform for integrating implant components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227511/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#20
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Maysam Ghovanloo, Byunghun Lee, Bruce Ash, Xingyuan Tong, Pyungwoo Yeon, Abdollah Mirbozorgi, Helmut Eckhardt
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm(3) neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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