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https://www.readbyqxmd.com/read/29934530/prognostic-significance-of-infarct-size-and-location-the-case-of-insular-stroke
#1
Carlos Laredo, Yashu Zhao, Salvatore Rudilosso, Arturo Renú, José Carlos Pariente, Ángel Chamorro, Xabier Urra
The prognostic relevance of strokes in different locations is debated. For example, insular strokes have been associated with increased mortality, but this association could reflect their greater severity. In two independent cohorts of patients with supratentorial ischemic stroke (n = 90 and 105), we studied the prognostic consequences of lesion size and location using voxel-based lesion-symptom mapping before and after volume control, which better accounts for total lesion volume. Strokes affecting the insula were larger than non-insular strokes (28 vs 2cc and 25 vs 3cc, p < 0...
June 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29933562/early-abobotulinumtoxina-dysport-%C3%A2-in-post-stroke-adult-upper-limb-spasticity-ontime-pilot-study
#2
Raymond L Rosales, Jovita Balcaitiene, Hugues Berard, Pascal Maisonobe, Khean Jin Goh, Witsanu Kumthornthip, Mazlina Mazlan, Lydia Abdul Latif, Mary Mildred D Delos Santos, Chayaporn Chotiyarnwong, Phakamas Tanvijit, Odessa Nuez, Keng He Kong
The ONTIME study investigated whether early post-stroke abobotulinumtoxinA injection delays appearance or progression of upper limb spasticity (ULS) symptoms. ONTIME (NCT02321436) was a 28-week, exploratory, double-blind, randomized, placebo-controlled study of abobotulinumtoxinA 500U in patients with ULS (Modified Ashworth Scale [MAS] score &ge; 2) 2⁻12 weeks post-stroke. Patients were either symptomatic or asymptomatic (only increased MAS) at baseline. Primary efficacy outcome measure: time between injection and visit at which re-injection criteria were met (MAS &ge; 2 and &ge;1, sign of symptomatic spasticity: pain, involuntary movements, impaired active or passive function)...
June 21, 2018: Toxins
https://www.readbyqxmd.com/read/29933207/multi-targeting-effects-of-a-new-synthetic-molecule-jm-20-in-experimental-models-of-cerebral-ischemia
#3
REVIEW
Yanier Nuñez-Figueredo, Jeney Ramírez-Sánchez, Gilberto L Pardo Andreu, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O Souza
Ischemic stroke is a major cause of death and disability worldwide. Thrombolysis by tissue plasminogen activator is the only pharmacological treatment approved for clinical practice, but has a narrow therapeutic window and poor efficacy when the cell death cascade is activated. Numerous drugs that are thought to protect neurons against injury have previously failed in human trials despite showing efficacy in experimental models of stroke. Herein, we reviewed the main pre-clinical results of the neuroprotective effects of JM-20, a new hybrid molecule, against brain ischemia...
February 12, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29932374/endovascular-treatment-for-emergent-large-vessel-occlusion-due-to-severe-intracranial-atherosclerotic-stenosis
#4
Dong-Hun Kang, Woong Yoon, Seul Kee Kim, Byung Hyun Baek, Yun Young Lee, Yong-Won Kim, Yong-Sun Kim, Yang-Ha Hwang, Joon-Tae Kim, Man Seok Park
OBJECTIVE The optimal treatment strategy for patients with emergent large vessel occlusion (ELVO) due to underlying severe intracranial atherosclerotic stenosis (ICAS) is unclear. The purpose of this study was to compare treatment outcomes from intracranial angioplasty with or without stenting and intraarterial infusion of a glycoprotein IIb/IIIa inhibitor in patients with ELVO due to severe ICAS, and to investigate predictors of outcome after endovascular therapy in such patients. METHODS A total of 140 consecutive patients with ELVO attributable to severe ICAS underwent endovascular therapy at two stroke centers (A and B)...
