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https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#1
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28515606/gender-based-assessment-of-survival-in-trauma-hemorrhagic-shock-a-retrospective-analysis-of-indian-population
#2
Pankaj Verma, Sanjeev Bhoi, Upendra Baitha, Tej Prakash Sinha, Prakash Ranjan Mishra
INTRODUCTION: Trauma-hemorrhagic shock (THS) is a leading cause of death. Female rats and women experience better outcomes in terms of survival after major trauma as compared to males. There are limited data in Indian population. Authors studied the gender-based outcome of patients with Class IV hemorrhagic shock due to blunt trauma and the distribution of factors among males and females which are known to affect outcome. MATERIALS AND METHODS: It was a retrospective study with data of trauma victims between January 2008 and July 2013...
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28506480/the-epidemiology-of-inpatient-pediatric-trauma-in-united-states-hospitals-2000-to-2011
#3
Jamie Oliver, Jacob Avraham, Spiros Frangos, Sandra Tomita, Charles DiMaggio
BACKGROUND: This study provides important updates to the epidemiology of pediatric trauma in the United States. METHODS: Age-specific epidemiologic analysis of the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample, representing 2.4 million pediatric traumatic injury discharges in the US from 2000 to 2011. We present yearly data with overlying loess smoothing lines, proportions of common injuries and surgical procedures, and survey-adjusted logistic regression analysis...
April 30, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28505080/first-insights-into-human-fingertip-regeneration-by-echo-doppler-imaging-and-wound-microenvironment-assessment
#4
Paris Jafari, Camillo Muller, Anthony Grognuz, Lee Ann Applegate, Wassim Raffoul, Pietro G di Summa, Sébastien Durand
Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the response to tissue loss from a wound repair process towards regeneration. When analyzing by Immunoassay the wound exudate from occlusive dressings, the concentrations of brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates than in burn wounds (used as controls for wound repair versus regeneration)...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28501766/therapeutic-effects-of-zerumbone-in-an-alkali-burned-corneal-wound-healing-model
#5
Jong Won Kim, Hyuneui Jeong, Myeon-Sik Yang, Chae Woong Lim, Bumseok Kim
Cornea is an avascular transparent tissue. Ocular trauma caused by a corneal alkali burn induces corneal neovascularization (CNV), inflammation, and fibrosis, leading to vision loss. The purpose of this study was to examine the effects of Zerumbone (ZER) on corneal wound healing caused by alkali burns in mice. CNV was induced by alkali-burn injury in BALB/C female mice. Topical ZER (three times per day, 3μl each time, at concentrations of 5, 15, and 30μM) was applied to treat alkali-burned mouse corneas for 14 consecutive days...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28501568/polytrauma-induced-hepatic-stress-response-and-the-development-of-liver-insulin-resistance
#6
Robert M Akscyn, J Lee Franklin, Tatyana A Gavrikova, Joseph L Messina
Insulin resistance and metabolic dysfunction are common following injury. Polytrauma is defined as combined injuries to more than one body part or organ system, and is common in modern warfare, as well as automobile and industrial accidents. Polytrauma can include any combination of burn injury, fracture, hemorrhage, trauma to the extremities, and blunt or penetrating trauma. Multiple minor injuries are often more deleterious than a more severe single injury. To investigate the mechanisms of development of insulin resistance following injury, we have developed a rat model of polytrauma which combined soft tissue trauma with burn injury and penetrating gastrointestinal (GI) trauma...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28501385/full-and-partial-thickness-burns-from-spontaneous-combustion-of-e-cigarette-lithium-ion-batteries-with-review-of-literature
#7
Daniela Treitl, Rachele Solomon, Dafney L Davare, Rafael Sanchez, Chauniqua Kiffin
BACKGROUND: In recent years, the use of electronic cigarettes (e-cigarettes) has increased worldwide. Most electronic nicotine delivery systems use rechargeable lithium-ion batteries, which are relatively safe, but in rare cases these batteries can spontaneously combust, leading to serious full and partial thickness burn injuries. Explosions from lithium-ion batteries can cause a flash fire and accelerant-related burn injuries. CASE REPORT: A retrospective chart review was conducted of 3 patients with lithium-ion battery burns seen at our Level I community-based trauma center...
May 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28495236/fireworks-type-injury-pattern-and-permanent-impairment-following-severe-fireworks-related-injuries
#8
Brinkley K Sandvall, Lauren Jacobson, Erin A Miller, Ryan E Dodge, D Alex Quistberg, Ali Rowhani-Rahbar, Monica S Vavilala, Jeffrey B Friedrich, Kari A Keys
BACKGROUND: There is a paucity of clinical data on severe fireworks-related injuries, and the relationship between firework types, injury patterns, and magnitude of impairment is not well understood. Our objective was to describe the relationship between fireworks type, injury patterns, and impairment. METHODS: Retrospective case series (2005-2015) of patients who sustained consumer fireworks-related injuries requiring hospital admission and/or an operation at a Level 1 Trauma/Burn Center...
