Yukiko Takemori-Sakai, Kenji Satou, Yasuko Senda, Youko Nakamura, Hatsumi Otani, Akiko Maekawa, Hiroyasu Oe, Megumi Oshima, Shiori Yoneda-Nakagawa, Taro Miyagawa, Koichi Sato, Hisayuki Ogura, Mika Mori, Taizo Wada, Yoshio Sakai, Masahiro Yutani, Takuhiro Matsumura, Yukako Fujinaga, Toshifumi Gabata, Takashi Wada, Yasunori Iwata
INTRODUCTION: Clostridioides difficile (C. difficile) produces three kinds of toxins: toxin A (enterotoxin), toxin B (cytotoxin), and C. difficile transferase (CDT), a binary toxin. Some strains show positivity only for toxin B. These strains reportedly possess a gene for toxin A, tcdA. However, toxin A production is inhibited due to a mutated stop codon and/or deletion within the tcdA gene. Here for the first case in Japan, we describe toxin genomes and proteins of a strain possessing only toxin B and lacking a complete tcdA gene, along with clinical manifestations...
May 2022: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy