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https://www.readbyqxmd.com/read/29043407/changes-in-swallowing-symptoms-and-esophageal-motility-after-thyroid-surgery-a-prospective-cohort-study
#1
Jesper Roed Sorensen, Simone Markoew, Helle Døssing, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
INTRODUCTION: Swallowing difficulties, the pathophysiology behind which is incompletely understood, have been reported in 47-83% of goiter patients referred for thyroidectomy. We aimed at examining the influence of thyroid surgery on swallowing symptoms and esophageal motility. METHODS: Thirty-three patients with benign nodular goiter undergoing thyroid surgery were included. All completed high-resolution esophageal manometry examinations and the goiter symptom scale score, assessed by the thyroid-specific patient-reported outcome measure...
October 11, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29042858/expanding-the-role-of-thyroid-stimulating-hormone-in-skeletal-physiology
#2
REVIEW
Ramkumarie Baliram, Rauf Latif, Mone Zaidi, Terry F Davies
The dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in particular, its action on osteoblasts and osteoclasts. It has also been recently discovered that the bone marrow microenvironment acts as an endocrine circuit with bone marrow-resident macrophages capable of producing a novel TSH-β subunit variant (TSH-βv), which may modulate skeletal physiology...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29040069/effects-of-1-year-growth-hormone-replacement-therapy-on-thyroid-volume-and-function-of-the-children-and-adolescents-with-idiopathic-growth-hormone-deficiency
#3
Meliksah Keskin, Elvan Bayramoglu, Zehra Aycan
BACKGROUND: There are different opinions about the effects of growth hormone replacement therapy (GHRT) on thyroid function and volume. This study aimed to assess the effects of GHRT on thyroid volume and function in the children and adolescents with growth hormone (GH) deficiency. METHODS: A total of 29 patients diagnosed with GH deficiency were enrolled in the study. The control group consisted of 29 cases matched for age, gender and pubertal period with the patients...
October 17, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29039144/transoral-endoscopic-thyroidectomy-via-a-vestibular-approach-why-and-how
#4
Gianlorenzo Dionigi, Young Jun Chai, Ralph P Tufano, Angkoon Anuwong, Hoon Yub Kim
The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a novel, scar-free surgical procedure that does not require visible incisions. Indications for TOETVA are as follows: predicted gland width on diagnostic imaging ≤10 cm; a thyroid volume outline of <45 mL or dominant nodule dimension of ≤50 mm; three or four Bethesda lesions; a primary papillary microcarcinoma without local or distant metastasis; and patient request for optimal esthetic results. Contraindications are as follows: patients unfit for general anesthesia; precedent radiation in the head, neck, upper mediastinum; antecedent neck surgery; recurrent goiter; a gland volume of >45 mL or main nodule diameter of >50 mm; and documentation of lymph node or distant metastases, tracheal/esophageal infiltration, preoperative laryngeal nerve palsy, hyperthyroidism, mediastinal goiter, or an oral abscess...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29036015/transient-pituitary-acth-dependent-cushing-syndrome-caused-by-an-immune-checkpoint-inhibitor-combination
#5
Jeremy Lupu, Cécile Pages, Pauline Laly, Julie Delyon, Marie Laloi, Antoine Petit, Nicole Basset-Seguin, Imen Oueslati, Anne-Marie Zagdanski, Jacques Young, Clara Bouche, Céleste Lebbé, Jean-François Gautier
Immune checkpoint inhibitors have improved survival in numerous advanced malignancies, but are associated with a number of immune-related adverse events, including endocrinopathies. Endogenous Cushing's syndrome (CS) is a rare disorder resulting from exposure to high levels of circulating cortisol. CS can be caused either by adrenal cortex tumors or hyperplasia or by pituitary or extra-pituitary tumors over-secreting ACTH (known as ACTH-dependent CS). We report the first case of transient ACTH-dependent CS, which appeared after combined ipilimumab and nivolumab therapy...
October 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29034595/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-cytopathologic-findings-and-differential-diagnosis
#6
Mohammed T Lilo, Justin A Bishop, Matthew T Olson, Syed Z Ali
Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes...
October 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29024099/intrathyroidal-carotid-artery-and-nonrecurring-right-recurrent-laryngeal-nerve-a-case-report
#7
Aaron Baker, Elizabeth E Cottrill, Olivia Munizza, Kathryn McGillen, Tyler McKinnon, David Goldenberg
BACKGROUND: When performing thyroidectomy, knowledge of normal anatomy and variants is vital to avoid injuring nearby structures. Typically, the bilateral carotids course posterolateral to the thyroid gland. We describe a rare variant of an intrathyroidal carotid artery, not previously described in the literature. METHODS: A 23-year-old woman with a strong family history of thyroid cancer presented with a left thyroid nodule, and a fine-needle aspiration biopsy revealing papillary thyroid carcinoma...