June 22, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29931981/supplementation-of-lactobacillus-plantarum-improves-markers-of-metabolic-dysfunction-induced-by-a-high-fat-diet
#5
Alice Martinic, Javad Barouei, Zach Bendiks, Darya Mishchuk, Dustin D Heeney, Roy Martin, Maria L Marco, Carolyn M Slupsky
Obesity is a prevalent chronic condition in many developed and developing nations that raises the risk for developing heart disease, stroke, and diabetes. Previous studies have shown that consuming particular probiotic strains of Lactobacillus is associated with improvement in the obese and diabetic phenotype; however, the mechanisms of these beneficial effects are not well understood. In this study, C57BL/6J male mice were fed a lard-based high fat diet for 15 weeks with Lactobacillus plantarum supplementation NCIMB8826 (Lp) between weeks 10 and 15 (n=10 per group)...
June 22, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29931649/one-year-efficacy-and-safety-of-routine-prasugrel-in-patients-with-acute-coronary-syndromes-treated-with-percutaneous-coronary-intervention-results-of-the-prospective-rijnmond-collective-cardiology-research-study
#6
T Yetgin, E Boersma, P C Smits, A G de Vries, E Huijskens, F Zijlstra, M M J M van der Linden, R J M van Geuns
OBJECTIVE: To investigate 1‑year outcomes with routine prasugrel treatment after acute coronary syndrome (ACS) in a large-scale registry. METHODS: The Rijnmond Collective Cardiology Research registry is a prospective, observational study that enrolled 4,258 consecutive ACS patients treated with percutaneous coronary intervention (PCI) with 1‑year follow-up. Patients received prasugrel as first-choice antiplatelet agent, except for increased bleeding risk patients in which clopidogrel was recommended...
June 21, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29928251/intravenous-thrombolysis-may-not-improve-clinical-outcome-of-acute-ischemic-stroke-patients-without-a-baseline-vessel-occlusion
#7
Huiqiao Tian, Mark W Parsons, Christopher R Levi, Xin Cheng, Richard I Aviv, Neil J Spratt, Timothy J Kleinig, Billy O'Brien, Kenneth S Butcher, Longting Lin, Jingfen Zhang, Qiang Dong, Chushuang Chen, Andrew Bivard
Background and Purpose: The benefit of thrombolysis in ischemic stroke patients without a visible vessel occlusion still requires investigation. This study tested the hypothesis that non-lacunar stroke patients with no visible vessel occlusion on baseline imaging would have a favorable outcome regardless of treatment with alteplase. Methods: We utilized a prospectively collected registry of ischemic stroke patients [the International Stroke Perfusion Imaging Registry (INSPIRE)] who had baseline computed tomographic perfusion and computed tomographic angiography...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29927399/-cerebral-atherosclerosis-a-biomarker-profile
#8
M M Tanashyan, O V Lagoda, A N Evdokimenko, A A Shabalina, A A Raskurazhev
AIM: To assess the changes in several biomarkers in patients with atherosclerosis of brachiocephalic arteries and shape a biomarker profile of cerebral atherosclerosis as an integrative index. MATERIAL AND METHODS: The study included 124 patients with atherosclerotic lesions of internal carotid arteries (82 men and 42 women) aged from 37 to 73 years. The patients were stratified by history of prior stroke into 'asymptomatic' and 'symptomatic'. Along with general clinical and neurological examinations, ultrasound analysis of brachiocephalic arteries, neuroimaging, identification of biomarkers reflecting different stages of atherogenesis and evaluation of pathomorphological parameters of atherosclerotic plaques removed during carotid endarterectomy surgery were performed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29926842/predicting-functional-outcome-of-ischemic-stroke-patients-in-romania-based-on-plasma-crp-stnfr-1-d-dimers-ngal-and-nse-measured-using-a-biochip-array
#9
Adina Huţanu, Mihaela Iancu, Rodica Bălaşa, Smaranda Maier, Minodora Dobreanu
In cerebral ischemia, evaluation of multiple biomarkers involved in various pathological pathways is a useful tool in assessing the outcome of the patients even from the early stages of the disease. In this study we investigated the utility of a panel of 5 peripheral biomarkers of inflammatory status, neuronal destruction and secondary fibrinolysis in the acute phase of ischemia, and evaluated the impact of these biomarkers on functional outcome after ischemic stroke. The 5 biomarkers (plasma CRP, D-Dimers, sTNFR-1, NGAL and NSE) were measured using a biochip array technology...
June 21, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29926828/catgut-implantation-at-acupoints-increases-the-expression-of-glutamate-aspartate-transporter-and-glial-glutamate-transporter-1-in-the-brain-of-rats-with-spasticity-after-stroke
#10
Rui-Qing Li, Ming-Yue Wan, Jing Shi, Hui-Ling Wang, Fei-Lai Liu, Cheng-Mei Liu, Jin Huang, Ren-Chao Liu, Le Ma, Xiao-Dong Feng
Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats. However, the underlying mechanisms are poorly understood. In this study, we used the rat middle cerebral artery occlusion model of stroke. Three days after surgery, absorbable surgical catgut sutures were implanted at Dazhui (GV14), Jizhong (GV6), Houhui, Guanyuan (CV4) and Zhongwan (CV12). The Zea Longa score was used to assess neurological function. The Modified Ashworth Scale was used to evaluate muscle tension...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29925578/on-the-lift-optimal-aspect-ratio-of-a-revolving-wing-at-low-reynolds-number
#11
T Jardin, T Colonius
Lentink & Dickinson (2009 J. Exp. Biol. 212 , 2705-2719. (doi:10.1242/jeb.022269)) showed that rotational acceleration stabilized the leading-edge vortex on revolving, low aspect ratio (AR) wings and hypothesized that a Rossby number of around 3, which is achieved during each half-stroke for a variety of hovering insects, seeds and birds, represents a convergent high-lift solution across a range of scales in nature. Subsequent work has verified that, in particular, the Coriolis acceleration plays a key role in LEV stabilization...
June 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29925174/-management-of-blood-pressure-in-acute-ischemic-stroke-a-meta-analysis
#12
Q Huang, J Z Zhang, J Wu
Objective: We are aiming at conducting a meta-analysis of the literature to elucidate the efficacy and safety of anti-hypertension therapy in acute stage of ischemic stroke (AIS). Methods: Researches on the efficacy and safety of anti-hypertension therapy published on PubMed before 1st September 2017 were independently retrieved by two authors.Clinical benign prognosis and death measured as modified Rankin Scale (mRS) ≤2 and mRS=6 were taken as primary indicators of efficacy and safety, respectively.A meta-analysis of included randomized controlled trials (RCTs) was performed by RevMan 5...
June 19, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29923930/prophylactic-seizure-medication-and-health-related-quality-of-life-after-intracerebral-hemorrhage
#13
Andrew M Naidech, Jennifer Beaumont, Kathryn Muldoon, Eric M Liotta, Matthew B Maas, Matthew B Potts, Babak S Jahromi, David Cella, Shyam Prabhakaran, Jane L Holl
OBJECTIVES: Prophylactic levetiracetam is currently used in ~40% of patients with intracerebral hemorrhage, and the potential impact of levetircetam on health-related quality of life is unknown. We tested the hypothesis that prophylactic levetiracetam is independently associated with differences in cognitive function health-related quality of life. DESIGN: Patients with intracerebral hemorrhage were enrolled in a prospective cohort study. We performed mixed models for T-scores of health-related quality of life, referenced to the U...