April 25, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28486306/therapeutic-use-of-stem-cells-in-treatment-of-burn-injuries
#9
Jasmine Z Cheng, Ali Farrokhi, Aziz Ghahary, Reza B Jalili
Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost. Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychologic sequelae. The goal of burn wound healing research is to fully repair and restore skin's original structure and functionality while minimizing problems such as hypertrophic scarring and contracture. One of the ways this can be achieved is through augmentation of the skin's natural healing process using the regenerative capability of stem cells...
May 8, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28484423/evaluation-of-salivary-cytokines-for-diagnosis-of-both-trauma-induced-and-genetic-heterotopic-ossification
#10
Hsiao Hsin Sung Hsieh, Michael T Chung, Ronald M Allen, Kavitha Ranganathan, Joe Habbouche, David Cholok, Jonathan Butts, Arminder Kaura, Ramkumar Tiruvannamalai-Annamalai, Chris Breuler, Caitlin Priest, Shawn J Loder, John Li, Shuli Li, Jan Stegemann, Steven L Kunkel, Benjamin Levi
PURPOSE: Heterotopic ossification (HO) occurs in the setting of persistent systemic inflammation. The identification of reliable biomarkers can serve as an early diagnostic tool for HO, especially given the current lack of effective treatment strategies. Although serum biomarkers have great utility, they can be inappropriate or ineffective in traumatic acute injuries and in patients with fibrodysplasia ossificans progressiva (FOP). Therefore, the goal of this study is to profile the cytokines associated with HO using a different non-invasive source of biomarkers...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28483163/changing-state-of-pediatric-injuries-in-south-africa-an-analysis-of-surveillance-data-from-a-pediatric-emergency-department-from-2007-to-2011
#11
Hadley K H Wesson, Abdulgafoor M Bachani, Patricia Mtambeka, Dorothy Schulman, Chiedza Mavengere, Alastair John Ward Millar, Adnan A Hyder, Arjan Bastiaan van As
BACKGROUND: Pediatric injuries are associated with significant morbidity and mortality, especially in low- and middle-income countries. Data to characterize the cause and risk factors associated with childhood injuries in low- and middle-income countries are very scarce. The aim of this study is to describe the cause of pediatric injuries and their possible changes between 2007 and 2011 using hospital-based data in Cape Town, South Africa. METHODS: Data from injured children <13 years of age who presented to the Red Cross War Memorial Children's Hospital's emergency department in 2007 and 2011 were captured in Childsafe South Africa's trauma surveillance system...
May 5, 2017: Surgery
https://www.readbyqxmd.com/read/28481839/high-ratio-plasma-resuscitation-does-not-improve-survival-in-pediatric-trauma-patients
#12
Jeremy W Cannon, Michael A Johnson, Robert C Caskey, Matthew A Borgman, Lucas P Neff
BACKGROUND: Damage control resuscitation (DCR) including balanced resuscitation with high ratios of plasma (PLAS) and platelets (PLT) to packed red blood cells (PRBC) improves survival in adult patients. We sought to evaluate the effect of a high ratio PLAS to PRBC resuscitation strategy in massively transfused pediatric patients with combat injuries. METHODS: The Department of Defense Trauma Registry (DoDTR) was queried from 2001-2013 for pediatric trauma patients (<18 years)...
May 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28470640/vermeidung-von-feuer-brand-explosion-im-op
#13
Hartmut Gehring, Klaas Rackebrandt
The combination of an oxidant source, ignition energy and flammable material is the reason for fire, burning and explosion (FBE) in the OR. Attending anaesthesiologists face these risks in their daily routine. Mostly, a situation with FBE arises in an unexpected situation. It is essential to have at hand a catalogue of measures to prevent severe injuries to patients and avoid material damages. There is a systematic way to decrease the risk: awareness and definition of high-risk situations; team work; building up a strategy to avoid the occurrence of fire, burning and explosion in high-risk situations...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28467220/myofascial-manual-lymphatic-drainage-for-burn-trauma-a-service-evaluation
#14
Anna Loskotová, Jitka Loskotová, Ivan Suchanek, Pavel Brychta, Bretislav Lipový
Improving microcirculation in the area of a wound is an important aspect of wound healing. It can be improved by a new manual methodology: myofascial-manual lymphatic drainage (M-MLD). This hybrid technique uses elements of musculoskeletal medicine and manual lymphatic drainage. Through palpation, M-MLD therapeutically affects the functional pathology of soft tissues, with reflection in trigger points, and also the functional pathology of lymphatic system, namely by lymphostasis in particular regional lymph nodes...
