keyword
MENU ▼
Read by QxMD icon Read
search

thyroid gland

keyword
https://www.readbyqxmd.com/read/29455549/multiple-endocrine-neoplasia-2a-men-2a-syndrome
#1
J Breza, J Breza
INTRODUCTION: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism. MATERIAL AND METHODS: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification)...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29452667/overview-on-the-management-of-non-gastric-malt-lymphomas
#2
REVIEW
Irene Defrancesco, Luca Arcaini
Extranodal marginal zone B-cell lymphomas (EMZLs) of the mucosa-associated lymphoid tissue (MALT) are indolent lymphomas which can present at any extranodal site. The most frequent localizations (other than stomach) are ocular adnexa, salivary gland, skin, lung and thyroid. Chronic inflammation and antigenic stimulation are a potential risk for the development of MALT lymphomas. While Helicobacter Pylori (HP) is known to be associated with gastric MALT lymphoma and antibiotic therapy is effective in the setting of HP-positive, other microorganisms (such as Chlamydophila Psittaci, Campylobacter Jejiuni, Borrelia Burgdoferi) have been implicated in the pathogenesis of non-gastric MALT lymphomas...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#3
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29449887/role-of-the-t-and-b-lymphocytes-in-pathogenesis-of-autoimmune-thyroid-diseases
#4
Marta Rydzewska, Michał Jaromin, Izabela Elżbieta Pasierowska, Karlina Stożek, Artur Bossowski
Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. The differentiation of CD4+ cells in the specific setting of immune mediators (for example cytokines, chemokines) results in differentiation of various T cell subsets...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29449729/parotid-metastasis-of-renal-cell-carcinoma-mimicking-primary-clear-cell-oncocytoma-report-of-a-case-and-brief-review-of-the-literature
#5
B J Rocca, A Gini, C Calandra, A Ginori, F Crivelli
Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. RCC has an unpredictable behavior and the unique potential to metastasize to nearly every organ in the body. Though not as frequent, metastatic RCC to the head and neck has been identified in the thyroid, salivary glands, skull base, sinuses, pharynx, tonsils, tongue, lip and skin...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449722/current-usefulness-of-aspiration-cytology-fnac-in-the-head-and-neck-diagnosis
#6
S Dallari, P M Gusella, P Campanella, M Ciommi, P Pantanetti, E Tortato, A Castriotta
Background: Fine Needle Aspiration Cytology (FNAC) is a well established and widely used method for both a preliminary and sometime final non-invasive pathologic diagnosis. FNAC is a simple and inexpensive diagnostic tool and should represent the standard of care in developing and resource-poor countries while maintaining its diagnostic usefulness in developed and advanced ones. Methods: The concordance between preoperative FNAC and final histology was evaluated in 168 patients operated on at the Otorhinolaryngology Unit, "A...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29448931/effects-of-different-extracts-of-curcumin-on-tpc1-papillary-thyroid-cancer-cell-line
#7
Angelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito
BACKGROUND: The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014)...
February 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29446693/hyperparathyroidism-mimicking-metastatic-bone-disease-a-case-report-and-review-of-literature
#8
Monica Gupta, Lalita Singhal, Akshay Kumar
Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis...
February 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29445473/graves-disease-coexisting-with-resistance-to-thyroid-hormone-a-rare-case
#9
Hongping Sun, Shuhang Xu, Shaofeng Xie, Wen Cao, Guofang Chen, Hongjie Di, Rendong Zheng, Xingjia Li, Xiaodong Mao, Chao Liu
A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29445392/how-many-parathyroid-glands-can-be-identified-during-thyroidectomy-evidence-based-data-for-medical-experts
#10
Elisabeth Gschwandtner, Rudolf Seemann, Claudia Bures, Lejla Preldzic, Eduard Szucsik, Michael Hermann
Background: The purpose of this study is to provide guidance for medical experts regarding malpractice claims on permanent hypoparathyroidism by analyzing the number of parathyroid glands (PGs) identified during thyroidectomy and the clinical outcome. Methods: Parathyroid findings were documented in a standardized protocol for 357 patients undergoing thyroidectomy and treated by a single specialized surgeon. The resected thyroid was routinely dissected for accidentally removed PGs with consecutive autotransplantation and the pathological report also described unintentionally resected PGs...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29445071/a-case-report-of-thyroid-metastasis-from-p16-positive-oropharyngeal-squamous-cell-carcinoma
#11
Masao Takenobu, Sueyoshi Moritani, Kana Yoshioka, Tsuyoshi Morisaki, Hiroya Kitano
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy...
