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https://www.readbyqxmd.com/read/28339873/evaluation-of-lyme-disease-test-utilization-in-a-low-prevalence-region
#1
Jenna Khan, Patrick Mathias
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28330884/evaluation-of-biom%C3%A3-rieux-s-dissociated-vidas-lyme-igm-ii-lym-and-igg-ii-lyg-as-a-first-tier-diagnostic-assay-for-lyme-disease
#2
Claudia R Molins, Mark J Delorey, Adam Replogle, Christopher Sexton, Martin E Schriefer
The recommended laboratory diagnostic approach for Lyme disease is a standard two-tiered testing (STTT) algorithm where the first-tier is typically an enzyme immunoassay (EIA) that if positive or equivocal is reflexed to Western immunoblotting as the second-tier. bioMérieux manufacturers one of the most commonly used first-tier EIAs in the U.S., the combined IgM/IgG VIDAS (LYT). Recently, bioMérieux launched its dissociated first-tier tests, the VIDAS Lyme IgM II (LYM) and IgG II (LYG) EIAs, which use purified recombinant test antigens and a different algorithm than STTT...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28329259/evaluation-of-modified-2-tiered-serodiagnostic-testing-algorithms-for-early-lyme-disease
#3
John A Branda, Klemen Strle, Lise E Nigrovic, Paul M Lantos, Timothy J Lepore, Nitin S Damle, Mary Jane Ferraro, Allen C Steere
Background.: The conventional 2-tiered serologic testing protocol for Lyme disease (LD), an enzyme immunoassay (EIA) followed by immunoglobulin M and immunoglobulin G Western blots, performs well in late-stage LD but is insensitive in patients with erythema migrans (EM), the most common manifestation of the illness. Western blots are also complex, difficult to interpret, and relatively expensive. In an effort to improve test performance and simplify testing in early LD, we evaluated several modified 2-tiered testing (MTTT) protocols, which use 2 assays designed as first-tier tests sequentially, without the need of Western blots...
January 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329033/quantitative-vs-qualitative-use-of-lyme-elisa
#4
Jason P Jaan Peter Naktin
No abstract text is available yet for this article.
February 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28327498/activity-of-sulfa-drugs-and-their-combinations-against-stationary-phase-b-burgdorferi-in-vitro
#5
Jie Feng, Shuo Zhang, Wanliang Shi, Ying Zhang
Lyme disease is a most common vector-borne disease in the US. Although the majority of Lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, one possibility is that persisting organisms are not killed by current Lyme antibiotics. In our previous studies, we screened an FDA drug library and an NCI compound library on B. burgdorferi and found some drug hits including sulfa drugs as having good activity against B...
March 22, 2017: Antibiotics
https://www.readbyqxmd.com/read/28303129/there-is-a-method-to-the-madness-strategies-to-study-host-complement-evasion-by-lyme-disease-and-relapsing-fever-spirochetes
#6
REVIEW
Ashley L Marcinkiewicz, Peter Kraiczy, Yi-Pin Lin
Lyme disease and relapsing fever are caused by various Borrelia species. Lyme disease borreliae, the most common vector-borne pathogens in both the U.S. and Europe, are transmitted by Ixodes ticks and disseminate from the site of tick bites to tissues leading to erythema migrans skin rash, arthritis, carditis, and neuroborreliosis. Relapsing fever borreliae, carried by ticks and lice, trigger reoccurring fever episodes. Following transmission, spirochetes survive in the blood to induce bacteremia at the early stages of infection, which is thought to promote evasion of the host complement system...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28291638/lyme-disease-emergency-department-considerations
#7
Nathan D Applegren, Chadd K Kraus
BACKGROUND: Lyme disease (LD) is the most common vector-borne illness in North America. Reported cases of LD have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. Greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. Cases are reported primarily in the Northeastern United States, Wisconsin, and Minnesota, with children having the highest incidence of LD among all age groups...
March 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28287618/metabolomics-of-the-tick-borrelia-interaction-during-the-nymphal-tick-blood-meal
#8
J Charles Hoxmeier, Amy C Fleshman, Corey D Broeckling, Jessica E Prenni, Marc C Dolan, Kenneth L Gage, Lars Eisen
The causal agents of Lyme disease in North America, Borrelia burgdorferi and Borrelia mayonii, are transmitted primarily by Ixodes scapularis ticks. Due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. Metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host via tick saliva...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286500/diet-induced-obesity-does-not-alter-tigecycline-treatment-efficacy-in-murine-lyme-disease
#9
Helena Pětrošová, Azad Eshghi, Zoha Anjum, Nataliya Zlotnikov, Caroline E Cameron, Tara J Moriarty
Obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. Furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. However, studies on the treatment of bacterial infections in the context of obesity are scarce. To address this research gap, we assessed efficacy of antibiotic treatment in diet-induced obese mice infected with the Lyme disease pathogen, Borrelia burgdorferi...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28285585/searching-for-lyme-borreliosis-in-australia-results-of-a-canine-sentinel-study
#10
Peter J Irwin, Ian D Robertson, Mark E Westman, Martine Perkins, Reinhard K Straubinger
BACKGROUND: Lyme borreliosis is a common tick-borne disease of the northern hemisphere that is caused by bacterial spirochaetes of the Borrelia burgdorferi (sensu lato) (Bbsl) complex. To date, there has been no convincing evidence for locally-acquired Lyme borreliosis on the Australian continent and there is currently a national debate concerning the nature and distributions of zoonotic tick-transmitted infectious disease in Australia. In studies conducted in Europe and the United States, dogs have been used as sentinels for tick-associated illness in people since they readily contact ticks that may harbour zoonotic pathogens...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28279540/electrocardiographic-progression-of-acute-lyme-disease
#11
Laiden Suarez Fuster, Enes Elvin Gul, Adrian Baranchuk
Lyme carditis poses a challenge to physicians given dramatic clinical presentations like the one presented in this case. Quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation. This is the first case in the literature that has captured the electrocardiographic evolution of Lyme carditis, day by day until complete resolution.
March 1, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28277054/symptom-load-and-general-function-among-patients-with-erythema-migrans-a-prospective-study-with-a-1-year-follow-up-after-antibiotic-treatment-in-norwegian-general-practice
#12
Knut Eirik Eliassen, Reidar Hjetland, Harald Reiso, Morten Lindbæk, Hedda Tschudi-Madsen
OBJECTIVE: Promptly treated erythema migrans (EM) has good prognosis. However, some patients report persistent symptoms. Do patients with EM have more symptoms than the general population? We describe individual symptoms and general function in EM-patients at time of diagnosis and one year after treatment. DESIGN: Prospective study with 1-year follow up after treatment. Questionnaires included a modified version of the Subjective Health Complaints Inventory, comprising three additional Lyme borreliosis (LB) related symptoms...
February 28, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28270812/borrelia-burgdorferi-keeps-moving-and-carries-on-a-review-of-borrelial-dissemination-and-invasion
#13
REVIEW
Jenny A Hyde
Borrelia burgdorferi is the etiological agent of Lyme disease, a multisystemic, multistage, inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic complications when not treated with antibiotics shortly after exposure. The spirochetal bacterium transmits through the Ixodes vector colonizing the dermis of a mammalian host prior to hematogenous dissemination and invasion of distal tissues all the while combating the immune response as it traverses through its pathogenic lifecycle...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28265270/borrelia-burgdorferi-manipulates-innate-and-adaptive-immunity-to-establish-persistence-in-rodent-reservoir-hosts
#14
REVIEW
Karen E Tracy, Nicole Baumgarth
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and other incidental hosts can develop Lyme disease, a serious inflammatory syndrome characterized by tissue inflammation of joints, heart, muscles, skin, and CNS. Although B. burgdorferi infection induces both innate and adaptive immune responses, they are ultimately ineffective in clearing the infection from reservoir hosts, leading to bacterial persistence...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28261565/borrelia-diversity-and-co-infection-with-other-tick-borne-pathogens-in-ticks
#15
Cristian Raileanu, Sara Moutailler, Ionuţ Pavel, Daniela Porea, Andrei D Mihalca, Gheorghe Savuta, Muriel Vayssier-Taussat
Identifying Borrelia burgdorferi as the causative agent of Lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in Europe and the USA. The medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as Borrelia spp., Anaplasma phagocytophilum, Rickettsia spp., Bartonella spp., "Candidatus Neoehrlichia mikurensis", and tick-borne encephalitis virus in questing ticks in Romania, a gateway into Europe...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28261180/tick-humoral-responses-marching-to-the-beat-of-a-different-drummer
#16
REVIEW
Adela S Oliva Chávez, Dana K Shaw, Ulrike G Munderloh, Joao H F Pedra
Ticks transmit a variety of human pathogens, including Borrelia burgdorferi, the etiological agent of Lyme disease. Multiple pathogens that are transmitted simultaneously, termed "coinfections," are of increasing importance and can affect disease outcome in a host. Arthropod immunity is central to pathogen acquisition and transmission by the tick. Pattern recognition receptors recognize pathogen-associated molecular patterns and induce humoral responses through the Toll and Immune Deficiency (IMD) pathways...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28260991/detection-of-lyme-disease-bacterium-borrelia-burgdorferi-sensu-lato-in-blacklegged-ticks-collected-in-the-grand-river-valley-ontario-canada
#17
John D Scott, Janet E Foley, John F Anderson, Kerry L Clark, Lance A Durden
We document the presence of blacklegged ticks, Ixodes scapularis, in the Grand River valley, Centre Wellington, Ontario. Overall, 15 (36%) of 42 I. scapularis adults collected from 41 mammalian hosts (dogs, cats, humans) were positive for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s.l.). Using real-time PCR testing and DNA sequencing of the flagellin (fla) gene, we determined that Borrelia amplicons extracted from I. scapularis adults belonged to B. burgdorferi sensu stricto (s.s.), which is pathogenic to humans and certain domestic animals...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28259789/evaluation-of-a-serological-test-for-the-diagnosis-of-borrelia-miyamotoi-disease-in-europe
#18
Setareh Jahfari, Denis S Sarksyan, Nadezda M Kolyasnikova, Joppe W Hovius, Hein Sprong, Alexander E Platonov
BACKGROUND: Borrelia miyamotoi causes systemic febrile illness and is transmitted by the same tick species that transmits Borrelia burgdorferi sensu lato and tick-borne encephalitis virus. We describe a serological test using a fragment of glycerophosphodiester phosphodiesterase (GlpQ) as an antigen, and determined its performance in well-defined patient categories. METHODS: Serum of patients with PCR-confirmed Borrelia miyamotoi disease (BMD), Lyme borreliosis (LB), tick-borne encephalitis (TBE), and healthy blood donors (HBD) were collected in Udmurt Republic, Russia...
March 1, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28256234/vancomycin-reduces-cell-wall-stiffness-and-slows-swim-speed-of-the-lyme-disease-bacterium
#19
Michael W Harman, Alex E Hamby, Ross Boltyanskiy, Alexia A Belperron, Linda K Bockenstedt, Holger Kress, Eric R Dufresne, Charles W Wolgemuth
Borrelia burgdorferi, the spirochete that causes Lyme disease, is a tick-transmitted pathogen that requires motility to invade and colonize mammalian and tick hosts. These bacteria use a unique undulating flat-wave shape to penetrate and propel themselves through host tissues. Previous mathematical modeling has suggested that the morphology and motility of these spirochetes depends crucially on the flagellar/cell wall stiffness ratio. Here, we test this prediction using the antibiotic vancomycin to weaken the cell wall...
February 28, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28251023/determination-of-seroprevalence-of-borrelia-burgdorferi-igg-in-adult-population-living-in-trabzon
#20
Merve Cora, Neşe Kaklıkkaya, Murat Topbaş, Gamze Çan, Asuman Yavuzyılmaz, İlknur Tosun, Faruk Aydın
BACKGROUND: Lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in Turkey even though studies on its seroprevalence are limited. AIMS: To determine the seroprevalence of Lyme borreliosis in part of north-eastern Tur-key (in the city of Trabzon), and to identify possible relationships between seropositivity and various factors such as location, gender, age group, occupation, income, and educational level. STUDY DESIGN: Retrospective cross-sectional study...
January 2017: Balkan Medical Journal
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