October 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29022781/near-infrared-autofluorescence-imaging-to-detect-parathyroid-glands-in-thyroid-surgery
#8
R Ladurner, N Al Arabi, U Guendogar, Kkj Hallfeldt, H Stepp, Jks Gallwas
Objective To identify and save parathyroid glands during thyroidectomy by displaying their autofluorescence. Methods Autofluorescence imaging was carried out during thyroidectomy with and without central lymph node dissection. After visual recognition by the surgeon, the parathyroid glands and the surrounding tissue were exposed to near-infrared light with a wavelength of 690-770 nm using a modified Karl Storz near infrared/indocyanine green endoscopic system. Parathyroid tissue was expected to show near infrared autofluorescence at 820 nm, captured in the blue channel of the camera...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29022276/diagnosis-and-treatment-of-tsh-secreting-adenomas-review-of-a-longtime-experience-in-a-reference-center
#9
D M Nazato, J Abucham
PURPOSE: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. METHODS: A series of 11 patients with TSH-secreting and cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. RESULTS: The mean age at diagnosis was 37 years (range 18-80 years; median 23 years); the ratio of male-to-female patients was similar (6M:5F)...
October 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#10
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019001/anaplastic-thyroid-cancer-and-hyperfractionated-accelerated-radiotherapy-hart-with-and-without-surgery
#11
Anne-Birgitte Jacobsen, Krystyna K Grøholt, Bianca Lorntzsen, Terje A Osnes, Ragnhild Sørum Falk, Eva Sigstad
Anaplastic carcinoma of the thyroid gland (ATC) is one of the most aggressive cancers in humans. With insufficient treatment, the disease most often leads to death in suffocation. From 2002, our treatment strategy has been hyperfractionated accelerated radiotherapy (HART) with high doses (64 Gy) to the neck, followed by surgery 4-8 weeks later if feasible, with the aim to gain control in the neck. After a pathology review, 51 patients were diagnosed with ATC in the period 2002-2014 in the south-east of Norway...
October 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29017816/oral-and-dermal-diflubenzuron-exposure-causes-a-hypothalamic-pituitary-thyroid-hpt-axis-disturbance-in-the-mongolian-racerunner-eremias-argus
#12
Jing Chang, Huili Wang, Peng Xu, Baoyuan Guo, Jianzhong Li, Yinghuan Wang, Wei Li
Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kg(-1) DFB once a week for 42 days through oral or dermal routes. Their body weight, plasma thyroid hormone levels, thyroid gland histology and the transcription of hypothalamic-pituitary-thyroid (HPT) axis-related genes in different tissues were assessed to explore the effects of DFB on the HPT axis of lizards...
October 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28993239/regulation-of-nadph-oxidase-nox4-by-delta-iodolactone-il-%C3%AE-in-thyroid-cancer-cells
#13
Thomasz Lisa, Romina Oglio, Leonardo Salvarredi, Marina Perona, Luciano Rossich, Silvia Copelli, Mario Pisarev, Guillermo Juvenal
INTRODUCTION: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, biosynthesized by the thyroid, were postulated as intermediaries in the action of iodide. Among these, iodolactone (IL-δ) and 2-iodohexadecanal (2-IHDA) have shown to inhibit several thyroid parameters. The antiproliferative effect of IL-δ is not restricted to the thyroid gland...