May 1, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28459270/towards-a-culturally-appropriate-trauma-assessment-in-a-south-african-zulu-community
#15
Thebe Madigoe, Jonathan Burns, Muyu Zhang, Ugasvaree Subramaney
OBJECTIVE: To develop a culture specific screening tool for trauma, and to determine whether it would significantly increase the probability of eliciting traumatic events and associated symptoms when added to a Western diagnostic tool for trauma. METHOD: A convenience sample of 1 hundred Zulu speaking volunteers was recruited in the North-Eastern KwaZulu-Natal region of South Africa. A demographic questionnaire, the Post Traumatic Stress Disorder (PTSD) section of the Structured Clinical Interview for DSM Disorders, Axis I, Research Version (SCID-I RV), and a Zulu Culture-Specific Trauma Experience Questionnaire (Z-CTEQ) designed for this study were administered to the participants...
May 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28459266/trauma-and-mental-health-in-south-africa-overview
#16
Gail E Wyatt, April Thames, Leickness Simbayi, Dan J Stein, Jonathan Burns, Mashudu Maselesele
Provides an introduction to this special edition of Psychological Trauma. The papers included in this special section focus on aspects of trauma and the effects of trauma in a cultural context that pertains to the way of life in South Africa. These articles highlight the complexities of the effects of trauma and call for tailored interventions to address the lasting effects on health and mental health. (PsycINFO Database Record
May 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28458029/heparin-mimetic-peptide-nanofiber-gel-promotes-regeneration-of-full-thickness-burn-injury
#17
Fatih Yergoz, Nurcan Hastar, Cagla Eren Cimenci, Alper Devrim Ozkan, Turgay Tekinay, Mustafa O Guler, Ayse B Tekinay
Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, functional and biodegradable peptide nanofiber gels for the improved healing of burn wounds to alleviate the progressive loss of tissue function at the post-burn wound site. These bioactive nanofiber gels form scaffolds that recapitulate the structure and function of the native extracellular matrix through signaling peptide epitopes, which can trigger angiogenesis through their affinity to basic growth factors...
April 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28457980/reversal-of-trauma-induced-coagulopathy-using-first-line-coagulation-factor-concentrates-or-fresh-frozen-plasma-retic-a-single-centre-parallel-group-open-label-randomised-trial
#18
Petra Innerhofer, Dietmar Fries, Markus Mittermayr, Nicole Innerhofer, Daniel von Langen, Tobias Hell, Gottfried Gruber, Stefan Schmid, Barbara Friesenecker, Ingo H Lorenz, Mathias Ströhle, Verena Rastner, Susanne Trübsbach, Helmut Raab, Benedikt Treml, Dieter Wally, Benjamin Treichl, Agnes Mayer, Christof Kranewitter, Elgar Oswald
BACKGROUND: Effective treatment of trauma-induced coagulopathy is important; however, the optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy using fresh frozen plasma (FFP) or coagulation factor concentrates (CFC) for the reversal of trauma-induced coagulopathy, the arising transfusion requirements, and consequently the development of multiple organ failure. METHODS: This single-centre, parallel-group, open-label, randomised trial was done at the Level 1 Trauma Center in Innsbruck Medical University Hospital (Innsbruck, Austria)...
April 27, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28452901/effect-of-pain-and-analgesia-on-compensatory-reserve
#19
Carmen Hinojosa-Laborde, Jessie Renee D Fernandez, Gary W Muniz, Corinne D Nawn, Rebecca K Burns, Thuan H Le, Kathy B Porter, John T Hardy, Victor A Convertino
BACKGROUND: The measurement of the body's capacity to compensate for reduced blood volume can be assessed with a Compensatory Reserve Measurement (CRM). The CRM, which is calculated from changes in features of the arterial waveform, represents the integration of compensatory mechanisms during states of low tissue perfusion and oxygenation such as hemorrhage. This study was designed to test the hypothesis that pain which activates compensatory mechanisms and analgesia that result in reduced blood pressure are associated with lower compensatory reserve...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28449529/do-hospitals-need-oncological-critical-care-units
#20
EDITORIAL
Abby Koch, William Checkley
Since the inception of critical care as a formal discipline in the late 1950s, we have seen rapid specialization to many types of intensive care units (ICUs) to accommodate evolving life support technologies and novel therapies in various disciplines of medicine. Indeed, the field has expanded such that specialized ICUs currently exist to address critical care problems in medicine, cardiology, neurology and neurosurgery, trauma, burns, organ transplant and cardiothoracic surgeries. Specialization does not only need new infrastructure, but also training and staffing of health care providers, ancillary staff, and development and implementation of processes of care...
March 2017: Journal of Thoracic Disease
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