June 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29922355/ischaemic-haemorrhagic-stroke-in-a-child-with-new-onset-type-1-diabetes-mellitus
#14
Noor Shafina Mohd Nor, Choong Yi Fong, Kartini Rahmat, Wan Mun Vanessa Lee, Azriyanti Anuar Zaini, Muhammad Yazid Jalaludin
Cerebral oedema is the most common neurological complication of diabetic ketoacidosis (DKA). However, ischaemic and haemorrhagic brain injury has been reported infrequently. A 10-year old girl who was previously well presented with severe DKA. She was tachycardic with poor peripheral perfusion but normotensive. However, two fast boluses totalling 40 ml/kg normal saline were given. She was transferred to another hospital where she was intubated due to drowsiness. Rehydration fluid (maintenance and 48-hour correction for 7...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922211/short-and-long-term-efficacy-of-modafinil-at-improving-quality-of-life-in-stroke-survivors-a-post-hoc-sub-study-of-the-modafinil-in-debilitating-fatigue-after-stroke-trial
#15
Thomas P Lillicrap, Christopher R Levi, Elizabeth Holliday, Mark William Parsons, Andrew Bivard
Background: The phase-II modafinil in debilitating fatigue after stroke trial demonstrated that modafinil improves fatigue and quality of life in severely fatigued stroke survivors. For this study, we sought to examine the interaction between fatigue and quality of life after stroke and determine whether reducing fatigue resulted in improved quality of life. In addition, we followed up a subset of patients 12-months after the trial to assess the long-term outcomes of modafinil therapy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29916357/-aphasia-rapid-test-translation-adaptation-and-validation-studies-for-the-portuguese-population
#16
Miguel Tábuas-Pereira, Sandra Freitas, José Beato-Coelho, Joana Ribeiro, Joana Parra, Cristina Martins, Miguel Silva, Maria Assunção Matos, Ana Rita Nogueira, Fernando Silva, João Sargento-Freitas, Gustavo Cordeiro, Luís Cunha, Isabel Santana
INTRODUCTION: Classical aphasia evaluation scales are too long to use in the context of acute stroke or as a monitoring tool. The Aphasia Rapid Test is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in less than 3 minutes. We aimed to adapt and validate this scale for European Portuguese. MATERIAL AND METHODS: We evaluated 56 acute stroke patients in the first and in the seventh days post-stroke. In the seventh day, patients were evaluated by two independent raters, to evaluate inter-rater agreement...
May 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29916136/the-effect-of-aerobic-exercise-on-stroke-rehabilitation
#17
Hande Gezer, Ozgur Zeliha Karaahmet, Eda Gurcay, Deniz Dulgeroglu, Aytul Cakci
BACKGROUND AND AIMS: To compare the effects of aerobic exercise and conventional exercise that were applied during the rehabilitation process on the aerobic capacity, motor function, activity limitation, quality of life, depression level, and sleep quality in subacute stroke patients. METHODS: The patients were divided into two groups; aerobic exercise group (n = 22) or conventional exercise group (n = 20). Both groups participated in a conventional stroke rehabilitation program; however, aerobic exercise program was applied only for the patients in group 1...
June 19, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29916129/depressive-symptoms-in-stroke-patients-treated-and-non-treated-with-intravenous-thrombolytic-therapy-a-1-year-follow-up-study
#18
Barbara Grabowska-Fudala, Krystyna Jaracz, Krystyna Górna, Izabela Miechowicz, Izabela Wojtasz, Jan Jaracz, Radosław Kaźmierski
INTRODUCTION: This is a prospective study, first to compare the frequency of depressive symptoms in stroke survivors treated, and non-treated, with intravenous thrombolysis and second, to explore relationships between post-stroke depression (PSD) and stroke treatment modalities, taking into account other possible determinants of PSD, including post-traumatic stress symptoms. METHODS: Groups of 73 thrombolysed and 73 non-thrombolysed patients matched for age and gender were examined at 3 and 12 months after discharge...
June 18, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29915811/related-factors-of-early-mortality-in-young-adults-with-cerebral-hemorrhage
#19
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29915125/beyond-large-vessel-occlusion-strokes-distal-occlusion-thrombectomy
#20
Jonathan A Grossberg, Leticia C Rebello, Diogo C Haussen, Mehdi Bouslama, Meredith Bowen, Clara M Barreira, Samir R Belagaje, Michael R Frankel, Raul G Nogueira
BACKGROUND AND PURPOSE: Endovascular therapy is the standard of care for the treatment of proximal large vessel occlusion strokes. Its safety and efficacy in the treatment of distal intracranial occlusions has not been well studied. METHODS: The data that support the findings of this study are available from the corresponding author on reasonable request. Retrospective review of a prospectively collected endovascular database (2010-2015, n=949) for all patients with distal intracranial occlusions treated endovascularly...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
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