October 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28988434/maternal-and-obstetrical-outcome-in-35-cases-of-well-differentiated-thyroid-carcinoma-during-pregnancy
#14
Jan Boucek, Jorine de Haan, Michael J Halaska, Jan Plzak, Kristel Van Calsteren, Christianne J M de Groot, Karina Dahl Steffensen, Robert Fruscio, Elske T Massolt, Philipp Klaritsch, Paolo Zola, Frédéric Amant
OBJECTIVES/HYPOTHESIS: Thyroid cancer, with 6% to 10% of cancer diagnoses, is one of the most common malignancies during pregnancy. Its treatment poses a risk for the pregnancy, as the thyroid gland plays a crucial role in the evolution of pregnancy. The aim of this study is to evaluate treatment of primary well-differentiated thyroid carcinoma during pregnancy and fetal and maternal outcomes. STUDY DESIGN: This is an international cohort study. METHODS: Primary thyroid cancer patients were identified from the database of the International Network on Cancer, Infertility, and Pregnancy registration study...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988411/how-reliably-can-computed-tomography-predict-thyroid-invasion-prior-to-laryngectomy
#15
Andrew S Harris, Carl D Passant, Duncan R Ingrams
OBJECTIVES/HYPOTHESIS: There is little evidence to support the removal of thyroid tissue during total laryngectomy. Although oncological control of the tumor is the priority, thyroidectomy can lead to hypothyroidism and hypoparathyroidism. This study aimed to test the usefulness of preoperative computed tomography in predicting histological invasion of the thyroid. STUDY DESIGN: Ambispective cohort study. METHODS: All patients undergoing total laryngectomy for squamous cell carcinoma at one center from 2006 to 2016 were included...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28985753/correction-to-breast-cancer-metastases-to-the-thyroid-gland-an-uncommon-sentinel-for-diffuse-metastatic-disease-a-case-report-and-literature-review
#16
Agata M Plonczak, Aimee N DiMarco, Roberto Dina, Dorothy M Gujral, Fausto F Palazzo
No abstract text is available yet for this article.
October 6, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28985747/thyroid-hemiagenesis-and-hashimoto-s-thyroditis-diagnostic-and-treatment-pitfalls
#17
Minghao Wang, Lingmi Hou, Maoshan Chen, Lin Ren, Peng Tang, Yi Zhang, Jun Jiang
BACKGROUND: Thyroid hemiagenesis (TH) is a rare congenital disease with absence of a thyroid lobe; most patients have no clinical symptoms. The etiology of TH remains unclear. In this paper, we describe a rare case of TH and congenital absence of the ipsilateral parathyroid gland, found during the operation, combined with the autoimmune disease Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis. CASE PRESENTATION: A 31-year-old woman was admitted to our hospital because of a mass in the right neck...
October 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28984197/circular-rna-expression-profiles-and-features-in-human-tissues-a-study-using-rna-seq-data
#18
Tianyi Xu, Jing Wu, Ping Han, Zhongming Zhao, Xiaofeng Song
BACKGROUND: Circular RNA (circRNA) is one type of noncoding RNA that forms a covalently closed continuous loop. Similar to long noncoding RNA (lncRNA), circRNA can act as microRNA (miRNA) 'sponges' to regulate gene expression, and its abnormal expression is related to diseases such as atherosclerosis, nervous system disorders and cancer. So far, there have been no systematic studies on circRNA abundance and expression profiles in human adult and fetal tissues. RESULTS: We explored circRNA expression profiles using RNA-seq data for six adult and fetal normal tissues (colon, heart, kidney, liver, lung, and stomach) and four gland normal tissues (adrenal gland, mammary gland, pancreas, and thyroid gland)...
October 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28980762/case-report-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-imaging-of-a-patient-with-multiple-endocrine-gland-metastases-from-small-cell-lung-cancer
#19
Hongguang Zhao, Chenghe Lin, Benzheng Jiao, Ri Sa, Sen Hou, Songbai Xu
Synchronous multiple endocrine gland metastasis caused by small cell lung cancer (SCLC) is rare. A patient was investigated for primary cancer because of suspected brain metastasis on computed tomography (CT). Baseline (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT was positive in the lung and multiple endocrine glands (right thyroid, right breast, pancreatic body, right adrenal gland, and left ovary). Histopathology confirmed small cell lung cancer. The patient's symptoms were alleviated after chemotherapy and brain radiotherapy...
October 5, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28980441/endoscopic-surgery-in-japan-the-12th-national-survey-2012-2013-by-the-japan-society-for-endoscopic-surgery
#20
Toshio Bandoh, Norio Shiraishi, Yuichi Yamashita, Toshiro Terachi, Makoto Hashizume, Shigeo Akira, Toshiaki Morikawa, Yuko Kitagawa, Katsuhiko Yanaga, Shunsuke Endo, Kiyoshi Onishi, Shuji Takiguchi, Yasuhiro Tamaki, Toru Hasegawa, Hiromitsu Mimata, Minoru Tabata, Ryohei Yozu, Masafumi Inomata, Sumio Matsumoto, Seigo Kitano, Masahiko Watanabe
In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and usefulness of endoscopic surgery have been evaluated. With the acceptance of endoscopic surgery as less invasive than open surgery, the number of the endoscopic procedures continues to increase in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has had an important role in the development of endoscopic surgery in Japan...
October 4, 2017: Asian Journal of Endoscopic Surgery
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