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Burn and trauma

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https://www.readbyqxmd.com/read/29455343/the-first-isolation-of-westerdykella-dispersa-in-a-critically-burned-patient
#1
Bretislav Lipovy, Iva Kocmanova, Jakub Holoubek, Marketa Hanslianova, Matej Bezdicek, Hana Rihova, Ivan Suchanek, Pavel Brychta
Patients with critical thermal trauma belong to one of the most high-risk groups for development of infectious complications. Fungal infections are not among frequent complications during therapy of patients with thermal trauma, yet their incidence dramatically aggravates the prognosis for patients with this disorder. In the case report, we present the case of a young man with a critical burn, where Westerdykella dispersa was isolated. Identification of the pathogen was provided with a combination of cultivation and molecular biological confirmation...
February 17, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29454710/experiences-of-guilt-shame-and-blame-in-those-affected-by-burns-a-qualitative-systematic-review
#2
REVIEW
Rachel Kornhaber, Charmaine Childs, Michelle Cleary
BACKGROUND: A significant burn can severely impact the lives of survivors and their carers. This systematic review sought to incorporate the experiences of guilt, blame and shame across the lifespan for burn survivors, their families as well as the experiences of the parents of burned children. METHODS: A systematic review of qualitative studies on the experiences and perspectives of guilt, blame and shame by those affected by burn trauma across the lifespan. The databases, Pubmed, Scopus, EMBASE, CINAHL, PsychINFO were systematically searched...
February 14, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29453974/genetically-modified-bone-mesenchymal-stem-cells-with-tgf-%C3%AE-3-improve-wound-healing-and-reduce-scar-tissue-formation-in-a-rabbit-model
#3
Mingyong Li, Lin Qiu, Wei Hu, Xiang Deng, Hanfeng Xu, Youhan Cao, Zijian Xiao, Liangyu Peng, Shawn Johnson, Lyundup Alexey, Paul A Kingston, Qing Li, Yuanyuan Zhang
Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β 3 ), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model...
February 14, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29448962/non-viral-gene-delivery-systems-for-tissue-repair-and-regeneration
#4
REVIEW
Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang, Chunmao Han
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29442525/comparative-analysis-of-mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-dental-pulp-as-sources-of-cell-therapy-for-zone-of-stasis-burns
#5
Ozan Luay Abbas, Orhan Özatik, Zeynep Burçin Gönen, Serdal Öğüt, Fikriye Yasemin Özatik, Hasan Salkın, Ahmet Musmul
INTRODUCTION: The implantation of mesenchymal stem cells (MSCs) has been shown to exert benefits for the survival of the zone-of-stasis. However, the clinical experience indicates the importance of selecting the right source and type of stem cells. Therefore, we planned the current study to perform a quantitative comparison of MSCs isolated from three different sources to provide information useful in selection of the optimal source and to see whether critical mechanisms are conserved between different populations...
February 14, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29439775/right-ventricular-fractional-area-of-change-is-predictive-of-ventilator-support-days-in-trauma-and-burn-patients
#6
Duraid Younan, David C Pigott, C Blayke Gibson, John P Gullett, Ahmed Zaky
Echocardiography has contributed to the care of critically ill patients but there remains a need for more publications about its association with outcomes to confirm its role. We conducted a retrospective review of trauma and burn patients that were admitted to our intensive care unit between 2015 and 2017 that underwent hemodynamic transesophageal echocardiography. Data collected included demographics, clinical and laboratory data. Right ventricle fractional area of change (RVFAC) measurements were performed on still mages obtained from mid-esophageal four-chamber-view clips...
February 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29438815/new-onset-squamous-cell-carcinoma-in-previous-split-thickness-skin-graft-donor-site
#7
Vincent J Noori, Kanika Trehan, Alisa Savetamal, Damien W Carter
INTRODUCTION: Marjolin' s ulcer, an aggressive ulcerating squamous cell carcinoma, is a well-known phenomenon that occurs in chronically inflamed or scarred tissue; however, squamous cell carcinoma arising in the acute setting after tissue trauma - specifically autograft donor harvest sites for burns - is a rare, but notable event. METHODS: This case series describes three instances of squamous cell carcinoma diagnosed in split-thickness skin graft donor sites in the immediate post-operative period...
