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https://www.readbyqxmd.com/read/28943834/cutaneous-lyme-borreliosis-guideline-of-the-german-dermatology-society
#1
Heidelore Hofmann, Volker Fingerle, Klaus-Peter Hunfeld, Hans-Iko Huppertz, Andreas Krause, Sebastian Rauer, Bernhard Ruf
This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.) interdisciplinary guideline: "Lyme Borreliosis - Diagnosis and Treatment, development stage S3". The guideline is directed at physicians in private practices and clinics who treat Lyme borreliosis...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28939383/prevalence-of-borrelia-burgdorferi-and-borrelia-miyamotoi-in-questing-ixodes-ricinus-ticks-from-four-sites-in-the-uk
#2
Scott J Layzell, Daniel Bailey, Mick Peacey, Patricia A Nuttall
Borrelia miyamotoi is a spirochete bacterium related to Borrelia burgdorferi sensu lato, the cause of Lyme borreliosis, and vectored by ticks. In 2014, B. miyamotoi was identified in three questing Ixodes ricinus collected in the UK. We sought to confirm the presence of B. miyamotoi in the UK. Ticks were collected from four locations not previously investigated for B. miyamotoi or B. burgdorferi s.l. and of which two are considered as Lyme borreliosis "hotspots" based on hospital records of the disease. We independently confirm that B...
September 18, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28937997/molecular-detection-of-borrelia-burgdorferi-sensu-lato-an-analytical-comparison-of-real-time-pcr-protocols-from-five-different-scandinavian-laboratories
#3
Malin Lager, Maximilian Faller, Peter Wilhelmsson, Vivian Kjelland, Åshild Andreassen, Rimtas Dargis, Hanne Quarsten, Ram Dessau, Volker Fingerle, Gabriele Margos, Sølvi Noraas, Katharina Ornstein, Ann-Cathrine Petersson, Andreas Matussek, Per-Eric Lindgren, Anna J Henningsson
INTRODUCTION: Lyme borreliosis (LB) is the most common tick transmitted disease in Europe. The diagnosis of LB today is based on the patient´s medical history, clinical presentation and laboratory findings. The laboratory diagnostics are mainly based on antibody detection, but in certain conditions molecular detection by polymerase chain reaction (PCR) may serve as a complement. AIM: The purpose of this study was to evaluate the analytical sensitivity, analytical specificity and concordance of eight different real-time PCR methods at five laboratories in Sweden, Norway and Denmark...
2017: PloS One
https://www.readbyqxmd.com/read/28931143/lyme-disease-vs-baggio-yoshinari-syndrome-in-a-returned-traveller-from-brazil
#4
Victor P Vien, Raghav Bassi, Timea Maxim, Isaac I Bogoch
No abstract text is available yet for this article.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28929088/microbial-invasion-vs-tick-immune-regulation
#5
REVIEW
Daniel E Sonenshine, Kevin R Macaluso
Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28927817/development-and-evaluation-of-a-two-step-multiplex-taqman-real-time-pcr-assay-for-detection-quantification-of-different-genospecies-of-borrelia-burgdorferi-sensu-lato
#6
Mónica Nunes, Ricardo Parreira, Teresa Carreira, João Inácio, Maria Luísa Vieira
Nowadays, at least four clinically important B. burgdorferi sensu lato (s.l.) genospecies (B. afzelii, B. garinii, B. burgdorferi sensu stricto (s.s.) and B. lusitaniae) circulate in Portugal. Each genospecies has a different tropism that resuls in a diverse array of clinical manifestations. The standard diagnostic procedure used is normally simple, nevertheless, during the "window-period" phase, in which specific antibodies cannot yet be detected, diagnosis becomes difficult, and calls for reliable, sensitive and specific laboratory methods, such as molecular tests...
September 11, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28919803/empirical-validation-of-the-horowitz-multiple-systemic-infectious-disease-syndrome-questionnaire-for-suspected-lyme-disease
#7
Maryalice Citera, Phyllis R Freeman, Richard I Horowitz
PURPOSE: Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms that mimic other illnesses. A validated Lyme disease screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated such a screening tool, namely the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28919405/exploration-of-stable-isotope-analysis-for-tick-host-identification
#8
Kathleen LoGiudice, Kathryn Kurchena, Katherine Christopher, Natasha Scott
Due to the problem of tick-borne diseases, there is a need to better understand the importance of different host species in maintaining enzootic disease cycles. We explored the utility of stable isotope analysis to identify the larval hosts of questing ixodid ticks. In laboratory experiments, we used Ixodes scapularis and two host species that are important in the Lyme disease system in eastern North America. First, we tested how effectively a short-term dietary tracer ((13)C in corn) was reflected in molted ticks...
September 7, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28918538/genetic-manipulation-of-borrelia-spp
#9
Dan Drecktrah, D Scott Samuels
The spirochetes Borrelia (Borreliella) burgdorferi and Borrelia hermsii, the etiologic agents of Lyme disease and relapsing fever, respectively, cycle in nature between an arthropod vector and a vertebrate host. They have extraordinarily unusual genomes that are highly segmented and predominantly linear. The genetic analyses of Lyme disease spirochetes have become increasingly more sophisticated, while the age of genetic investigation in the relapsing fever spirochetes is just dawning. Molecular tools available for B...
September 17, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28918069/studies-that-report-unexpected-positive-blood-cultures-for-lyme-borrelia-are-they-valid
#10
REVIEW
Gary P Wormser, Eugene D Shapiro, Franc Strle
Positive blood cultures for Lyme borrelia have been well documented in untreated patients with early Lyme disease. In this report we review the validity of three studies that reported the recovery of Borrelia burgdorferi sensu lato from the blood of a high proportion of patients for whom no evidence was presented, and no claim was made, that the patients had untreated early Lyme disease. In two of the studies the patients had been treated extensively with antibiotics for Lyme disease before the cultures were obtained...
July 29, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28911326/borrelia-infection-and-risk-of-celiac-disease
#11
Armin Alaedini, Benjamin Lebwohl, Gary P Wormser, Peter H Green, Jonas F Ludvigsson
BACKGROUND: Environmental factors, including infectious agents, are speculated to play a role in the rising prevalence and the geographic distribution of celiac disease, an autoimmune disorder. In the USA and Sweden where the regional variation in the frequency of celiac disease has been studied, a similarity with the geographic distribution of Lyme disease, an emerging multisystemic infection caused by Borrelia burgdorferi spirochetes, has been found, thus raising the possibility of a link...
September 15, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28904853/lyme-disease-and-youtubetm-a-cross-sectional-study-of-video-contents
#12
Corey H Basch, Lindsay A Mullican, Kwanza D Boone, Jingjing Yin, Alyssa Berdnik, Marina E Eremeeva, Isaac Chun-Hai Fung
OBJECTIVES: Lyme disease is the most common tick-borne disease. People seek health information on Lyme disease from YouTube(TM) videos. In this study, we investigated if the contents of Lyme disease-related YouTube(TM) videos varied by their sources. METHODS: Most viewed English YouTube(TM) videos (n = 100) were identified and manually coded for contents and sources. RESULTS: Within the sample, 40 videos were consumer-generated, 31 were internet-based news, 16 were professional, and 13 were TV news...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28903521/treatment-related-complications-in-children-hospitalized-with-disseminated-lyme-disease
#13
Christine Chang, Kristen A Feemster, Susan Coffin, Lori K Handy
We describe here treatment approaches and treatment-related complications in 138 hospitalized children with disseminated Lyme disease. The patients who received parenteral antibiotics had a higher rate of complications than those who received oral therapy (15.4 vs 4.2 per 1000 days of therapy, respectively; P < .05). Oral therapy should be used preferentially if either route is supported by current guidelines.
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28903511/fatal-deer-tick-virus-infection-in-maine
#14
Catherine E Cavanaugh, Paul L Muscat, Sam R Telford, Heidi Goethert, William Pendlebury, Susan P Elias, Rebecca Robich, Margret Welch, Charles B Lubelczyk, Robert P Smith
Deer tick virus (DTV), a genetic variant (lineage II) of Powassan virus, is a rare cause of encephalitis in North America. We report a fatal case of DTV encephalitis following a documented bite from an Ixodes scapularis tick and the erythema migrans rash associated with Lyme disease.
