Albert Grinshpun, Anatoli Kustanovich, Daniel Neiman, Roni Lehmann-Werman, Aviad Zick, Karen Meir, Elez Vainer, Roy Z Granit, Amit Arad, Noa Daskal, Ruth Schwartz, Eli Sapir, Myriam Maoz, Esther Tahover, Joshua Moss, Iddo Z Ben-Dov, Tamar Peretz, Ayala Hubert, Ruth Shemer, Yuval Dor
The standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. In recent years, new treatment approaches have led to higher rates of complete tumor eradication combined with organ-preservation strategies. However, better tools are still needed to personalize therapy for the individual patient. In this prospective observational study, we analyzed colon-derived cell-free (cf)DNA (c-cfDNA) using a tissue-specific DNA methylation signature, and its association with therapy outcomes...
April 1, 2023: International Journal of Cancer. Journal International du Cancer