February 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29437639/soluble-gpvi-is-elevated-in-injured-patients-shedding-is-mediated-by-fibrin-activation-of-gpvi
#8
Samantha J Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios, Robert J Dinsdale, Christine S-M Lee, Natalie S Poulter, Robert K Andrews, Peter Hampson, Christopher M Wearn, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Woei Ming Lee, Tariq Iqbal, Naiem Moiemen, Steve P Watson, Cécile Oury, Paul Harrison, Elizabeth E Gardiner
Soluble glycoprotein VI (sGPVI) is shed from the platelet surface and is a marker of platelet activation in thrombotic conditions. We assessed sGPVI levels together with patient and clinical parameters in acute and chronic inflammatory conditions, including patients with thermal injury and inflammatory bowel disease and patients admitted to the intensive care unit (ICU) for elective cardiac surgery, trauma, acute brain injury, or prolonged ventilation. Plasma sGPVI was measured by enzyme-linked immunosorbent assay and was elevated on day 14 after thermal injury, and was higher in patients who developed sepsis...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29436882/type-d-personality-and-elevated-psychological-symptoms-in-early-adjustment-of-severe-burn-injury-patients
#9
Ajdin Mujezinovic, Julia Kwiet, Rachel Kornhaber, Rachael Holt, Jeffrey Streimer, John Vandervord, Vanessa Rogers, Joanne Shaw, Jeremy Law, Michelle Cleary, Loyola McLean
Severe burn injuries are highly traumatic requiring lengthy recovery. High levels of distress in the early stages of treatment have been associated with poor physical and psychosocial recovery outcomes. Identifying traits relating to distress and personal coping styles may aid screening. Type-D, or 'distressed', personality may be such a trait. Type-D personality refers to an ongoing personality organization defined by a tendency to experience greater negative emotions and thoughts while simultaneously socially inhibiting their expression (Denollet et al...
February 13, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29430145/nasal-reconstruction-with-silicone-using-customised-impression-technique
#10
Sanath Shetty, Fahad Mohammed, Janavi Kamath, K Kamalakanth Shenoy
Facial defects can result from a variety of reasons including trauma, burns, infections, congenital disorders, and neoplasms which require surgical correction or prosthetic rehabilitation or both. Prosthetic replacement using various materials is the treatment of choice when other surgical options are not possible. This report presents a case of acquired nasal defect secondary to a surgically operated adenoid cystic carcinoma using silicone as the material of choice.
January 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29427450/reconstruction-of-the-plantar-toe-with-a-distal-reverse-instep-sensory-island-flap
#11
Mohammad Ali Hosseinian, Ali Gharibi Loron, Behzad Nemati Honar
BACKGROUND: Plantar toe ulcers are a challenging surgical problem. There are several methods for reconstruction, but no attention has been given to the preservation of sensation. This report proposes a method to provide protective sensation for the reconstructed area. PATIENTS AND METHODS: The ulcers of seven patients ranged from 2 × 3 to 7 × 3 cm with defects of the plantar first toe and distal metatarsus, including four burns, a trauma, a diabetic ulcer, and a neuropathy injury reconstructed with a distal reverse instep sensory island (DRISI) flap...
February 10, 2018: Microsurgery
https://www.readbyqxmd.com/read/29417308/burn-induced-multiple-organ-injury-and-protective-effect-of-lutein-in-rats
#12
Huda O AbuBakr, Samira H Aljuaydi, Shimaa M Abou-Zeid, Amanallah El-Bahrawy
Thermal injury may lead to multiple organ dysfunction through release of proinflammatory mediators and reactive oxygen radicals. This study investigated the effects of thermal injury on remote organs of rats and the possible protective effect of lutein. Thermal trauma was induced in the back of rats by exposing them to 90 °C bath for 10 s. Rats were sacrificed 48 h after burn, and blood samples were collected to monitor liver and kidney functions. Tissue samples from liver, kidneys, and lungs were taken for studying oxidative stress parameters, gene expressions of TNF-α and Casp-3, besides histopathological examination...
February 7, 2018: Inflammation
https://www.readbyqxmd.com/read/29411494/post-pyloric-feeding-tube-placement-in-critically-ill-patients-extending-the-scope-of-practice-for-australian-dietitians
#13
Rosalie Yandell, Marianne Chapman, Stephanie O'Connor, Alison Shanks, Kylie Lange, Adam Deane
AIM: To determine whether the placement of a post-pyloric feeding tube (PPFT) can be taught safely and effectively to a critical care dietitian. METHODS: This is a prospective observational study conducted in an adult intensive care unit (ICU). The intervention consisted of 19 attempts at post-pyloric intubation by the dietitian. The 10 'learning' attempts were performed by the dietitian under the direction of an experienced (having completed in excess of 50 successful tube placements) user...
February 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29403192/use-of-the-conut-index-as-a-predictor-of-integration-of-cutaneous-grafts-in-burn-patients
#14
Jaime Aron Garcia-Espinoza, Verónica Belem Aguilar-Aragón, Sergio García-Méndez
Objective: To present the initial experience of 12 patients with burns treated with cutaneous grafts and to analyse the variables that influence their integration. Materials and Methods: We analysed data from 12 patients seen in a year in the regional hospital of high speciality of Oaxaca. Quantified variables: Age, sex, burned body surface, depth of burn, airway injury, nutritional status by CONUT index, type of graft, development of local infection and days of hospital stay...