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28899886/brainstem-encephalitis-and-acute-polyneuropathy-associated-with-hepatitis-e-infection
#15
Omar Jabbar Salim, Amy Davidson, Kathy Li, John Paul Leach, Craig Heath
A 59-year-old man presented with feverish illness. His Glasgow Coma Scale was 15, had reduced visual acuity in the left eye with partial left ptosis and mild left hemiparesis with an extensor left plantar. Over 48 hours, he accrued multiple cranial nerves palsies and progressed to a flaccid paralysis necessitating admission to an intensive care unit.Cerebrospinal fluid (CSF) study showed 20 lymphocytes and raised protein. Viral and bacterial PCRs were negative. Samples for Lyme, blood-borne viruses, syphilis and autoantibodies were also negative...
September 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28898716/celebrity-over-science-an-analysis-of-lyme-disease-video-content-on-youtube
#16
N Yiannakoulias, R Tooby, S L Sturrock
Lyme disease has been a subject of medical controversy for several decades. In this study we looked at the availability and type of content represented in a (n = 700) selection of YouTube videos on the subject of Lyme disease. We classified video content into a small number of content areas, and studied the relationship between these content areas and 1) video views and 2) video likeability. We found very little content uploaded by government or academic institutions; the vast majority of content was uploaded by independent users...
September 5, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28898274/periplasmic-flagella-in-borrelia-burgdoferi-function-to-maintain-cellular-integrity-upon-external-stress
#17
Bharath Kumar, Kelly Miller, Nyles W Charon, Justin Legleiter
Tapping mode atomic force microscopy (AFM) in solution was used to analyze the role of the internally located periplasmic flagella (PFs) of the Lyme disease spirochete Borrelia burgdorferi in withstanding externally applied cellular stresses. By systematically imaging immobilized spirochetes with increasing tapping forces, we found that mutants that lack PFs are more readily compressed and damaged by the imaging process compared to wild-type cells. This finding suggest that the PFs, aside from being essential for motility and involved in cell shape, play a cytoskeletal role in dissipating energy and maintaining cellular integrity in the presence of external stress...
2017: PloS One
https://www.readbyqxmd.com/read/28887186/to-test-or-not-to-test-laboratory-support-for-the-diagnosis-of-lyme-borreliosis
#18
REVIEW
Ram B Dessau, Alje P van Dam, Volker Fingerle, Jeremy Gray, Joppe Hovius, Klaus-Peter Hunfeld, Benoit Jaulhac, Olaf Kahl, Wolfgang Kristoferitsch, Per-Eric Lindgren, Mateusz Markowicz, Sally Mavin, Katharina Ornstein, Tobias Rupprecht, Gerold Stanek, Franc Strle
BACKGROUND: Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for Lyme borreliosis is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost effective health management. AIM: The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected Lyme borreliosis...
September 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28882852/human-seroprevalence-of-borrelia-miyamotoi-in-manitoba-canada-in-2011-2014-a-cross-sectional-study
#19
Kamran Kadkhoda, Cecilia Dumouchel, Janna Brancato, Ainsley Gretchen, Peter J Krause
BACKGROUND: Hard tick-borne relapsing fever caused by Borrelia miyamotoi has been reported in Russia, the Netherlands, Germany, Japan and the northeastern and upper midwestern United States. We sought to investigate the presence of B. miyamotoi infection in humans in Manitoba, Canada. METHODS: Two hundred fifty sera collected from residents of Manitoba with suspected Lyme disease between 2011 and 2014 were tested for Borrelia burgdorferi antibody using a C6 peptide enzyme-linked immunosorbent assay (ELISA) followed by Western blot...
September 6, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28878005/citrate-anticoagulant-improves-the-sensitivity-of-borreliella-borrelia-burgdorferi-plasma-culture
#20
Adriana R Marques, Xiuli Yang, Alexis A Smith, Xuran Zhuang, Siu-Ping Turk, Carla D Williams, Melissa A Law, Alan G Barbour, Utpal Pal
The ability of cultivating Borreliella (Borrelia) burgdorferi is a cornerstone of Lyme disease research.….
September 6, 2017: Journal of Clinical Microbiology
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