February 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29443775/primary-undifferentiated-pleomorphic-sarcoma-of-the-thyroid-a-case-report-and-review-of-the-literature
#12
REVIEW
Qiang Chen, Qing Huang, Jia-Xin Yan, Chao Li, Jin-Yi Lang
RATIONALE: Primary undifferentiated pleomorphic sarcoma is extremely rare in the thyroid, and can be easily misdiagnosed as anaplastic thyroid cancer. PATIENT CONCERNS: We present a case of a 71-year-old woman who presented with a rapidly growing painless mass in the neck. DIAGNOSES-INTERVENTIONS-OUTCOMES: Computed tomography showed a large hypointense mass with hyperdense areas involving whole of the right lobe of thyroid gland and fine-needle aspiration cytology found a few atypical cells...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442475/association-of-heterogeneity-of-the-thyroid-gland-with-matrix-metalloproteinase-3-in-rheumatoid-arthritis-patients-with-hashimoto-s-thyroiditis
#13
Toshiki Nagasaki, Yuki Nagata, Yosuke Wakita, Shinsuke Yamada, Hitoshi Goto, Yasuo Imanishi, Naoyoshi Onoda, Masanori Emoto, Masaaki Inaba
PURPOSE: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity. METHODS: Fifty three consecutive RA patients were prospectively separated into two groups on the basis of the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, heterogeneity index (HI) was determined ultrasonographically...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29442352/guidelines-of-polish-national-societies-diagnostics-and-treatment-of-thyroid-carcinoma-2018-update
#14
Barbara Jarząb, Marek Dedecjus, Dorota Słowińska-Klencka, Andrzej Lewiński, Zbigniew Adamczewski, Ryszard Anielski, Maciej Bagłaj, Agata Bałdys-Waligórska, Marcin Barczyński, Tomasz Bednarczuk, Artur Bossowski, Monika Buziak-Bereza, Ewa Chmielik, Andrzej Cichocki, Agnieszka Czarniecka, Rafał Czepczyński, Janusz Dzięcioł, Tomasz Gawlik, Daria Handkiewicz-Junak, Kornelia Hasse-Lazar, Alicja Hubalewska-Dydejczyk, Krystian Jażdżewski, Beata Jurecka-Lubieniecka, Michał Kalemba, Grzegorz Kamiński, Małgorzata Karbownik-Lewińska, Mariusz Klencki, Beata Kos-Kudła, Agnieszka Kotecka-Blicharz, Aldona Kowalska, Jolanta Krajewska, Aleksandra Kropińska, Aleksandra Kukulska, Emilia Kulik, Andrzej Kułakowski, Krzysztof Kuzdak, Dariusz Lange, Aleksandra Ledwon, Elżbieta Lewandowska-Jabłońska, Katarzyna Łącka, Barbara Michalik, Anna Nasierowska-Guttmejer, Janusz Nauman, Marek Niedziela, Ewa Małecka-Tendera, Małgorzata Oczko-Wojciechowska, Tomasz Olczyk, Ewa Paliczka-Cieślik, Lech Pomorski, Zbigniew Puch, Józef Roskosz, Marek Ruchała, Dagmara Rusinek, Stanisław Sporny, Agata Stanek-Widera, Zoran Stojcev, Aleksandra Syguła, Anhelli Syrenicz, Sylwia Szpak-Ulczok, Tomasz Tomkalski, Zbigniew Wygoda, Jan Włoch, Ewa Zembala-Nożyńska
Significant advances have been made in thyroid can-cer research in recent years, therefore relevant clinical guidelines need to be updated. The current Polish guidelines "Diagnostics and Treatment of Thyroid Carcinoma" have been formulated at the "Thyroid Cancer and Other Malignancies of Endocrine Glands" conference held in Wisła in November 2015 [1].
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442081/qualitative-and-quantitative-salivary-changes-and-subjective-oral-dryness-among-patients-with-thyroid-dysfunction
#15
Meghal Mehul Naik, Vaishnavee Vassandacoumara
Context: There is a paucity of literature regarding the effects of thyroid disorders on the oral cavity by influencing the salivary gland function. Aims: This study aims to understand the qualitative and quantitative changes that thyroid disorder can cause in the salivary function. Settings and Design: After obtaining ethical clearance, 46 consecutive newly diagnosed thyroid dysfunction patients were enrolled in this cross-sectional study, along with 45 age-and sex-matched controls...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440273/relationship-between-the-dimerization-of-thyroglobulin-and-its-ability-to-form-triiodothyronine
#16
Cintia E Citterio, Yoshiaki Morishita, Nada Dakka, Balaji Veluswamy, Peter Arvan
Thyroglobulin (TG) is the most abundant thyroid gland protein, a dimeric iodoglycoprotein (660 kDa). TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3). The primary site for T3 synthesis in TG involves an iodotyrosine acceptor at the antepenultimate Tyr residue (at the extreme carboxyl-terminus of the protein). The carboxyl-terminal region of TG is comprised of the CholinEsterase-Like (ChEL) domain followed by a short unique tail sequence...
February 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29436694/lrig1-negatively-regulates-ret-mutants-and-is-downregulated-in-thyroid-cancer
#17
David Lindquist, Fernando C Alsina, Carl Herdenberg, Catharina Larsson, Jo Höppener, Na Wang, Gustavo Paratcha, Miklós Tarján, Tibor Tot, Roger Henriksson, Håkan Hedman
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1 expression levels are associated with patient survival in many cancer types. In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC...
February 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29436670/hypothyroidism-increases-cyclooxygenase-2-levels-and-pro-inflammatory-response-and-decreases-cell-proliferation-and-neuroblast-differentiation-in-the-hippocampus
#18
Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Hyo Young Jung, Jin Young Chung, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
The present study investigated the effects of hypothyroidism on cyclooxygenase-2 (COX-2) and pro‑inflammatory cytokines in the dentate gyrus to elucidate the roles of COX‑2 in the hypothyroid hippocampus. Hypothyroidism was induced in rats by treating with 0.03% 2‑mercapto‑1‑methyl‑imidazole dissolved in drinking water for 5 weeks. The animals were sacrificed at 12 weeks of age. Hypothyroidism rats exhibited decreased triiodothyronine and thyroxine levels in the serum, while the levels of thyroid‑stimulating hormone and the weight of thyroid glands were significantly higher in the hypothyroid rats compared with those in the vehicle‑treated group...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435119/a-dual-mechanism-of-activation-of-the-sonic-hedgehog-pathway-in-anaplastic-thyroid-cancer-crosstalk-with-ras-braf-mek-pathway-and-ligand-secretion-by-tumor-stroma
#19
Alessia Parascandolo, Mikko O Laukkanen, Nancy De Rosa, Clara Ugolini, Maria Carmela Cantisani, Anna Maria Cirafici, Fulvio Basolo, Massimo Santoro, Maria Domenica Castellone
Sonic Hedgehog (Shh) pathway regulates embryonic development of different organs including the thyroid gland. The aberrant activation of Shh signaling has been found in several types of cancer and according to recent evidences it represents an important regulator of tumor-stroma interaction. In this study, we have analyzed expression, activation and molecular mechanisms regulating the Shh pathway and its involvement in the modulation of tumor stroma interaction in anaplastic thyroid cancer (ATC) cells. Our results suggest that Shh signaling undergoes a dual mechanism of induction in ATC cells: 1) a basal non-canonical Smo-dependent activation of Gli transcription factor that is partly caused by interaction with the RAS/BRAF/MEK oncogenic pathway and is characterized by the absence of Shh ligand expression in thyroid cancer cells and 2) a paracrine response of cancer cells to Shh ligand secreted by tumor stroma (fibroblasts and mesenchymal stromal cells, MSCs) inducing cancer cell migration and in vitro tumorigenesis...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29429003/parathyroid-autotransplantation-in-thyroid-surgery
#20
REVIEW
Antonio Sitges-Serra, Leyre Lorente-Poch, Juan Sancho
BACKGROUND: Careful parathyroid gland dissection and in situ preservation was the time-honored approach to prevent parathyroid failure after total thyroidectomy. The relative success of parathyroid autotransplantation of hyperplastic parathyroid tissue in patients with renal or hereditary hyperparathyroidism did popularize the use of normal parathyroid tissue autografts during thyroidectomy to prevent permanent hypoparathyroidism. Proof of autograft function in this setting, however, is controversial...
February 10, 2018: Langenbeck's Archives of Surgery
keyword
keyword
55929
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"