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29402688/respiratory-oxygen-uptake-is-associated-with-survival-in-a-cohort-of-ventilated-trauma-and-burn-patients
#15
Duraid Younan, Chee Paul Lin, Robert Johnson, Robert Clark, Lisa Smith, Jean-Francois Pittet, Mali Mathru, David W Miller
BACKGROUND: Little data is available in the literature about the role of end tidal oxygen in critically ill patients. We sought to identify the association between the level of respiratory oxygen and clinical outcomes in critically-ill ventilated trauma and burn patients. METHODS: A retrospective cohort of 55 trauma and burn patients from 2010 to 2016 was collected. Exposures of interest included a) expiratory end tidal oxygen (ETO2) and b) the difference between FiO2 and ETO2 (uptake)...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29400077/severe-unintentional-injuries-to-ohio-children-what-we-should-be-addressing-at-well-child-visits
#16
Victoria M Wurster Ovalle, Wendy J Pomerantz, Michael A Gittelman
This was a retrospective study examining severe injuries to Ohio children in order to provide pediatricians with targeted injury talking points at well visits. We included children ≤14 years old from the Ohio Trauma Acute Care Registry with severe unintentional injuries from January 1, 2003, to December 31, 2012. There were 45 347 patients; 611 died, and the mean age was 6.8 years. Fractures/dislocations were common (46.6%), and many injuries occurred at home (49.1%). In children ≤2 years old, the leading causes of injury were falls and burns/fire; falls and motor vehicle collisions (MVCs) predominated above this age...
February 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/29395761/cyanide-poisoning-is-a-possible-cause-of-cardiac-arrest-among-fire-victims-and-empiric-antidote-treatment-may-improve-outcomes
#17
Yasuhiko Kaita, Takehiko Tarui, Takahiro Shoji, Hiroshi Miyauchi, Yoshihiro Yamaguchi
BACKGROUND: Carbon monoxide and cyanide poisoning are important causes of death due to fire. Carbon monoxide is more regularly assessed than cyanide at the site of burn or smoke inhalation treatment due to its ease in assessment and simplicity to treat. Although several forensic studies have demonstrated the significance of cyanide poisoning in fire victims using blood cyanide levels, the association between the cause of cardiac arrest and the concentration of cyanide among fire victims has not been sufficiently investigated...
January 22, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29395411/are-we-headed-for-a-shortage-of-burn-care-providers-in-canada
#18
Sebastian Q Vrouwe, Marc G Jeschke, Joel S Fish
INTRODUCTION: Specialized burn care is categorized as an essential component in the criteria for provincial/state and regional trauma systems. Studies in the United States and New Zealand found a need for more burn surgeons and anticipated a severe shortage in the future. The purpose of this study is to describe the current active workforce of burn surgeons in Canada and forecast any perceived shortages in the future. METHODS: Burn care providers were identified from each metropolitan area across Canada...
January 29, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29395410/risk-factors-for-burn-injuries-and-fire-safety-awareness-among-patients-hospitalized-at-a-public-hospital-in-nairobi-kenya-a-case-control-study
#19
Joseph K Wanjeri, Mary Kinoti, Tom H A M Olewe
INTRODUCTION: Burn injuries are some of the most physically and psychologically devastating forms of trauma and most common injuries affecting children, especially in the home environment. They are more prevalent and are a public health problem in developing countries mainly because of poor socio-economic conditions. Effective prevention programs should be guided by the results of well-designed studies aimed at investigating risk factors for burns. STUDY OBJECTIVE: To establish the risk factors for burn injuries among patients hospitalized at the Kenyatta National Hospital (KNH)...
January 29, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29395396/measuring-serum-albumin-levels-at-0-and-24h-effect-on-the-accuracy-of-clinical-evaluations-in-the-prediction-of-burn-related-mortality
#20
Hassan Rafiezadeh Shahi, Mehrdad Vahedian, Mitra Movahedi, Kambiz Bahaadinbeigy, Morteza Hashemian, Amirhossein Mirafzal
OBJECTIVES: To evaluate whether measuring serum albumin levels in clinical assessments affects the accuracy of mortality predictions in large burns and to compare patients' serum albumin levels at hour 0(Alb0h) and hour 24(Alb24h) following their admission. METHODS: This prospective observational study was performed at an academic burn unit. Aged between 16 and 65, patients who presented with burns on more than 20% of total body surface area (%TBSA) were included...
January 27, 2018: Burns: Journal of the International Society for Burn Injuries
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