Hui Wang, Jurgen Seidel, Christopher Bartos, Russell Byrum, Philip J Sayre, Kurt Cooper, Yu Cong, Dong-Yun Kim, Claudia Calcagno, Jens H Kuhn, Anya Crane, Jiro Wada, Reed F Johnson, Dima A Hammoud, Ji Hyun Lee
Positron emission tomography (PET) is becoming an important tool for the investigation of emerging infectious diseases in animal models. Usually, PET imaging is performed after intravenous (IV) radiotracer administration. However, IV injections are difficult to perform in some small animals, such as golden hamsters. This challenge is particularly evident in longitudinal imaging studies, and even more so in maximum containment settings used to study high-consequence pathogens. We propose the use of intramuscular (IM) administration of 2-deoxy-2[18 F]fluoro-D-glucose ([18 F]F-FDG) for PET imaging of hamsters in a biosafety level 4 (BSL-4) laboratory setting...
November 11, 2022: Viruses